Idiopathic inflammatory myopathies associated interstitial lung disease_West China Medical Journal

Authors：

HU Yidan ,  LIU Gang , XIE Qibing

Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

LIU Gang, Email: neoliugang@163.com

Keywords：

Idiopathic inflammatory myopathies; Myositis-specific autoantibodies; Interstitial lung diseases; Inflammatory myopathies associated interstitial lung disease

DOI：

10.7507/1002-0179.201805070

Video：

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Idiopathic inflammatory myopathies are a group of connective tissue diseases characterized by nonsuppurative inflammation of the striated muscle. At present, the diagnostic criteria for polymyositis/dermatomyositis classification proposed by Bohan and Peter in 1976 is mainly used clinically. In clinical observations, it is found that myopathy involves not only skin and muscle but also affects many systems of the body. Interstitial lung disease occupies an important part, and it is an important cause of death of patients with inflammatory myopathy. Patients with idiopathic myositis should be examined as early as possible by high-resolution CT to improve the detection rate of myositis-associated interstitial lung disease and start treatment as soon as possible. At the same time, the patients with myositis have different clinical manifestations due to specific antibodies in the serum; some specific antibodies may indicate poor prognosis and poor treatment response. Timely screening of patients with positive myositis-specific antibodies in patients with the pulmonary interstitial disease can help the patient’s diagnosis and treatment process.

Citation： HU Yidan, LIU Gang, XIE Qibing. Idiopathic inflammatory myopathies associated interstitial lung disease. West China Medical Journal, 2018, 33(12): 1544-1548. doi: 10.7507/1002-0179.201805070 Copy

