The role of anti-Müllerian hormone in polycystic ovary syndrome_West China Medical Journal

Authors：

ZHANG Yizhuo ¹ ,  ZHANG Yuehui ¹ , HAN Yanhua ¹ , WANG Lijing ² , LIU Chang ² , ZHANG Jiao ³

1. the First Department of Gynaecology, the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin, Heilongjiang 150040, P. R. China;
2. Department of Obstetrics and Gynecology, the First Hospital of Harbin, Harbin, Heilongjiang 150010, P. R. China;
3. Traditional Chinese Medicine Hall, the Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin, Heilongjiang 150001, P. R. China;

Corresponding author：

ZHANG Yuehui, Email: chizishui-04@163.com

Keywords：

Anti-Müllerian hormone; Polycystic ovary syndrome; Follicular development

DOI：

10.7507/1002-0179.201911250

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Polycystic ovary syndrome is one of the common reproductive endocrine diseases in women in recent years. A large number of studies have found that serum anti-Müllerian hormone levels in patients with polycystic ovary syndrome are significantly higher than those in normal women, especially in anovulatory patients with polycystic ovary syndrome. This article briefly introduces the relationship between follicular development, hyperandrogenemia, obesity, and insulin resistance in the pathological manifestations of polycystic ovary syndrome and anti-Müllerian hormone, and the application of anti-Müllerian hormone in assisted reproduction, ovarian reserve and diagnosis in patients with polycystic ovary syndrome. It aims to provide a basis for better use of anti-Müllerian in the diagnosis and treatment of polycystic ovary syndrome.

Citation： ZHANG Yizhuo, ZHANG Yuehui, HAN Yanhua, WANG Lijing, LIU Chang, ZHANG Jiao. The role of anti-Müllerian hormone in polycystic ovary syndrome. West China Medical Journal, 2020, 35(11): 1399-1403. doi: 10.7507/1002-0179.201911250 Copy

