Periodontitis and benign prostatic hyperplasia and prostatitis_West China Medical Journal

Authors：

LUO Hua ^1,2 ,  WEI Qiang ²

1. Department of Urology, the Second People’s Hospital of Deyang, Deyang, Sichuan 618000, P. R. China;
2. Department of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

WEI Qiang, Email: weiqiang933@163.com

Keywords：

Periodontitis; Benign prostatic hyperplasia; Chronic prostatitis

DOI：

10.7507/1002-0179.201909104

Video：

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Prostate disease is one of the most common urological disease. A large number of studies have shown that prostate disease is related to changes in the local microenvironment. Periodontitis is a chronic inflammatory disease characterized by the destruction of periodontal tissue caused by a variety of pathogenic microorganisms. Its pathogenesis may involve many factors. Periodontitis may have adverse effects on cardiovascular, respiratory, digestive and endocrine systems. Recent studies have found that chronic periodontitis is associated with the occurrence and development of benign prostatic hyperplasia and prostatitis, but the relationship is not clear. Therefore, further research is needed. This article elaborates on inflammation and benign prostatic hyperplasia and prostatitis, periodontitis and prostatitis, and periodontitis and benign prostatic hyperplasia, aiming to provide certain ideas for clinical research and diagnosis and treatment.

Citation： LUO Hua, WEI Qiang. Periodontitis and benign prostatic hyperplasia and prostatitis. West China Medical Journal, 2021, 36(7): 990-994. doi: 10.7507/1002-0179.201909104 Copy

