Analysis of the reported epidemic situation of pulmonary tuberculosis in the elderly patients at West China Hospital of Sichuan University_West China Medical Journal

Authors：

ZENG Qinghui ^1,2 , HUANG Wenzhi ^1,2 , PENG Yalan ^1,2 , WANG Yantong ^1,2 , ZONG Zhiyong ¹ , CHEN Yi ² , HU Ti ³ ,  QIAO Fu ^1,2

1. Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. Department of Infection Control, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
3. West China School of Nursing, Sichuan University / Department of Intensive Care Unit, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

QIAO Fu, Email: 114558366@qq.com

Keywords：

Pulmonary tuberculosis; epidemic analysis; elderly

DOI：

10.7507/1002-0179.202401134

Video：

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Objective To analyze the report status of the pulmonary tuberculosis in the elderly people aged ≥ 65 years old. Methods The reported data of senile pulmonary tuberculosis and the whole population pulmonary tuberculosis at West China Hospital of Sichuan University between January 1, 2012 and December 31, 2022 were retrospective selection. Descriptive methods were used to analyze the different characteristics and etiology of senile pulmonary tuberculosis. Results A total of 2 182 senile pulmonary tuberculosis were reported. The report was mainly positive reports of etiology [1091 cases (50.00%)], and the component ratio increased year by year (χ²=49.986, P<0.001). The proportion of senile pulmonary tuberculosis in the whole population pulmonary tuberculosis increased from 17.62% in 2012 to 29.04% in 2022, and the difference between different years was statistically significant (χ²=40.261, P<0.001). In the reported patients, the male to female ratio was 2.30∶1. There were 7 cases of rifampicin resistant, 1 091 cases of etiology positivity, 674 cases of etiology negativity, and 410 cases of no etiology results. The number of reported cases in the age group of 65-74 was higher than that in the age group of 75 and above. The seasonal distribution was not obvious (concentration<0.3). The patients were mainly from other cities of the province [919 cases (42.12%)], and the Department of Pulmonary and Critical Care Medicine (including the Tuberculosis Ward) was reported the most [1439 cases (65.95%)]. The majority of occupations were retired individuals [952 cases (43.63%)]. Conclusions From 2012 to 2022, the prevention and treatment of senile pulmonary tuberculosis has achieved some results, but the overall burden is still very heavy. The detection of senile pulmonary tuberculosis should be strengthened.

Citation： ZENG Qinghui, HUANG Wenzhi, PENG Yalan, WANG Yantong, ZONG Zhiyong, CHEN Yi, HU Ti, QIAO Fu. Analysis of the reported epidemic situation of pulmonary tuberculosis in the elderly patients at West China Hospital of Sichuan University. West China Medical Journal, 2024, 39(3): 373-377. doi: 10.7507/1002-0179.202401134 Copy

