Analysis of the influencing factors of frailty in maintenance hemodialysis patients and its correlation with sleep_West China Medical Journal

Authors：

GAO Menglin , ZENG Ying , WANG Xue , YANG Yujie ,  YUAN Huaihong

Department of Nephrology, West China Hospital, Sichuan University / West China School of Nursing, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

YUAN Huaihong, Email: yuanhuaihong@wchscu.cn

Keywords：

Maintenance hemodialysis; Pittsburgh Sleep Quality Index; frail; influencing factors; correlation

DOI：

10.7507/1002-0179.202106180

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To understand the incidence of frailty in maintenance hemodialysis (MHD) patients, and to explore the correlation and influencing factors of frailty in MHD patients, so as to provide some basis for the intervention of frailty in MHD patients. Methods Patients who underwent MHD in the Department of Nephrology of West China Hospital of Sichuan University from January to March 2021 were selected. Frail scale and Pittsburgh Sleep Quality Index (PSQI) were used for evaluation, and the influencing factors of frail in patients with MHD and its correlation with frail were analyzed. Results A total of 141 patients with MHD were included, including 57 cases without frailty (40.43%), 71 cases in early frailty (50.35%), and 13 cases in frailty (9.22%). 54 cases (38.30%) had very good sleep quality, 56 cases (39.72%) had good sleep quality, 24 cases (17.02%) had average sleep quality, and 7 cases (4.96%) had very poor sleep quality. The frailty of MHD patients was positively correlated with age (r_s=0.265, P=0.002), PSQI (r_s=0.235, P=0.005) and magnesium (r_s=0.280, P=0.001). Logistic regression analysis showed that the influencing factors of MHD patients’ frailty were gender [odds ratio (OR) =4.321, 95%confidence interval (CI) (1.525, 12.243), P=0.006], PSQI [OR=1.110, 95%CI (1.009, 1.222), P=0.032], magnesium [OR=122.072, 95%CI (4.752, 3 135.528), P=0.004], hypertension [OR=0.112, 95%CI (0.023, 0.545), P=0.007] and other diseases [OR=0.102, 95%CI (0.019, 0.552), P=0.008]. Conclusions The incidence of frailty in MHD patients is high. Gender, PSQI, magnesium, hypertension and other diseases are the influencing factors of frailty in MHD patients, and there is a correlation between frailty and sleep. It is suggested that renal medical staff should pay more attention to the assessment of MHD frailty and sleep, and carry out multi-disciplinary personalized intervention to improve the quality of life of MHD patients.

Citation： GAO Menglin, ZENG Ying, WANG Xue, YANG Yujie, YUAN Huaihong. Analysis of the influencing factors of frailty in maintenance hemodialysis patients and its correlation with sleep. West China Medical Journal, 2022, 37(2): 242-247. doi: 10.7507/1002-0179.202106180 Copy

