Protective effect of exosome on organs after ischemia-reperfusion injury_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

HUANG Jinglan ,  KANG Bingyao , QU Yi ,  MU Dezhi

Department of Pediatrics, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China;

Corresponding author：

KANG Bingyao, Email: Ïkangbingyao2016@163.com; MU Dezhi, Email: mudz@scu.edu.cn

Keywords：

Exosome; ischemia-reperfusion; organ injury; treatment

DOI：

10.7507/1002-1892.201701104

Video：

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Objective To investigate the protective effect of the exosome on the organ damage induced by ische-mia-reperfusion (I/R) so as to provide a new way for the treatment of I/R damage. Methods The literature related to the treatment of I/R damage was reviewed and analyzed. Results The exosome volume is small and it is present in blood, cerebrospinal fluid, and urine, which has the function to cross the blood-brain barrier, and protect the heart, brain and other organs after I/R damage. Conclusion Exosome is a new material for the treatment of I/R organ injury, and it is important to understand the protective effect and possible mechanism.

Citation： HUANG Jinglan, KANG Bingyao, QU Yi, MU Dezhi. Protective effect of exosome on organs after ischemia-reperfusion injury. Chinese Journal of Reparative and Reconstructive Surgery, 2017, 31(6): 751-754. doi: 10.7507/1002-1892.201701104 Copy

