Diagnosis and treatment of emergency complications after oocyte retrieval with assisted reproductive technology_West China Medical Journal

Authors：

YANG Yihong ¹ , CHEN Hanxiao ² , XU Jiawen ² ,  QIN Lang ¹

1. Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University / Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education; Chengdu, Sichuan 610041, P. R. China;
2. West China School of Medicine, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

QIN Lang, Email: cacier@126.com

Keywords：

Assisted reproductive technology; Emergency complication; Ovarian hyperstimulation syndrome

DOI：

10.7507/1002-0179.201705090

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To retrospectively analyze the emergency complications of the patients after oocyte retrieval with assisted reproductive technology (ART), and analyze the corresponding strategies. Methods The clinical data of patients after oocyte retrieval with ART between January and December 2016 were retrospectively anayzed. The postoperative emergency complications were observed. Results A total of 5 013 patients were included in the study. The common emergency complications after oocyte retrieval included vaginal bleeding in 137 cases (2.73%) , ovarian hyperstimulation syndrome (OHSS) in 35 (0.69%), hematuria caused by bladder injury in 11 cases (0.21%), pelvic infection in 3 (0.06%), and vagal reflex in 2 (0.04%). OHSS was related to age, the number of basal follicles, the number of oviposaccharides and the estradiol level on the day of human chorionic gonadotropin injection, but not related to the body mass index and the number of days of gonadotropin use; which might be misdiagnosed most likely. Conclusions OHSS is one of the common and severe emergency complications after oocyte retrieval with ART, which should be concerned. Active treatment of complications is helpful to reduce the incidence of emergency complications after oocyte retrieval with ART.

Citation： YANG Yihong, CHEN Hanxiao, XU Jiawen, QIN Lang. Diagnosis and treatment of emergency complications after oocyte retrieval with assisted reproductive technology. West China Medical Journal, 2017, 32(6): 828-832. doi: 10.7507/1002-0179.201705090 Copy

1.	于传鑫, 李儒芝. 妇科内分泌疾病治疗学. 上海: 复旦大学出版社, 2009: 2.
2.	刘风华, 杨业洲, 张松英, 等. 辅助生殖技术并发症诊断及处理共识. 生殖与避孕, 2015, 35(7): 431-439.
3.	姜婷. 阴道超声引导穿刺取卵术的并发症及处理. 医学综述, 2014, 20(7): 1274-1277.
4.	丰有吉, 沈坚. 妇产科学. 北京: 人民卫生出版社, 2002: 413.
5.	Kahnberg A, Enskog A, Brännström M, et al. Prediction of ovarian hyperstimulation syndrome in women undergoing in vitro fertilization. Acta Obstet Gynecol Scand, 2009, 88(12): 1373-1381.
6.	姜李乐, 曹国昌, 梁琳琳, 等. 卵巢过度刺激综合征的研究现状. 国际生殖健康计划生育杂志, 2013(5): 391-394.
7.	Practice Committee of the American Society for Reproductive Medicine. Prevention and treatment of moderate and severe ovarian hyperstimulation syndrome: a guideline. Fertil Steril, 2016, 106(7): 1634-1647.
8.	龙志晶, 张秀萍, 武学清. 年龄及体质量指数对卵巢过度刺激综合征的影响. 实用医技杂志, 2015(4): 355-356.
9.	Lee TH, Liu CH, Huang CC, et al. Serum anti-Müllerian hormone and estradiol levels as predictors of ovarian hyperstimulation syndrome in assisted reproduction technology cycles. Hum Reprod, 2008, 23(1): 160-167.
10.	岳廷妍, 余小娟, 陈梦真, 等. 82 例中、重度卵巢过度刺激综合征相关因素分析. 中国妇幼保健, 2016(18): 3677-3680.
11.	贾津. 分析卵巢过度刺激综合征的相关危险因素. 实用妇科内分泌电子杂志, 2015, 2(7): 65, 67.
12.	Jayaprakasan K, Chan YE, Islam RA, et al. Prediction of in vitro fertilization outcome at different antral follicle count thresholds in a prospective cohort of 1, 012 women. Fertil Steril, 2012, 98(3): 657-663.
13.	Luke B, Brown MB, Morbeck DE, et al. Factors associated with ovarian hyperstimulation syndrome (OHSS) and its effect on assisted reproductive technology (ART) treatment and outcome. Fertil Steril, 2010, 94(4): 1399-1404.
14.	马天仲, 韦冰, 宋丽君, 等. 卵巢过度刺激综合征的发生危险因素 Logisitic 回归分析. 深圳中西医结合杂志, 2016, 26(13): 1-4, 封3.
15.	Aramwit P, Pruksananonda K, Kasettratat N, et al. Risk factors for ovarian hyperstimulation syndrome in Thai patients using gonadotropins for in vitro fertilization. Am J Health Syst Pharm, 2008, 65(12): 1148-1153.
16.	Kwee J, Elting ME, Schats R, et al. Ovarian volume and antral follicle count for the prediction of low and hyper responders with in vitro fertilization. Reprod Biol Endocrinol, 2007, 5: 9.
17.	Steward RG, Lan L, Shah AA, et al. Oocyte number as a predictor for ovarian hyperstimulation syndrome and live birth: an analysis of 256, 381 in vitro fertilization cycles. Fertil Steril, 2014, 101(4): 967-973.
18.	郑敏, 龙雯晴. 辅助生殖技术中非多囊卵巢综合征患者发生卵巢过度刺激综合征的高危因素分析. 诊断学理论与实践, 2016(3): 287-290.
19.	黄家佳, 杨健之. 卵巢过度刺激综合征危险因素及发病机制的研究进展. 生殖与避孕, 2011, 31(4): 283-287.
20.	何丽. 卵巢过度刺激综合征的误诊分析. 中国医学工程, 2014, 22(2): 135.