1.	Homburg R, Crawford G. The role of AMH in anovulation associated with PCOS: a hypothesis. Hum Reprod, 2014, 29(6): 1117-1121.
2.	Saxena U, Ramani M, Singh P. Role of AMH as diagnostic tool for polycystic ovarian syndrome. J Obstet Gynaecol India, 2018, 68(2): 117-122.
3.	Dumont A, Robin G, Catteau-Jonard S, et al. Role of anti-Müllerian hormone in pathophysiology, diagnosis and treatment of polycystic ovary syndrome: a review. Reprod Biol Endocrinol, 2015, 13: 137.
4.	Shi Y, Li L, Zhou J, et al. Efficacy of electroacupuncture in regulating the imbalance of AMH and FSH to improve follicle development and hyperandrogenism in PCOS rats. Biomed Pharmacother, 2019, 113: 108687.
5.	Matsuzaki T, Munkhzaya M, Iwasa T, et al. Relationship between serum anti-Mullerian hormone and clinical parameters in polycystic ovary syndrome. Endocr J, 2017, 64(5): 531-541.
6.	张欣, 邓琳琳. 雄激素抑制剂对 PCOS 患者血清 AMH 等指标的影响初探. 现代妇产科进展, 2012, 21(6): 482-483.
7.	梁光林, 郑文玲, 刘传勇, 等. PCOS 患者内分泌代谢异常与 AMH 水平的关系研究. 中国医药科学, 2018, 8(15): 254-256.
8.	彭璇, 李霞, 辜敏. 多囊卵巢综合征患者血清抗苗勒氏管激素与游离睾酮指数的相关性研究. 中国妇幼保健, 2015, 30(34): 5960-5962.
9.	Gorsic LK, Kosova G, Werstein B, et al. Pathogenic anti-Müllerian hormone variants in polycystic ovary syndrome. J Clin Endocrinol Metab, 2017, 102(8): 2862-2872.
10.	李金萍, 王焱. 高雄激素和非高雄激素型多囊卵巢综合征患者血清抗苗勒管激素分泌特点及诊断效能比较. 实用妇科内分泌电子杂志, 2017, 4(5): 50, 52.
11.	王小霞, 邓翠. PCOS 患者血清 AMH 水平与胰岛素抵抗及雄激素的相关性研究. 湖北民族学院学报(医学版), 2017, 34(2): 8-10, 14.
12.	Bothou A, Koutlaki N, Iatrakis G, et al. AntiMüllerian hormone as indicator of ovarian dysfunction. Acta Endocrinol (Buchar), 2017, 13(2): 237-245.
13.	Verma AK, Rajbhar S, Mishra J, et al. Anti-Mullerian hormone:a marker of ovarian reserve and its association with polycystic ovarian syndrome. J Clin Diagn Res, 2016, 10(12): QC10-QC12.
14.	周密, 丁旭, 宋晖, 等. 多囊卵巢综合征患者血清抗苗勒管激素与肥胖、胰岛素抵抗程度的相关性分析. 现代生物医学进展, 2018, 18(10): 1916-1921.
15.	刘增娟, 徐磊. 多囊卵巢综合征患者血清抗苗勒氏管激素水平与胰岛素抵抗及雄激素的相关性评价. 中外医疗, 2019, 38(23): 26-28.
16.	余莎, 刘明铭, 关嵩青, 等. 多囊卵巢综合征患者血清 AMH 与胰岛素抵抗水平的关系. 深圳中西医结合杂志, 2017, 27(1): 1-3.
17.	Foroozanfard F, Samimi M, Almadani KH, et al. Effect of metformin on the anti-Müllerian hormone level in infertile women with polycystic ovarian syndrome. Electron Physician, 2017, 9(12): 5969-5973.
18.	Szafarowska M, Dziech E, Kaleta B, et al. Anti-Müllerian hormone level is associated with vitamin D receptor polymorphisms in women with polycystic ovary syndrome. J Assist Reprod Genet, 2019, 36(6): 1281-1289.