1.	Ling TW, Khuan L, Baharom A, et al. Coping strategies of patients with end stage kidney disease on hemodialysis: a systematic review. Nephrol Nurs J, 2021, 48(1): 31-48.
2.	Nitta K, Hanafusa N, Tsuchiya K. Role of frailty on outcomes of dialysis patients. Contrib Nephrol, 2018, 195: 102-109.
3.	Wennberg AMV, St Louis EK. Interconnectedness among frailty, sleep, and cognition: recent findings and clinical implications. Int Psychogeriatr, 2019, 31(6): 763-766.
4.	蔡康琴, 李伟, 王莉, 等. 血液透析患者衰弱现状的调查研究. 护理学杂志, 2019, 34(11): 24-27.
5.	Buysse DJ, Reynolds CF 3rd, Monk TH, et al. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res, 1989, 28(2): 193-213.
6.	李九红, 黄伶智, 任小红, 等. 维持性血液透析患者症状困扰与睡眠质量和生活质量的相关性研究. 中国护理管理, 2016, 16(1): 25-29.
7.	Chowdhury R, Peel NM, Krosch M, et al. Frailty and chronic kidney disease: a systematic review. Arch Gerontol Geriatr, 2017, 68: 135-142.
8.	Takeuchi H, Uchida HA, Kakio Y, et al. The prevalence of frailty and its associated factors in Japanese hemodialysis patients. Aging Dis, 2018, 9(2): 192-207.
9.	陈琰, 郑淑蓓, 郑育, 等. 维持性血液透析患者的衰弱情况及其影响因素. 中华肾脏病杂志, 2017, 33(10): 763-769.
10.	吴淑琳, 宋洁, 肖萍, 等. 维持性血液透析患者衰弱发生率及影响因素的系统评价. 中华护理教育, 2021, 18(4): 352-357.
11.	van Loon IN, Goto NA, Boereboom FTJ, et al. Frailty screening tools for elderly patients incident to dialysis. Clin J Am Soc Nephrol, 2017, 12(9): 1480-1488.
12.	赵敬娜, 罗莉, 苏香彪, 等. 维持性血液透析患者严重睡眠障碍调查及原因分析. 中国血液净化, 2019, 18(11): 783-786.
13.	刘美君, 崔文鹏, 苗里宁, 等. 维持性血液透析患者睡眠障碍的研究进展. 中国全科医学, 2020, 23(29): 3712-3718, 3728.
14.	Pourmotabbed A, Boozari B, Babaei A, et al. Sleep and frailty risk:a systematic review and meta-analysis. Sleep Breath, 2020, 24(3): 1187-1197.
15.	李九红, 黄伶智, 任小红, 等. 中药足浴对维持性血液透析患者睡眠质量和症状困扰的影响研究. 中国全科医学, 2016, 19(10): 1207-1212.
16.	郑伟, 李珊, 李亚新, 等. 住院老年患者衰弱与认知功能障碍的关系. 现代医学, 2018, 46(3): 326-330.
17.	夏宇晓, 于红静, 周英, 等. 老年人衰弱研究新进展. 全科护理, 2019, 17(1): 20-23.
18.	Lu C, Wang Y, Wang D, et al. Hypomagnesemia and short-term mortality in elderly maintenance hemodialysis patients. Kidney Dis (Basel), 2020, 6(2): 109-118.
19.	Santiago LM, Gobbens RJJ, Mattos IE, et al. A comparison between physical and biopsychosocial measures of frailty: prevalence and associated factors in Brazilian older adults. Arch Gerontol Geriatr, 2019, 81: 111-118.
20.	Aprahamian I, Sassaki E, Dos Santos MF, et al. Hypertension and frailty in older adults. J Clin Hypertens (Greenwich), 2018, 20(1): 186-192.
21.	郭潇潇, 高静, 向玉萍, 等. 老年 2 型糖尿病患者慢性并发症与衰弱的关联性研究. 中国疗养医学, 2019, 28(3): 225-229.
22.	王湾湾, 李园园, 石小天, 等. 老年住院患者衰弱的影响因素分析及其与营养不良的相关性研究. 中国全科医学, 2021, 24(6): 678-684.
23.	Tabara Y, Kohara K, Ochi M, et al. Association of office-based frailty score with hypertensive end organ damage in the J-SHIPP cross-sectional study. Int J Cardiol, 2016, 216: 25-31.