1.	da Silva APB, Alluri LSC, Bissada NF, et al. Association between oral pathogens and prostate cancer: building the relationship. Am J Clin Exp Urol, 2019, 7(1): 1-10.
2.	Lloyd GL, Marks JM, Ricke WA. Benign prostatic hyperplasia and lower urinary tract symptoms: what is the role and significance of inflammation?. Curr Urol Rep, 2019, 20(9): 54.
3.	蒋茂, 薛晓文, 程伟, 等. 良性前列腺增生与前列腺慢性炎症的相关性研究进展. 药学与临床研究, 2019, 27(4): 294-299.
4.	刘城城, 韩广玮, 陈江川, 等. 牙周炎对慢性细菌性前列腺炎大鼠前列腺的影响. 局解手术学杂志, 2015(1): 6-10.
5.	Zhang M, Luo C, Cui K, et al. Chronic inflammation promotes proliferation in the prostatic stroma in rats with experimental autoimmune prostatitis: study for a novel method of inducing benign prostatic hyperplasia in a rat model. World J Urol, 2020, 38(11): 2933-2943.
6.	Fan Y, Yang L, Wei Q, et al. Toll-like receptor 10(TLR10) exhibits suppressive effects on inflammation of prostate epithelial cells. Asian J Androl, 2019, 21(4): 393-399.
7.	Soler R, Andersson KE, Chancellor MB, et al. Future direction in pharmacotherapy for non-neurogenic male lower urinary tract symptoms. Eur Urol, 2013, 64(4): 610-621.
8.	Cakir SS, Polat EC, Ozcan L, et al. The effect of prostatic inflammation on clinical outcomes in patients with benign prostate hyperplasia. Prostate Int, 2018, 6(2): 71-74.
9.	Taoka R, Kakehi Y. The influence of asymptomatic inflammatory prostatitis on the onset and progression of lower urinary tract symptoms in men with histologic benign prostatic hyperplasia. Asian J Urol, 2017, 4(3): 158-163.
10.	Nickel JC, Freedland SJ, Castro-Santamaria R, et al. Chronic prostate inflammation predicts symptom progression in patients with chronic prostatitis/chronic pelvic pain. J Urol, 2017, 198(1): 122-128.
11.	Roehrborn CG, Kaplan SA, Noble WD, et al. The impact of acute or chronic inflammation in baseline biopsy on the risk of clinical progression of BPH: results from the MTOPS study. J Urol, 2005, 173(4): 346.
12.	Zhang Q, Pang S, Zhang Y, et al. Association between inflammation and lower urinary tract symptoms of benign prostatic hyperplasia. Urol J, 2020, 17(5): 505-511.
13.	De Nunzio C, Presicce F, Tubaro A. Inflammatory mediators in the development and progression of benign prostatic hyperplasia. Nat Rev Urol, 2016, 13(10): 613-626.
14.	Madersbacher S, Sampson N, Culig Z. Pathophysiology of benign prostatic hyperplasia and benign prostatic enlargement: a mini-review. Gerontology, 2019, 65(5): 458-464.
15.	Funahashi Y, Wang Z, O’Malley KJ, et al. Influence of E.coli-induced prostatic inflammation on expression of androgen-responsive genes and transforming growth factor beta 1 cascade genes in rats. Prostate, 2015, 75(4): 381-389.
16.	Di Silverio F, Gentile V, De Matteis A, et a1. Distribution of inflammation, pre-malignant lesions, incidental carcinoma in histologically confirmed benign prostatic hyperplasia: a retrospective analysis. Eur Urol, 2003, 43(2): 164-175.
17.	Sebastianelli A, Gacci M. Current status of the relationship between metabolic syndrome and lower urinary tract symptoms. Eur Urol Focus, 2018, 4(1): 25-27.
18.	彭彩霞, 史晓凤, 李昱卓, 等. 代谢综合征诱导炎症反应与下尿路症状相关性研究进展. 临床泌尿外科杂志, 2019, 34(11): 920-925.
19.	Hyun JS. Clinical significance of prostatic calculi: a review. World J Mens Health, 2018, 36(1): 15-21.
20.	Shoskes DA, Lee CT, Murphy D, et al. Incidence and significance of prostatic stones in men with chronic prostatitis/chronic pelvic pain syndrome. Urology, 2007, 70(2): 235-238.
21.	Soric T, Selimovic M, Bakovic L, et al. Clinical and biochemical influence of prostatic stones. Urol Int, 2017, 98(4): 449-455.
22.	Babaev EA, Balmasova IP, Mkrtumyan AM, et al. Metagenomic analysis of gingival sulcus microbiota and pathogenesis of periodontitis associated with type 2 diabetes mellitus. Bull Exp Biol Med, 2017, 163(6): 718-721.
