Research progress on the correlationship between gastroparesis and intestinal flora_West China Medical Journal

Authors：

ZHANG Xiumei ¹ , XU Zhihong ¹ , XIONG Xin ¹ , FENG Caiju ¹ , TANG Shilin ¹ ,  HE Suyu ^1,2

1. Graduate School of Zunyi Medical University, Zunyi, Guizhou 563000, P. R. China;
2. The Fourth Department of Digestive Disease Center, Suining Central Hospital, Suining, Sichuan 629000, P. R. China;

Corresponding author：

HE Suyu, Email: hesuyu2009@163.com

Keywords：

Gastroparesis; intestinal flora; postoperative gastroparesis; diabetic gastroparesis; idiopathic gastroparesis

DOI：

10.7507/1002-0179.202207018

Video：

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Abstract Full text Figures/Tables Video References Cited by

Gastroparesis is a gastrointestinal motility disorder that refers to delayed gastric emptying in the absence of mechanical obstruction. Clinical manifestations include postprandial fullness and epigastric discomfort, abdominal distension, nausea, and vomiting. According to its etiology, it can be divided into three categories: surgery-related gastroparesis, non-surgery-related gastroparesis and idiopathic gastroparesis. Non-surgery-related gastroparesis is common clinically. At present, the exact pathogenesis of gastroparesis remains to be unclear. The intestinal flora is huge and abundant. It participates in a variety of physiological functions of the host. Studies have confirmed that the intestinal flora is related to perioperative treatment measures, surgical stress, and various system diseases (endocrine and metabolic system diseases, nervous system diseases, and immune system diseases), especially the weakening of gastrointestinal motility, and gastrointestinal motility. Attenuation can further promote the occurrence and development of gastroparesis. Based on the current research, this article reviews the research on the correlation between gastroparesis and intestinal flora.

Citation： ZHANG Xiumei, XU Zhihong, XIONG Xin, FENG Caiju, TANG Shilin, HE Suyu. Research progress on the correlationship between gastroparesis and intestinal flora. West China Medical Journal, 2022, 37(11): 1726-1734. doi: 10.7507/1002-0179.202207018 Copy

