Visualization analysis of microfluidics research status_Journal of Biomedical Engineering

Authors：

WEI Wei ¹ , WU Ruijun ¹ , SANG Xiaodong ¹ , LIANG Tianyu ² , LI Zhifei ¹ , LI Zhi ¹ , YANG Yang ¹ ,  SU Yue ¹

1. China National Center for Biotechnology Development, Beijing 100039, P. R. China;
2. Supervision Service Center for Science and Technology Funds, Ministry of Science and Technology, Beijing 100038, P. R. China;

Corresponding author：

SU Yue, Email: suyue@cncbd.org.cn

Keywords：

Microfluidics; CiteSpace; Bibliometrics; In vitro diagnostic

DOI：

10.7507/1001-5515.202201054

Video：

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Microfluidics is the science and technology to manipulate small amounts of fluids in micro/nano-scale space. Multiple modules could be integrated into microfluidic device, and due to its advantages of microminiaturization and controllability, microfluidics has drawn extensive attention since its birth. In this paper, the literature data related to microfluidics research from January 1, 2006 to December 31, 2021 were obtained from Web of Science Core Collection database. CiteSpace 5.8.R3 software was used for bibliometrics analysis, so as to explore the research progress and development trends of microfluidics research at home and abroad. Based on the analysis of 50 129 articles, it could be seen that microfluidics was a hot topic of global concern, and the United States had a certain degree of authority in this field. Massachusetts Institute of Technology and Harvard University not only had a high number of publications, but also had strong influence and extensive cooperation network. Combined with ultrasonic, surface modification and sensor technology, researchers constructed paper-based microfluidic, droplet microfluidic and digital microfluidic platforms, which were applied in the field of immediate diagnosis, nucleic acid and circulating tumor cell analysis of in vitro diagnosis and organ-on-a-chip. China was one of the countries with a high level of research in the field of microfluidics, while the industrialization of high-end products needed to be improved. As people’s demand for disease risk prediction and health management increased, promoting microfluidic technological innovation and achievement transformation is of great significance to safeguard people’s life and health.

Citation： WEI Wei, WU Ruijun, SANG Xiaodong, LIANG Tianyu, LI Zhifei, LI Zhi, YANG Yang, SU Yue. Visualization analysis of microfluidics research status. Journal of Biomedical Engineering, 2022, 39(3): 551-560. doi: 10.7507/1001-5515.202201054 Copy

