Influencing factors of postoperative survival in patient with gastric cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

XIAO Zhengjie ¹ ,  TIAN Qinggang ² , HAI Erhan ³

1. Department of General Surgery, The Fourth Affiliated Hospital of Baotou Medical College, Baotou, Inner Mongolia 014040, P. R. China;
2. Department of Oncology Surgery, The Fourth Hospital of Baotou City, Baotou, Inner Mongolia 014030, P. R. China;
3. Department of General Surgery, Baotou Central Hospital, Baotou, Inner Mongolia 014040, P. R. China;

Corresponding author：

TIAN Qinggang, Email: tianqinggang2004@163.com

Keywords：

gastric cancer; survival time; influencing factor

DOI：

10.7507/1007-9424.202009057

Video：

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Objective To explore the related factors of postoperative survival of patient with gastric cancer, so as to provide the corresponding evidence support for the prognosis evaluation.Methods The clinicopathologic data of patients with gastric cancer who underwent surgical treatment in the Fourth Affiliated Hospital of Baotou Medical College and the Fourth Hospital of Baotou City from January 2006 to December 2009 were retrospectively collected. The influences of clinicopathologic data (gender, age, tumor size, tumor location, lymph node metastasis, tumor thrombus, tumor differentiation, TNM stage, operation mode, and postoperative chemotherapy) on postoperative survival of patients with gastric cancer were analyzed. Univariate analysis was used to analyze the influencing factors of postoperative survival in the patients with gastric cancer and Cox proportional hazards regression was used to analyze the independent risk factors.Results A total of 80 patients with gastric cancer were included in this study. Up to December 31, 2014, the median survival time at 50% cumulative survival rate was 95 months. Univariate analysis showed that the survival of patients with gastric cancer was related to tumor size, lymph node metastasis, tumor differentiation, and TNM stage (P<0.05). Further multivariate analysis showed that later TNM stage was an independent risk factor for affecting postoperative survival of patients with gastric cancer (P<0.05).Conclusion Postoperative survival of patients with gastric cancer is related to tumor size, lymph node metastasis, tumor differentiation, and TNM stage; And later TNM stage is an independent risk factor for affecting survival of patients with gastric cancer.

Citation： XIAO Zhengjie, TIAN Qinggang, HAI Erhan. Influencing factors of postoperative survival in patient with gastric cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2021, 28(7): 884-887. doi: 10.7507/1007-9424.202009057 Copy

