Research progress on intestinal microbiome characteristics and treatment strategies of childhood obesity_West China Medical Journal

Authors：

CAI Rui ^1,2 , GAO Rui ^1,2 , QIN Lang ^1,2 , ZHANG Qiong ³ , CHEN Mingli ³ , LIU Xiumei ³ ,  WANG Huiqing ^2,4

1. The Reproductive Medical Center, Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. Key Laboratory of Birth Defects and Related of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
3. Department of Obstetrics and Gynecology, Ziyang Maternal and Child Health Care Hospital, Ziyang, Sichuan 641300, P. R. China;
4. Department of Paediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

WANG Huiqing, Email: wanghuiqing@scu.edu.cn

Keywords：

Childhood obesity; intestinal microbiome; treatment strategy; probiotics; prebiotics; fecal microbiota transplantation

DOI：

10.7507/1002-0179.202307135

Video：

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Abstract Full text Figures/Tables Video References Cited by

Childhood obesity is a global public health problem that seriously affects the normal growth and development of children. In recent years, a large number of studies have pointed out that the intestinal microbiome is closely related to childhood obesity, and the treatment strategies targeting the intestinal microbiome have a certain improvement effect on childhood obesity. This article elaborates on the establishment and development of intestinal microbiome, intestinal microbiome characteristics, the mechanisms of intestinal microbiome involvement in the occurrence and development of childhood obesity, and potential intervention strategies, so as to provide more ideas for basic and clinical research on childhood obesity.

Citation： CAI Rui, GAO Rui, QIN Lang, ZHANG Qiong, CHEN Mingli, LIU Xiumei, WANG Huiqing. Research progress on intestinal microbiome characteristics and treatment strategies of childhood obesity. West China Medical Journal, 2023, 38(8): 1121-1127. doi: 10.7507/1002-0179.202307135 Copy