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2.	Wang Y, Zhang L, Li Y, et al. Exosomes/microvesicles from induced pluripotent stem cells deliver cardioprotective miRNAs and prevent cardiomyocyte apoptosis in the ischemic myocardium. Int J Cardiol, 2015, 192: 61-69.
3.	Kalani A, Chaturvedi P, Kamat PK, et al. Curcumin-loaded embryonic stem cell exosomes restored neurovascular unit following ischemia-reperfusion injury. Int J Biochem Cell Biol, 2016, 79: 360-369.
4.	Zeng M, Wei X, Wu Z, et al. Simulated ischemia/reperfusion- induced p65-Beclin 1-dependent autophagic cell death in human umbilical vein endothelial cells. Sci Rep, 2016, 6: 37448.
5.	Chen HH, Lai PF, Lan YF, et al. Exosomal ATF3 RNA attenuates pro-inflammatory gene MCP-1 transcription in renal ischemia-reperfusion. J Cell Physiol, 2014, 229(9): 1202-1211.
6.	Arslan F, Lai RC, Smeets MB, et al. Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury. Stem Cell Res, 2013, 10(3): 301-312.
7.	Colombo M, Raposo G, Théry C. Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. Annu Rev Cell Dev Biol, 2014, 30: 255-289.
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9.	Willms E, Johansson HJ, Mäger I, et al. Cells release subpopulations of exosomes with distinct molecular and biological properties. Sci Rep, 2016, 6: 22519.
10.	Skotland T, Ekroos K, Kauhanen D, et al. Molecular lipid species in urinary exosomes as potential prostate cancer biomarkers. Eur J Cancer, 2017, 70: 122-132.
11.	Sun L, Xu R, Sun X, et al. Safety evaluation of exosomes derived from human umbilical cord mesenchymal stromal cell. Cytotherapy, 2016, 18(3): 413-422.
12.	Munagala R, Aqil F, Jeyabalan J, et al. Bovine milk-derived exosomes for drug delivery. Cancer Lett, 2016, 371(1): 48-61.
13.	Lässer C, Alikhani VS, Ekström K, et al. Human saliva, plasma and breast milk exosomes contain RNA: uptake by macrophages. J Transl Med, 2011, 9: 9.
14.	Timmers L, Lim SK, Arslan F, et al. Reduction of myocardial infarct size by human mesenchymal stem cell conditioned medium. Stem Cell Res, 2007, 1(2): 129-137.
15.	Zhang ZW, Yang JJ, Yan WY, et al. Pretreatment of Cardiac Stem Cells With Exosomes Derived From Mesenchymal Stem Cells Enhances Myocardial Repair. Journal of the American Heart Association, 2016, 5: e002856.
16.	Zhao Y, Sun L, Cao W, et al. Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Relieve Acute Myocardial Ischemic Injury. Stem Cell Int, 2015, (2015): 761643.
17.	Ibrahim AG, Cheng K, Marbán E. Exosomes as critical agents of cardiac regeneration triggered by cell therapy. Stem Cell Reports, 2014, 2(5): 606-619.
18.	Feng Y, Huang W, Wani M, et al. Ischemic preconditioning potentiates the protective effect of stem cells through secretion of exosomes by targeting Mecp2 via miR-22. PLoS One, 2014, 9(2): e88685.
19.	Agarwal U, George A, Bhutani S, et al. Experimental, Systems and Computational Approaches to Understanding the MicroRNA-Mediated Reparative Potential of Cardiac Progenitor Cell-Derived Exosomes From Pediatric Patients. Circ Res, 2016. [Epub ahead of print].
20.	Vicencio JM, Yellon DM, Sivaraman V, et al. Plasma exosomes protect the myocardium from ischemia-reperfusion injury. J Am Coll Cardiol, 2015, 65(15): 1525-1536.
21.	Cappellesso R, Tinazzi A, Giurici T, et al. Programmed cell death 4 and microRNA 21 inverse expression is maintained in cells and exosomes from ovarian serous carcinoma effusions. Cancer Cytopathol, 2014, 122(9): 685-693.
22.	Guo S, Bai R, Liu W, et al. MicroRNA-210 is upregulated by hypoxia- inducible factor-1α in the stromal cells of giant cell tumors of bone. Mol Med Rep, 2015, 12(4): 6185-6192.
23.	Wang K, Jiang Z, Webster KA, et al. Enhanced cardioprotection by human endometrium mesenchymal stem cells driven by Exosomal MicroRNA-21. Stem Cells Transl Med, 2016, 6(1): 209-222.
24.	Arslan F, Lai RC, Smeets MB, et al. Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury. Stem Cell Res, 2013,10(3): 301-312.
25.	Park DR, Ko R, Kwon SH, et al. FlexPro MD, a Mixture of Krill Oil, Astaxanthin, and Hyaluronic Acid, Suppresses Lipopolysaccharide-Induced Inflammatory Cytokine Production Through Inhibition of NF-κB. J Med Food, 2016, 19(12): 1196-1203.
26.	Shi Z, Lian A, Zhang F. Nuclear factor-κB activation inhibitor attenuates ischemia reperfusion injury and inhibits Hmgb1 expression. Inflamm Res, 2014, 63(11): 919-925.
27.	Miller K, Dixit S, Bredlau AL, et al. Delivery of a drug cache to glioma cells overexpressing platelet-derived growth factor receptor using lipid nanocarriers. Nanomedicine (Lond), 2016, 11(6): 581-595.
28.	Xin H, Katakowski M, Wang F, et al. MicroRNA cluster miR-17-92 Cluster in Exosomes Enhance Neuroplasticity and Functional Recovery After Stroke in Rats. Stroke, 2017, 48(3): 747-753.
29.	Drommelschmidt K, Serdar M, Bendix I, et al. Mesenchymal stem cell-derived extracellular vesicles ameliorate inflammationinduced preterm brain injury. Brain Behav lmmun, 2017, 60: 220-232.
30.	Xin H, Li Y, Cui Y, et al. Systemic administration of exosomes released from mesenchymal stromal cells promote functional recovery and neurovascular plasticity after stroke in rats. J Cereb Blood Flow Metab, 2013, 33(11): 1711-1715.
31.	Xin H, Li Y, Liu Z, et al. MiR-133b promotes neural plasticity and functional recovery after treatment of stroke with multipotent mesenchymal stromal cells in rats via transfer of exosome-enriched extracellular particles. Stem Cells, 2013, 31(12): 2737-2746.
32.	Xin H, Li Y, Buller B, et al. Exosome-mediated transfer of miR-133b from multipotent mesenchymal stromal cells to neural cells contributes to neurite outgrowth. Stem Cells, 2012, 30(7): 1556-1564.
33.	Guitart K, Loers G, Buck F, et al. Improvement of neuronal cell survival by astrocyte-derived exosomes under hypoxic and ischemic conditions depends on prion protein. Glia, 2016, 64(6): 896-910.
34.	Haney MJ, Klyachko NL, Zhao Y, et al. Exosomes as drug delivery vehicles for Parkinson’s disease therapy. J Control Release, 2015, 207: 18-30.
35.	Caponnetto F, Manini I, Skrap M, et al. Size-dependent cellular uptake of exosomes. Nanomedicine, 2016, 13(3): 1011-1020.

