Analysis of <i>Helicobacter pylori</i> infection and its risk factors among health examination participants in a general hospital_West China Medical Journal

Authors：

SONG Yu ¹ ,  ZHOU Yunzhu ¹ , XUE Peili ¹ , CAI Zhouquan ¹ , LAN Yajia ²

1. Department of Health Management, Sichuan Science City Hospital, Mianyang, Sichuan 621000, P. R. China;
2. Department of Occupational and Environmental Medicine, West China School of Public Health, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

ZHOU Yunzhu, Email: yunzhu_zhou@163.com

Keywords：

Helicobacter pylori; Infection rate; Risk factors

DOI：

10.7507/1002-0179.202002261

Video：

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Objective To investigate and analyze the prevalence and influencing factors of Helicobacter pylori (Hp), to provide scientific basis for the development of Hp infection prevention and control program.Methods The Hp infection of healthy population who received ¹³C-urea breath test in Sichuan Science City Hospital from January to December 2018 were retrospectively analyzed. Medical examination reports were collected and sorted out. We compared the gender and age differences of Hp infection, and binary logistic regression analysis was performed to analyze the risk factors of Hp infection.Results A total of 8 093 healthy participants were included, including 5 530 males (68.33%) and 2 563 females (31.67%). The infection rate of Hp was 37.80% (3 059/8 093) in all subjects. The infection rate of males [39.48% (2 183/5 530)] was significantly higher than that of females [34.18% (876/2 563)] (χ²=20.899, P<0.001). The infection rate of 50-59 years old group was the highest (43.87%), and that of <30 years old group was the lowest (30.93%). The difference of Hp infection rate among different age groups was statistically significant (χ²=64.577, P<0.001). Logistic regression analysis showed that male [odds ratio (OR) =1.257, P<0.001], 40-49 years old (OR=1.446, P<0.001), 50-59 years old (OR=1.756, P<0.001), 60-69 years old (OR=1.512, P<0.001), high total cholesterol level (OR=1.221, P=0.003) and obesity (OR=1.403, P<0.001) were risk factors for Hp infection.Conclusions The prevalence of Hp infection in the general hospital is lower than the national average level, and male, 40-69 years old, high total cholesterol level and obesity are predictors of Hp infection. Effective measures should be taken to prevent and control the infection of Hp.

Citation： SONG Yu, ZHOU Yunzhu, XUE Peili, CAI Zhouquan, LAN Yajia. Analysis of Helicobacter pylori infection and its risk factors among health examination participants in a general hospital. West China Medical Journal, 2021, 36(4): 493-498. doi: 10.7507/1002-0179.202002261 Copy

1.	何涛君, 吴正林, 钟小强, 等. 乙肝患者 HBV 载量与 IgA, IgG, IgM 及 C3, C4 相关性研究. 现代检验医学杂志, 2015, 30(4): 67-70.
2.	Nam SY, Ryu KH, Park BJ, et al. Effects of Helicobacter pylori infection and its eradication on lipid profiles and cardiovascular diseases. Helicobacter, 2015, 20(2): 125-132.
3.	Xie C, Lu NH. Review: clinical management of Helicobacter pylori infection in China. Helicobacter, 2014, 20(1): 1-10.
4.	刘捷, 王永红, 罗蓉, 等. 重庆地区 ¹³C 尿素呼气试验阳性的健康体检人群幽门螺杆菌感染率及相关危险因素分析. 重庆医科大学学报, 2017, 42(10): 1358-1362.
5.	中国肥胖问题工作组. 中国成人超重与肥胖症预防与控制指南(节录). 营养学报, 2004, 26(1): 1-4.
6.	Vilaichone RK, Mahachai V, Shiota S, et al. Extremely high prevalence of Helicobacter pylori infection in Bhutan. World J Gastroenterol, 2013, 19(18): 2806-2810.
7.	Hunt RH, Xiao SD, Megraud F, et al. Helicobacter pylori in developing countries. World gastroenterology organisation global guideline. J Gastrointestin Liver Dis, 2011, 20(3): 299-304.
8.	唐怀蓉, 范云洁, 刘莎. 成都地区幽门螺杆菌感染现状及相关影响因素分析. 四川大学学报(医学版), 2014, 45(5): 823-826.
9.	孟凡娜, 孙丽. 重庆地区健康体检人群中幽门螺旋杆菌感染现状研究分析. 现代检验医学杂志, 2018, 33(5): 121-122, 125.
10.	Park JY, Forman D, Waskito LA, et al. Epidemiology of Helicobacter pylori and CagA-positive infections and global variations in gastric cancer. Toxins (Basel), 2018, 10(4): 163.
11.	Hu Y, Zhu Y, Lu N. Novel and effective therapeutic regimens for Helicobacter pylori in an era of increasing antibiotic resistance. Front Cell Infect Microbiol, 2017, 7: 168.
12.	Syam AF, Miftahussurur M, Makmun D, et al. Risk factors and prevalence of Helicobacter pylori in five largest islands of Indonesia: a preliminary study. PLoS One, 2015, 10(11): e140186.
13.	Marušić M, Majstorović Barać K, Bilić A, et al. Do gender and age influence the frequency of Helicobacter pylori infection?. Wien Klin Wochenschr, 2013, 125(21-22): 714-716.
14.	于海婧. 吸烟饮酒对胃部疾病幽门螺旋杆菌感染的影响. 局解手术学杂志, 2011, 20(1): 84.
15.	Kopacova M, Koupil I, Seifert B, et al. Blood pressure and stature in Helicobacter pylori positive and negative persons. World J Gastroenterol, 2014, 20(19): 5625-5631.
16.	Roman S, Pandolfino JE. Environmental-lifestyle related factors. Best Pract Res Clin Gastroenterol, 2010, 24(6): 847-859.
17.	林燕, 杨国胜, 潘克勤. 52 例老年幽门螺杆菌感染者胃黏膜病变观察. 浙江预防医学, 2003, 15(9): 62-63.
18.	Salles N. Helicobacter pylori infection in elderly patients. Rev Med Interne, 2007, 28(6): 400-411.
19.	张玫, 汤哲, 汤欣, 等. 社会因素对老年人群幽门螺杆菌感染的影响. 世界华人消化杂志, 2005, 13(14): 1779-1780.
20.	李琳, 张婉红, 陈伟才, 等. 幽门螺旋杆菌感染和年龄与血脂异常的临床相关性研究. 江西医药, 2018, 53(7): 685-687.
21.	Jeon CY, Haan MN, Cheng C, et al. Helicobacter pylori infection is associated with an increased rate of diabetes. Diabetes Care, 2012, 35(3): 520-525.

