紧密连接蛋白-3与肿瘤_West China Medical Journal

Authors：

 冯璐 ¹ , 胡晓松 ² ,  李娟 ³

1. ;
2. ;
3. ;

Corresponding author：

冯璐, Email: 524261326@qq.com; 李娟, Email: juanjuan0609@sohu.com

Keywords：

紧密连接蛋白-3; 肿瘤; 产气荚膜梭菌肠毒素受体

DOI：

10.7507/1002-0179.20150678

Video：

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Abstract Full text Figures/Tables Video References Cited by

紧密连接蛋白-3（Claudin-3）是参与细胞间紧密连接构成的重要蛋白分子，具有维持上皮细胞及内皮细胞的屏障功能，并对细胞旁物质选择渗透性和细胞极化等重要生理功能有决定作用。近来研究发现，锌指转录因子、表皮生长因子等信号分子参与调节Claudin-3的基因表达，而Claudin-3蛋白的异常表达与多种恶性肿瘤的发生发展有着密切关系。现对Claudin-3分子在多种肿瘤中的表达情况及可能的作用进行综述。

Citation： 冯璐, 胡晓松, 李娟. 紧密连接蛋白-3与肿瘤. West China Medical Journal, 2015, 30(12): 2360-2363. doi: 10.7507/1002-0179.20150678 Copy

1.	Furuse M, Fujita K, Hiiragi T, et al. Claudin-1 and -2:novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin[J]. J Cell Biol, 1998, 141(7):1539-1550.
2.	Schneeberger EE, Lynch RD. The tight junction:a multifunctional complex[J]. Am J Physiol Cell Physiol, 2004, 286(6):C1213-C1228.
3.	English DP, Santin AD. Claudins overexpression in ovarian cancer:potential targets for Clostridium Perfringens Enterotoxin (CPE) based diagnosis and therapy[J]. Int J Mol Sci, 2013, 14(5):10412-10437.
4.	Günzel D, Yu AS. Claudins and the modulation of tight junction permeability[J]. Physiol Rev, 2013, 93(2):525-569.
5.	Ionescu Popescu C, Liliac L, Ceauşu RA, et al. CLDN3 expression and significance-breast carcinoma versus ovarian carcinoma[J]. Rom J Morphol Embryol, 2013, 54(1):99-106.
6.	Twiss F, Oldenkamp M, Hiemstra A, et al. HGF signaling regulates Claudin-3 dynamics through its C-terminal tyrosine residues[J]. Tissue Barriers, 2013, 1(4):e27425.
7.	Mccole DF. Phosphatase regulation of intercellular junctions[J]. Tissue Barriers, 2013, 1(5):e26713.
8.	Guntaka SR, Samak G, Seth A, et al. Epidermal growth factor protects the apical junctional complexes from hydrogen peroxide in bile duct epithelium[J]. Lab Invest, 2011, 91(9):1396-1409.
9.	Ogawa M, Kojima T, Someya M, et al. Epidermal growth factor modulates claudins and tight junctional functions in ovarian cancer cell lines[J]. Histochem Cell Biol, 2012, 138(2):323-338.
10.	Yamauchi K, Rai T, Kobayashi K, et al. Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins[J]. Proc Natl Acad Sci USA, 2004, 101(13):4690-4694.
11.	Pan XY, Wang B, Che YC, et al. Expression of claudin-3 and claudin-4 in normal, hyperplastic, and malignant endometrial tissue[J]. Int J Gynecol Cancer, 2007, 17(1):233-241.
12.	Kobayashi K, Oyama S, Numata A, et al. Lipopolysaccharide disrupts the milk-blood barrier by modulating claudins in mammary alveolar tight junctions[J]. PLoS One, 2013, 8(4):e62187.
