Relationship between Peripheral Neuropathy and Anti-Ro/La in Patients with Primary Sjögren Syndrome_West China Medical Journal

Authors：

CHENG Jia , WU Rui.

Department of Rheumatology, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu, Sichuan 610072, P. R. China;

Corresponding author：

Keywords：

原发性干燥综合征; 周围神经病变; 干燥综合征A型抗体; 干燥综合征B型抗体

DOI：

10.7507/1002-0179.20130588

Video：

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目的　探讨原发性干燥综合征周围神经病变的发生与干燥综合征A型/B型抗体（抗SSA/SSB抗体）的关系。方法　纳入2009年1月－2011年12月期间门诊及住院收治的原发性干燥综合征患者88例。所有患者均接受神经系统检查，采用蛋白质印迹法检测抗SSA抗体和抗SSB抗体，利用全自动化学发光仪检测血清维生素B12水平。结果　88例原发性干燥综合征患者中有27例（30.7%）存在周围神经病变。有或无周围神经病变的患者在年龄、性别、病程等一般情况方面无明显不同。有周围神经病变和无周围神经病变的原发性干燥综合征患者抗SSA抗体阳性率分别为70.4%（19/27）、70.5%（43/61），差异无统计学意义（χ2=0.000，P=0.991）；抗SSA/SSB抗体双阳性率分别为63.0%（17/27）、14.8%（9/61），差异有统计学意义（χ2=17.416，P=0.000）；血清维生素B12水平分别为（390 ± 55）、（410 ± 86）pg/dL，差异无统计学意义（t=0.908，P=0.370）。结论　周围神经病变在原发性干燥综合征患者中较常见，且周围神经病变的发生多伴随血清抗SSA/SSB抗体阳性。

Citation： CHENG Jia,WU Rui.. Relationship between Peripheral Neuropathy and Anti-Ro/La in Patients with Primary Sjögren Syndrome. West China Medical Journal, 2013, 28(12): 1862-1864. doi: 10.7507/1002-0179.20130588 Copy

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2.	Brito-Zerón P, Akasbi M, Bosch X, et al. Classification and characterisation of peripheral neuropathies in 102 patients with primary Sjögren’ s syndrome[J]. Clin Exp Rheumatol, 2012, 31(1): 103-110.
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6.	Tzioufas AG, Wassmuth R, Dafni UG, et al. Clinical, immunological, and immunogenetic aspects of autoantibody production against Ro/SSA, La/SSB and their linear epitopes in primary Sjögren’s syndrome (pSS): a European multicentre study[J]. Ann Rheum Dis, 2002, 61(5): 398-404.
7.	Goëb V, Salle V, Duhaut P, et al. Clinical significance of autoantibodies recognizing Sjögren’s syndrome A(SSA), SSB, calpastatin and alpha-fodrin in primary Sjögren’s syndrome[J]. Clin Exp Immunol, 2007, 148(2): 281-287.
8.	中华医学会风湿病学分会. 干燥综合征诊治指南(草案)[J]. 中华风湿病学杂志, 2003, 7(7): 446-448.
9.	Smoleńska Z, Pawłowska J, Zdrojewski Z, et al. Increased percentage of CD8+CD28- T cells correlates with clinical activity in primary Sjögren’s syndrome[J]. Cell Immunol, 2012, 278(1-2): 143-151.
10.	杨美兰, 刘云, 张志, 等. 原发性干燥综合征并神经系统损害22例临床分析[J]. 海南医学, 2008, 19(9): 113, 119.
11.	董怡, 赵岩, 郭晓萍. 原发性干燥综合征诊断标准的初步研究[J]. 中华内科杂志, 1996, 35(2): 114-117.
12.	Gono T, Kawaguchi Y, Katsumata Y, et al. Clinical manifestations of neurological involvement in primary Sjögren’s syndrome[J]. Clin Rheumatol, 2011, 30(4): 485-490.
13.	Pavlakis PP, Alexopoulos H, Kosmidis ML, et al. Peripheral neuropathies in Sjögren syndrome: a new reappraisal[J]. J Neurol Neurosurg Psychiat, 2011, 82(7): 798-802.
14.	Chai J, Herrmann DN, Stanton M, et al. Painful small-fiber neuropathy in Sjogren syndrome[J]. Neurology, 2005, 65(6): 925-927.
15.	Dali-Youcef N, Andrès E. An update on cobalamin deficiency in adults[J]. QJM, 2009, 102(1): 17-28.
16.	Lorber M, Gershwin ME, Shoenfeld Y. The coexistence of systemic lupus erythematosus with other autoimmune diseases: the kaleidoscope of autoimmunity[J]. Semin Arthritis Rheum, 1994, 24(2): 105-113.

