Establishment of reference intervals for platelet-related parameters in the elderly in Longquanyi District of Chengdu_West China Medical Journal

Authors：

LI Shuhua ^1,2 , LIAO Hongyan ¹ , MA Li ³ , ZHAO Guojiang ² ,  HE Dongmei ⁴ , KANG Xin ⁴ , YANG Lixi ⁵ , DAI Qin ⁶

1. Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. Department of Laboratory Medicine, the First People’s Hospital of Longquanyi District, Chengdu, Sichuan 610100, P. R. China;
3. West China School of Nursing / Institute of Hospital Management / Outpatient Department, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
4. Emergency Department, the First People’s Hospital of Longquanyi District, Chengdu, Sichuan 610100, P. R. China;
5. Department of Obstetrics, the First People’s Hospital of Longquanyi District, Chengdu, Sichuan 610100, P. R. China;
6. Department of Ophthalmology, the First People’s Hospital of Longquanyi District, Chengdu, Sichuan 610100, P. R. China;

Corresponding author：

HE Dongmei, Email: li370782178@163.com

Keywords：

The elderly; platelet-related parameters; reference interval

DOI：

10.7507/1002-0179.202210211

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Objective To establish the reference intervals for platelet-related parameters among the elderly population in Longquanyi District, Chengdu. Methods From November 1st to December 31st 2021, elderly individuals aged between 60 and 80 years were selected from the Longquanyi branch of a natural population cohort study initiated by West China Hospital of Sichuan University in 2021. Complete blood cell analysis was performed to obtain the platelet-related parameters. IBM SPSS Statistics 25 software was used to analyze the data and establish the reference intervals for platelet-related parameters among the elderly population in Longquanyi District. Results A total of 1938 reference individuals were selected by inclusion and exclusion criteria, and finally 1669 reference individuals, including 665 males and 1004 females, were included to establish the reference intervals after excluding outliers. The reference range of blood platelet count was (95.03-301.32)×10⁹/L for elderly men and (112.13-320.75)×10⁹/L for elderly women, respectively. The reference range of mean platelet volume was 8.97-13.80 fL for elderly men and 9.10-13.90 fL for elderly women, respectively. The reference range of plateletcrit was 0.13%-0.30% for elderly men and 0.14%-0.32% for elderly women, respectively. The reference range of platelet distribution width was 15.80-16.90 for elderly men and 15.70-16.90 for elderly women, respectively. Conclusion It is of practical significance to establish platelet-related parameters in the elderly in local region.

Citation： LI Shuhua, LIAO Hongyan, MA Li, ZHAO Guojiang, HE Dongmei, KANG Xin, YANG Lixi, DAI Qin. Establishment of reference intervals for platelet-related parameters in the elderly in Longquanyi District of Chengdu. West China Medical Journal, 2024, 39(4): 599-603. doi: 10.7507/1002-0179.202210211 Copy

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19.	张艺凡, 苏倍倍, 靳津, 等. MLR、MPV 与 2 型糖尿病患者肾小管损伤的相关性研究. 医学研究杂志, 2022, 51(6): 72-77.
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1. 卫生部临床检验标准专业委员会. 血细胞分析参考区间: WS/T 405-2012. 北京: 中国标准出版社, 2012.
2. 黄燕, 张珏, 张文霞, 等. 上海地区 29 614 例健康成人血小板相关参数分析. 临床输血与检验, 2021, 23(4): 506-510.
3. 丁宁, 王琳. 血小板参数参考区间的建立与分析. 临床血液学杂志, 2018, 31(6): 467-470.
4. 江虹, 陈思, 蔡力力, 等. 中国老年健康人群血常规检测结果多中心调查. 中华检验医学杂志, 2021, 44(1): 25-31.
5. 丛玉隆, 金大鸣, 王鸿利, 等. 中国人群血小板各项参数的调查分析. 中华检验医学杂志, 2004, 27(6): 35-37.
6. 卫生部临床检验标准专业委员会. 临床实验室检验项目参考区间的制定: WS/T 402-2012. 北京: 中国标准出版社, 2012.
7. 王鑫, 赵琴, 邓肇达, 等. 老年类风湿性关节炎治疗进展. 中国骨伤, 2017, 30(6): 576-580.
8. Berman S, Bucher J, Koyfman A, et al. Emergent complications of rheumatoid arthritis. J Emerg Med, 2018, 55(5): 647-658.
9. 杨仲岳, 陈晓梅, 石亚妹, 等. 中性粒细胞/淋巴细胞、血小板/淋巴细胞比值在类风湿关节炎中的研究进展. 中华医学杂志, 2020, 100(47): 3818-3820.
10. 胡盛寿. 中国心血管健康与疾病报告(2019). 北京: 科学出版社, 2020: 142-150.
11. Białas AJ, Siewiera K, Watała C, et al. Mitochondrial functioning abnormalities observed in blood platelets of chronic smoke-exposed guinea pigs - a pilot study. Int J Chron Obstruct Pulmon Dis, 2018, 13: 3707-3717.
12. Ibrahim H, Schutt RC, Hannawi B, et al. Association of immature platelets with adverse cardiovascular outcomes. J Am Coll Cardiol, 2014, 64(20): 2122-2129.
13. 韩良富, 卞晓洁, 潘赟, 等. 血小板参数在急性心肌梗死临床评估中的作用. 中华急诊医学杂志, 2016, 25(3): 349-355.
14. 耿子悦, 许雪丹, 王秋红, 等. 不同血压水平人群中血小板参数与新发脑卒中发生风险的关联性研究. 中华流行病学杂志, 2021, 42(9): 1580-1585.
15. 李欣明. 脑梗死患者免疫状态和血小板参数及活化指标的变化分析. 国际医药卫生导报, 2017, 23(15): 2394-2396.
16. 牟严艳, 叶中慧, 林梅珍, 等. 糖尿病流行病学研究进展. 糖尿病新世界, 2019, 22(4): 196-198.
17. Przygodzki T, Luzak B, Kassassir H, et al. Diabetes and hyperglycemia affect platelet GPIIIa expression. effects on adhesion potential of blood platelets from diabetic patients under in vitro flow conditions. Int J Mol Sci, 2020, 21(9): 3222.
18. 程亚琦, 尚进, 赵占正. 血小板压积对糖尿病进展至糖尿病肾病的预测效能. 中国实用医刊, 2020, 47(8): 5-8.
19. 张艺凡, 苏倍倍, 靳津, 等. MLR、MPV 与 2 型糖尿病患者肾小管损伤的相关性研究. 医学研究杂志, 2022, 51(6): 72-77.
20. 李子安, 阿祥仁, 冯建明, 等. 西宁市 8876 名健康汉族成人静脉血血小板相关参数参考值范围研究. 检验医学, 2012, 27(8): 681-683.

West China Medical Journal

Establishment of reference intervals for platelet-related parameters in the elderly in Longquanyi District of Chengdu

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