1.	Global Burden of Disease Cancer Collaboration, Fitzmaurice C, Allen C, et al. Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 32 cancer groups, 1990 to 2015: A systematic analysis for the global burden of disease study. JAMA Oncol, 2017, 3(4): 524-548.
2.	Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 2018, 68(6): 394-424.
3.	Eusebi LH, Telese A, Marasco G, et al. Gastric cancer prevention strategies: A global perspective. J Gastroenterol Hepatol, 2020, 35(9): 1495-1502.
4.	Machlowska J, Baj J, Sitarz M, et al. Gastric cancer: epidemiology, risk factors, classification, genomic characteristics and treatment strategies. Int J Mol Sci, 2020, 21(11): 4012.
5.	Habib R, Akhtar J, Taqi M, et al. Lentiviral vector-mediated survivin shRNA delivery in gastric cancer cell lines significantly inhibits cell proliferation and tumor growth. Oncol Rep, 2015, 34(2): 859-867.
6.	徐冉, 杨年钊, 赵海远, 等. 多灶性胃癌病人淋巴结转移危险因素及预后分析. 临床外科杂志, 2020, 28(8): 774-777.
7.	许巧玲, 郑鸿. 伊立替康联合阿帕替尼治疗晚期胃癌预后分析. 肿瘤研究与临床, 2020, 32(6): 419-423.
8.	Zhao Z, Fan Y, Sun Y, et al. Efficacy of conversion surgery on stage Ⅳ gastric cancer and its prognosis analysis. Panminerva Med, 2020 May 14. Online ahead of print.
9.	崔勇, 张荣香, 王福立, 等. 新辅助化疗联合术后同步放化疗治疗Ⅲ期胃癌的疗效分析. 中国肿瘤临床, 2016, 43(17): 747-752.
10.	李敏娜, 路宁, 王艺璇, 等. 中青年与老年胃癌术后患者的临床病理特点和预后因素—基于 SEER 数据库的分析. 现代肿瘤医学, 2020, 28(14): 2467-2473.
11.	李静. miRNA-451 表达与胃癌患者预后相关性分析. 慢性病学杂志, 2020, 21(7): 974-976.
12.	马翔. 胃癌手术治疗后超长期生存患者预后因素分析. 肿瘤研究与临床, 2019, 31(9): 630-632.
13.	蒋大平, 徐华平, 方华进, 等. 影响胃癌根治术后患者预后效果的相关因素分析. 中国现代医学杂志, 2020, 30(4): 39-43.
14.	廖玉麟, 徐宏涛, 周煜. 营养状况及心理因素对胃癌患者半年生存率及生存质量的影响. 中国现代医生, 2016, 54(10): 30-33.
15.	Amin MB, Greene FL, Edge SB, et al. The Eighth Edition AJCC Cancer Staging Manual: Continuing to build a bridge from a population-based to a more “personalized” approach to cancer staging. CA Cancer J Clin, 2017, 67(2): 93-99.
16.	Liu JY, Peng CW, Yang XJ, et al. The prognosis role of AJCC/UICC 8 th edition staging system in gastric cancer, a retrospective analysis. Am J Transl Res, 2018, 10(1): 292-303.
17.	Kanagavel D, Fedyanin M, Tryakin A, et al. Second-line treatment of metastatic gastric cancer: Current options and future directions. World J Gastroenterol, 2015, 21(41): 11621-11635.
18.	Guan E, Tian F, Liu Z. A novel risk score model for stomach adenocarcinoma based on the expression levels of 10 genes. Oncol Lett, 2020, 19(2): 1351-1367.
19.	周红, 郭春光, 陈应泰, 等. 早期胃癌非治愈性内镜黏膜下剥离术后的治疗策略研究. 中华肿瘤杂志, 2019, 41(11): 865-869.
20.	Xu W, Beeharry MK, Liu W, et al. Preoperative chemotherapy for gastric cancer: personal interventions and precision medicine. Biomed Res Int, 2016, 2016: 3923585.
21.	Seevaratnam R, Bocicariu A, Cardoso R, et al. How many lymph nodes should be assessed in patients with gastric cancer? A systematic review. Gastric Cancer, 2012, 15 Suppl 1: S70-S88.
22.	魏晟宏, 陈路川, 叶再生, 等. 胃癌肿瘤大小的临床病理特征及预后分析(附 753 例报告). 福建医药杂志, 2017, 39(6): 88-91.
23.	Deng JY, Liang H. Clinical significance of lymph node metastasis in gastric cancer. World J Gastroenterol, 2014, 20(14): 3967-3975.
24.	Min CL, Zhang AX, Qin J. Increased expression of miR-601 is associated with poor prognosis and tumor progression of gastric cancer. Diagn Pathol, 2019, 14(1): 107.
25.	周薇薇, 雷海科, 李小升, 等. 2 187 例胃癌患者生存随访调查及预后影响因素研究. 消化肿瘤杂志(电子版), 2020, 12(2): 105-111.
26.	Zheng Z, Liu Y, Bu Z, et al. Prognostic role of lymph node metastasis in early gastric cancer. Chin J Cancer Res, 2014, 26(2): 192-199.
27.	Yamada S, Hatta W, Shimosegawa T, et al. Different risk factors between early and late cancer recurrences in patients without additional surgery after noncurative endoscopic submucosal dissection for early gastric cancer. Gastrointest Endosc, 2019, 89(5): 950-960.
28.	Bang YJ, Van Cutsem E, Feyereislova A, et al. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet, 2010, 376(9742): 687-697.
29.	Yang Y, Yin X, Sheng L, et al. Perioperative chemotherapy more of a benefit for overall survival than adjuvant chemotherapy for operable gastric cancer: an updated meta-analysis. Sci Rep, 2015, 5: 12850.