1.	Marie I, Hatron PY, Dominique S, et al. Short-term and long-term outcomes of interstitial lung disease in polymyositis and dermatomyositis a series of 107 patients. Arthritis Rheum, 2011, 63(11): 3439-3447.
2.	中华医学会呼吸病学分会间质性肺疾病学组. 特发性肺纤维化诊断和治疗中国专家共识. 中华结核和呼吸杂志, 2016, 39(6): 427-432.
3.	谢苗苗, 蔡后荣. 特发性炎性肌病自身抗体与间质性肺疾病的研究进展. 中华结核和呼吸杂志, 2017, 40(11): 870-873.
4.	Fujisawa T, Suda T, Nakamura Y, et al. Differences in clinical features and prognosis of interstitial lung diseases between polymyositis and dermatomyositis. J Rheumatol, 2005, 32(1): 58-64.
5.	Connors GR, Christopher-Stine L, Oddis CV, et al. Interstitial lung disease associated with the idiopathic inflammatory myopathies: what progress has been made in the past 35 years?. J Chest, 2010, 138(6): 1464-1474.
6.	Malkan A, Cappelen-Smith C, Beran R, et al. Anti-synthetase syndrome associated with anti PL-12 and anti-signal recognition particle antibodies and a necrotizing auto-immune myositis. J Clin Neurosci, 2015, 22(2): 396-398.
7.	Cojocaru M, Cojocaru IM, Chicos B. New insights into antisynthetase syndrome. Maedica, 2016, 11(2): 130-135.
8.	黄慧, 邵池, 李珊, 等. 特发性炎性肌病相关性间质性肺疾病的诊治进展. 中华结核和呼吸杂志, 2017, 40(8): 625-628.
9.	Mescam-Mancini L, Allenbach Y, Hervier BA, et al. Anti-Jo-1 antibody-positive patients show a characteristic necrotizing perifascicular myositis. Brain, 2015, 138(9): 2485-2492.
10.	Marie I, Josse S, Decaux O, et al. Comparison of long-term outcome between anti-Jo1- and anti-PL7/PL12 positive patients with antisynthetase syndrome. Autoimmun Rev, 2012, 11(10): 739-745.
11.	Kalluri M, Sahn SA, Oddis CV, et al. Clinical profile of Anti-PL-12 autoantibody cohort study and review of the literature. Chest, 2009, 135(6): 1550-1556.
12.	王怡, 李颖, 李升锦. 抗 MDA5 抗体对成年及幼年型皮肌炎合并间质性肺病诊断效能的 meta 分析. 临床检验杂志, 2018(1): 46-52.
13.	So H, Ip RW, Wong VT, et al. Analysis of anti-melanoma differentiation-associated gene 5 antibody in Hong Kong Chinese patients with idiopathic inflammatory myopathies: diagnostic utility and clinical correlations. Int J Rheum Dis, 2018, 21(5): 1076-1081.
14.	Palterer B, Vitiello G, Carraresi A, et al. Bench to bedside review of myositis autoantibodies. Clin Mol Allergy, 2018, 16(1): 5.
15.	Hengstman G, ter Laak HJ, Egberts WM, et al. Anti-signal recognition particle autoantibodies: marker of a necrotising myopathy. Ann Rheum Dis, 2006, 65(12): 1635-1638.
16.	Cottin V, Thivolet-Bejui F, Reynaud-Gaubert M, et al. Interstitial lung disease in amyopathic dermatomyositis, dermatomyositis and polymyositis. Eur Respir J, 2003, 22(2): 245-250.
17.	Suzuki S, Nishikawa A, Kuwana MA, et al. Inflammatory myopathy with anti-signal recognition particle antibodies: case series of 100 patients. Orphanet J Rare Dis, 2015, 10(1): 1-9.
18.	王涛, 石景丽, 张亚妹, 等. 抗 Mi-2 抗体不同亚型的临床异质性研究. 中日友好医院学报, 2017, 31(1): 7-10, 17.
19.	李珊珊, 葛永鹏, 杨阚波, 等. 皮肌炎患者 427 例肌炎特异性抗体谱及与临床特征相关性分析. 中华风湿病学杂志, 2017, 21(9): 585-594.
20.	许丛丛, 王培光. 皮肌炎自身抗体检测研究进展. 国际皮肤性病学杂志, 2017, 43(6): 325-328.
21.	Yang HB, Lu X, Peng QL, et al. Differential clinical associations of anti-nuclear matrix protein 2 autoantibodies in patients with idiopathic inflammatory myopathies. Arthritis Rheumatol, 2018, 70(8): 1288-1297.
22.	Tard C, Tiffreau V, Jaillette E, et al. Anti-HMGCR antibody-related necrotizing autoimmune myopathy mimicking muscular dystrophy. Neuropediatrics, 2017, 48(6): 473-476.
23.	王盼, 任立红. 特发性炎症性肌病的诊治进展. 现代医学, 2018(1): 97-100.
24.	陈珊珊, 李华敏, 陈建寿, 等. 大剂量 N-乙酰半胱氨酸联合糖皮质激素治疗慢性阻塞性肺疾病并肺间质纤维化的临床疗效. 实用心脑肺血管病杂志, 2017, 25(3): 97-100.
25.	刘萍, 秦兴国. 间质性肺疾病治疗研究进展. 国际呼吸杂志, 2015, 35(16): 1251-1254.
26.	刘玉叶, 陈秀敏, 黄闰月, 等. 利妥昔单抗治疗特发性炎性肌病的系统评价. 临床与病理杂志, 2015, 35(12): 2095-2101.
27.	Tralleroaraguás E, Berastegui C, Lópezcorbeto M, et al. SAT0339 lung transplantation in patients with interstitial lung disease associated with antisynthetase and anti-mda5 syndromes. experience from a reference spanish hospital. Eur Congr Rheumatol, 2017, 76(Suppl 2): 900.1-900.
28.	Malkan A, Cordato D, Griffith N, et al. 10. Anti-synthetase syndrome associated with necrotizing myositis – Utility of myositis specific autoantibodies in predicting prognosis and choice of treatment. Clin Neurophysiol, 2014, 125(4): e4.