23.	Suresh S, Mahendra J, Sudhakar U, et a1. Evaluation of plasma reactive oxygen metabolites levels in obese subjects with periodontal disease. Indian J Dent Res, 2016, 27(2): 155-159.
24.	van Dyke TE, van Winkelhoff AJ. Infection and inflammatory mechanisms. J Periodontol, 2013, 84(Suppl 4): S1-S7.
25.	Buhlin K, Hultin M, Norderyd O, et al. Risk factors for atherosclerosis in cases with severe periodontitis. J Clin Periodontol, 2009, 36(7): 541-549.
26.	Fu E, Cheng CM, Chung CH, et al. Association of chronic periodontitis with prostatic hyperplasia and prostatitis: a population-based cohort study in Taiwan. J Periodontol, 2021, 92(1): 72-86.
27.	Boyapati R, Swarna C, Devulapalli N, et al. Unveiling the link between prostatitis and periodontitis. Contemp Clin Dent, 2018, 9(4): 524-529.
28.	尹良胜. 慢性牙周炎患者治疗前后血清前列腺特异性抗原水平的变化及意义. 牙体牙髓牙周病学杂志, 2018, 28(10): 580-584.
29.	Joshi N, Bissada NF, Bodner D, et al. Association between periodontal disease and prostate-specific antigen levels in chronic prostatitis patients. J Periodontol, 2010, 81(6): 864-869.
30.	Estemalik J, Demko C, Bissada NF, et al. Simultaneous detection of oral pathogens in subgingival plaque and prostatic fluid of men with periodontal and prostatic diseases. J Periodontol, 2017, 88(9): 823-829.
31.	王馨. 牙源性病灶的诊断. 中国伤残医学, 2013(2): 218.
32.	Leivadaros E, van der Velden U, Bizzarro S, et al. A pilot study into measurements of markers of atherosclerosis in periodontitis. J Periodontol, 2005, 76(1): 121-128.
33.	Yamatake K, Maeda M, Kadowaki T, et al. Role for gingipains in porphyromonas gingivalis traffic to phagolysosomes and survival in human aortic endothelial cells. Infect Immun, 2007, 75(5): 2090-2100.
34.	Ebersole JL, Novak MJ, Michalowicz BS, et al. Systemic immune responses in pregnancy and periodontitis: relationship to pregnancy outcomes in the obstetrics and periodontal therapy (OPT) study. J Periodontol, 2009, 80(6): 953-960.
35.	郑富军, 马芬, 田小龙. 慢性牙周炎患者牙龈组织中TLR2、TLR4、CD14的表达水平及意义. 临床和实验医学杂志, 2018, 17(19): 2079-2082.
36.	Noack B, Genco RJ, Trevisan M, et al. Periodontal infections contribute to elevated systemic C-reactive protein level. J Periodontol, 2001, 72(9): 1221-1227.
37.	周栩茹, 谢玲玲, 许宏宇, 等. 血清热休克蛋白70、细胞因子信号转导负调控因子3与妊娠期高血压患者免疫因子的关系及其预测价值分析. 中国综合临床, 2019, 35(1): 63-68.
38.	申叶, 杨孜, 陈扬, 等. 轻中度妊娠期高血压孕妇的孕期血压控制和维持水平对母儿结局的影响. 中华妇产科杂志, 2017, 52(9): 586-593.
39.	Takai H, Furuse N, Ogata Y. Anti-heat shock protein 70 levels in gingival crevicular fluid of Japanese patients with chronic periodontitis. J Oral Sci, 2020, 62(3): 281-284.
40.	王悦颖, 林梅, 王蕾, 等. 慢性牙周炎和慢性牙周炎合并慢性阻塞性肺疾病患者血清中IL-2、IL-4、IL-6、IL-10、IFN-γ及TNF-α的检测及临床意义. 中国医师杂志, 2017, 19(8): 1148-1151.
41.	Untergasser G, Rumpold H, Plas E, et al. High levels of zinc ions induce loss of mitochondrial potential and degradation of antiapoptotic Bcl-2 protein in in vitro cultivated human prostate epithelial cells. Biochem Biophys Res Commun, 2000, 279(2): 607-614.
42.	牛保华, 高楠, 李宝珍. 牙龈炎牙周炎患者发锌含量及细胞免疫的变化. 微量元素与健康研究, 2002, 19(4): 28-29.
43.	姚本栈, 黄慧, 程灶火, 等. 心理社会因素与慢性牙周炎的相关性研究. 口腔医学, 2013, 33(6): 404-406.
44.	Gandaglia G, Zaffuto E, Fossati N, et al. The role of prostatic inflammation in the development and progression of benign and malignant diseases. Curr Opin Urol, 2017, 27(2): 99-106.
45.	Coussens LM, Werb Z. Inflammation and cancer. Nature, 2002, 420(6917): 860-867.
46.	王旭, 童钰鑫, 张佳喻, 等. 慢性牙周炎与微量营养素. 中华老年口腔医学杂志, 2019, 17(3): 178-181.
47.	Abreu OJ, Tatakis DN, Elias-Boneta AR, et a1. Low vitamin D status strongly associated with periodontitis in Puerto Rican adults. BMC Oral Health, 2016, 16(1): 89.
48.	Murphy AB, Nyame YA, Batai K, et al. Does prostate volume correlate with vitamin D deficiency among men undergoing prostate biopsy?. Prostate Cancer Prostatic Dis, 2017, 20(1): 55-60.
49.	Yalçınkaya S, Eren E, Eroglu M, et a1. Deficiency of vitamin D and elevated aldosterone in prostate hyperplasia. Adv Clin Exp Med, 2014, 23(3): 441-446.