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3.	谭文倩, 万燕萍, 龚德华, 等. 2020 年湖南省老年肺结核患者流行特征及就诊情况分析. 实用预防医学, 2022, 29(12): 1473-1476.
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6.	张亚敬, 姜影, 孙浩, 等. 154 例老年肺结核患者的发现与治疗转归情况分析. 结核与肺部疾病杂志, 2023, 4(1): 48-53.
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11.	王荣, 杨晨, 苗瑞芬, 等. 南京市 2011—2019 年≥65 岁老年肺结核病例特征分析. 华南预防医学, 2021, 47(11): 1470-1473.
12.	中华人民共和国国家卫生和计划生育委员会. 肺结核诊断标准(WS288-2017). 新发传染病电子杂志, 2018, 3(1): 59-61.
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15.	郭祖超. 医用数理统计方法. 3 版. 北京: 人民卫生出版社, 1988.
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18.	滕人聪, 李涛, 李玉红, 等. 2015—2021 年全国 65 岁及以上老年肺结核患者登记情况分析. 中国防痨杂志, 2023, 45(4): 367-371.
19.	Kuznetsov VN, Grjibovski AM, Mariandyshev AO, et al. A comparison between passive and active case finding in TB control in the Arkhangelsk region. Int J Cireumpolar Health, 2014, 73: 23515.
20.	Dorman SE, Schumacher SG, Alland D, et al. Xpert MTB/RIF ultra for detection of mycobacterium tuberculosis and rifampicin resistance: a prospective multicentre diagnostic accuracy study. Lancet Infect Dis, 2018, 18(1): 76-84.
21.	Ou X, Li Q, Xia H, et al. Diagnostic accuracy of the PURE-LAMP test for pulmonary tuberculosis at the county-level laboratory in China. PLoS One, 2014, 9(5): e94544.
22.	焦琳, 胡雪姣, 应斌武. 基于人工智能策略优化结核病诊断. 华西医学, 2018, 33(8): 935-938.
23.	陈雪融. 新中国成立 70 年结核防治成就. 现代预防医学, 2019, 46(15): 2689-2691,2700.
24.	郑静静, 戴平一, 王斌, 等. 2016—2020 年浙江省宁海县老年肺结核患者耐药状况及危险因素分析. 上海预防医学, 2022, 34(4): 322-325.
25.	奚莹, 唐军, 乔瑞君, 等. 249 例老年肺结核患者耐药状况及产生耐多药的危险因素分析. 中国防痨杂志, 2021, 43(6): 636-641.
26.	陈燕梅, 温文沛, 吴惠忠, 等. 2016—2020 年广东省结核病耐药监测结果分析. 中国防痨杂志, 2022, 44(7): 685-689.
27.	范琳, 刘一典, 肖和平. 国内《耐药结核病化学治疗指南(2019 年)》与相关共识的特色及要点分析. 中国防痨杂志, 2020, 42(2): 91-94.
28.	郭海萍, 逄宇. 全面落实肺结核诊断国家行业标准提高分子技术诊断耐药结核病能力. 结核与肺部疾病杂志, 2020, 1(3): 103-105.
29.	苏华林, 唐利红, 马琼锦, 等. 2009—2019 年上海市闵行区肺结核流行特征分析. 公共卫生与预防医学, 2020, 31(6): 71-74.
30.	Yew WW, Yoshiyama T, Leung CC, et al. Epidemiological, clinical and mechanistic perspectives of tuberculosis in older people. Respirology, 2018, 23(6): 567-575.
31.	Murali S, Krishnamoorthy Y, Knudsen S, et al. Comparison of profile and treatment outcomes between elderly and non-elderly tuberculosis patients in Puducherry and Tamil Nadu, South India. PLoS One, 2021, 16(8): e0256773.
32.	杨莹, 房云霞, 翟亚楠, 等. 国内老年结核病流行病学研究现状. 医学动物防制, 2023, 39(1): 82-85.
33.	Zhang H, Xin H, Li X, et al. A dose-response relationship of smoking with tuberculosis infection: a cross-sectional study among 21008 rural residents in China. PLoS One. PLoS One, 2017, 12(4): e0175183.
34.	GBD Tuberculosis Collaborators. The global burden of tuberculosis: results from the global burden of disease study 2015. Lancet Infect Dis, 2018, 18(3): 261-284.
35.	Takahashi T, Sex differences in immune responses. Science, 2021, 371(6527): 347-348.
36.	Zhang CY, Zhao F, Xia YY, et al. Prevalence and risk factors of active pulmonary tuberculosis among elderly people in China: a population based cross-sectional study. Infect Dis Poverty, 2019, 8(1): 7.
37.	Koo HK, Min J, Kim HW, et al. Prediction of treatment failure and compliance in patients with tuberculosis. BMC Infect Dis, 2020, 20(1): 622.
38.	Wang Y, Gan Y, Zhang J, et al. Analysis of the current status and associated factors of tuberculosis knowledge, attitudes, and practices among elderly people in Shenzhen: a cross-sectional study. BMC Public Health, 2021, 21(1): 1163.
39.	Pengpid S, Peltzer K. Knowledge, attitudes, and practices regarding tuberculosis in timor-leste: results from the demographic and health survey 2016. J Prev Med Public Health, 2019, 52(2): 115-122.
40.	李婷, 刘双, 逯嘉, 等. 2011—2020 年四川省肺结核发病年龄变化趋势分析. 中国防痨杂志, 2022, 44(8): 808-814.
41.	余雅, 胡代玉, 吴成果, 等. 重庆市 2011—2018 年贫困区县肺结核流行特征. 中国热带医学, 2020, 20(5): 429-433.
42.	张灿有, 陈卉, 张慧, 等. 2011—2020 年全国 65 岁及以上老年人肺结核报告发病情况分析. 中华疾病控制杂志, 2022, 26(11): 1252-1258.
43.	熊自超, 陈锦峰, 郭庚秀. 2015—2019 年某三甲综合性医院呼吸道传染病临床分布特征. 解放军预防医学杂志, 2020, 38(9): 107-110.
44.	郑珍慧, 江巧敏, 张尊敬. 基于倾向性评分法评估耐药肺结核患者疾病感知与服药依从性的相关性. 中国全科医学杂志, 2023, 21(11): 1872-1875.

