Analysis of influencing factors for pulmonary infection after radical resection of colon cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

YAN Jing ^1,2 ,  XIAO Kemin ² , HE Jinxing ²

1. Basic Medical College, Wuhan University, Wuhan 430000, P.R.China;
2. Department of General Surgery, People’s Hospital of Daye City, Daye, Hubei 435100, P.R.China;

Corresponding author：

XIAO Kemin, Email: hsbxkm@163.com

Keywords：

pulmonary infection; radical resection of colon cancer; influencing factor

DOI：

10.7507/1007-9424.201611098

Video：

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Objective To explore the influencing factors for pulmonary infection after radical resection of colon cancer. Methods A cohort study included 56 patients who underwent radical resection of colon cancer in People’s Hospital of Daye City from Oct. 2014 to Oct. 2016 were followed-up prospectively, to observe the occurrence of pulmonary infection, and collectting the related factors for pulmonary infection in addition. Results The clinical data of 53 patients were finalized and the clinical data of these patients were complete. Among them, 13 patients suffered from pulmonary infection after radical resection of colon cancer, and 40 patients had no obvious exacerbation and no complicated pulmonary infection. Results of logistic regression showed that, value of forced expiratory volume in1 second/forced vital capacity (OR=1.174, P=0.033), operative time (OR=1.638, P=0.012), levels of postoperative copeptin (OR=1.328, P=0.032), and procalcitonin (OR=1.465, P=0.042) were risk factors for pulmonary infection after radical resection of colon cancer. Receiver operating characteristic curve (ROC) showed that, operative time was 6.207-hour, postoperative copeptin level was 10.420 pmol/L, and the postoperative procalcitonin level was 3.676 ng/mL, which had the best predictive effect on predicting pulmonary infection after radical resection of colon cancer. Conclusions Value of forced expiratory volume in 1 second/forced vital capacity, operative time, levels of copeptin and procalcitonin after operation are the independent influencing factors for pulmonary infection after radical resection of colon cancer, and it has best prognostic outcome when the operative time is 6.207-hour, postoperative copeptin level is 10.420 pmol/L, and the postoperative procalcitonin level is 3.676 ng/mL.

Citation： YAN Jing, XIAO Kemin, HE Jinxing. Analysis of influencing factors for pulmonary infection after radical resection of colon cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2017, 24(8): 970-974. doi: 10.7507/1007-9424.201611098 Copy

