The research progress of Caveolin-1 protein in the field of Alzheimer’s disease_West China Medical Journal

Authors：

ZHANG Xi ¹ ,  YUAN Depei ¹ , ZENG Chuhua ² , MAO Jianqin ²

1. School of Basic Medical Sciences, Hubei University of Chinese Medicine, Wuhan, Hubei 430065, P. R. China;
2. Medical School, Hubei University for Nationalities, Enshi, Hubei 445000, P. R. China;

Corresponding author：

YUAN Depei, Email: ydp7880@163.com

Keywords：

Caveolin-1; Alzheimer’s disease; Review

DOI：

10.7507/1002-0179.201812022

Video：

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Caveolin-1 (Cav-1) protein plays a very important role in the central nervous system, and is closely related to Alzheimer’s disease (AD). Through literature review, this article summarizes the present research status of Cav-1 protein in the field of AD from three aspects: the relationship between Cav-1 gene and AD; the relationship of Cav-1 protein with learning and memory; the relationship of Cav-1 protein with amyloid β-protein and Tau protein. And the aim of this paper is to provide a new thought and evidence for exploring the mechanism of AD via Cav-1 protein.

Citation： ZHANG Xi, YUAN Depei, ZENG Chuhua, MAO Jianqin. The research progress of Caveolin-1 protein in the field of Alzheimer’s disease. West China Medical Journal, 2019, 34(3): 338-342. doi: 10.7507/1002-0179.201812022 Copy