1. 宋敏, 陆普选, 方伟军, 等. 2022 年 WHO 全球结核病报告: 全球与中国关键数据分析. 新发传染病电子杂志, 2023, 8(1): 87-92.
2. Murray CJ, Ortblad KF, Guinovart C, et al. Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990-2013: a systematic analysis for the global burden of disease study 2013. Lancet, 2014, 384(9947): 1005-1070.
3. 谭文倩, 万燕萍, 龚德华, 等. 2020 年湖南省老年肺结核患者流行特征及就诊情况分析. 实用预防医学, 2022, 29(12): 1473-1476.
4. World Health Organization. Global tuberculosis report 2021. Geneva: World Health Organization, 2021.
5. 鲁周琴, 张正斌, 王晓君, 等. 2016—2020 年武汉市老年肺结核疫情特征分析. 公共卫生与预防医学, 2023, 34(1): 35-38.
6. 张亚敬, 姜影, 孙浩, 等. 154 例老年肺结核患者的发现与治疗转归情况分析. 结核与肺部疾病杂志, 2023, 4(1): 48-53.
7. 国务院办公厅. 国务院办公厅关于印发“十三五”全国结核病防治规划的通知. 中华人民共和国国务院公报, 2017(7): 32-37.
8. 中华医学会结核病学分会. 老年肺结核诊断与治疗专家共识(2023 版). 中华结核和呼吸杂志, 2023, 46(11): 1068-1084.
9. Gardner Toren K, Spitters C, Pecha M, et al. Tuberculosis in older adults: Seattle and King county, Washington. Clin Infect Dis, 2020, 70(6): 1202-1207.
10. Sharma M, Onozaki I, Nunn P. TB in older people in Asia: why it is important. Int J Tubere Lung Dis, 2021, 25(7): 521-524.
11. 王荣, 杨晨, 苗瑞芬, 等. 南京市 2011—2019 年≥65 岁老年肺结核病例特征分析. 华南预防医学, 2021, 47(11): 1470-1473.
12. 中华人民共和国国家卫生和计划生育委员会. 肺结核诊断标准(WS288-2017). 新发传染病电子杂志, 2018, 3(1): 59-61.
13. 国家卫生健康委办公厅. 国家卫生健康委办公厅关于调整肺结核传染病报告分类的通知. (2019-03-21)[2024-01-03]. http://www.nhc.gov.cn/jkj/s3589/201903/d779ae48db6446c28d1f5371ef09f5ab.shtml.
14. 国家卫生计生委办公厅. 国家卫生计生委办公厅关于印发传染病信息报告管理规范(2015 年版)的通知. 中华人民共和国国家卫生和计划生育委员会公报, 2015(10): 36-42.
15. 郭祖超. 医用数理统计方法. 3 版. 北京: 人民卫生出版社, 1988.
16. 国家卫生健康委, 国家发展改革委, 教育部, 等. 关于印发遏制结核病行动计划(2019—2022 年)的通知. 中华人民共和国国家卫生健康委员会公报, 2019(Z1): 13-17.
17. 谢玮, 方怡, 雷宇, 等. 2014—2019 年广州市老年肺结核疫情特征. 热带医学杂志, 2021, 21(8): 1069-1073.
18. 滕人聪, 李涛, 李玉红, 等. 2015—2021 年全国 65 岁及以上老年肺结核患者登记情况分析. 中国防痨杂志, 2023, 45(4): 367-371.
19. Kuznetsov VN, Grjibovski AM, Mariandyshev AO, et al. A comparison between passive and active case finding in TB control in the Arkhangelsk region. Int J Cireumpolar Health, 2014, 73: 23515.
20. Dorman SE, Schumacher SG, Alland D, et al. Xpert MTB/RIF ultra for detection of mycobacterium tuberculosis and rifampicin resistance: a prospective multicentre diagnostic accuracy study. Lancet Infect Dis, 2018, 18(1): 76-84.
21. Ou X, Li Q, Xia H, et al. Diagnostic accuracy of the PURE-LAMP test for pulmonary tuberculosis at the county-level laboratory in China. PLoS One, 2014, 9(5): e94544.
22. 焦琳, 胡雪姣, 应斌武. 基于人工智能策略优化结核病诊断. 华西医学, 2018, 33(8): 935-938.
23. 陈雪融. 新中国成立 70 年结核防治成就. 现代预防医学, 2019, 46(15): 2689-2691,2700.
24. 郑静静, 戴平一, 王斌, 等. 2016—2020 年浙江省宁海县老年肺结核患者耐药状况及危险因素分析. 上海预防医学, 2022, 34(4): 322-325.
25. 奚莹, 唐军, 乔瑞君, 等. 249 例老年肺结核患者耐药状况及产生耐多药的危险因素分析. 中国防痨杂志, 2021, 43(6): 636-641.