13.	Kwon MJ, Kim SS, Choi YL, et al. Derepression of CLDN3 and CLDN4 during ovarian tumorigenesis is associated with loss of repressive histone modifications[J]. Carcinogenesis, 2010, 31(6):974-983.
14.	Casagrande F, Cocco E, Bellone S, et al. Eradication of chemotherapy-resistant CD44⁺ human ovarian cancer stem cells in mice by intraperitoneal administration of clostridium perfringens enterotoxin[J]. Cancer, 2011, 117(24):5519-5528.
15.	Yoshida H, Sumi T, Zhi X, et al. Claudin-4:a potential therapeutic target in chemotherapy-resistant ovarian cancer[J]. Anticancer Res, 2011, 31(4):1271-1277.
16.	Huang YH, Bao Y, Peng W, et al. Claudin-3 gene silencing with siRNA suppresses ovarian tumor growth and metastasis[J]. Proc Natl Acad Sci USA, 2009, 106(9):3426-3430.
17.	Shang X, Lin X, Alvarez E, et al. Tight junction proteins claudin-3 and claudin-4 control tumor growth and metastases[J]. Neoplasia, 2012, 14(10):974-985.
18.	Long H, Crean CD, Lee WH, et al. Expression of clostridium perfringens enterotoxin receptors claudin-3 and claudin-4 in prostate cancer epithelium[J]. Cancer Res, 2001, 61(21):7878-7881.
19.	Sheehan GM, Kallakury BV, Sheehan CE, et al. Loss of claudins-1 and -7 and expression of claudins-3 and -4 correlate with prognostic variables in prostatic adenocarcinomas[J]. Hum Pathol, 2007, 38(4):564-569.
20.	Bartholow TL, Chandran UR, Becich MJ, et al. Immunohistochemical profiles of claudin-3 in primary and metastatic prostatic adenocarcinoma[J]. Diagn Pathol, 2011, 6:12.
21.	郭振营,马军. Claudin-1、Claudin-3在胃癌组织中的表达及意义[J]. 山东医药, 2009, 49(1):55-56.
22.	Oliveira SS, Morgado-Díaz JA. Claudins:multifunctional players in epithelial tight junctions and their role in cancer[J]. Cell Mol Life Sci, 2007, 64(1):17-28.
23.	De Souza WF, Fortunato-Miranda N, Robbs BK, et al. Claudin-3 overexpression increases the malignant potential of colorectal cancer cells:roles of ERK1/2 and PI3K-Akt as modulators of EGFR signaling[J]. PLoS One, 2013, 8(9):e74994.
24.	Montgomery E, Mamelak AJ, Gibson M, et al. Overexpression of claudin proteins in esophageal adenocarcinoma and its precursor lesions[J]. Appl Immunohistochem Mol Morphol, 2006, 14(1):24-30.
25.	韩凤艳, 刘爱东. 喉鳞癌组织中Claudin-3和E-cad表达的临床意义[J]. 中国老年学杂志, 2011, 31(2):202-203.
26.	Soini Y. Expression of claudins l, 2, 3, 4, 5 and 7 in various types of tumours[J]. Histopathology, 2005, 46(5):551-560.
27.	李娟, 涂媛, 蒋莉莉, 等. Snail和Claudin-3在非小细胞肺癌中的表达及意义[J]. 中国肺癌杂志, 2012(10):583-590.
28.	Yuan X, Lin X, Manorek G, et al. Recombinant CPE fused to tumor necrosis factor targets human ovarian cancer cells expressing the claudin-3 and claudin-4 receptors[J]. Mol Cancer Ther, 2009, 8(7):1906-1915.
29.	Takahashi A, Kondoh M, Yagi K. Non-invasive drug delivery system with the claudin binder[J]. Yakugaku Zasshi, 2011, 131(11):1583-1587.