1. 于传鑫, 李儒芝. 妇科内分泌疾病治疗学. 上海: 复旦大学出版社, 2009: 2.
2. 刘风华, 杨业洲, 张松英, 等. 辅助生殖技术并发症诊断及处理共识. 生殖与避孕, 2015, 35(7): 431-439.
3. 姜婷. 阴道超声引导穿刺取卵术的并发症及处理. 医学综述, 2014, 20(7): 1274-1277.
4. 丰有吉, 沈坚. 妇产科学. 北京: 人民卫生出版社, 2002: 413.
5. Kahnberg A, Enskog A, Brännström M, et al. Prediction of ovarian hyperstimulation syndrome in women undergoing in vitro fertilization. Acta Obstet Gynecol Scand, 2009, 88(12): 1373-1381.
6. 姜李乐, 曹国昌, 梁琳琳, 等. 卵巢过度刺激综合征的研究现状. 国际生殖健康计划生育杂志, 2013(5): 391-394.
7. Practice Committee of the American Society for Reproductive Medicine. Prevention and treatment of moderate and severe ovarian hyperstimulation syndrome: a guideline. Fertil Steril, 2016, 106(7): 1634-1647.
8. 龙志晶, 张秀萍, 武学清. 年龄及体质量指数对卵巢过度刺激综合征的影响. 实用医技杂志, 2015(4): 355-356.
9. Lee TH, Liu CH, Huang CC, et al. Serum anti-Müllerian hormone and estradiol levels as predictors of ovarian hyperstimulation syndrome in assisted reproduction technology cycles. Hum Reprod, 2008, 23(1): 160-167.
10. 岳廷妍, 余小娟, 陈梦真, 等. 82 例中、重度卵巢过度刺激综合征相关因素分析. 中国妇幼保健, 2016(18): 3677-3680.
11. 贾津. 分析卵巢过度刺激综合征的相关危险因素. 实用妇科内分泌电子杂志, 2015, 2(7): 65, 67.
12. Jayaprakasan K, Chan YE, Islam RA, et al. Prediction of in vitro fertilization outcome at different antral follicle count thresholds in a prospective cohort of 1, 012 women. Fertil Steril, 2012, 98(3): 657-663.
13. Luke B, Brown MB, Morbeck DE, et al. Factors associated with ovarian hyperstimulation syndrome (OHSS) and its effect on assisted reproductive technology (ART) treatment and outcome. Fertil Steril, 2010, 94(4): 1399-1404.
14. 马天仲, 韦冰, 宋丽君, 等. 卵巢过度刺激综合征的发生危险因素 Logisitic 回归分析. 深圳中西医结合杂志, 2016, 26(13): 1-4, 封3.
15. Aramwit P, Pruksananonda K, Kasettratat N, et al. Risk factors for ovarian hyperstimulation syndrome in Thai patients using gonadotropins for in vitro fertilization. Am J Health Syst Pharm, 2008, 65(12): 1148-1153.
16. Kwee J, Elting ME, Schats R, et al. Ovarian volume and antral follicle count for the prediction of low and hyper responders with in vitro fertilization. Reprod Biol Endocrinol, 2007, 5: 9.
17. Steward RG, Lan L, Shah AA, et al. Oocyte number as a predictor for ovarian hyperstimulation syndrome and live birth: an analysis of 256, 381 in vitro fertilization cycles. Fertil Steril, 2014, 101(4): 967-973.
18. 郑敏, 龙雯晴. 辅助生殖技术中非多囊卵巢综合征患者发生卵巢过度刺激综合征的高危因素分析. 诊断学理论与实践, 2016(3): 287-290.
19. 黄家佳, 杨健之. 卵巢过度刺激综合征危险因素及发病机制的研究进展. 生殖与避孕, 2011, 31(4): 283-287.
20. 何丽. 卵巢过度刺激综合征的误诊分析. 中国医学工程, 2014, 22(2): 135.

Previous Article
Analysis of risk factors of hypertension combined with cerebral hemorrhage
Next Article
Effects of taurine on ventricular remodeling of rats with acute myocardial infarction

West China Medical Journal

Diagnosis and treatment of emergency complications after oocyte retrieval with assisted reproductive technology

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content