1. 　Yamashita H, Eri T, Ueda Y, et al. Diagnosis and treatment of primary Sjögren syndrome-associated peripheral neuropathy: a six-case series[J/OL]. Mod Rheumatol, 2012. http://link.springer.com/content/pdf/10.1007%2Fs10165-012-0767-x.pdf.
2. 　Brito-Zerón P, Akasbi M, Bosch X, et al. Classification and characterisation of peripheral neuropathies in 102 patients with primary Sjögren’ s syndrome[J]. Clin Exp Rheumatol, 2012, 31(1): 103-110.
3. 　Youinou P, Pers JO. Latest update on the primary Sjögren’s syndrome[J]. Presse Med, 2012, 41(9 Pt 2): e437-e439.
4. 　郝慧琴, 黄烽. 原发性干燥综合征系统表现及其临床治疗进展[J]. 中华风湿病学杂志, 2006, 10(1): 49-52.
5. 　Tzioufas AG, Tatouli IP, Moutsopoulos HM. Autoantibodies in Sjögren’s syndrome: clinical presentation and regulatory mechanisms[J]. Presse Med, 2012, 41(9 Pt 2): e451-e460.
6. 　Tzioufas AG, Wassmuth R, Dafni UG, et al. Clinical, immunological, and immunogenetic aspects of autoantibody production against Ro/SSA, La/SSB and their linear epitopes in primary Sjögren’s syndrome (pSS): a European multicentre study[J]. Ann Rheum Dis, 2002, 61(5): 398-404.
7. 　Goëb V, Salle V, Duhaut P, et al. Clinical significance of autoantibodies recognizing Sjögren’s syndrome A(SSA), SSB, calpastatin and alpha-fodrin in primary Sjögren’s syndrome[J]. Clin Exp Immunol, 2007, 148(2): 281-287.
8. 　中华医学会风湿病学分会. 干燥综合征诊治指南(草案)[J]. 中华风湿病学杂志, 2003, 7(7): 446-448.
9. 　Smoleńska Z, Pawłowska J, Zdrojewski Z, et al. Increased percentage of CD8+CD28- T cells correlates with clinical activity in primary Sjögren’s syndrome[J]. Cell Immunol, 2012, 278(1-2): 143-151.
10. 　杨美兰, 刘云, 张志, 等. 原发性干燥综合征并神经系统损害22例临床分析[J]. 海南医学, 2008, 19(9): 113, 119.
11. 　董怡, 赵岩, 郭晓萍. 原发性干燥综合征诊断标准的初步研究[J]. 中华内科杂志, 1996, 35(2): 114-117.
12. 　Gono T, Kawaguchi Y, Katsumata Y, et al. Clinical manifestations of neurological involvement in primary Sjögren’s syndrome[J]. Clin Rheumatol, 2011, 30(4): 485-490.
13. 　Pavlakis PP, Alexopoulos H, Kosmidis ML, et al. Peripheral neuropathies in Sjögren syndrome: a new reappraisal[J]. J Neurol Neurosurg Psychiat, 2011, 82(7): 798-802.
14. 　Chai J, Herrmann DN, Stanton M, et al. Painful small-fiber neuropathy in Sjogren syndrome[J]. Neurology, 2005, 65(6): 925-927.
15. 　Dali-Youcef N, Andrès E. An update on cobalamin deficiency in adults[J]. QJM, 2009, 102(1): 17-28.
16. 　Lorber M, Gershwin ME, Shoenfeld Y. The coexistence of systemic lupus erythematosus with other autoimmune diseases: the kaleidoscope of autoimmunity[J]. Semin Arthritis Rheum, 1994, 24(2): 105-113.

West China Medical Journal

Relationship between Peripheral Neuropathy and Anti-Ro/La in Patients with Primary Sjögren Syndrome

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