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3.	Kichloo A, Dahiya DS, Wani F, et al. Diabetic and non-diabetic gastroparesis: a retrospective comparative outcome study from the nationwide inpatient sample. Gastroenterology Res, 2021, 14(1): 21-30.
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1. Rey E, Choung RS, Schleck CD, et al. Prevalence of hidden gastroparesis in the community: the gastroparesis “iceberg”. J Neurogastroenterol Motil, 2012, 18(1): 34-42.
2. Jung HK, Choung RS, Locke GR 3rd, et al. The incidence, prevalence, and outcomes of patients with gastroparesis in olmsted county, minnesota, from 1996 to 2006. Gastroenterology, 2009, 136(4): 1225-1233.
3. Kichloo A, Dahiya DS, Wani F, et al. Diabetic and non-diabetic gastroparesis: a retrospective comparative outcome study from the nationwide inpatient sample. Gastroenterology Res, 2021, 14(1): 21-30.
4. Dinan TG, Cryan JF. Gut instincts: microbiota as a key regulator of brain development, ageing and neurodegeneration. J Physiol, 2017, 595(2): 489-503.
5. 周敏, 朱京慈, 尹华华. 乳酸杆菌对重型颅脑损伤大鼠胃肠动力障碍的影响. 护理研究, 2010, 24(7): 581-584.
6. Ye Y, Yin Y, Huh SY, et al. Epidemiology, etiology and treatment of gastroparesis: real-world evidence from a large US national claims database. Gastroenterology, 2022, 162(1): 109-121.e5.
7. He S, Jia Y, Xu F, et al. Transient delayed gastric emptying following laparoscopic Nissen fundoplication for gastroesophageal reflux disease. Langenbecks Arch Surg, 2021, 406(5): 1397-1405.
8. Benedix F, Willems T, Kropf S, et al. Risk factors for delayed gastric emptying after esophagectomy. Langenbecks Arch Surg, 2017, 402(3): 547-554.
9. Egboh SC, Abere S. Gastroparesis: a multidisciplinary approach to management. Cureus, 2022, 14(1): e21295.
10. Vilchez-Vargas R, Salm F, Znalesniak EB, et al. Profiling of the bacterial microbiota along the murine alimentary tract. Int J Mol Sci, 2022, 23(3): 1783.
11. Zheng C, Chen T, Wang Y, et al. A randomised trial of probiotics to reduce severity of physiological and microbial disorders induced by partial gastrectomy for patients with gastric cancer. J Cancer, 2019, 10(3): 568-576.
12. Husebye E, Hellström PM, Sundler F, et al. Influence of microbial species on small intestinal myoelectric activity and transit in germ-free rats. Am J Physiol Gastrointest Liver Physiol, 2001, 280(3): G368-G380.
13. Dimidi E, Christodoulides S, Scott SM, et al. Mechanisms of action of probiotics and the gastrointestinal microbiota on gut motility and constipation. Adv Nutr, 2017, 8(3): 484-494.
14. Zheng Z, Tang J, Hu Y, Zhang W. Role of gut microbiota-derived signals in the regulation of gastrointestinal motility. Front Med (Lausanne), 2022, 9: 961703.
15. 叶博. 短链脂肪酸促进人和小鼠 gastroids 中产 ghrelin 细胞分化和小鼠胃排空的生理机制研究. 上海: 上海第二军医大学, 2015.
16. 张管平, 夏虎平. 顽固性便秘患者菌群移植前后肠道菌群变化及与肠道动力的相关性. 现代消化及介入诊疗, 2020, 25(1): 5-10.
17. Zheng LJ, Ma JC, Fang D, et al. The quantification and assessment of depression and anxiety in patients with postoperative gastroparesis syndrome. Ther Clin Risk Manag, 2018, 14: 551-556.
18. Tog C, Liu DS, Lim HK, et al. Risk factors for delayed gastric emptying following laparoscopic repair of very large hiatus hernias. BJS Open, 2017, 1(3): 75-83.
19. Oteri V, Martinelli A, Crivellaro E, et al. The impact of preoperative anxiety on patients undergoing brain surgery: a systematic review. Neurosurg Rev, 2021, 44(6): 3047-3057.
20. Russo R, Cristiano C, Avagliano C, et al. Gut-brain axis: role of lipids in the regulation of inflammation, pain and CNS diseases. Curr Med Chem, 2018, 25(32): 3930-3952.
21. Bailey MT, Coe CL. Maternal separation disrupts the integrity of the intestinal microflora in infant rhesus monkeys. Dev Psychobiol, 1999, 35(2): 146-155.
22. O’Mahony SM, Marchesi JR, Scully P, et al. Early life stress alters behavior, immunity and microbiota in rats: implications for irritable bowel syndrome and psychiatric illnesses. Biol Psychiatry, 2009, 65(3): 263-267.
23. Xiao HW, Ge C, Feng GX, et al. Gut microbiota modulates alcohol withdrawal-induced anxiety in mice. Toxicol Lett, 2018, 287: 23-30.
24. 李松泽, 黄泽清. 乳腺癌患者抑郁症状与肠道微生物相关性研究. 中国微生态学杂志, 2019, 31(6): 647-650.
25. Nikolova VL, Smith MRB, Hall LJ, et al. Perturbations in gut microbiota composition in psychiatric disorders: a review and meta-analysis. JAMA Psychiatry, 2021, 78(12): 1343-1354.
26. Tomova A, Bukovsky I, Rembert E, et al. The effects of vegetarian and vegan diets on gut microbiota. Front Nutr, 2019, 6: 47.
