• 1. First Clinical College, Zunyi Medical University, Zunyi, Guizhou 563000, P. R. China;
  • 2. Endoscopy Center, Suining Central Hospital, Suining, Sichuan 629000, P. R. China;
  • 3. Fourth Department of the Digestive Disease Center, Suining Central Hospital, Suining, Sichuan 629000, P. R. China;
HE Suyu, Email: hesuyu2009@163.com
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Gastroesophageal reflux disease (GERD) is a common, chronic disease of the digestive system. In recent years, endoluminal therapy for GERD has become a research hotspot. The reduced anti-reflux barrier function plays an important role in the occurrence of GERD. Peroral endoscopic therapy can improve the defect of anti-reflux barrier function. According to the involved layers, the endoscopic therapy can be classified as transmural which represented by transoral incisionless and transoral incisionless fundoplication, and non-transmural which represented by peroral endoscopic cardia constriction and radiofrequency ablation. This article reviews the progress of endoscopic non-full-thickness therapy for GERD in recent years, and introduces the action mechanism of peroral endoscopic therapy of GERD, the therapy of the mucosal layer and muscle layer of anti-reflux barrier, and other treatments. The purpose is to provide a reference for further exploring suitable endoscopic treatment of GERD.

Citation: XU Fei, XIONG Xin, JING Xiaojuan, HE Suyu. Clinical research progress of peroral endoscopic non-full-thickness therapy for gastroesophageal reflux disease. West China Medical Journal, 2021, 36(7): 979-985. doi: 10.7507/1002-0179.202002325 Copy

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