1.	张玫莹, 朱铁年, 赵瑞景, 等. 小凹蛋白-1 调控表皮生长因子受体活化对恶性黑色素瘤细胞生物学行为的影响. 解放军医药杂志, 2018, 30(4): 46-50.
2.	杨娟丽. Caveolin-1 调控表皮生长因子受体活化对结直肠癌细胞增殖和转移的影响. 石家庄: 河北医科大学, 2018.
3.	于卫民, 姬建胜, 王冬冬. RNA 干扰 Caveolin-1 基因表达抑制食管癌细胞增殖侵袭及 PI3K/AKT 信号通路的研究. 中国地方病防治杂志, 2018, 33(3): 357.
4.	钟义良, 张融融, 黄思源, 等. 急性脑梗死患者血清陷窝蛋白 1 水平与早期神经功能恶化的关系. 上海交通大学学报(医学版), 2017, 37(12): 1678-1681.
5.	郑庆玲. Caveolin-1 的生物学结构及在肿瘤研究中的进展. 现代医药卫生, 2007, 23(24): 3710-3711.
6.	Ohadi M, Heshmati Y, Mirabzadeh A. P01-99 Extreme alleles at the human caveolin 1 gene novel purine complex and risk of Alzheimer’s disease. Eur Psychiatry, 2009, 24(Suppl 1): S487.
7.	Heshmati Y, Mirabzadeh A, Feizzade G, et al. A novel polymorphic purine complex at the 1.5 kb upstream region of the human caveolin-1 gene and risk of Alzheimer’s disease; extra-short alleles and accumulated allele homozygosity. Am J Med Genet B Neuropsychiatr Genet, 2009, 150B(2): 248-253.
8.	Zarif Yeganeh M, Mirabzadeh A, Khorram Khorshid HR, et al. Novel extreme homozygote haplotypes at the human caveolin 1 gene upstream purine complex in sporadic Alzheimer’s disease. Am J Med Genet B Neuropsychiatr Genet, 2010, 153B(1): 347-349.
9.	Heidari A, Behmanesh M, Sahraian MA, et al. The human caveolin 1 gene upstream purine complex and neurodegeneration-a common signature. J Neuroimmunol, 2011, 236(1/2): 106-110.
10.	Heidari A, Hosseinkhani S, Talebi S, et al. Haplotypes across the human caveolin 1 gene upstream purine complex significantly alter gene expression: implication in neurodegenerative disorders. Gene, 2012, 505(1): 186-189.
11.	吴平. ApoE 基因多态性和cav-1 基因上游 PPC 长度多态性与 AD、MCI 和 VD 的相关性研究. 上海: 复旦大学, 2009.
12.	Gioiosa L, Raggi C, Ricceri LJ, et al. Altered emotionality, spatial memory and cholinergic function in caveolin-1 knock-out mice. Behav Brain Res, 2008, 188(2): 255-262.
13.	王红霞. 不同年龄大鼠脑内 Caveolin-1 蛋白的表达及其与学习记忆关系研究. 大连: 辽宁师范大学, 2006.
14.	邹伟, 王红霞, 刘晶, 等. 大鼠脑内 caveolin-1 蛋白的表达及其在分辨学习中的作用. 生理学报, 2006, 58(5): 429-434.
15.	嵇志红, 邹伟. 空间学习记忆训练对大鼠海马 Caveolin-1 蛋白表达的影响. 大连大学学报, 2013(6): 35-37, 43.
16.	王璐. Caveolin-1 蛋白在空间学习记忆中的作用及其信号转导机制的研究. 大连: 辽宁师范大学, 2008.
17.	Egawa J, Schilling JM, Cui W, et al. Neuron-specific caveolin-1 overexpression improves motor function and preserves memory in mice subjected to brain trauma. FASEB J, 2017, 31(8): 3403-3411.
18.	袁林. 固本健脑法对 MCI 大鼠学习记忆能力及海马 Caveolin-1 的影响. 武汉: 湖北中医药大学, 2011.
19.	陈冬冬. 新型钒氧配合物对糖尿病小鼠学习记忆功能损伤的干预及与 Caveolin-1 表达的关系. 大连: 辽宁师范大学, 2009.
20.	姜梅. 基于肾藏志理论的肾虚质大鼠海马区学习记忆蛋白 ERK1 及 Caveolin-1 表达研究. 咸阳: 陕西中医药大学, 2017.
21.	Ikezu T, Trapp BD, Song KS, et al. Caveolae, plasma membrane microdomains for α-secretase-mediated processing of the amyloid precursor protein. J Biol Chem, 1998, 273(17): 10485-10495.
22.	Hattori C, Asai M, Onishi H, et al. BACE1 interacts with lipid raft proteins. J Neurosci Res, 2006, 84(4): 912-917.
23.	Head BP, Peart JN, Panneerselvam M, et al. Loss of caveolin-1 accelerates neurodegeneration and aging. PLoS One, 2010, 5(12): e15697.
24.	Jang SK, Yu JM, Kim ST, et al. An Aβ42 uptake and degradation via Rg3 requires an activation of caveolin, clathrin and a beta-degrading enzymes in microglia. Eur J Pharmacol, 2015, 758: 1-10.
25.	Pietri M, Dakowski C, Hannaoui SA, et al. PDK1 decreases TACE-mediated alpha-secretase activity and promotes disease progression in prion and Alzheimer’s diseases. Nat Med, 2013, 19(9): 1124-1131.
26.	Hashimoto M, Hossain S, Katakura M, et al. The binding of Aβ_1-42 to lipid rafts of RBC is enhanced by dietary docosahexaenoic acid in rats: implicates to Alzheimer’s disease. Biochimica et Biophysica Acta, 2015, 1848(6): 1402-1409.
27.	Zhu DH, Su YC, Fu BM, et al. Magnesium reduces blood-brain barrier permeability and regulates amyloid-beta transcytosis. Mol Neurobiol, 2018, 55(9): 7118-7131.
28.	András IE, Eum SY, Toborek M. Lipid rafts and functional caveolae regulate HIV-induced amyloid beta accumulation in brain endothelial cells. Biochem Biophys Res Commun, 2012, 421(2): 177-183.
29.	Van Helmond ZK, Miners JS, Bednall E, et al. Caveolin-1 and-2 and their relationship to cerebral amyloid angiopathy in Alzheimer’s disease. Neuropathol Appl Neurobiol, 2007, 33(3): 317-327.
30.	Kang QM, Xiang YE, Li D, et al. MiR-124-3p attenuates hyperphosphorylation of tau protein-induced apoptosis via caveolin-1-PI3K/Akt/GSK3 beta pathway in N2a/APP695swe cells. Oncotarget, 2017, 8(15): 24314-24326.
31.	Wu J, Zhou SL, Pi LH, et al. High glucose induces formation of tau hyperphosphorylation via Cav-1-mTOR pathway: a potential molecular mechanism for diabetes-induced cognitive dysfunction. Oncotarget, 2017, 8(25): 40843-40856.
32.	Zhao YL, Song JN, Ma XD, et al. Rosiglitazone ameliorates diffuse axonal injury by reducing loss of tau and up-regulating caveolin-1 expression. Neural Regen Res, 2016, 11(6): 944-950.
33.	朱耀乾. 固本健脑法对 AD 模型大鼠海马区 Caveolin-1、树突棘、P-tau 的影响. 恩施: 湖北民族学院, 2015.
34.	胡玉萍, 王平, 袁德培, 等. 固本健脑法对 Alzheimer 病模型大鼠海马区树突棘及 P-tau 的影响. 世界科学技术-中医药现代化, 2016, 18(1): 53-59.
35.	陈谦峰. 固本健脑法对 AD 细胞模型的作用及 Caveolin-1、P-tau 影响的研究. 武汉: 湖北中医药大学, 2015.
36.	Sun J, Zhang X, Wang C, et al. Curcumin decreases hyperphosphorylation of tau by down-regulating caveolin-1/GSK-3β in N2a/APP695swe cells and APP/PS1 double transgenic Alzheimer’s disease mice. Am J Chin Med, 2017, 45(8): 1667-1682.
37.	孙洁芸. 姜黄素通过 Caveolin-1 在 AD 中发挥神经保护作用的分子机制. 重庆: 重庆医科大学, 2014.
38.	向月, 张雄, 杨军, 等. miR-124-3p 通过负调控 Caveolin-1 表达降低 N2a/APPswe 细胞内 Tau 蛋白磷酸化水平. 基础医学与临床, 2015, 35(5): 579-584.