1.	Reyes D R, Iossifidis D, Auroux P A, et al. Micro total analysis systems. 1. Introduction, theory, and technology. Anal Chem 2002, 74(12): 2623-2636.
2.	Yager P, Edwards T, Fu E, et al. Microfluidic diagnostic technologies for global public health. Nature, 2006, 442(7101): 412-418.
3.	El-Ali J, Sorger P K, Jensen K F. Cells on chips. Nature, 2006, 442(7101): 403-411.
4.	DeMello A J. Control and detection of chemical reactions in microfluidic systems. Nature, 2006, 442(7101): 394-402.
5.	Sackmann E K, Fulton A L, Beebe D J. The present and future role of microfluidics in biomedical research. Nature, 2014, 507(7491): 181-189.
6.	Research and Markets. Microfluidic Device Systems - Global Market Trajectory & Analytics (2021-04) [2022-01-25]. https://www.researchandmarkets.com/reports/4806479/microfluidic-device-systems-global-market#rela4-5449009.
7.	栾春娟, 侯海燕, 王贤文. 国际科技政策研究热点与前沿的可视化分析. 科学学研究, 2009, 27(2): 240-243.
8.	陈悦, 陈超美, 刘则渊, 等. CiteSpace知识图谱的方法论功能. 科学学研究, 2015, 33(2): 242-253.
9.	Lien K Y, Hung L Y, Huang T B, et al. Rapid detection of influenza A virus infection utilizing an immunomagnetic bead-based microfluidic system. Biosens Bioelectron, 2011, 26(9): 3900-3907.
10.	Wu M H, Huang S B, Lee G B. Microfluidic cell culture systems for drug research. Lab Chip, 2010, 10(8): 939-956.
11.	Su C H, Tsai M H, Lin C Y, et al. Dual aptamer assay for detection of Acinetobacter baumannii on an electromagnetically-driven microfluidic platform. Biosens Bioelectron, 2020, 159: 112148.
12.	Nawar S, Stolaroff J K, Ye C, et al. Parallelizable microfluidic dropmakers with multilayer geometry for the generation of double emulsions. Lab Chip, 2020, 20(1): 147-154.
13.	Lu H, Mutafopulos K, Heyman J A, et al. Rapid additive-free bacteria lysis using traveling surface acoustic waves in microfluidic channels. Lab Chip, 2019, 19(24): 4064-4070.
14.	Klein A M, Mazutis L, Akartuna I, et al. Droplet barcoding for single-cell transcriptomics applied to embryonic stem cells. Cell, 2015, 161(5): 1187-1201.
15.	Chakraborty S. Electroosmotically driven capillary transport of typical non-Newtonian biofluids in rectangular microchannels. Anal Chim Acta, 2007, 605(2): 175-184.
16.	Chakraborty S. Electrokinetics with blood. Electrophoresis, 2019, 40(1): 180-189.
17.	Virumbrales-Muñoz M, Ayuso J M, Gong M M, et al. Microfluidic lumen-based systems for advancing tubular organ modeling. Chem Soc Rev, 2020, 49(17): 6402-6442.
18.	Nichol J W, Koshy S T, Bae H, et al. Cell-laden microengineered gelatin methacrylate hydrogels. Biomaterials, 2010, 31(21): 5536-5544.
19.	Sun W, Luo Z, Lee J, et al. Organ-on-a-chip for cancer and immune organs modeling. Adv Healthc Mater, 2019, 8(4): e1801363.
20.	Nasiri R, Shamloo A, Ahadian S, et al. Microfluidic-based approaches in targeted cell/particle separation based on physical properties: Fundamentals and applications. Small, 2020, 16(29): e2000171.
21.	Whitesides G M. The origins and the future of microfluidics. Nature, 2006, 442(7101): 368-373.
22.	Teh S Y, Lin R, Hung L H, et al. Droplet microfluidics. Lab Chip, 2008, 8(2): 198-220.
23.	Bhatia S N, Ingber D E. Microfluidic organs-on-chips. Nat Biotechnol, 2014, 32(8): 760-772.
24.	Yetisen A K, Akram M S, Lowe C R. Paper-based microfluidic point-of-care diagnostic devices. Lab Chip, 2013, 13(12): 2210-2251.
