Risk factors of multidrug-resistant organism infection in patients with car accident injuries in intensive care unit_West China Medical Journal

Authors：

 CHEN Jing , ZHENG Xiaojia , LIAO Tianfen , XIANG Qian

1. Department of Healthcare-associated Infection Control Center, Sichuan Provincial People’s Hospital & Sichuan Academy of Medical Sciences, Chengdu, Sichuan 610072, P. R. China;

Corresponding author：

CHEN Jing, Email: cjlwy0217@163.com

Keywords：

Car accident injury; multidrug-resistant organism infection; risk factor

DOI：

10.7507/1002-0179.202401022

Video：

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Objective To investigate the risk factors of multidrug-resistant organism (MDRO) infection in patients with car accident injuries in intensive care unit (ICU), providing clinical guidance for reducing MDRO infection in car accident patients. Methods The clinical data of patients with car accident injuries in Sichuan Provincial People’s Hospital between January 1st 2019 and February 28th 2023 were collected, and the relevant data were analyzed retrospectively to explore the risk factors of MDRO infection. Results A total of 141 patients with car accident injuries were collected, of whom 30 had MDRO infection. The proportions of males (P=0.012), indwelling catheters (P=0.005), mechanical ventilation (P=0.001), length of hospital stay (P<0.001), and total treatment costs (P<0.001) in the infection group were higher than those in the non-infection group. Multiple logistic regression analysis showed that male [odds ratio (OR)=3.797, 95% confidence interval (CI) (1.174, 12.275), P=0.026], mechanical ventilation [OR=4.596, 95%CI (1.538, 13.734), P=0.006], and length of hospital stay≥20 d [OR=1.014, 95%CI (1.001, 1.028), P=0.037] were independent risk factors for MDRO infection in car accident patients. Conclusions Male, mechanical ventilation, and increased length of hospital stay are independent risk factors for MDRO infection in car accident patients. For such patients, the prevention and control measures of hospital infection should be strictly implemented to reduce the risk of infection.

Citation： CHEN Jing, ZHENG Xiaojia, LIAO Tianfen, XIANG Qian. Risk factors of multidrug-resistant organism infection in patients with car accident injuries in intensive care unit. West China Medical Journal, 2024, 39(3): 383-386. doi: 10.7507/1002-0179.202401022 Copy

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18.	林沛钰, 王爱平. 急性髓系白血病患者诱导缓解化疗期间症状与生活质量现状及影响因素分析. 护士进修杂志, 2022, 37(12): 1136-1140.
19.	何怡蓓, 王文博, 谭积善, 等. 成都某三甲医院多重耐药菌的临床分布特点及耐药性分析. 现代生物医学进展, 2022, 22(3): 500-505, 458.
20.	Wang RH, Wen WX, Jiang ZP, et al. The clinical value of neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), platelet-to-lymphocyte ratio (PLR) and systemic inflammation response index (SIRI) for predicting the occurrence and severity of pneumonia in patients with intracerebral hemorrhage. Front Immunol, 2023, 14: 1115031.

1. 邵青青. 急诊车祸伤病人的心理反应特点及对患者实施针对性护理的效果分析. 航空航天医学杂志, 2022, 33(9): 1127-1130.
2. 巩树梅, 颜婷婷, 刘晓虹. 团体认知行为干预对意外创伤者创伤后成长的效果研究. 护理学杂志, 2015, 30(22): 74-77.
3. 孙乐平, 缪麒, 王殿深, 等. AIS-ISS 评分在法医病理学伤病关系分析中的应用. 中国法医学杂志, 2019, 34(3): 218-221.
4. Seong H, Lee SK, Cheon JH, et al. Fecal microbiota transplantation for multidrug-resistant organism: efficacy and response prediction. J Infect, 2020, 81(5): 719-725.
5. Jean SS, Gould IM, Lee WS, et al. New drugs for multidrug-resistant Gram-negative organisms: time for stewardship. Drugs, 2019, 79(7): 705-714.
6. Deering RW, Whalen KE, Alvarez I, et al. Identification of a bacteria-produced benzisoxazole with antibiotic activity against multi-drug resistant Acinetobacter baumannii. J Antibiot (Tokyo), 2021, 74(6): 370-380.
7. 杨晋如, 刘丹, 谈宜斌, 等. 重症医学科多重耐药菌感染风险因素的网状路径分析. 中国感染控制杂志, 2020, 19(2): 148-154.
8. Tatarelli P, Mikulska M. Multidrug-resistant bacteria in hematology patients: emerging threats. Future Microbiol, 2016, 11: 767-780.
9. Kollef MH, Torres A, Shorr AF, et al. Nosocomial infection. Crit Care Med, 2021, 49(2): 169-187.
10. 刘济, 方旭, 杨滢, 等. 某医院多重耐药菌医院感染特征及变化趋势分析. 中国消毒学杂志, 2023, 40(10): 776-778.
11. 中华人民共和国卫生部. 医院感染诊断标准(试行). 中华医学杂志, 2001, 81(5): 61-67.
12. 卫生部办公厅关于印发《多重耐药菌医院感染预防与控制技术指南(试行)》的通知. 中华人民共和国卫生部公报, 2011(2): 59-61.
13. 白伟, 张小华. 自体输血与异体输血在腹部手术患者中的应用时对凝血功能与血液流变学的影响. 血栓与止血学, 2020, 26(2): 252-254.
14. 汪璐璐, 刘安诺, 李惠萍, 等. 创伤后成长与创伤后应激障碍症状相关性的 meta 分析. 中国心理卫生杂志, 2016, 30(1): 23-28.
15. 吴拥军. 神经外科术后病人创伤后成长与心理弹性及疾病感知的关系. 护理研究, 2015, 29(15): 1839-1842.
16. Iwu CD, Patrick SM. An insight into the implementation of the global action plan on antimicrobial resistance in the WHO African region: a roadmap for action. Int J Antimicrob Agents, 2021, 58(4): 106411.
17. 杨修文, 崔俊昌, 赵进, 等. 碳青霉烯类耐药肺炎克雷伯菌血流感染的临床特征与死亡危险因素分析. 中国感染与化疗杂志, 2018, 18(2): 142-149.
18. 林沛钰, 王爱平. 急性髓系白血病患者诱导缓解化疗期间症状与生活质量现状及影响因素分析. 护士进修杂志, 2022, 37(12): 1136-1140.
19. 何怡蓓, 王文博, 谭积善, 等. 成都某三甲医院多重耐药菌的临床分布特点及耐药性分析. 现代生物医学进展, 2022, 22(3): 500-505, 458.
20. Wang RH, Wen WX, Jiang ZP, et al. The clinical value of neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), platelet-to-lymphocyte ratio (PLR) and systemic inflammation response index (SIRI) for predicting the occurrence and severity of pneumonia in patients with intracerebral hemorrhage. Front Immunol, 2023, 14: 1115031.

West China Medical Journal

Risk factors of multidrug-resistant organism infection in patients with car accident injuries in intensive care unit

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