26. 陈燕梅, 温文沛, 吴惠忠, 等. 2016—2020 年广东省结核病耐药监测结果分析. 中国防痨杂志, 2022, 44(7): 685-689.
27. 范琳, 刘一典, 肖和平. 国内《耐药结核病化学治疗指南(2019 年)》与相关共识的特色及要点分析. 中国防痨杂志, 2020, 42(2): 91-94.
28. 郭海萍, 逄宇. 全面落实肺结核诊断国家行业标准提高分子技术诊断耐药结核病能力. 结核与肺部疾病杂志, 2020, 1(3): 103-105.
29. 苏华林, 唐利红, 马琼锦, 等. 2009—2019 年上海市闵行区肺结核流行特征分析. 公共卫生与预防医学, 2020, 31(6): 71-74.
30. Yew WW, Yoshiyama T, Leung CC, et al. Epidemiological, clinical and mechanistic perspectives of tuberculosis in older people. Respirology, 2018, 23(6): 567-575.
31. Murali S, Krishnamoorthy Y, Knudsen S, et al. Comparison of profile and treatment outcomes between elderly and non-elderly tuberculosis patients in Puducherry and Tamil Nadu, South India. PLoS One, 2021, 16(8): e0256773.
32. 杨莹, 房云霞, 翟亚楠, 等. 国内老年结核病流行病学研究现状. 医学动物防制, 2023, 39(1): 82-85.
33. Zhang H, Xin H, Li X, et al. A dose-response relationship of smoking with tuberculosis infection: a cross-sectional study among 21008 rural residents in China. PLoS One. PLoS One, 2017, 12(4): e0175183.
34. GBD Tuberculosis Collaborators. The global burden of tuberculosis: results from the global burden of disease study 2015. Lancet Infect Dis, 2018, 18(3): 261-284.
35. Takahashi T, Sex differences in immune responses. Science, 2021, 371(6527): 347-348.
36. Zhang CY, Zhao F, Xia YY, et al. Prevalence and risk factors of active pulmonary tuberculosis among elderly people in China: a population based cross-sectional study. Infect Dis Poverty, 2019, 8(1): 7.
37. Koo HK, Min J, Kim HW, et al. Prediction of treatment failure and compliance in patients with tuberculosis. BMC Infect Dis, 2020, 20(1): 622.
38. Wang Y, Gan Y, Zhang J, et al. Analysis of the current status and associated factors of tuberculosis knowledge, attitudes, and practices among elderly people in Shenzhen: a cross-sectional study. BMC Public Health, 2021, 21(1): 1163.
39. Pengpid S, Peltzer K. Knowledge, attitudes, and practices regarding tuberculosis in timor-leste: results from the demographic and health survey 2016. J Prev Med Public Health, 2019, 52(2): 115-122.
40. 李婷, 刘双, 逯嘉, 等. 2011—2020 年四川省肺结核发病年龄变化趋势分析. 中国防痨杂志, 2022, 44(8): 808-814.
41. 余雅, 胡代玉, 吴成果, 等. 重庆市 2011—2018 年贫困区县肺结核流行特征. 中国热带医学, 2020, 20(5): 429-433.
42. 张灿有, 陈卉, 张慧, 等. 2011—2020 年全国 65 岁及以上老年人肺结核报告发病情况分析. 中华疾病控制杂志, 2022, 26(11): 1252-1258.
43. 熊自超, 陈锦峰, 郭庚秀. 2015—2019 年某三甲综合性医院呼吸道传染病临床分布特征. 解放军预防医学杂志, 2020, 38(9): 107-110.
44. 郑珍慧, 江巧敏, 张尊敬. 基于倾向性评分法评估耐药肺结核患者疾病感知与服药依从性的相关性. 中国全科医学杂志, 2023, 21(11): 1872-1875.

West China Medical Journal

Analysis of the reported epidemic situation of pulmonary tuberculosis in the elderly patients at West China Hospital of Sichuan University

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