1. Ling TW, Khuan L, Baharom A, et al. Coping strategies of patients with end stage kidney disease on hemodialysis: a systematic review. Nephrol Nurs J, 2021, 48(1): 31-48.
2. Nitta K, Hanafusa N, Tsuchiya K. Role of frailty on outcomes of dialysis patients. Contrib Nephrol, 2018, 195: 102-109.
3. Wennberg AMV, St Louis EK. Interconnectedness among frailty, sleep, and cognition: recent findings and clinical implications. Int Psychogeriatr, 2019, 31(6): 763-766.
4. 蔡康琴, 李伟, 王莉, 等. 血液透析患者衰弱现状的调查研究. 护理学杂志, 2019, 34(11): 24-27.
5. Buysse DJ, Reynolds CF 3rd, Monk TH, et al. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res, 1989, 28(2): 193-213.
6. 李九红, 黄伶智, 任小红, 等. 维持性血液透析患者症状困扰与睡眠质量和生活质量的相关性研究. 中国护理管理, 2016, 16(1): 25-29.
7. Chowdhury R, Peel NM, Krosch M, et al. Frailty and chronic kidney disease: a systematic review. Arch Gerontol Geriatr, 2017, 68: 135-142.
8. Takeuchi H, Uchida HA, Kakio Y, et al. The prevalence of frailty and its associated factors in Japanese hemodialysis patients. Aging Dis, 2018, 9(2): 192-207.
9. 陈琰, 郑淑蓓, 郑育, 等. 维持性血液透析患者的衰弱情况及其影响因素. 中华肾脏病杂志, 2017, 33(10): 763-769.
10. 吴淑琳, 宋洁, 肖萍, 等. 维持性血液透析患者衰弱发生率及影响因素的系统评价. 中华护理教育, 2021, 18(4): 352-357.
11. van Loon IN, Goto NA, Boereboom FTJ, et al. Frailty screening tools for elderly patients incident to dialysis. Clin J Am Soc Nephrol, 2017, 12(9): 1480-1488.
12. 赵敬娜, 罗莉, 苏香彪, 等. 维持性血液透析患者严重睡眠障碍调查及原因分析. 中国血液净化, 2019, 18(11): 783-786.
13. 刘美君, 崔文鹏, 苗里宁, 等. 维持性血液透析患者睡眠障碍的研究进展. 中国全科医学, 2020, 23(29): 3712-3718, 3728.
14. Pourmotabbed A, Boozari B, Babaei A, et al. Sleep and frailty risk:a systematic review and meta-analysis. Sleep Breath, 2020, 24(3): 1187-1197.
15. 李九红, 黄伶智, 任小红, 等. 中药足浴对维持性血液透析患者睡眠质量和症状困扰的影响研究. 中国全科医学, 2016, 19(10): 1207-1212.
16. 郑伟, 李珊, 李亚新, 等. 住院老年患者衰弱与认知功能障碍的关系. 现代医学, 2018, 46(3): 326-330.
17. 夏宇晓, 于红静, 周英, 等. 老年人衰弱研究新进展. 全科护理, 2019, 17(1): 20-23.
18. Lu C, Wang Y, Wang D, et al. Hypomagnesemia and short-term mortality in elderly maintenance hemodialysis patients. Kidney Dis (Basel), 2020, 6(2): 109-118.
19. Santiago LM, Gobbens RJJ, Mattos IE, et al. A comparison between physical and biopsychosocial measures of frailty: prevalence and associated factors in Brazilian older adults. Arch Gerontol Geriatr, 2019, 81: 111-118.
20. Aprahamian I, Sassaki E, Dos Santos MF, et al. Hypertension and frailty in older adults. J Clin Hypertens (Greenwich), 2018, 20(1): 186-192.
21. 郭潇潇, 高静, 向玉萍, 等. 老年 2 型糖尿病患者慢性并发症与衰弱的关联性研究. 中国疗养医学, 2019, 28(3): 225-229.
22. 王湾湾, 李园园, 石小天, 等. 老年住院患者衰弱的影响因素分析及其与营养不良的相关性研究. 中国全科医学, 2021, 24(6): 678-684.
23. Tabara Y, Kohara K, Ochi M, et al. Association of office-based frailty score with hypertensive end organ damage in the J-SHIPP cross-sectional study. Int J Cardiol, 2016, 216: 25-31.

West China Medical Journal

Analysis of the influencing factors of frailty in maintenance hemodialysis patients and its correlation with sleep

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content