1. da Silva APB, Alluri LSC, Bissada NF, et al. Association between oral pathogens and prostate cancer: building the relationship. Am J Clin Exp Urol, 2019, 7(1): 1-10.
2. Lloyd GL, Marks JM, Ricke WA. Benign prostatic hyperplasia and lower urinary tract symptoms: what is the role and significance of inflammation?. Curr Urol Rep, 2019, 20(9): 54.
3. 蒋茂, 薛晓文, 程伟, 等. 良性前列腺增生与前列腺慢性炎症的相关性研究进展. 药学与临床研究, 2019, 27(4): 294-299.
4. 刘城城, 韩广玮, 陈江川, 等. 牙周炎对慢性细菌性前列腺炎大鼠前列腺的影响. 局解手术学杂志, 2015(1): 6-10.
5. Zhang M, Luo C, Cui K, et al. Chronic inflammation promotes proliferation in the prostatic stroma in rats with experimental autoimmune prostatitis: study for a novel method of inducing benign prostatic hyperplasia in a rat model. World J Urol, 2020, 38(11): 2933-2943.
6. Fan Y, Yang L, Wei Q, et al. Toll-like receptor 10(TLR10) exhibits suppressive effects on inflammation of prostate epithelial cells. Asian J Androl, 2019, 21(4): 393-399.
7. Soler R, Andersson KE, Chancellor MB, et al. Future direction in pharmacotherapy for non-neurogenic male lower urinary tract symptoms. Eur Urol, 2013, 64(4): 610-621.
8. Cakir SS, Polat EC, Ozcan L, et al. The effect of prostatic inflammation on clinical outcomes in patients with benign prostate hyperplasia. Prostate Int, 2018, 6(2): 71-74.
9. Taoka R, Kakehi Y. The influence of asymptomatic inflammatory prostatitis on the onset and progression of lower urinary tract symptoms in men with histologic benign prostatic hyperplasia. Asian J Urol, 2017, 4(3): 158-163.
10. Nickel JC, Freedland SJ, Castro-Santamaria R, et al. Chronic prostate inflammation predicts symptom progression in patients with chronic prostatitis/chronic pelvic pain. J Urol, 2017, 198(1): 122-128.
11. Roehrborn CG, Kaplan SA, Noble WD, et al. The impact of acute or chronic inflammation in baseline biopsy on the risk of clinical progression of BPH: results from the MTOPS study. J Urol, 2005, 173(4): 346.
12. Zhang Q, Pang S, Zhang Y, et al. Association between inflammation and lower urinary tract symptoms of benign prostatic hyperplasia. Urol J, 2020, 17(5): 505-511.
13. De Nunzio C, Presicce F, Tubaro A. Inflammatory mediators in the development and progression of benign prostatic hyperplasia. Nat Rev Urol, 2016, 13(10): 613-626.
14. Madersbacher S, Sampson N, Culig Z. Pathophysiology of benign prostatic hyperplasia and benign prostatic enlargement: a mini-review. Gerontology, 2019, 65(5): 458-464.
15. Funahashi Y, Wang Z, O’Malley KJ, et al. Influence of E.coli-induced prostatic inflammation on expression of androgen-responsive genes and transforming growth factor beta 1 cascade genes in rats. Prostate, 2015, 75(4): 381-389.
16. Di Silverio F, Gentile V, De Matteis A, et a1. Distribution of inflammation, pre-malignant lesions, incidental carcinoma in histologically confirmed benign prostatic hyperplasia: a retrospective analysis. Eur Urol, 2003, 43(2): 164-175.
17. Sebastianelli A, Gacci M. Current status of the relationship between metabolic syndrome and lower urinary tract symptoms. Eur Urol Focus, 2018, 4(1): 25-27.
18. 彭彩霞, 史晓凤, 李昱卓, 等. 代谢综合征诱导炎症反应与下尿路症状相关性研究进展. 临床泌尿外科杂志, 2019, 34(11): 920-925.
19. Hyun JS. Clinical significance of prostatic calculi: a review. World J Mens Health, 2018, 36(1): 15-21.
20. Shoskes DA, Lee CT, Murphy D, et al. Incidence and significance of prostatic stones in men with chronic prostatitis/chronic pelvic pain syndrome. Urology, 2007, 70(2): 235-238.
21. Soric T, Selimovic M, Bakovic L, et al. Clinical and biochemical influence of prostatic stones. Urol Int, 2017, 98(4): 449-455.
22. Babaev EA, Balmasova IP, Mkrtumyan AM, et al. Metagenomic analysis of gingival sulcus microbiota and pathogenesis of periodontitis associated with type 2 diabetes mellitus. Bull Exp Biol Med, 2017, 163(6): 718-721.