1. Furuse M, Fujita K, Hiiragi T, et al. Claudin-1 and -2:novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin[J]. J Cell Biol, 1998, 141(7):1539-1550.
2. Schneeberger EE, Lynch RD. The tight junction:a multifunctional complex[J]. Am J Physiol Cell Physiol, 2004, 286(6):C1213-C1228.
3. English DP, Santin AD. Claudins overexpression in ovarian cancer:potential targets for Clostridium Perfringens Enterotoxin (CPE) based diagnosis and therapy[J]. Int J Mol Sci, 2013, 14(5):10412-10437.
4. Günzel D, Yu AS. Claudins and the modulation of tight junction permeability[J]. Physiol Rev, 2013, 93(2):525-569.
5. Ionescu Popescu C, Liliac L, Ceauşu RA, et al. CLDN3 expression and significance-breast carcinoma versus ovarian carcinoma[J]. Rom J Morphol Embryol, 2013, 54(1):99-106.
6. Twiss F, Oldenkamp M, Hiemstra A, et al. HGF signaling regulates Claudin-3 dynamics through its C-terminal tyrosine residues[J]. Tissue Barriers, 2013, 1(4):e27425.
7. Mccole DF. Phosphatase regulation of intercellular junctions[J]. Tissue Barriers, 2013, 1(5):e26713.
8. Guntaka SR, Samak G, Seth A, et al. Epidermal growth factor protects the apical junctional complexes from hydrogen peroxide in bile duct epithelium[J]. Lab Invest, 2011, 91(9):1396-1409.
9. Ogawa M, Kojima T, Someya M, et al. Epidermal growth factor modulates claudins and tight junctional functions in ovarian cancer cell lines[J]. Histochem Cell Biol, 2012, 138(2):323-338.
10. Yamauchi K, Rai T, Kobayashi K, et al. Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins[J]. Proc Natl Acad Sci USA, 2004, 101(13):4690-4694.
11. Pan XY, Wang B, Che YC, et al. Expression of claudin-3 and claudin-4 in normal, hyperplastic, and malignant endometrial tissue[J]. Int J Gynecol Cancer, 2007, 17(1):233-241.
12. Kobayashi K, Oyama S, Numata A, et al. Lipopolysaccharide disrupts the milk-blood barrier by modulating claudins in mammary alveolar tight junctions[J]. PLoS One, 2013, 8(4):e62187.
13. Kwon MJ, Kim SS, Choi YL, et al. Derepression of CLDN3 and CLDN4 during ovarian tumorigenesis is associated with loss of repressive histone modifications[J]. Carcinogenesis, 2010, 31(6):974-983.
14. Casagrande F, Cocco E, Bellone S, et al. Eradication of chemotherapy-resistant CD44⁺ human ovarian cancer stem cells in mice by intraperitoneal administration of clostridium perfringens enterotoxin[J]. Cancer, 2011, 117(24):5519-5528.
15. Yoshida H, Sumi T, Zhi X, et al. Claudin-4:a potential therapeutic target in chemotherapy-resistant ovarian cancer[J]. Anticancer Res, 2011, 31(4):1271-1277.
16. Huang YH, Bao Y, Peng W, et al. Claudin-3 gene silencing with siRNA suppresses ovarian tumor growth and metastasis[J]. Proc Natl Acad Sci USA, 2009, 106(9):3426-3430.
17. Shang X, Lin X, Alvarez E, et al. Tight junction proteins claudin-3 and claudin-4 control tumor growth and metastases[J]. Neoplasia, 2012, 14(10):974-985.
18. Long H, Crean CD, Lee WH, et al. Expression of clostridium perfringens enterotoxin receptors claudin-3 and claudin-4 in prostate cancer epithelium[J]. Cancer Res, 2001, 61(21):7878-7881.
19. Sheehan GM, Kallakury BV, Sheehan CE, et al. Loss of claudins-1 and -7 and expression of claudins-3 and -4 correlate with prognostic variables in prostatic adenocarcinomas[J]. Hum Pathol, 2007, 38(4):564-569.
20. Bartholow TL, Chandran UR, Becich MJ, et al. Immunohistochemical profiles of claudin-3 in primary and metastatic prostatic adenocarcinoma[J]. Diagn Pathol, 2011, 6:12.
21. 郭振营,马军. Claudin-1、Claudin-3在胃癌组织中的表达及意义[J]. 山东医药, 2009, 49(1):55-56.
22. Oliveira SS, Morgado-Díaz JA. Claudins:multifunctional players in epithelial tight junctions and their role in cancer[J]. Cell Mol Life Sci, 2007, 64(1):17-28.
23. De Souza WF, Fortunato-Miranda N, Robbs BK, et al. Claudin-3 overexpression increases the malignant potential of colorectal cancer cells:roles of ERK1/2 and PI3K-Akt as modulators of EGFR signaling[J]. PLoS One, 2013, 8(9):e74994.
24. Montgomery E, Mamelak AJ, Gibson M, et al. Overexpression of claudin proteins in esophageal adenocarcinoma and its precursor lesions[J]. Appl Immunohistochem Mol Morphol, 2006, 14(1):24-30.
25. 韩凤艳, 刘爱东. 喉鳞癌组织中Claudin-3和E-cad表达的临床意义[J]. 中国老年学杂志, 2011, 31(2):202-203.
26. Soini Y. Expression of claudins l, 2, 3, 4, 5 and 7 in various types of tumours[J]. Histopathology, 2005, 46(5):551-560.
27. 李娟, 涂媛, 蒋莉莉, 等. Snail和Claudin-3在非小细胞肺癌中的表达及意义[J]. 中国肺癌杂志, 2012(10):583-590.
28. Yuan X, Lin X, Manorek G, et al. Recombinant CPE fused to tumor necrosis factor targets human ovarian cancer cells expressing the claudin-3 and claudin-4 receptors[J]. Mol Cancer Ther, 2009, 8(7):1906-1915.
29. Takahashi A, Kondoh M, Yagi K. Non-invasive drug delivery system with the claudin binder[J]. Yakugaku Zasshi, 2011, 131(11):1583-1587.

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