1.	Nakano T, Araki K, Nakatani H, et al. Effects of geldanamycin and thalidomide on the Th1/Th2 cytokine balance in mice subjected to operative trauma. Surgery, 2007, 141(4): 490-500.
2.	张永波. 32 例结肠癌术后肺部感染病例的临床分析. 中国医药导刊, 2004, 16(1): 29-31.
3.	Lee IK, Sung NY, Lee YS, et al. The survival rate and prognostic factors in 26 perforated colorectal cancer patients. Int J Colorectal Dis, 2007, 22(5): 467-473.
4.	刘晓珑, 崔海燕, 刘立新, 等. 结肠癌术后肺部感染的免疫学因素分析. 山西医药杂志, 2010, 39(8): 707-709.
5.	杨红晖, 姚小红, 黄秀良. 全麻气管插管术后患者肺部感染的调查分析. 中华医院感染学杂志, 2009, 19(21): 2868-2869.
6.	华锋, 王斌, 崔恩海. 和肽素对呼吸机相关性肺炎预后判断的临床意义. 中华医院感染学杂志, 2013, 23(4): 743-745.
7.	付春毅, 温伟, 张新超. 和肽素能否成为急危重症的一个良好生物学标记物. 中国急救医学, 2014, 34(11): 1044-1047.
8.	Watanabe T, Itabashi M, Shimada Y, et al. Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2010 for the treatment of colorectal cancer. Int J Clin Oncol, 2012, 17(1): 1-29.
9.	中国抗癌协会大肠癌专业委员会腹腔镜外科学组, 中华医学会外科分会腹腔镜与内镜外科学组. 腹腔镜结肠直肠癌根治手术操作指南(2006版). 外科理论与实践, 2006, 11(5): 462-464.
10.	华学洪, 李凤鸣. 老年人全麻下上腹部手术后肺部感染的临床分析. 泸州医学院学报, 2010, 33(2): 183-184.
11.	Biondo S, Kreisler E, Millan M, et al. Differences in patient postoperative and long-term outcomes between obstructive and perforated colonic cancer. Am J Surg, 2008, 195(4): 427-432.
12.	张素玲, 马俊美. 老年患者实施开胸手术后合并肺部感染的危险因素分析. 安徽医药, 2015, 19(2): 355-357.
13.	于鲁源, 陈素丽. 气管插管全麻复合硬膜外麻醉对结肠癌患者术后肺部感染的影响. 现代消化及介入诊疗, 2016, 21(2): 287-289.
14.	杨永凯, 张帆, 薛少华, 等. 脑出血合并肺部感染患者血清降钙素原、和肽素水平变化及其临床意义. 重庆医学, 2015, 44(34): 4802-4805.
15.	卞淼, 安莲华, 张宏涛, 等. 血清合肽素对呼吸衰竭患者预后评估的临床意义. 中国全科医学, 2014, 17(4): 414-417.
16.	Du JM, Sang G, Jang CM, et al. Relationship between plasm copeptin levels and complications of community acquired pneumonia in preschool children. Peptides, 2013, 45(7): 61-65.
17.	杨永凯, 张帆, 薛少华, 等. 血清和肽素、降钙素原对脑出血合并肺部感染早期诊断及判断预后的价值. 重庆医学, 2015, 44(18): 2483-2485.
18.	Salem TA, Molloy RG, O’Dwyer PJ. Prospective study on the role of C-reactive protein (CRP) in patients with an acute abdomen. Ann R Coll Surg Engl, 2007, 89(3): 233-237.
19.	李玉勤, 唐炜, 金胜利. 和肽素在小儿社区获得性肺炎中的变化及意义. 广东医学, 2014, 35(24): 3855-3857.
20.	方明, 张琳, 王道标, 等. 急性肺损伤患者血清及肺泡灌洗液和肽素水平变化的临床分析. 中华危重症医学杂志(电子版), 2011, 4(3): 155-161.
21.	魏益群, 孙钢, 杨淑梅. 和肽素与降钙素原联合测定在脓毒血症早期诊断及预后判断的临床意义. 中华医院感染学杂志, 2011, 21(18): 3801-3803.
22.	Lee JH, Chan YH, Lai OF, et al. Vasopressin and copeptin levels in children with sepsis and septic shock. Intensive Care Med, 2013, 39(4): 747-753.
23.	阎萍, 张纳新, 曾金洁, 等. 吸烟对慢性阻塞性肺疾病患者炎症反应及和肽素水平的影响. 中国老年学杂志, 2016, 36(15): 3754-3756.
24.	Soontornniyomkij V, Lynch MD, Mermash S, et al. Cerebral micro infarcts associated with severe cerebral beta-amyloid angiopathy. Brain Pathol, 2010, 20(2): 459-467.