1. Salvadori M, Rosso G, Bertoni E. Update on ischemia-reperfusion injury in kidney transplantation: Pathogenesis and treatment. World J Transplant, 2015, 5(2): 52-67.
2. Wang Y, Zhang L, Li Y, et al. Exosomes/microvesicles from induced pluripotent stem cells deliver cardioprotective miRNAs and prevent cardiomyocyte apoptosis in the ischemic myocardium. Int J Cardiol, 2015, 192: 61-69.
3. Kalani A, Chaturvedi P, Kamat PK, et al. Curcumin-loaded embryonic stem cell exosomes restored neurovascular unit following ischemia-reperfusion injury. Int J Biochem Cell Biol, 2016, 79: 360-369.
4. Zeng M, Wei X, Wu Z, et al. Simulated ischemia/reperfusion- induced p65-Beclin 1-dependent autophagic cell death in human umbilical vein endothelial cells. Sci Rep, 2016, 6: 37448.
5. Chen HH, Lai PF, Lan YF, et al. Exosomal ATF3 RNA attenuates pro-inflammatory gene MCP-1 transcription in renal ischemia-reperfusion. J Cell Physiol, 2014, 229(9): 1202-1211.
6. Arslan F, Lai RC, Smeets MB, et al. Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury. Stem Cell Res, 2013, 10(3): 301-312.
7. Colombo M, Raposo G, Théry C. Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. Annu Rev Cell Dev Biol, 2014, 30: 255-289.
8. Balusu S, Van Wonterghem E, De Rycke R, et al. Identification of a novel mechanism of blood-brain communication during peripheral inflammation via choroid plexus-derived extracellular vesicles. EMBO Mol Med, 2016, 8(10): 1162-1183.
9. Willms E, Johansson HJ, Mäger I, et al. Cells release subpopulations of exosomes with distinct molecular and biological properties. Sci Rep, 2016, 6: 22519.
10. Skotland T, Ekroos K, Kauhanen D, et al. Molecular lipid species in urinary exosomes as potential prostate cancer biomarkers. Eur J Cancer, 2017, 70: 122-132.
11. Sun L, Xu R, Sun X, et al. Safety evaluation of exosomes derived from human umbilical cord mesenchymal stromal cell. Cytotherapy, 2016, 18(3): 413-422.
12. Munagala R, Aqil F, Jeyabalan J, et al. Bovine milk-derived exosomes for drug delivery. Cancer Lett, 2016, 371(1): 48-61.
13. Lässer C, Alikhani VS, Ekström K, et al. Human saliva, plasma and breast milk exosomes contain RNA: uptake by macrophages. J Transl Med, 2011, 9: 9.
14. Timmers L, Lim SK, Arslan F, et al. Reduction of myocardial infarct size by human mesenchymal stem cell conditioned medium. Stem Cell Res, 2007, 1(2): 129-137.
15. Zhang ZW, Yang JJ, Yan WY, et al. Pretreatment of Cardiac Stem Cells With Exosomes Derived From Mesenchymal Stem Cells Enhances Myocardial Repair. Journal of the American Heart Association, 2016, 5: e002856.
16. Zhao Y, Sun L, Cao W, et al. Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Relieve Acute Myocardial Ischemic Injury. Stem Cell Int, 2015, (2015): 761643.
17. Ibrahim AG, Cheng K, Marbán E. Exosomes as critical agents of cardiac regeneration triggered by cell therapy. Stem Cell Reports, 2014, 2(5): 606-619.
18. Feng Y, Huang W, Wani M, et al. Ischemic preconditioning potentiates the protective effect of stem cells through secretion of exosomes by targeting Mecp2 via miR-22. PLoS One, 2014, 9(2): e88685.
19. Agarwal U, George A, Bhutani S, et al. Experimental, Systems and Computational Approaches to Understanding the MicroRNA-Mediated Reparative Potential of Cardiac Progenitor Cell-Derived Exosomes From Pediatric Patients. Circ Res, 2016. [Epub ahead of print].