23. Suresh S, Mahendra J, Sudhakar U, et a1. Evaluation of plasma reactive oxygen metabolites levels in obese subjects with periodontal disease. Indian J Dent Res, 2016, 27(2): 155-159.
24. van Dyke TE, van Winkelhoff AJ. Infection and inflammatory mechanisms. J Periodontol, 2013, 84(Suppl 4): S1-S7.
25. Buhlin K, Hultin M, Norderyd O, et al. Risk factors for atherosclerosis in cases with severe periodontitis. J Clin Periodontol, 2009, 36(7): 541-549.
26. Fu E, Cheng CM, Chung CH, et al. Association of chronic periodontitis with prostatic hyperplasia and prostatitis: a population-based cohort study in Taiwan. J Periodontol, 2021, 92(1): 72-86.
27. Boyapati R, Swarna C, Devulapalli N, et al. Unveiling the link between prostatitis and periodontitis. Contemp Clin Dent, 2018, 9(4): 524-529.
28. 尹良胜. 慢性牙周炎患者治疗前后血清前列腺特异性抗原水平的变化及意义. 牙体牙髓牙周病学杂志, 2018, 28(10): 580-584.
29. Joshi N, Bissada NF, Bodner D, et al. Association between periodontal disease and prostate-specific antigen levels in chronic prostatitis patients. J Periodontol, 2010, 81(6): 864-869.
30. Estemalik J, Demko C, Bissada NF, et al. Simultaneous detection of oral pathogens in subgingival plaque and prostatic fluid of men with periodontal and prostatic diseases. J Periodontol, 2017, 88(9): 823-829.
31. 王馨. 牙源性病灶的诊断. 中国伤残医学, 2013(2): 218.
32. Leivadaros E, van der Velden U, Bizzarro S, et al. A pilot study into measurements of markers of atherosclerosis in periodontitis. J Periodontol, 2005, 76(1): 121-128.
33. Yamatake K, Maeda M, Kadowaki T, et al. Role for gingipains in porphyromonas gingivalis traffic to phagolysosomes and survival in human aortic endothelial cells. Infect Immun, 2007, 75(5): 2090-2100.
34. Ebersole JL, Novak MJ, Michalowicz BS, et al. Systemic immune responses in pregnancy and periodontitis: relationship to pregnancy outcomes in the obstetrics and periodontal therapy (OPT) study. J Periodontol, 2009, 80(6): 953-960.
35. 郑富军, 马芬, 田小龙. 慢性牙周炎患者牙龈组织中TLR2、TLR4、CD14的表达水平及意义. 临床和实验医学杂志, 2018, 17(19): 2079-2082.
36. Noack B, Genco RJ, Trevisan M, et al. Periodontal infections contribute to elevated systemic C-reactive protein level. J Periodontol, 2001, 72(9): 1221-1227.
37. 周栩茹, 谢玲玲, 许宏宇, 等. 血清热休克蛋白70、细胞因子信号转导负调控因子3与妊娠期高血压患者免疫因子的关系及其预测价值分析. 中国综合临床, 2019, 35(1): 63-68.
38. 申叶, 杨孜, 陈扬, 等. 轻中度妊娠期高血压孕妇的孕期血压控制和维持水平对母儿结局的影响. 中华妇产科杂志, 2017, 52(9): 586-593.
39. Takai H, Furuse N, Ogata Y. Anti-heat shock protein 70 levels in gingival crevicular fluid of Japanese patients with chronic periodontitis. J Oral Sci, 2020, 62(3): 281-284.
40. 王悦颖, 林梅, 王蕾, 等. 慢性牙周炎和慢性牙周炎合并慢性阻塞性肺疾病患者血清中IL-2、IL-4、IL-6、IL-10、IFN-γ及TNF-α的检测及临床意义. 中国医师杂志, 2017, 19(8): 1148-1151.
41. Untergasser G, Rumpold H, Plas E, et al. High levels of zinc ions induce loss of mitochondrial potential and degradation of antiapoptotic Bcl-2 protein in in vitro cultivated human prostate epithelial cells. Biochem Biophys Res Commun, 2000, 279(2): 607-614.
42. 牛保华, 高楠, 李宝珍. 牙龈炎牙周炎患者发锌含量及细胞免疫的变化. 微量元素与健康研究, 2002, 19(4): 28-29.
43. 姚本栈, 黄慧, 程灶火, 等. 心理社会因素与慢性牙周炎的相关性研究. 口腔医学, 2013, 33(6): 404-406.
44. Gandaglia G, Zaffuto E, Fossati N, et al. The role of prostatic inflammation in the development and progression of benign and malignant diseases. Curr Opin Urol, 2017, 27(2): 99-106.
45. Coussens LM, Werb Z. Inflammation and cancer. Nature, 2002, 420(6917): 860-867.
46. 王旭, 童钰鑫, 张佳喻, 等. 慢性牙周炎与微量营养素. 中华老年口腔医学杂志, 2019, 17(3): 178-181.
47. Abreu OJ, Tatakis DN, Elias-Boneta AR, et a1. Low vitamin D status strongly associated with periodontitis in Puerto Rican adults. BMC Oral Health, 2016, 16(1): 89.
48. Murphy AB, Nyame YA, Batai K, et al. Does prostate volume correlate with vitamin D deficiency among men undergoing prostate biopsy?. Prostate Cancer Prostatic Dis, 2017, 20(1): 55-60.
49. Yalçınkaya S, Eren E, Eroglu M, et a1. Deficiency of vitamin D and elevated aldosterone in prostate hyperplasia. Adv Clin Exp Med, 2014, 23(3): 441-446.

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