1. Nakano T, Araki K, Nakatani H, et al. Effects of geldanamycin and thalidomide on the Th1/Th2 cytokine balance in mice subjected to operative trauma. Surgery, 2007, 141(4): 490-500.
2. 张永波. 32 例结肠癌术后肺部感染病例的临床分析. 中国医药导刊, 2004, 16(1): 29-31.
3. Lee IK, Sung NY, Lee YS, et al. The survival rate and prognostic factors in 26 perforated colorectal cancer patients. Int J Colorectal Dis, 2007, 22(5): 467-473.
4. 刘晓珑, 崔海燕, 刘立新, 等. 结肠癌术后肺部感染的免疫学因素分析. 山西医药杂志, 2010, 39(8): 707-709.
5. 杨红晖, 姚小红, 黄秀良. 全麻气管插管术后患者肺部感染的调查分析. 中华医院感染学杂志, 2009, 19(21): 2868-2869.
6. 华锋, 王斌, 崔恩海. 和肽素对呼吸机相关性肺炎预后判断的临床意义. 中华医院感染学杂志, 2013, 23(4): 743-745.
7. 付春毅, 温伟, 张新超. 和肽素能否成为急危重症的一个良好生物学标记物. 中国急救医学, 2014, 34(11): 1044-1047.
8. Watanabe T, Itabashi M, Shimada Y, et al. Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2010 for the treatment of colorectal cancer. Int J Clin Oncol, 2012, 17(1): 1-29.
9. 中国抗癌协会大肠癌专业委员会腹腔镜外科学组, 中华医学会外科分会腹腔镜与内镜外科学组. 腹腔镜结肠直肠癌根治手术操作指南(2006版). 外科理论与实践, 2006, 11(5): 462-464.
10. 华学洪, 李凤鸣. 老年人全麻下上腹部手术后肺部感染的临床分析. 泸州医学院学报, 2010, 33(2): 183-184.
11. Biondo S, Kreisler E, Millan M, et al. Differences in patient postoperative and long-term outcomes between obstructive and perforated colonic cancer. Am J Surg, 2008, 195(4): 427-432.
12. 张素玲, 马俊美. 老年患者实施开胸手术后合并肺部感染的危险因素分析. 安徽医药, 2015, 19(2): 355-357.
13. 于鲁源, 陈素丽. 气管插管全麻复合硬膜外麻醉对结肠癌患者术后肺部感染的影响. 现代消化及介入诊疗, 2016, 21(2): 287-289.
14. 杨永凯, 张帆, 薛少华, 等. 脑出血合并肺部感染患者血清降钙素原、和肽素水平变化及其临床意义. 重庆医学, 2015, 44(34): 4802-4805.
15. 卞淼, 安莲华, 张宏涛, 等. 血清合肽素对呼吸衰竭患者预后评估的临床意义. 中国全科医学, 2014, 17(4): 414-417.
16. Du JM, Sang G, Jang CM, et al. Relationship between plasm copeptin levels and complications of community acquired pneumonia in preschool children. Peptides, 2013, 45(7): 61-65.
17. 杨永凯, 张帆, 薛少华, 等. 血清和肽素、降钙素原对脑出血合并肺部感染早期诊断及判断预后的价值. 重庆医学, 2015, 44(18): 2483-2485.
18. Salem TA, Molloy RG, O’Dwyer PJ. Prospective study on the role of C-reactive protein (CRP) in patients with an acute abdomen. Ann R Coll Surg Engl, 2007, 89(3): 233-237.
19. 李玉勤, 唐炜, 金胜利. 和肽素在小儿社区获得性肺炎中的变化及意义. 广东医学, 2014, 35(24): 3855-3857.
20. 方明, 张琳, 王道标, 等. 急性肺损伤患者血清及肺泡灌洗液和肽素水平变化的临床分析. 中华危重症医学杂志(电子版), 2011, 4(3): 155-161.
21. 魏益群, 孙钢, 杨淑梅. 和肽素与降钙素原联合测定在脓毒血症早期诊断及预后判断的临床意义. 中华医院感染学杂志, 2011, 21(18): 3801-3803.
22. Lee JH, Chan YH, Lai OF, et al. Vasopressin and copeptin levels in children with sepsis and septic shock. Intensive Care Med, 2013, 39(4): 747-753.
23. 阎萍, 张纳新, 曾金洁, 等. 吸烟对慢性阻塞性肺疾病患者炎症反应及和肽素水平的影响. 中国老年学杂志, 2016, 36(15): 3754-3756.
24. Soontornniyomkij V, Lynch MD, Mermash S, et al. Cerebral micro infarcts associated with severe cerebral beta-amyloid angiopathy. Brain Pathol, 2010, 20(2): 459-467.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Analysis of influencing factors for pulmonary infection after radical resection of colon cancer

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