20. Vicencio JM, Yellon DM, Sivaraman V, et al. Plasma exosomes protect the myocardium from ischemia-reperfusion injury. J Am Coll Cardiol, 2015, 65(15): 1525-1536.
21. Cappellesso R, Tinazzi A, Giurici T, et al. Programmed cell death 4 and microRNA 21 inverse expression is maintained in cells and exosomes from ovarian serous carcinoma effusions. Cancer Cytopathol, 2014, 122(9): 685-693.
22. Guo S, Bai R, Liu W, et al. MicroRNA-210 is upregulated by hypoxia- inducible factor-1α in the stromal cells of giant cell tumors of bone. Mol Med Rep, 2015, 12(4): 6185-6192.
23. Wang K, Jiang Z, Webster KA, et al. Enhanced cardioprotection by human endometrium mesenchymal stem cells driven by Exosomal MicroRNA-21. Stem Cells Transl Med, 2016, 6(1): 209-222.
24. Arslan F, Lai RC, Smeets MB, et al. Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury. Stem Cell Res, 2013,10(3): 301-312.
25. Park DR, Ko R, Kwon SH, et al. FlexPro MD, a Mixture of Krill Oil, Astaxanthin, and Hyaluronic Acid, Suppresses Lipopolysaccharide-Induced Inflammatory Cytokine Production Through Inhibition of NF-κB. J Med Food, 2016, 19(12): 1196-1203.
26. Shi Z, Lian A, Zhang F. Nuclear factor-κB activation inhibitor attenuates ischemia reperfusion injury and inhibits Hmgb1 expression. Inflamm Res, 2014, 63(11): 919-925.
27. Miller K, Dixit S, Bredlau AL, et al. Delivery of a drug cache to glioma cells overexpressing platelet-derived growth factor receptor using lipid nanocarriers. Nanomedicine (Lond), 2016, 11(6): 581-595.
28. Xin H, Katakowski M, Wang F, et al. MicroRNA cluster miR-17-92 Cluster in Exosomes Enhance Neuroplasticity and Functional Recovery After Stroke in Rats. Stroke, 2017, 48(3): 747-753.
29. Drommelschmidt K, Serdar M, Bendix I, et al. Mesenchymal stem cell-derived extracellular vesicles ameliorate inflammationinduced preterm brain injury. Brain Behav lmmun, 2017, 60: 220-232.
30. Xin H, Li Y, Cui Y, et al. Systemic administration of exosomes released from mesenchymal stromal cells promote functional recovery and neurovascular plasticity after stroke in rats. J Cereb Blood Flow Metab, 2013, 33(11): 1711-1715.
31. Xin H, Li Y, Liu Z, et al. MiR-133b promotes neural plasticity and functional recovery after treatment of stroke with multipotent mesenchymal stromal cells in rats via transfer of exosome-enriched extracellular particles. Stem Cells, 2013, 31(12): 2737-2746.
32. Xin H, Li Y, Buller B, et al. Exosome-mediated transfer of miR-133b from multipotent mesenchymal stromal cells to neural cells contributes to neurite outgrowth. Stem Cells, 2012, 30(7): 1556-1564.
33. Guitart K, Loers G, Buck F, et al. Improvement of neuronal cell survival by astrocyte-derived exosomes under hypoxic and ischemic conditions depends on prion protein. Glia, 2016, 64(6): 896-910.
34. Haney MJ, Klyachko NL, Zhao Y, et al. Exosomes as drug delivery vehicles for Parkinson’s disease therapy. J Control Release, 2015, 207: 18-30.
35. Caponnetto F, Manini I, Skrap M, et al. Size-dependent cellular uptake of exosomes. Nanomedicine, 2016, 13(3): 1011-1020.

Chinese Journal of Reparative and Reconstructive Surgery

Protective effect of exosome on organs after ischemia-reperfusion injury

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