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2.	Spradley FT. Metabolic abnormalities and obesity’s impact on the risk for developing preeclampsia. Am J Physiol Regul Integr Comp Physiol, 2017, 312(1): R5-R12.
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1. Carbone A, Al Salhi Y, Tasca A, et al. Obesity and kidney stone disease: a systematic review. Minerva Urol Nefrol, 2018, 70(4): 393-400.
2. Spradley FT. Metabolic abnormalities and obesity’s impact on the risk for developing preeclampsia. Am J Physiol Regul Integr Comp Physiol, 2017, 312(1): R5-R12.
3. Carrizales-Sánchez AK, García-Cayuela T, Hernández-Brenes C, et al. Gut microbiota associations with metabolic syndrome and relevance of its study in pediatric subjects. Gut Microbes, 2021, 13(1): 1960135.
4. Whitaker RC, Wright JA, Pepe MS, et al. Predicting obesity in young adulthood from childhood and parental obesity. N Engl J Med, 1997, 337(13): 869-873.
5. Sandhu KV, Sherwin E, Schellekens H, et al. Feeding the microbiota-gut-brain axis: diet, microbiome, and neuropsychiatry. Transl Res, 2017, 179: 223-244.
6. Guyton K, Alverdy JC. The gut microbiota and gastrointestinal surgery. Nat Rev Gastroenterol Hepatol, 2017, 14(1): 43-54.
7. Tang WW, Hazen SL. Dietary metabolism, gut microbiota and acute heart failure. Heart, 2016, 102(11): 813-814.
8. Wei Y, Liang J, Su Y, et al. The associations of the gut microbiome composition and short-chain fatty acid concentrations with body fat distribution in children. Clin Nutr, 2021, 40(5): 3379-3390.
9. Scheithauer TPM, Rampanelli E, Nieuwdorp M, et al. Gut microbiota as a trigger for metabolic inflammation in obesity and type 2 diabetes. Front Immunol, 2020, 11: 571731.
10. Tian M, Li Q, Zheng T, et al. Maternal microbe-specific modulation of the offspring microbiome and development during pregnancy and lactation. Gut Microbes, 2023, 15(1): 2206505.
11. Tun HM, Bridgman SL, Chari R, et al. Roles of birth mode and infant gut microbiota in intergenerational transmission of overweight and obesity from mother to offspring. JAMA Pediatr, 2018, 172(4): 368-377.
12. Lou YC, Olm MR, Diamond S, et al. Infant gut strain persistence is associated with maternal origin, phylogeny, and traits including surface adhesion and iron acquisition. Cell Rep Med, 2021, 2(9): 100393.
13. Leiby JS, McCormick K, Sherrill-Mix S, et al. Lack of detection of a human placenta microbiome in samples from preterm and term deliveries. Microbiome, 2018, 6(1): 196.
14. Sanidad KZ, Zeng MY. Neonatal gut microbiome and immunity. Curr Opin Microbiol, 2020, 56: 30-37.
15. Palmer C, Bik EM, DiGiulio DB, et al. Development of the human infant intestinal microbiota. PLoS Biol, 2007, 5(7): e177.
16. Shao Y, Forster SC, Tsaliki E, et al. Stunted microbiota and opportunistic pathogen colonization in caesarean-section birth. Nature, 2019, 574(7776): 117-121.
17. Korpela K, Helve O, Kolho KL, et al. Maternal fecal microbiota transplantation in cesarean-born infants rapidly restores normal gut microbial development: a proof-of-concept study. Cell, 2020, 183(2): 324-334. e5.
18. Parigi SM, Eldh M, Larssen P, et al. Breast milk and solid food shaping intestinal immunity. Front Immunol, 2015, 6: 415.
19. Differding MK, Mueller NT. Human milk bacteria: seeding the infant gut?. Cell Host Microbe, 2020, 28(2): 151-153.
20. Haddad EN, Sugino KY, Kerver JM, et al. The infant gut microbiota at 12 months of age is associated with human milk exposure but not with maternal pre-pregnancy body mass index or infant BMI-for-age z-scores. Curr Res Physiol, 2021, 4: 94-102.
21. Forbes JD, Azad MB, Vehling L, et al. Association of exposure to formula in the hospital and subsequent infant feeding practices with gut microbiota and risk of overweight in the first year of life. JAMA Pediatr, 2018, 172(7): e181161.
22. Fouhy F, Watkins C, Hill CJ, et al. Perinatal factors affect the gut microbiota up to four years after birth. Nat Commun, 2019, 10(1): 1517.
23. Milani C, Duranti S, Bottacini F, et al. The first microbial colonizers of the human gut: composition, activities, and health implications of the infant gut microbiota. Microbiol Mol Biol Rev, 2017, 81(4): e00036-17.
24. Derrien M, Alvarez AS, de Vos WM. The gut microbiota in the first decade of life. Trends Microbiol, 2019, 27(12): 997-1010.
25. Ruggles KV, Wang J, Volkova A, et al. Changes in the gut microbiota of urban subjects during an immersion in the traditional diet and lifestyle of a rainforest village. mSphere, 2018, 3(4): e00193-18.
26. Dong TS, Gupta A. Influence of early life, diet, and the environment on the microbiome. Clin Gastroenterol Hepatol, 2019, 17(2): 231-242.
27. Turnbaugh PJ, Ley RE, Mahowald MA, et al. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature, 2006, 444(7122): 1027-1031.
28. Ley RE, Bäckhed F, Turnbaugh P, et al. Obesity alters gut microbial ecology. Proc Natl Acad Sci U S A, 2005, 102(31): 11070-11075.