27. Moreira Júnior RE, de Carvalho LM, Dos Reis DC, et al. Diet-induced obesity leads to alterations in behavior and gut microbiota composition in mice. J Nutr Biochem, 2021, 92: 108622.
28. 王明钊, 王亮, 周岩冰, 等. 不同处理因素对大鼠肠道菌群的影响. 中国普通外科杂志, 2012, 21(5): 568-572.
29. Deng Y, Liu W, Wang J, et al. Intermittent fasting improves lipid metabolism through changes in gut microbiota in diet-induced obese mice. Med Sci Monit, 2020, 26: e926789.
30. Karl JP, Hatch AM, Arcidiacono SM, et al. Effects of psychological, environmental and physical stressors on the gut microbiota. Front Microbiol, 2018, 9: 2013.
31. Wan X, Bi J, Gao X, et al. Partial enteral nutrition preserves elements of gut barrier function, including innate immunity, intestinal alkaline phosphatase (IAP) level, and intestinal microbiota in mice. Nutrients, 2015, 7(8): 6294-6312.
32. Heneghan AF, Pierre JF, Tandee K, et al. Parenteral nutrition decreases paneth cell function and intestinal bactericidal activity while increasing susceptibility to bacterial enteroinvasion. JPEN J Parenter Enteral Nutr, 2014, 38(7): 817-824.
33. 王平, 李成林, 吉敏, 等. 老年人上腹部术后胃瘫的营养支持治疗. 中国误诊学杂志, 2011, 11(2): 268-270.
34. Hasler WL, Wilson LA, Nguyen LA, et al. Opioid use and potency are associated with clinical features, quality of life and use of resources in patients with gastroparesis. Clin Gastroenterol Hepatol, 2019, 17(7): 1285-1294.e1.
35. Walker AW, Flint HJ. Editorial: further evidence that proton pump inhibitors may impact on the gut microbiota. Aliment Pharmacol Ther, 2016, 43(10): 1104-1105.
36. Wang F, Meng J, Zhang L, et al. Morphine induces changes in the gut microbiome and metabolome in a morphine dependence model. Sci Rep, 2018, 8(1): 3596.
37. Akbarali HI, Dewey WL. Gastrointestinal motility, dysbiosis and opioid-induced tolerance: is there a link?. Nat Rev Gastroenterol Hepatol, 2019, 16(6): 323-324.
38. Lim HC, Kim JH, Youn YH, et al. Effects of the addition of mosapride to gastroesophageal reflux disease patients on proton pump inhibitor: a prospective randomized, double-blind study. J Neurogastroenterol Motil, 2013, 19(4): 495-502.
39. Levy EI, Hoang DM, Vandenplas Y. The effects of proton pump inhibitors on the microbiome in young children. Acta Paediatr, 2020, 109(8): 1531-1538.
40. Freedberg DE, Lamousé-Smith ES, Lightdale JR, et al. Use of acid suppression medication is associated with risk for C.difficile infection in infants and children: a population-based study. Clin Infect Dis, 2015, 61(6): 912-917.
41. Heidinger M, Gorkiewicz G, Freisinger O, et al. Ulcerative reflux esophagitis associated with Clostridium ventriculi following hiatoplasty-is antibiotic treatment necessary? A case report. Z Gastroenterol, 2020, 58(5): 456-460.
42. Lötstedt B, Boyer D, Visner G, et al. The impact of gastrointestinal dysmotility on the aerodigestive microbiome of pediatric lung transplant recipients. J Heart Lung Transplant, 2021, 40(3): 210-219.
43. Patangia DV, Anthony Ryan C, Dempsey E, et al. Impact of antibiotics on the human microbiome and consequences for host health. Microbiologyopen, 2022, 11(1): e1260.
44. Ge X, Ding C, Zhao W, et al. Antibiotics-induced depletion of mice microbiota induces changes in host serotonin biosynthesis and intestinal motility. J Transl Med, 2017, 15(1): 13.
45. McFarland LV, Ozen M, Dinleyici EC, et al. Comparison of pediatric and adult antibiotic-associated diarrhea and Clostridium difficile infections. World J Gastroenterol, 2016, 22(11): 3078-3104.
46. Helander EM, Webb MP, Menard B, et al. Metabolic and the surgical stress response considerations to improve postoperative recovery. Curr Pain Headache Rep, 2019, 23(5): 33.
47. Mizuta M, Endo I, Yamamoto S, et al. Perioperative supplementation with bifidobacteria improves postoperative nutritional recovery, inflammatory response, and fecal microbiota in patients undergoing colorectal surgery: a prospective, randomized clinical trial. Biosci Microbiota Food Health, 2016, 35(2): 77-87.
48. Wagner NRF, Zaparolli MR, Cruz MRR, et al. Postoperative changes in intestinal microbiota and use of probiotics in roux-en-y gastric bypass and sleeve vertical gastrectomy: an integrative review. Arq Bras Cir Dig, 2018, 31(4): e1400.
49. Medina DA, Pedreros JP, Turiel D, et al. Distinct patterns in the gut microbiota after surgical or medical therapy in obese patients. Peer J, 2017, 5: e3443.
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West China Medical Journal

Research progress on the correlationship between gastroparesis and intestinal flora

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