1. Marie I, Hatron PY, Dominique S, et al. Short-term and long-term outcomes of interstitial lung disease in polymyositis and dermatomyositis a series of 107 patients. Arthritis Rheum, 2011, 63(11): 3439-3447.
2. 中华医学会呼吸病学分会间质性肺疾病学组. 特发性肺纤维化诊断和治疗中国专家共识. 中华结核和呼吸杂志, 2016, 39(6): 427-432.
3. 谢苗苗, 蔡后荣. 特发性炎性肌病自身抗体与间质性肺疾病的研究进展. 中华结核和呼吸杂志, 2017, 40(11): 870-873.
4. Fujisawa T, Suda T, Nakamura Y, et al. Differences in clinical features and prognosis of interstitial lung diseases between polymyositis and dermatomyositis. J Rheumatol, 2005, 32(1): 58-64.
5. Connors GR, Christopher-Stine L, Oddis CV, et al. Interstitial lung disease associated with the idiopathic inflammatory myopathies: what progress has been made in the past 35 years?. J Chest, 2010, 138(6): 1464-1474.
6. Malkan A, Cappelen-Smith C, Beran R, et al. Anti-synthetase syndrome associated with anti PL-12 and anti-signal recognition particle antibodies and a necrotizing auto-immune myositis. J Clin Neurosci, 2015, 22(2): 396-398.
7. Cojocaru M, Cojocaru IM, Chicos B. New insights into antisynthetase syndrome. Maedica, 2016, 11(2): 130-135.
8. 黄慧, 邵池, 李珊, 等. 特发性炎性肌病相关性间质性肺疾病的诊治进展. 中华结核和呼吸杂志, 2017, 40(8): 625-628.
9. Mescam-Mancini L, Allenbach Y, Hervier BA, et al. Anti-Jo-1 antibody-positive patients show a characteristic necrotizing perifascicular myositis. Brain, 2015, 138(9): 2485-2492.
10. Marie I, Josse S, Decaux O, et al. Comparison of long-term outcome between anti-Jo1- and anti-PL7/PL12 positive patients with antisynthetase syndrome. Autoimmun Rev, 2012, 11(10): 739-745.
11. Kalluri M, Sahn SA, Oddis CV, et al. Clinical profile of Anti-PL-12 autoantibody cohort study and review of the literature. Chest, 2009, 135(6): 1550-1556.
12. 王怡, 李颖, 李升锦. 抗 MDA5 抗体对成年及幼年型皮肌炎合并间质性肺病诊断效能的 meta 分析. 临床检验杂志, 2018(1): 46-52.
13. So H, Ip RW, Wong VT, et al. Analysis of anti-melanoma differentiation-associated gene 5 antibody in Hong Kong Chinese patients with idiopathic inflammatory myopathies: diagnostic utility and clinical correlations. Int J Rheum Dis, 2018, 21(5): 1076-1081.
14. Palterer B, Vitiello G, Carraresi A, et al. Bench to bedside review of myositis autoantibodies. Clin Mol Allergy, 2018, 16(1): 5.
15. Hengstman G, ter Laak HJ, Egberts WM, et al. Anti-signal recognition particle autoantibodies: marker of a necrotising myopathy. Ann Rheum Dis, 2006, 65(12): 1635-1638.
16. Cottin V, Thivolet-Bejui F, Reynaud-Gaubert M, et al. Interstitial lung disease in amyopathic dermatomyositis, dermatomyositis and polymyositis. Eur Respir J, 2003, 22(2): 245-250.
17. Suzuki S, Nishikawa A, Kuwana MA, et al. Inflammatory myopathy with anti-signal recognition particle antibodies: case series of 100 patients. Orphanet J Rare Dis, 2015, 10(1): 1-9.
18. 王涛, 石景丽, 张亚妹, 等. 抗 Mi-2 抗体不同亚型的临床异质性研究. 中日友好医院学报, 2017, 31(1): 7-10, 17.
19. 李珊珊, 葛永鹏, 杨阚波, 等. 皮肌炎患者 427 例肌炎特异性抗体谱及与临床特征相关性分析. 中华风湿病学杂志, 2017, 21(9): 585-594.
20. 许丛丛, 王培光. 皮肌炎自身抗体检测研究进展. 国际皮肤性病学杂志, 2017, 43(6): 325-328.
21. Yang HB, Lu X, Peng QL, et al. Differential clinical associations of anti-nuclear matrix protein 2 autoantibodies in patients with idiopathic inflammatory myopathies. Arthritis Rheumatol, 2018, 70(8): 1288-1297.
22. Tard C, Tiffreau V, Jaillette E, et al. Anti-HMGCR antibody-related necrotizing autoimmune myopathy mimicking muscular dystrophy. Neuropediatrics, 2017, 48(6): 473-476.
23. 王盼, 任立红. 特发性炎症性肌病的诊治进展. 现代医学, 2018(1): 97-100.
24. 陈珊珊, 李华敏, 陈建寿, 等. 大剂量 N-乙酰半胱氨酸联合糖皮质激素治疗慢性阻塞性肺疾病并肺间质纤维化的临床疗效. 实用心脑肺血管病杂志, 2017, 25(3): 97-100.
25. 刘萍, 秦兴国. 间质性肺疾病治疗研究进展. 国际呼吸杂志, 2015, 35(16): 1251-1254.
26. 刘玉叶, 陈秀敏, 黄闰月, 等. 利妥昔单抗治疗特发性炎性肌病的系统评价. 临床与病理杂志, 2015, 35(12): 2095-2101.
27. Tralleroaraguás E, Berastegui C, Lópezcorbeto M, et al. SAT0339 lung transplantation in patients with interstitial lung disease associated with antisynthetase and anti-mda5 syndromes. experience from a reference spanish hospital. Eur Congr Rheumatol, 2017, 76(Suppl 2): 900.1-900.
28. Malkan A, Cordato D, Griffith N, et al. 10. Anti-synthetase syndrome associated with necrotizing myositis – Utility of myositis specific autoantibodies in predicting prognosis and choice of treatment. Clin Neurophysiol, 2014, 125(4): e4.

West China Medical Journal

Idiopathic inflammatory myopathies associated interstitial lung disease

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