1. 何涛君, 吴正林, 钟小强, 等. 乙肝患者 HBV 载量与 IgA, IgG, IgM 及 C3, C4 相关性研究. 现代检验医学杂志, 2015, 30(4): 67-70.
2. Nam SY, Ryu KH, Park BJ, et al. Effects of Helicobacter pylori infection and its eradication on lipid profiles and cardiovascular diseases. Helicobacter, 2015, 20(2): 125-132.
3. Xie C, Lu NH. Review: clinical management of Helicobacter pylori infection in China. Helicobacter, 2014, 20(1): 1-10.
4. 刘捷, 王永红, 罗蓉, 等. 重庆地区 ¹³C 尿素呼气试验阳性的健康体检人群幽门螺杆菌感染率及相关危险因素分析. 重庆医科大学学报, 2017, 42(10): 1358-1362.
5. 中国肥胖问题工作组. 中国成人超重与肥胖症预防与控制指南(节录). 营养学报, 2004, 26(1): 1-4.
6. Vilaichone RK, Mahachai V, Shiota S, et al. Extremely high prevalence of Helicobacter pylori infection in Bhutan. World J Gastroenterol, 2013, 19(18): 2806-2810.
7. Hunt RH, Xiao SD, Megraud F, et al. Helicobacter pylori in developing countries. World gastroenterology organisation global guideline. J Gastrointestin Liver Dis, 2011, 20(3): 299-304.
8. 唐怀蓉, 范云洁, 刘莎. 成都地区幽门螺杆菌感染现状及相关影响因素分析. 四川大学学报(医学版), 2014, 45(5): 823-826.
9. 孟凡娜, 孙丽. 重庆地区健康体检人群中幽门螺旋杆菌感染现状研究分析. 现代检验医学杂志, 2018, 33(5): 121-122, 125.
10. Park JY, Forman D, Waskito LA, et al. Epidemiology of Helicobacter pylori and CagA-positive infections and global variations in gastric cancer. Toxins (Basel), 2018, 10(4): 163.
11. Hu Y, Zhu Y, Lu N. Novel and effective therapeutic regimens for Helicobacter pylori in an era of increasing antibiotic resistance. Front Cell Infect Microbiol, 2017, 7: 168.
12. Syam AF, Miftahussurur M, Makmun D, et al. Risk factors and prevalence of Helicobacter pylori in five largest islands of Indonesia: a preliminary study. PLoS One, 2015, 10(11): e140186.
13. Marušić M, Majstorović Barać K, Bilić A, et al. Do gender and age influence the frequency of Helicobacter pylori infection?. Wien Klin Wochenschr, 2013, 125(21-22): 714-716.
14. 于海婧. 吸烟饮酒对胃部疾病幽门螺旋杆菌感染的影响. 局解手术学杂志, 2011, 20(1): 84.
15. Kopacova M, Koupil I, Seifert B, et al. Blood pressure and stature in Helicobacter pylori positive and negative persons. World J Gastroenterol, 2014, 20(19): 5625-5631.
16. Roman S, Pandolfino JE. Environmental-lifestyle related factors. Best Pract Res Clin Gastroenterol, 2010, 24(6): 847-859.
17. 林燕, 杨国胜, 潘克勤. 52 例老年幽门螺杆菌感染者胃黏膜病变观察. 浙江预防医学, 2003, 15(9): 62-63.
18. Salles N. Helicobacter pylori infection in elderly patients. Rev Med Interne, 2007, 28(6): 400-411.
19. 张玫, 汤哲, 汤欣, 等. 社会因素对老年人群幽门螺杆菌感染的影响. 世界华人消化杂志, 2005, 13(14): 1779-1780.
20. 李琳, 张婉红, 陈伟才, 等. 幽门螺旋杆菌感染和年龄与血脂异常的临床相关性研究. 江西医药, 2018, 53(7): 685-687.
21. Jeon CY, Haan MN, Cheng C, et al. Helicobacter pylori infection is associated with an increased rate of diabetes. Diabetes Care, 2012, 35(3): 520-525.

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