The Value of Multi-voxel Proton Magnetic Resonance Spectroscopy Imaging in Assessing the Degree of Glioma Resection_West China Medical Journal

Authors：

LI Xiuli ,  XU Guohui , REN Jing , YANG Yujie , WANG Min , ZHOU Peng , CAO Ying.

Department of Radiology, Sichuan Cancer Hospital, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

XU Guohui, Email: lixiuli217814@163.com

Keywords：

磁共振波谱; 胶质瘤; 术后; 切除程度

DOI：

10.7507/1002-0179.20130539

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

目的　探讨3D-多体素磁共振波谱（MRS）在评估脑胶质瘤手术切除程度的价值。方法　对2011年6月－2012年4月32例脑胶质瘤患者术后行常规MRI及MRS检查，测定分析手术周边区域主要代谢产物N-乙酰天门冬氨酸（NAA）、胆碱（Cho）、肌酸（Cr）、Cho/NAA、Cho/Cr及NAA/Cr比值，对术后胶质瘤切除程度进行评价。同时通过术后病理检查结果评估肿瘤切除程度，再与MRS评估结果相比较。结果　32例中病理评估为9例全切除，23例为大部分切除；MRS评估为11例全切除，21例为大部分切除，评估结果与术后病理评估结果差异无统计学意义（P＞0.05）。结论　MRS可以无创评价胶质瘤切除程度，为胶质瘤预后判定及进一步治疗提供了重要的依据。

Citation： LI Xiuli,XU Guohui,REN Jing,YANG Yujie,WANG Min,ZHOU Peng,CAO Ying.. The Value of Multi-voxel Proton Magnetic Resonance Spectroscopy Imaging in Assessing the Degree of Glioma Resection. West China Medical Journal, 2013, 28(11): 1708-1711. doi: 10.7507/1002-0179.20130539 Copy

1.	Horská A, Barker PB, Imaging of brain tumors: MR Spectroscopy and metabolic imaging[J]. Neuroimaging Clin N Am, 2010, 20(3): 293-310.
2.	魏海港, 李传亭. 氢质子磁共振波谱成像在脑肿瘤中的临床应用[J].医学像学杂志, 2006, 16(8): 839-842.
3.	Croteau D, Scarpace L, Hearshen D, et al. Correlation between magnetic resonance spectroscopy imaging and image-guided biopsies: semiquantitative and qualitative histopathological analyses of patients with untreated glioma[J]. Neurosurgery, 2001, 49(4): 823-829.
4.	纪邦启, 宋磊, 刘斌. 1H-MRS 在脑胶质瘤诊断及分级中的应用[J]. 中国中西医结合影像学杂志, 2008, 6(4): 247-250.
5.	Arnold DL, Shoubridge EA, Villemure JG, et al. Proton and phosphorus magnetic resonance spectroscopy of human astrocytomas in vivo. Preliminary observations on tumor grading[J]. NMR Biomed 1990, 3(4): 184-189.
6.	Barker PB. N-acetyl aspartate: a neuronal marker?[J]. Ann Neurol, 2001, 49(4): 423-424.
7.	Yamasaki F, Kurisu k, Kajiwara Y, et al. Magnetic resonance spectroscopic detection of lactate is predictive of a poor prognosis in patients with diffuse intrinsic pontine glioma[J]. Neuro-Oncol, 2011, 13(7): 791-801.
8.	Florian CL, Preece NE, Bhakoo KK, et al. Cell type specific finger printing of meningioma and meningiomal cells by proton nuclear magnetic resonance spectroscopy[J]. Cancer Res, 1995, 55(1): 420-424.
9.	Payne GS, Leach MO. Applications of magnetic resonance spectroscopy in radiotherapy treatment planning[J]. Br J Radiol, 2006(79): S16-S26.
10.	Robertson PL. Advances in treatment of pediatric brain tumors. NeuroRx, 2006, 3(2): 276-291.
11.	Burtscher IM, Skagerberg G, Geijer B, et al. Proton MR spectroscopy and preoperative diagnostic accuracy: an evaluation of intracranial mass lesions characterized by stereotactic biopsy findings[J]. AJNR, 2000, 21(1): 84-93.
12.	Narayana A, Chang J, Thakur S, et al. Use of MR spectroscopy and functional imaging in the treatment planning of gliomas[J]. Br J Radiol 2007, 80(953): 374-354.
13.	Di Costanzo A, Scarabino T, Trojsi F, et al. Multiparametric 3T MR approach to the assessment of cerebral gliomas: tumor extent and malignancy[J]. Neuroradiology, 2006, 48(9): 622-631.

1. 　Horská A, Barker PB, Imaging of brain tumors: MR Spectroscopy and metabolic imaging[J]. Neuroimaging Clin N Am, 2010, 20(3): 293-310.
2. 　魏海港, 李传亭. 氢质子磁共振波谱成像在脑肿瘤中的临床应用[J].医学像学杂志, 2006, 16(8): 839-842.
3. 　Croteau D, Scarpace L, Hearshen D, et al. Correlation between magnetic resonance spectroscopy imaging and image-guided biopsies: semiquantitative and qualitative histopathological analyses of patients with untreated glioma[J]. Neurosurgery, 2001, 49(4): 823-829.
4. 　纪邦启, 宋磊, 刘斌. 1H-MRS 在脑胶质瘤诊断及分级中的应用[J]. 中国中西医结合影像学杂志, 2008, 6(4): 247-250.
5. 　Arnold DL, Shoubridge EA, Villemure JG, et al. Proton and phosphorus magnetic resonance spectroscopy of human astrocytomas in vivo. Preliminary observations on tumor grading[J]. NMR Biomed 1990, 3(4): 184-189.
6. 　Barker PB. N-acetyl aspartate: a neuronal marker?[J]. Ann Neurol, 2001, 49(4): 423-424.
7. 　Yamasaki F, Kurisu k, Kajiwara Y, et al. Magnetic resonance spectroscopic detection of lactate is predictive of a poor prognosis in patients with diffuse intrinsic pontine glioma[J]. Neuro-Oncol, 2011, 13(7): 791-801.
8. 　Florian CL, Preece NE, Bhakoo KK, et al. Cell type specific finger printing of meningioma and meningiomal cells by proton nuclear magnetic resonance spectroscopy[J]. Cancer Res, 1995, 55(1): 420-424.
9. 　Payne GS, Leach MO. Applications of magnetic resonance spectroscopy in radiotherapy treatment planning[J]. Br J Radiol, 2006(79): S16-S26.
10. 　Robertson PL. Advances in treatment of pediatric brain tumors. NeuroRx, 2006, 3(2): 276-291.
11. 　Burtscher IM, Skagerberg G, Geijer B, et al. Proton MR spectroscopy and preoperative diagnostic accuracy: an evaluation of intracranial mass lesions characterized by stereotactic biopsy findings[J]. AJNR, 2000, 21(1): 84-93.
12. 　Narayana A, Chang J, Thakur S, et al. Use of MR spectroscopy and functional imaging in the treatment planning of gliomas[J]. Br J Radiol 2007, 80(953): 374-354.
13. 　Di Costanzo A, Scarabino T, Trojsi F, et al. Multiparametric 3T MR approach to the assessment of cerebral gliomas: tumor extent and malignancy[J]. Neuroradiology, 2006, 48(9): 622-631.

West China Medical Journal

The Value of Multi-voxel Proton Magnetic Resonance Spectroscopy Imaging in Assessing the Degree of Glioma Resection

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content