1. 张玫莹, 朱铁年, 赵瑞景, 等. 小凹蛋白-1 调控表皮生长因子受体活化对恶性黑色素瘤细胞生物学行为的影响. 解放军医药杂志, 2018, 30(4): 46-50.
2. 杨娟丽. Caveolin-1 调控表皮生长因子受体活化对结直肠癌细胞增殖和转移的影响. 石家庄: 河北医科大学, 2018.
3. 于卫民, 姬建胜, 王冬冬. RNA 干扰 Caveolin-1 基因表达抑制食管癌细胞增殖侵袭及 PI3K/AKT 信号通路的研究. 中国地方病防治杂志, 2018, 33(3): 357.
4. 钟义良, 张融融, 黄思源, 等. 急性脑梗死患者血清陷窝蛋白 1 水平与早期神经功能恶化的关系. 上海交通大学学报(医学版), 2017, 37(12): 1678-1681.
5. 郑庆玲. Caveolin-1 的生物学结构及在肿瘤研究中的进展. 现代医药卫生, 2007, 23(24): 3710-3711.
6. Ohadi M, Heshmati Y, Mirabzadeh A. P01-99 Extreme alleles at the human caveolin 1 gene novel purine complex and risk of Alzheimer’s disease. Eur Psychiatry, 2009, 24(Suppl 1): S487.
7. Heshmati Y, Mirabzadeh A, Feizzade G, et al. A novel polymorphic purine complex at the 1.5 kb upstream region of the human caveolin-1 gene and risk of Alzheimer’s disease; extra-short alleles and accumulated allele homozygosity. Am J Med Genet B Neuropsychiatr Genet, 2009, 150B(2): 248-253.
8. Zarif Yeganeh M, Mirabzadeh A, Khorram Khorshid HR, et al. Novel extreme homozygote haplotypes at the human caveolin 1 gene upstream purine complex in sporadic Alzheimer’s disease. Am J Med Genet B Neuropsychiatr Genet, 2010, 153B(1): 347-349.
9. Heidari A, Behmanesh M, Sahraian MA, et al. The human caveolin 1 gene upstream purine complex and neurodegeneration-a common signature. J Neuroimmunol, 2011, 236(1/2): 106-110.
10. Heidari A, Hosseinkhani S, Talebi S, et al. Haplotypes across the human caveolin 1 gene upstream purine complex significantly alter gene expression: implication in neurodegenerative disorders. Gene, 2012, 505(1): 186-189.
11. 吴平. ApoE 基因多态性和cav-1 基因上游 PPC 长度多态性与 AD、MCI 和 VD 的相关性研究. 上海: 复旦大学, 2009.
12. Gioiosa L, Raggi C, Ricceri LJ, et al. Altered emotionality, spatial memory and cholinergic function in caveolin-1 knock-out mice. Behav Brain Res, 2008, 188(2): 255-262.
13. 王红霞. 不同年龄大鼠脑内 Caveolin-1 蛋白的表达及其与学习记忆关系研究. 大连: 辽宁师范大学, 2006.
14. 邹伟, 王红霞, 刘晶, 等. 大鼠脑内 caveolin-1 蛋白的表达及其在分辨学习中的作用. 生理学报, 2006, 58(5): 429-434.
15. 嵇志红, 邹伟. 空间学习记忆训练对大鼠海马 Caveolin-1 蛋白表达的影响. 大连大学学报, 2013(6): 35-37, 43.
16. 王璐. Caveolin-1 蛋白在空间学习记忆中的作用及其信号转导机制的研究. 大连: 辽宁师范大学, 2008.
17. Egawa J, Schilling JM, Cui W, et al. Neuron-specific caveolin-1 overexpression improves motor function and preserves memory in mice subjected to brain trauma. FASEB J, 2017, 31(8): 3403-3411.
18. 袁林. 固本健脑法对 MCI 大鼠学习记忆能力及海马 Caveolin-1 的影响. 武汉: 湖北中医药大学, 2011.
19. 陈冬冬. 新型钒氧配合物对糖尿病小鼠学习记忆功能损伤的干预及与 Caveolin-1 表达的关系. 大连: 辽宁师范大学, 2009.
20. 姜梅. 基于肾藏志理论的肾虚质大鼠海马区学习记忆蛋白 ERK1 及 Caveolin-1 表达研究. 咸阳: 陕西中医药大学, 2017.
21. Ikezu T, Trapp BD, Song KS, et al. Caveolae, plasma membrane microdomains for α-secretase-mediated processing of the amyloid precursor protein. J Biol Chem, 1998, 273(17): 10485-10495.
22. Hattori C, Asai M, Onishi H, et al. BACE1 interacts with lipid raft proteins. J Neurosci Res, 2006, 84(4): 912-917.