29. Houtman TA, Eckermann HA, Smidt H, et al. Gut microbiota and BMI throughout childhood: the role of firmicutes, bacteroidetes, and short-chain fatty acid producers. Sci Rep, 2022, 12(1): 3140.
30. Breuninger TA, Wawro N, Breuninger J, et al. Associations between habitual diet, metabolic disease, and the gut microbiota using latent Dirichlet allocation. Microbiome, 2021, 9(1): 61.
31. Yu Z, Yu XF, Zhao X, et al. Greater alteration of gut microbiota occurs in childhood obesity than in adulthood obesity. Front Pediatr, 2023, 11: 1087401.
32. Goffredo M, Mass K, Parks EJ, et al. Role of gut microbiota and short chain fatty acids in modulating energy harvest and fat partitioning in youth. J Clin Endocrinol Metab, 2016, 101(11): 4367-4376.
33. Ridaura VK, Faith JJ, Rey FE, et al. Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science, 2013, 341(6150): 1241214.
34. Mbakwa CA, Hermes GDA, Penders J, et al. Gut microbiota and body weight in school-aged children: the KOALA birth cohort study. Obesity (Silver Spring), 2018, 26(11): 1767-1776.
35. Ignacio A, Fernandes MR, Rodrigues VA, et al. Correlation between body mass index and faecal microbiota from children. Clin Microbiol Infect, 2016, 22(3): 258. e1-e8.
36. Riva A, Borgo F, Lassandro C, et al. Pediatric obesity is associated with an altered gut microbiota and discordant shifts in Firmicutes populations. Environ Microbiol, 2017, 19(1): 95-105.
37. Murga-Garrido SM, Orbe-Orihuela YC, Díaz-Benítez CE, et al. Alterations of the gut microbiome associated to methane metabolism in Mexican children with obesity. Children (Basel), 2022, 9(2): 148.
38. Hou YP, He QQ, Ouyang HM, et al. Human gut microbiota associated with obesity in chinese children and adolescents. Biomed Res Int, 2017, 2017: 7585989.
39. Galuppo B, Cline G, Van Name M, et al. Colonic fermentation and acetate production in youth with and without obesity. J Nutr, 2021, 151(11): 3292-3298.
40. McCann JR, Bihlmeyer NA, Roche K, et al. The pediatric obesity microbiome and metabolism study (POMMS): methods, baseline data, and early insights. Obesity (Silver Spring), 2021, 29(3): 569-578.
41. Fan Y, Pedersen O. Gut microbiota in human metabolic health and disease. Nat Rev Microbiol, 2021, 19(1): 55-71.
42. Mathur R, Amichai M, Chua KS, et al. Methane and hydrogen positivity on breath test is associated with greater body mass index and body fat. J Clin Endocrinol Metab, 2013, 98(4): E698-E702.
43. Canfora EE, Jocken JW, Blaak EE. Short-chain fatty acids in control of body weight and insulin sensitivity. Nat Rev Endocrinol, 2015, 11(10): 577-591.
44. Liang C, Guo M, Liu T, et al. Profiles of gut microbiota in children with obesity from Harbin, China and screening of strains with anti-obesity ability in vitro and in vivo. J Appl Microbiol, 2020, 129(3): 728-737.
45. Turnbaugh PJ, Gordon JI. The core gut microbiome, energy balance and obesity. J Physiol, 2009, 587(17): 4153-4158.
46. Bjursell M, Admyre T, Göransson M, et al. Improved glucose control and reduced body fat mass in free fatty acid receptor 2-deficient mice fed a high-fat diet. Am J Physiol Endocrinol Metab, 2011, 300(1): E211-E220.
47. Ejtahed HS, Soroush AR, Angoorani P, et al. Gut microbiota as a target in the pathogenesis of metabolic disorders: a new approach to novel therapeutic agents. Horm Metab Res, 2016, 48(6): 349-358.
48. Akagbosu CO, Nadler EP, Levy S, et al. The role of the gut microbiome in pediatric obesity and bariatric surgery. Int J Mol Sci, 2022, 23(23): 15421.
49. Sanchez M, Panahi S, Tremblay A. Childhood obesity: a role for gut microbiota?. Int J Environ Res Public Health, 2014, 12(1): 162-175.
50. de Vos WM, Tilg H, Van Hul M, et al. Gut microbiome and health: mechanistic insights. Gut, 2022, 71(5): 1020-1032.
51. Carvalho BM, Saad MJ. Influence of gut microbiota on subclinical inflammation and insulin resistance. Mediators Inflamm, 2013, 2013: 986734.
52. Khan MJ, Gerasimidis K, Edwards CA, et al. Role of gut microbiota in the aetiology of obesity: proposed mechanisms and review of the literature. J Obes, 2016, 2016: 7353642.
53. Castaner O, Goday A, Park YM, et al. The gut microbiome profile in obesity: a systematic review. Int J Endocrinol, 2018, 2018: 4095789.
54. Seimon RV, Taylor P, Little TJ, et al. Effects of acute and longer-term dietary restriction on upper gut motility, hormone, appetite, and energy-intake responses to duodenal lipid in lean and obese men. Am J Clin Nutr, 2014, 99(1): 24-34.
55. Pihl AF, Fonvig CE, Stjernholm T, et al. The role of the gut microbiota in childhood obesity. Child Obes, 2016, 12(4): 292-299.
56. Benítez-Páez A, Gómez Del Pugar EM, López-Almela I, et al. Depletion of Blautia species in the microbiota of obese children relates to intestinal inflammation and metabolic phenotype worsening. mSystems, 2020, 5(2): e00857-19.
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