1. Global Burden of Disease Cancer Collaboration, Fitzmaurice C, Allen C, et al. Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 32 cancer groups, 1990 to 2015: A systematic analysis for the global burden of disease study. JAMA Oncol, 2017, 3(4): 524-548.
2. Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 2018, 68(6): 394-424.
3. Eusebi LH, Telese A, Marasco G, et al. Gastric cancer prevention strategies: A global perspective. J Gastroenterol Hepatol, 2020, 35(9): 1495-1502.
4. Machlowska J, Baj J, Sitarz M, et al. Gastric cancer: epidemiology, risk factors, classification, genomic characteristics and treatment strategies. Int J Mol Sci, 2020, 21(11): 4012.
5. Habib R, Akhtar J, Taqi M, et al. Lentiviral vector-mediated survivin shRNA delivery in gastric cancer cell lines significantly inhibits cell proliferation and tumor growth. Oncol Rep, 2015, 34(2): 859-867.
6. 徐冉, 杨年钊, 赵海远, 等. 多灶性胃癌病人淋巴结转移危险因素及预后分析. 临床外科杂志, 2020, 28(8): 774-777.
7. 许巧玲, 郑鸿. 伊立替康联合阿帕替尼治疗晚期胃癌预后分析. 肿瘤研究与临床, 2020, 32(6): 419-423.
8. Zhao Z, Fan Y, Sun Y, et al. Efficacy of conversion surgery on stage Ⅳ gastric cancer and its prognosis analysis. Panminerva Med, 2020 May 14. Online ahead of print.
9. 崔勇, 张荣香, 王福立, 等. 新辅助化疗联合术后同步放化疗治疗Ⅲ期胃癌的疗效分析. 中国肿瘤临床, 2016, 43(17): 747-752.
10. 李敏娜, 路宁, 王艺璇, 等. 中青年与老年胃癌术后患者的临床病理特点和预后因素—基于 SEER 数据库的分析. 现代肿瘤医学, 2020, 28(14): 2467-2473.
11. 李静. miRNA-451 表达与胃癌患者预后相关性分析. 慢性病学杂志, 2020, 21(7): 974-976.
12. 马翔. 胃癌手术治疗后超长期生存患者预后因素分析. 肿瘤研究与临床, 2019, 31(9): 630-632.
13. 蒋大平, 徐华平, 方华进, 等. 影响胃癌根治术后患者预后效果的相关因素分析. 中国现代医学杂志, 2020, 30(4): 39-43.
14. 廖玉麟, 徐宏涛, 周煜. 营养状况及心理因素对胃癌患者半年生存率及生存质量的影响. 中国现代医生, 2016, 54(10): 30-33.
15. Amin MB, Greene FL, Edge SB, et al. The Eighth Edition AJCC Cancer Staging Manual: Continuing to build a bridge from a population-based to a more “personalized” approach to cancer staging. CA Cancer J Clin, 2017, 67(2): 93-99.
16. Liu JY, Peng CW, Yang XJ, et al. The prognosis role of AJCC/UICC 8 th edition staging system in gastric cancer, a retrospective analysis. Am J Transl Res, 2018, 10(1): 292-303.
17. Kanagavel D, Fedyanin M, Tryakin A, et al. Second-line treatment of metastatic gastric cancer: Current options and future directions. World J Gastroenterol, 2015, 21(41): 11621-11635.
18. Guan E, Tian F, Liu Z. A novel risk score model for stomach adenocarcinoma based on the expression levels of 10 genes. Oncol Lett, 2020, 19(2): 1351-1367.
19. 周红, 郭春光, 陈应泰, 等. 早期胃癌非治愈性内镜黏膜下剥离术后的治疗策略研究. 中华肿瘤杂志, 2019, 41(11): 865-869.
20. Xu W, Beeharry MK, Liu W, et al. Preoperative chemotherapy for gastric cancer: personal interventions and precision medicine. Biomed Res Int, 2016, 2016: 3923585.
21. Seevaratnam R, Bocicariu A, Cardoso R, et al. How many lymph nodes should be assessed in patients with gastric cancer? A systematic review. Gastric Cancer, 2012, 15 Suppl 1: S70-S88.
22. 魏晟宏, 陈路川, 叶再生, 等. 胃癌肿瘤大小的临床病理特征及预后分析(附 753 例报告). 福建医药杂志, 2017, 39(6): 88-91.
23. Deng JY, Liang H. Clinical significance of lymph node metastasis in gastric cancer. World J Gastroenterol, 2014, 20(14): 3967-3975.
24. Min CL, Zhang AX, Qin J. Increased expression of miR-601 is associated with poor prognosis and tumor progression of gastric cancer. Diagn Pathol, 2019, 14(1): 107.
25. 周薇薇, 雷海科, 李小升, 等. 2 187 例胃癌患者生存随访调查及预后影响因素研究. 消化肿瘤杂志(电子版), 2020, 12(2): 105-111.
26. Zheng Z, Liu Y, Bu Z, et al. Prognostic role of lymph node metastasis in early gastric cancer. Chin J Cancer Res, 2014, 26(2): 192-199.
27. Yamada S, Hatta W, Shimosegawa T, et al. Different risk factors between early and late cancer recurrences in patients without additional surgery after noncurative endoscopic submucosal dissection for early gastric cancer. Gastrointest Endosc, 2019, 89(5): 950-960.
28. Bang YJ, Van Cutsem E, Feyereislova A, et al. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet, 2010, 376(9742): 687-697.
29. Yang Y, Yin X, Sheng L, et al. Perioperative chemotherapy more of a benefit for overall survival than adjuvant chemotherapy for operable gastric cancer: an updated meta-analysis. Sci Rep, 2015, 5: 12850.

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Influencing factors of postoperative survival in patient with gastric cancer

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