19.	Zhang JF, Yu CM, Yan LL, et al. Effect of anti-mullerian hormone on stem cell factor in serum, follicular fluid and ovarian granular cells of polycystic ovarian syndrome patients. Eur Rev Med Pharmacol Sci, 2018, 22(22): 7877-7882.
20.	Arslan E, Gorkem U, Togrul C. Is there a relationship between vitamin D deficiency status and PCOS in infertile women?. Geburtshilfe Frauenheilkd, 2019, 79(7): 723-730.
21.	Vembu R, Reddy NS. Serum AMH level to predict the hyper response in women with PCOS and non-PCOS undergoing controlled ovarian stimulation in ART. J Hum Reprod Sci, 2017, 10(2): 91-94.
22.	于艳丽, 刘秀荣, 姚淑红. 血清抗苗勒管激素、黄体生成激素水平与多囊卵巢综合征不孕患者促排卵疗效的关系. 兰州大学学报(医学版), 2019, 45(4): 10-13, 19.
23.	欧阳璐, 王恩银, 李婧, 等. 抗苗勒管激素水平对多囊卵巢综合征患者行卵泡期长效长方案助孕结局的影响. 生殖医学杂志, 2019, 28(5): 451-456.
24.	Christiansen SC, Eilertsen TB, Vanky E, et al. Does AMH reflect follicle number similarly in women with and without PCOS?. PLoS One, 2016, 11(1): e0146739.
25.	张琦, 汤美玲, 沈澍. 血清 AMH 联合性激素检测在诊断多囊卵巢综合征患者中的应用研究. 中国实验诊断学, 2019, 23(8): 1344-1346.
26.	范芸, 解娟, 施瑞洁, 等. 抗苗勒氏管激素和卵泡刺激素对多囊卵巢综合征的诊断效能研究. 中国临床药理学杂志, 2019, 35(21): 2665-2667.
27.	Kim JY, Tfayli H, Michaliszyn SF, et al. Anti-Müllerian hormone in obese adolescent girls with polycystic ovary syndrome. J Adolesc Health, 2017, 60(3): 333-339.
28.	Song DK, Oh JY, Lee H, et al. Differentiation between polycystic ovary syndrome and polycystic ovarian morphology by means of an anti-Müllerian hormone cutoff value. Korean J Intern Med, 2017, 32(4): 690-698.
29.	Yue CY, Lu LK, Li M, et al. Threshold value of anti-Mullerian hormone for the diagnosis of polycystic ovary syndrome in Chinese women. PLoS One, 2018, 13(8): e0203129.
30.	Aydoğmuş H, Kelekçi S, Elmalı F, et al. Can we use serum anti-Mullerian hormone to differentiate the diagnosis between polycystic ovary syndrome patients and healthy women with polycystic ovarian morphology and regular menstrual cycles. Saudi Med J, 2018, 39(10): 1011-1016.
31.	陈颖, 陆娄凯奕, 张倩岚, 等. 抗苗勒管激素和内分泌代谢指标在多囊卵巢综合征诊断中的应用. 中华生殖与避孕杂志, 2018, 38(10): 847-851.
32.	Tokmak A, Timur H, Aksoy RT, et al. Is anti-Mullerian hormonea good diagnostic marker for adolescent and young adult patients with Polycystic ovary syndrome?. Turk J Obstet Gynecol, 2015, 12(4): 199-204.