25.	Martinez A W, Phillips S T, Wiley B J, et al. FLASH: a rapid method for prototyping paper-based microfluidic devices. Lab Chip, 2008, 8(12): 2146-2150.
26.	Chin C D, Linder V, Sia S K. Lab-on-a-chip devices for global health: past studies and future opportunities. Lab Chip, 2007, 7(1): 41-57.
27.	Song H, Chen D L, Ismagilov R F. Reactions in droplets in microfluidic channels. Angew Chem Int Ed Engl, 2006, 45(44): 7336-7356.
28.	Shang L, Cheng Y, Zhao Y. Emerging droplet microfluidics. Chem Rev, 2017, 117(12): 7964-8040.
29.	Martinez A W, Phillips S T, Whitesides G M, et al. Diagnostics for the developing world: microfluidic paper-based analytical devices. Anal Chem, 2010, 82(1): 3-10.
30.	Cate D M, Adkins J A, Mettakoonpitak J, et al. Recent developments in paper-based microfluidic devices. Anal Chem, 2015, 87(1): 19-41.
31.	Dittrich P S, Tachikawa K, Manz A. Micro total analysis systems. Latest advancements and trends. Anal Chem, 2006, 78(12): 3887-3908.
32.	陈超瑜, 马妍, 方群. 微流控器官芯片的研究进展. 分析化学, 2019, 47(11): 1711-1720.
33.	Emulate. Emulate endorses the FDA modernization act of 2021 (2021-12-07) [2022-01-25]. https: //emulatebio.com/fda-modernization-act/.
34.	Si L L, Bai H Q, Rodas M, et al. A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics. Nat Biomed Eng, 2021, 5(8): 815-829.
35.	Wang Y Q, Wang L, Zhu Y J, et al. Human brain organoid-on-a-chip to model prenatal nicotine exposure. Lab Chip, 2018, 18(6): 851-860.
36.	Park S E, Georgescu A, Huh D. Organoids-on-a-chip. Science, 2019, 364(6444): 960-965.
37.	Sun F, Ganguli A, Nguyen J, et al. Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract. Lab Chip, 2020, 20(9): 1621-1627.
38.	Chen C A, Yeh W S, Tsai T T, et al. Three-dimensional origami paper-based device for portable immunoassay applications. Lab Chip, 2019, 19(4): 598-607.
39.	Li X, Qin Z, Fu H, et al. Enhancing the performance of paper-based electrochemical impedance spectroscopy nanobiosensors: An experimental approach. Biosens Bioelectron, 2021, 177: 112672.
40.	Vogelstein B, Kinzler K W. Digital PCR. Proc Natl Acad Sci U S A, 1999, 96(16): 9236-9241.
41.	Hao N J, Zhang J X J. Microfluidic screening of circulating tumor biomarkers toward liquid biopsy. Sep Purif Rev, 2018, 47(1): 19-48.
42.	Zhang P, Zhou X, He M, et al. Ultrasensitive detection of circulating exosomes with a 3D-nanopatterned microfluidic chip. Nat Biomed Eng, 2019, 3(6): 438-451.
43.	Miccio L, Cimmino F, Kurelac I, et al. Perspectives on liquid biopsy for label-free detection of "circulating tumor cells" through intelligent lab-on-chips. View, 2020, 1(3): 20200034.
44.	唐曲, 胡文琪, 陈欢欢, 等. 微流控技术在循环肿瘤细胞异质性分析领域的应用. 中国科学: 化学, 2022, 52(1): 52-70.
45.	Yu M, Xu L, Tian F, et al. Rapid transport of deformation-tuned nanoparticles across biological hydrogels and cellular barriers. Nat Commun, 2018, 9(1): 2607.
46.	Cui P, Wang S. Application of microfluidic chip technology in pharmaceutical analysis: A review. J Pharm Anal, 2019, 9(4): 238-247.
47.	Miao L, Li L, Huang Y, et al. Delivery of mRNA vaccines with heterocyclic lipids increases anti-tumor efficacy by STING-mediated immune cell activation. Nat Biotechnol, 2019, 37(10): 1174-1185.
48.	Battat S, Weitz D A, Whitesides G M. An outlook on microfluidics: the promise and the challenge. Lab Chip, 2022, 22(3): 530-536.

