Analysis on the Correlation of Thrombopoietin and Anti-thrombopoietin Antibody with Thrombocytopenia in Patients with Primary Sjören Syndrome_West China Medical Journal

Authors：

 WuTong ,  ZhouBin , LongLi , ZhangJing

Department of Rheumatology, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu, Sichuan 610072, P. R. China;

Corresponding author：

ZhouBin, Email: bingb2917@163.com

Keywords：

Primary Sjö; gren syndrome; Thrombocytopenia; Thrombopoietin; Anti-thrombopoietin antibody

DOI：

10.7507/1002-0179.201600237

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Objective To analyze the correlation of thrombopoietin (TPO) and anti-TPO antibody with thrombocytopenia in patients with primary Sjögren syndrome (PSS). Methods We included in our study 40 PSS patients with thrombocytopenia (group A), 22 PSS patients who once had thrombocytopenia and returned to normal (group B), 40 PSS patients with normal platelet counts (group C) and 40 healthy controls (group D) between September 2013 and October 2014. Anti-TPO antibody was detected by indirect enzyme-linked immunosorbent assay (ELISA), and serum TPO levels were measured by ELISA. We analyzed the relationship between the assay results and the clinical manifestations and parameters. Results The serum TPO levels in groups A, B, and C were (129.74±17.47) , (330.23±18.07) and (364.19±12.25) pg/mL, respectively, and they were significantly higher than that in group D [(54.04±10.71) pg/mL] (P ＜ 0.05) . The serum level of TPO was positively correlated with CRP and IgA (r_s=0.224, P=0.039; r_s=0.239, P=0.033) , and was negatively correlated with C4 level (r_s=?0.220, P=0.041) , but it was not significantly correlated with platelet count, erythrocyte sedimentation rate, the level of antiphospholipid antibodies and the titer of antinuclear antibodies (P ＞ 0.05) . The positive rate of PSS patients was 20.59% (21/102) and the rate in groups A, B, and C was respectively 17.5% (7/40) , 22.72% (5/22) , and 22.5% (9/40) . There was no statistically significant difference between the positive and negative groups in various clinical indexes (P ＞ 0.05) . Conclusion AntiTPO antibody may not be the main mechanism of thrombocytopenia in PSS patients, and there is a certain correlation between TPO and inflammatory factors.

Citation： WuTong, ZhouBin, LongLi, ZhangJing. Analysis on the Correlation of Thrombopoietin and Anti-thrombopoietin Antibody with Thrombocytopenia in Patients with Primary Sjören Syndrome. West China Medical Journal, 2016, 31(5): 871-874. doi: 10.7507/1002-0179.201600237 Copy

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1. 青玉凤, 周京国, 杨明辉, 等. 原发性干燥综合征伴血液系统损害的临床分析[J]. 中华风湿病学杂志, 2009, 13(2) :117-119.
2. 兰丽敏. 原发性干燥综合征血液系统损害临床分析[J]. 河北中医, 2011, 33(9) : 1421-1423.
3. 王景, 宣磊, 董振华. 原发性干燥综合征合并血液系统损害研究概况[J]. 医学研究杂志, 2015, 44(3) : 169-171.
4. 苏江, 朱静, 周彬. 原发性干燥综合征血液系统损害与免疫学指标的相关性分析[J]. 西部医学, 2009, 21(11) : 1943-1944.
5. 谢雯. 原发性干燥综合征血液系统损害临床特点[J]. 现代实用医学, 2002, 14(8) : 409-410.
6. 程永静, 王芳, 张春媚, 等. 干燥综合征血液系统损害与免疫学及各临床指标的相关性分析[J]. 中国临床保健杂志, 2011, 14(3) : 230-231.
7. 任立敏, 何菁. 韩聚方, 等. 原发性干燥综合征合并血细胞减少临床分析[C]//首届全国中青年风湿病学学术大会论文汇编. 北京: 中华医学会风湿病学分会, 2004: 10.
8. 董怡. 论2002年干燥综合征分类(诊断)标准[J]. 中华风湿病学杂志, 2003, 7(1) : 1-2.
9. Kuter DJ, Begley CG. Recombinant human thrombopoietin: basic biology and evaluation of clinical studies[J]. Blood, 2002, 100(10) : 3457-3469.
10. Kaushansky K. Molecular mechanisms of thrombopoietin signaling[J]. Thromb Haemost, 2009, 7(Suppl 1) : 235-238.
11. 徐亮, 王元, 陈顺乐, 等. 系统性红斑狼疮血小板减少患者巨核祖细胞分化障碍[J]. 上海医学, 2004, 27(10) : 739-742, 791.
12. 罗雄燕, 武丽君, 吴凤霞, 等. 巨核细胞增殖与分化障碍在系统性红斑狼疮伴发血小板减少中的作用[J]. 中华临床医师杂志: 电子版, 2010, 4(2) : 150-153.
13. Vadhan-Raj S. Clinical experience with recombinant human thrombopoietin in chemotherapy-induced thrombocytopenia[J]. Semin Hematol, 2000, 37(2, 4) : 28-34.
14. 华宝来, 赵永强, 朱铁楠, 等. 血小板减少患者皮下注射重组人血小板生成素后抗体生成的动态监测[J]. 血栓与止血学, 2005, 11(2) : 59-61.
15. Füreder W, Firbas U, Nichol JL, et al. Serum thrombopoietin levels and anti-thrombopoietin antibodies in systemic lupus erythematosus[J]. Lupus, 2002, 11(4) : 221-226.
16. Ziakas PD, Routsias JG, Giannouli S, et al. Suspects in the tale of lupus-associated thrombocytopenia[J]. Clin Exp Immunol, 2006, 65(2) : 363.
17. Ziakas PD, Papadaki H, Psyllaki M, et al. Anti-thrombopoietin anti-bodies suppress megakaryocytic colony formation in vitro in patients with systemic lupus erythaematosus[J]. Ann Rheum Dis, 2008, 67(11) : 1643-1644.
18. 吴侗, 周彬, 龙丽, 等. 干燥综合征患者抗血小板生成素受体抗体与血小板减少的相关性研究[J]. 实用医院临床杂志, 2014, 11(2) : 63-66.
19. Lu C, Nossent J. Thrombopoietin levels in systemic lupus erythematosus are linked to inflammatory cytokines, but unrelated to thrombocytopenia or thrombosis[J]. Lupus, 2015, 24(1) : 18-24.

West China Medical Journal

Analysis on the Correlation of Thrombopoietin and Anti-thrombopoietin Antibody with Thrombocytopenia in Patients with Primary Sjören Syndrome

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