1. Homburg R, Crawford G. The role of AMH in anovulation associated with PCOS: a hypothesis. Hum Reprod, 2014, 29(6): 1117-1121.
2. Saxena U, Ramani M, Singh P. Role of AMH as diagnostic tool for polycystic ovarian syndrome. J Obstet Gynaecol India, 2018, 68(2): 117-122.
3. Dumont A, Robin G, Catteau-Jonard S, et al. Role of anti-Müllerian hormone in pathophysiology, diagnosis and treatment of polycystic ovary syndrome: a review. Reprod Biol Endocrinol, 2015, 13: 137.
4. Shi Y, Li L, Zhou J, et al. Efficacy of electroacupuncture in regulating the imbalance of AMH and FSH to improve follicle development and hyperandrogenism in PCOS rats. Biomed Pharmacother, 2019, 113: 108687.
5. Matsuzaki T, Munkhzaya M, Iwasa T, et al. Relationship between serum anti-Mullerian hormone and clinical parameters in polycystic ovary syndrome. Endocr J, 2017, 64(5): 531-541.
6. 张欣, 邓琳琳. 雄激素抑制剂对 PCOS 患者血清 AMH 等指标的影响初探. 现代妇产科进展, 2012, 21(6): 482-483.
7. 梁光林, 郑文玲, 刘传勇, 等. PCOS 患者内分泌代谢异常与 AMH 水平的关系研究. 中国医药科学, 2018, 8(15): 254-256.
8. 彭璇, 李霞, 辜敏. 多囊卵巢综合征患者血清抗苗勒氏管激素与游离睾酮指数的相关性研究. 中国妇幼保健, 2015, 30(34): 5960-5962.
9. Gorsic LK, Kosova G, Werstein B, et al. Pathogenic anti-Müllerian hormone variants in polycystic ovary syndrome. J Clin Endocrinol Metab, 2017, 102(8): 2862-2872.
10. 李金萍, 王焱. 高雄激素和非高雄激素型多囊卵巢综合征患者血清抗苗勒管激素分泌特点及诊断效能比较. 实用妇科内分泌电子杂志, 2017, 4(5): 50, 52.
11. 王小霞, 邓翠. PCOS 患者血清 AMH 水平与胰岛素抵抗及雄激素的相关性研究. 湖北民族学院学报(医学版), 2017, 34(2): 8-10, 14.
12. Bothou A, Koutlaki N, Iatrakis G, et al. AntiMüllerian hormone as indicator of ovarian dysfunction. Acta Endocrinol (Buchar), 2017, 13(2): 237-245.
13. Verma AK, Rajbhar S, Mishra J, et al. Anti-Mullerian hormone:a marker of ovarian reserve and its association with polycystic ovarian syndrome. J Clin Diagn Res, 2016, 10(12): QC10-QC12.
14. 周密, 丁旭, 宋晖, 等. 多囊卵巢综合征患者血清抗苗勒管激素与肥胖、胰岛素抵抗程度的相关性分析. 现代生物医学进展, 2018, 18(10): 1916-1921.
15. 刘增娟, 徐磊. 多囊卵巢综合征患者血清抗苗勒氏管激素水平与胰岛素抵抗及雄激素的相关性评价. 中外医疗, 2019, 38(23): 26-28.
16. 余莎, 刘明铭, 关嵩青, 等. 多囊卵巢综合征患者血清 AMH 与胰岛素抵抗水平的关系. 深圳中西医结合杂志, 2017, 27(1): 1-3.
17. Foroozanfard F, Samimi M, Almadani KH, et al. Effect of metformin on the anti-Müllerian hormone level in infertile women with polycystic ovarian syndrome. Electron Physician, 2017, 9(12): 5969-5973.
18. Szafarowska M, Dziech E, Kaleta B, et al. Anti-Müllerian hormone level is associated with vitamin D receptor polymorphisms in women with polycystic ovary syndrome. J Assist Reprod Genet, 2019, 36(6): 1281-1289.
19. Zhang JF, Yu CM, Yan LL, et al. Effect of anti-mullerian hormone on stem cell factor in serum, follicular fluid and ovarian granular cells of polycystic ovarian syndrome patients. Eur Rev Med Pharmacol Sci, 2018, 22(22): 7877-7882.
20. Arslan E, Gorkem U, Togrul C. Is there a relationship between vitamin D deficiency status and PCOS in infertile women?. Geburtshilfe Frauenheilkd, 2019, 79(7): 723-730.
21. Vembu R, Reddy NS. Serum AMH level to predict the hyper response in women with PCOS and non-PCOS undergoing controlled ovarian stimulation in ART. J Hum Reprod Sci, 2017, 10(2): 91-94.
22. 于艳丽, 刘秀荣, 姚淑红. 血清抗苗勒管激素、黄体生成激素水平与多囊卵巢综合征不孕患者促排卵疗效的关系. 兰州大学学报(医学版), 2019, 45(4): 10-13, 19.
23. 欧阳璐, 王恩银, 李婧, 等. 抗苗勒管激素水平对多囊卵巢综合征患者行卵泡期长效长方案助孕结局的影响. 生殖医学杂志, 2019, 28(5): 451-456.
24. Christiansen SC, Eilertsen TB, Vanky E, et al. Does AMH reflect follicle number similarly in women with and without PCOS?. PLoS One, 2016, 11(1): e0146739.
25. 张琦, 汤美玲, 沈澍. 血清 AMH 联合性激素检测在诊断多囊卵巢综合征患者中的应用研究. 中国实验诊断学, 2019, 23(8): 1344-1346.
26. 范芸, 解娟, 施瑞洁, 等. 抗苗勒氏管激素和卵泡刺激素对多囊卵巢综合征的诊断效能研究. 中国临床药理学杂志, 2019, 35(21): 2665-2667.
27. Kim JY, Tfayli H, Michaliszyn SF, et al. Anti-Müllerian hormone in obese adolescent girls with polycystic ovary syndrome. J Adolesc Health, 2017, 60(3): 333-339.
28. Song DK, Oh JY, Lee H, et al. Differentiation between polycystic ovary syndrome and polycystic ovarian morphology by means of an anti-Müllerian hormone cutoff value. Korean J Intern Med, 2017, 32(4): 690-698.
29. Yue CY, Lu LK, Li M, et al. Threshold value of anti-Mullerian hormone for the diagnosis of polycystic ovary syndrome in Chinese women. PLoS One, 2018, 13(8): e0203129.
30. Aydoğmuş H, Kelekçi S, Elmalı F, et al. Can we use serum anti-Mullerian hormone to differentiate the diagnosis between polycystic ovary syndrome patients and healthy women with polycystic ovarian morphology and regular menstrual cycles. Saudi Med J, 2018, 39(10): 1011-1016.
31. 陈颖, 陆娄凯奕, 张倩岚, 等. 抗苗勒管激素和内分泌代谢指标在多囊卵巢综合征诊断中的应用. 中华生殖与避孕杂志, 2018, 38(10): 847-851.
32. Tokmak A, Timur H, Aksoy RT, et al. Is anti-Mullerian hormonea good diagnostic marker for adolescent and young adult patients with Polycystic ovary syndrome?. Turk J Obstet Gynecol, 2015, 12(4): 199-204.

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