23. Head BP, Peart JN, Panneerselvam M, et al. Loss of caveolin-1 accelerates neurodegeneration and aging. PLoS One, 2010, 5(12): e15697.
24. Jang SK, Yu JM, Kim ST, et al. An Aβ42 uptake and degradation via Rg3 requires an activation of caveolin, clathrin and a beta-degrading enzymes in microglia. Eur J Pharmacol, 2015, 758: 1-10.
25. Pietri M, Dakowski C, Hannaoui SA, et al. PDK1 decreases TACE-mediated alpha-secretase activity and promotes disease progression in prion and Alzheimer’s diseases. Nat Med, 2013, 19(9): 1124-1131.
26. Hashimoto M, Hossain S, Katakura M, et al. The binding of Aβ_1-42 to lipid rafts of RBC is enhanced by dietary docosahexaenoic acid in rats: implicates to Alzheimer’s disease. Biochimica et Biophysica Acta, 2015, 1848(6): 1402-1409.
27. Zhu DH, Su YC, Fu BM, et al. Magnesium reduces blood-brain barrier permeability and regulates amyloid-beta transcytosis. Mol Neurobiol, 2018, 55(9): 7118-7131.
28. András IE, Eum SY, Toborek M. Lipid rafts and functional caveolae regulate HIV-induced amyloid beta accumulation in brain endothelial cells. Biochem Biophys Res Commun, 2012, 421(2): 177-183.
29. Van Helmond ZK, Miners JS, Bednall E, et al. Caveolin-1 and-2 and their relationship to cerebral amyloid angiopathy in Alzheimer’s disease. Neuropathol Appl Neurobiol, 2007, 33(3): 317-327.
30. Kang QM, Xiang YE, Li D, et al. MiR-124-3p attenuates hyperphosphorylation of tau protein-induced apoptosis via caveolin-1-PI3K/Akt/GSK3 beta pathway in N2a/APP695swe cells. Oncotarget, 2017, 8(15): 24314-24326.
31. Wu J, Zhou SL, Pi LH, et al. High glucose induces formation of tau hyperphosphorylation via Cav-1-mTOR pathway: a potential molecular mechanism for diabetes-induced cognitive dysfunction. Oncotarget, 2017, 8(25): 40843-40856.
32. Zhao YL, Song JN, Ma XD, et al. Rosiglitazone ameliorates diffuse axonal injury by reducing loss of tau and up-regulating caveolin-1 expression. Neural Regen Res, 2016, 11(6): 944-950.
33. 朱耀乾. 固本健脑法对 AD 模型大鼠海马区 Caveolin-1、树突棘、P-tau 的影响. 恩施: 湖北民族学院, 2015.
34. 胡玉萍, 王平, 袁德培, 等. 固本健脑法对 Alzheimer 病模型大鼠海马区树突棘及 P-tau 的影响. 世界科学技术-中医药现代化, 2016, 18(1): 53-59.
35. 陈谦峰. 固本健脑法对 AD 细胞模型的作用及 Caveolin-1、P-tau 影响的研究. 武汉: 湖北中医药大学, 2015.
36. Sun J, Zhang X, Wang C, et al. Curcumin decreases hyperphosphorylation of tau by down-regulating caveolin-1/GSK-3β in N2a/APP695swe cells and APP/PS1 double transgenic Alzheimer’s disease mice. Am J Chin Med, 2017, 45(8): 1667-1682.
37. 孙洁芸. 姜黄素通过 Caveolin-1 在 AD 中发挥神经保护作用的分子机制. 重庆: 重庆医科大学, 2014.
38. 向月, 张雄, 杨军, 等. miR-124-3p 通过负调控 Caveolin-1 表达降低 N2a/APPswe 细胞内 Tau 蛋白磷酸化水平. 基础医学与临床, 2015, 35(5): 579-584.

West China Medical Journal

The research progress of Caveolin-1 protein in the field of Alzheimer’s disease

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