1. Reyes D R, Iossifidis D, Auroux P A, et al. Micro total analysis systems. 1. Introduction, theory, and technology. Anal Chem 2002, 74(12): 2623-2636.
2. Yager P, Edwards T, Fu E, et al. Microfluidic diagnostic technologies for global public health. Nature, 2006, 442(7101): 412-418.
3. El-Ali J, Sorger P K, Jensen K F. Cells on chips. Nature, 2006, 442(7101): 403-411.
4. DeMello A J. Control and detection of chemical reactions in microfluidic systems. Nature, 2006, 442(7101): 394-402.
5. Sackmann E K, Fulton A L, Beebe D J. The present and future role of microfluidics in biomedical research. Nature, 2014, 507(7491): 181-189.
6. Research and Markets. Microfluidic Device Systems - Global Market Trajectory & Analytics (2021-04) [2022-01-25]. https://www.researchandmarkets.com/reports/4806479/microfluidic-device-systems-global-market#rela4-5449009.
7. 栾春娟, 侯海燕, 王贤文. 国际科技政策研究热点与前沿的可视化分析. 科学学研究, 2009, 27(2): 240-243.
8. 陈悦, 陈超美, 刘则渊, 等. CiteSpace知识图谱的方法论功能. 科学学研究, 2015, 33(2): 242-253.
9. Lien K Y, Hung L Y, Huang T B, et al. Rapid detection of influenza A virus infection utilizing an immunomagnetic bead-based microfluidic system. Biosens Bioelectron, 2011, 26(9): 3900-3907.
10. Wu M H, Huang S B, Lee G B. Microfluidic cell culture systems for drug research. Lab Chip, 2010, 10(8): 939-956.
11. Su C H, Tsai M H, Lin C Y, et al. Dual aptamer assay for detection of Acinetobacter baumannii on an electromagnetically-driven microfluidic platform. Biosens Bioelectron, 2020, 159: 112148.
12. Nawar S, Stolaroff J K, Ye C, et al. Parallelizable microfluidic dropmakers with multilayer geometry for the generation of double emulsions. Lab Chip, 2020, 20(1): 147-154.
13. Lu H, Mutafopulos K, Heyman J A, et al. Rapid additive-free bacteria lysis using traveling surface acoustic waves in microfluidic channels. Lab Chip, 2019, 19(24): 4064-4070.
14. Klein A M, Mazutis L, Akartuna I, et al. Droplet barcoding for single-cell transcriptomics applied to embryonic stem cells. Cell, 2015, 161(5): 1187-1201.
15. Chakraborty S. Electroosmotically driven capillary transport of typical non-Newtonian biofluids in rectangular microchannels. Anal Chim Acta, 2007, 605(2): 175-184.
16. Chakraborty S. Electrokinetics with blood. Electrophoresis, 2019, 40(1): 180-189.
17. Virumbrales-Muñoz M, Ayuso J M, Gong M M, et al. Microfluidic lumen-based systems for advancing tubular organ modeling. Chem Soc Rev, 2020, 49(17): 6402-6442.
18. Nichol J W, Koshy S T, Bae H, et al. Cell-laden microengineered gelatin methacrylate hydrogels. Biomaterials, 2010, 31(21): 5536-5544.
19. Sun W, Luo Z, Lee J, et al. Organ-on-a-chip for cancer and immune organs modeling. Adv Healthc Mater, 2019, 8(4): e1801363.
20. Nasiri R, Shamloo A, Ahadian S, et al. Microfluidic-based approaches in targeted cell/particle separation based on physical properties: Fundamentals and applications. Small, 2020, 16(29): e2000171.
21. Whitesides G M. The origins and the future of microfluidics. Nature, 2006, 442(7101): 368-373.
22. Teh S Y, Lin R, Hung L H, et al. Droplet microfluidics. Lab Chip, 2008, 8(2): 198-220.
23. Bhatia S N, Ingber D E. Microfluidic organs-on-chips. Nat Biotechnol, 2014, 32(8): 760-772.
24. Yetisen A K, Akram M S, Lowe C R. Paper-based microfluidic point-of-care diagnostic devices. Lab Chip, 2013, 13(12): 2210-2251.
25. Martinez A W, Phillips S T, Wiley B J, et al. FLASH: a rapid method for prototyping paper-based microfluidic devices. Lab Chip, 2008, 8(12): 2146-2150.
26. Chin C D, Linder V, Sia S K. Lab-on-a-chip devices for global health: past studies and future opportunities. Lab Chip, 2007, 7(1): 41-57.
27. Song H, Chen D L, Ismagilov R F. Reactions in droplets in microfluidic channels. Angew Chem Int Ed Engl, 2006, 45(44): 7336-7356.
28. Shang L, Cheng Y, Zhao Y. Emerging droplet microfluidics. Chem Rev, 2017, 117(12): 7964-8040.
29. Martinez A W, Phillips S T, Whitesides G M, et al. Diagnostics for the developing world: microfluidic paper-based analytical devices. Anal Chem, 2010, 82(1): 3-10.
30. Cate D M, Adkins J A, Mettakoonpitak J, et al. Recent developments in paper-based microfluidic devices. Anal Chem, 2015, 87(1): 19-41.
31. Dittrich P S, Tachikawa K, Manz A. Micro total analysis systems. Latest advancements and trends. Anal Chem, 2006, 78(12): 3887-3908.
32. 陈超瑜, 马妍, 方群. 微流控器官芯片的研究进展. 分析化学, 2019, 47(11): 1711-1720.
33. Emulate. Emulate endorses the FDA modernization act of 2021 (2021-12-07) [2022-01-25]. https: //emulatebio.com/fda-modernization-act/.
34. Si L L, Bai H Q, Rodas M, et al. A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics. Nat Biomed Eng, 2021, 5(8): 815-829.
35. Wang Y Q, Wang L, Zhu Y J, et al. Human brain organoid-on-a-chip to model prenatal nicotine exposure. Lab Chip, 2018, 18(6): 851-860.
36. Park S E, Georgescu A, Huh D. Organoids-on-a-chip. Science, 2019, 364(6444): 960-965.
37. Sun F, Ganguli A, Nguyen J, et al. Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract. Lab Chip, 2020, 20(9): 1621-1627.
38. Chen C A, Yeh W S, Tsai T T, et al. Three-dimensional origami paper-based device for portable immunoassay applications. Lab Chip, 2019, 19(4): 598-607.
39. Li X, Qin Z, Fu H, et al. Enhancing the performance of paper-based electrochemical impedance spectroscopy nanobiosensors: An experimental approach. Biosens Bioelectron, 2021, 177: 112672.
40. Vogelstein B, Kinzler K W. Digital PCR. Proc Natl Acad Sci U S A, 1999, 96(16): 9236-9241.
41. Hao N J, Zhang J X J. Microfluidic screening of circulating tumor biomarkers toward liquid biopsy. Sep Purif Rev, 2018, 47(1): 19-48.
42. Zhang P, Zhou X, He M, et al. Ultrasensitive detection of circulating exosomes with a 3D-nanopatterned microfluidic chip. Nat Biomed Eng, 2019, 3(6): 438-451.
43. Miccio L, Cimmino F, Kurelac I, et al. Perspectives on liquid biopsy for label-free detection of "circulating tumor cells" through intelligent lab-on-chips. View, 2020, 1(3): 20200034.
44. 唐曲, 胡文琪, 陈欢欢, 等. 微流控技术在循环肿瘤细胞异质性分析领域的应用. 中国科学: 化学, 2022, 52(1): 52-70.
45. Yu M, Xu L, Tian F, et al. Rapid transport of deformation-tuned nanoparticles across biological hydrogels and cellular barriers. Nat Commun, 2018, 9(1): 2607.
46. Cui P, Wang S. Application of microfluidic chip technology in pharmaceutical analysis: A review. J Pharm Anal, 2019, 9(4): 238-247.
47. Miao L, Li L, Huang Y, et al. Delivery of mRNA vaccines with heterocyclic lipids increases anti-tumor efficacy by STING-mediated immune cell activation. Nat Biotechnol, 2019, 37(10): 1174-1185.
48. Battat S, Weitz D A, Whitesides G M. An outlook on microfluidics: the promise and the challenge. Lab Chip, 2022, 22(3): 530-536.

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Visualization analysis of microfluidics research status

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