The Reduction of Adverse Drug Reaction Incidences of Colorectal Caner Patients Receiving Jianpi Herbs Combined with Chemotherapy: A Systematic Review_Chinese Journal of Evidence-Based Medicine

Authors：

 LIU Jing , ZHU Qi

Oncology Department, Shanghai Hospital of Traditional Chinese Medicine, Shanghai 200071, China;

Corresponding author：

LIU Jing, Email: 0651@stcmh.stnc.com

Keywords：

Key words Jianpi; Chemotherapy; Colorectal cancer; Adverse drug reaction; Systematic review; Randomized controlled trial

DOI：

10.7507/1672-2531.20090139

Video：

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Objective 　To assess reduction of adverse drug reaction incidence in patients with colorectal cancer receiving Jianpi herbs combined with chemotherapy.
Methods 　The randomized controlled trials (RCTs) comparing Jianpi herbs combined with chemotherapy were searched through CBMdisc, CJFD, Wangfang Data and PubMed. The search was updated to September 2007. Software RevMan5, provided by Cochrane Library, was used to perform meta-analysis.
Results 　Six RCTs were identified in this systematic review. All the methodology quality of the enrolled RCTs was gaded C. The pooled analysis showed that Jianpi herbs combined chemotherapy significantly reduced the incidences of grade I and grade II leucopenia [grade I with RR= 0.50 and 95%CI (0.31 to 0.80); grade II with RR= 0.37 and 95%CI (0.21 to 0.66)], grade II nausea and vomiting [RR= 0.51, 95%CI (0.31 to 0.84)] compared with routine chemotherapy. There was no statistical difference in reduction of neurotoxicity between the two groups.
Conclusion 　The methodological quality of the RCTs using Jianpi herbs combined with chemotherapy on treating colorectal cancer should be improved. Based on this systematic review, Jianpi herbs combined with chemotherapy may reduce the incidence of mild to moderate adverse drug reaction, such as leucopenia and nausea and vomiting, in patients with colorectal cancer. Well-designed RCTs are needed in the future.

Citation： LIU Jing,ZHU Qi. The Reduction of Adverse Drug Reaction Incidences of Colorectal Caner Patients Receiving Jianpi Herbs Combined with Chemotherapy: A Systematic Review. Chinese Journal of Evidence-Based Medicine, 2009, 09(7): 802-808. doi: 10.7507/1672-2531.20090139 Copy

1.	李连弟, 鲁凤珠, 张思维, 等. 中国恶性肿瘤死亡率20年变化趋势和近期预测分析. 中华肿瘤杂志, 1997, 19(1): 3-9.
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6.	黄智芬, 黎汉忠, 刘俊波, 等. 健脾消积汤配合化疗治疗晚期大肠癌疗效观察. 现代中西医结合杂志, 2005, 14(10): 1281-1282.
7.	刘静, 王维平, 周奕阳, 等. 健脾活血中药联合化疗治疗大肠癌术后患者的疗效观察. 中国中西医结合杂志, 2005, 25(3): 207-209.
8.	马骏, 王国骅, 蔡定芳, 等. 健脾消瘤方预防大肠癌术后转移复发的临床观察. 上海中医药杂志, 2005, 39(1): 24-25.
9.	胡爱民, 解传勇, 黎治平. 中药联合化疗治疗晚期大肠癌的疗效观察. 实用癌症杂志, 2006, 21(1): 74-76.
10.	张青, 赵文硕, 于洁, 等. 益气活血中药联合化疗治疗晚期大肠癌的临床研究. 中国中医药信息杂志, 2006, 13(10): 17-18.
11.	毅俊, 陈劲智, 黄伟贤, 等. 温肾健脾方配合化疗治疗老年进展期大肠癌的临床研究. 福建中医药, 2007, 38(4): 13-14.
12.	刘静, 张军, 朱琦. 中医药治疗大肠癌辨证用药分析. 辽宁中医杂志, 2006, 33(9): 1166-1167.
13.	刘静, 朱琦, 张军. 中医药治疗大肠癌临床研究文献的质量分析. 中国中医基础医学杂志, 2006, 12(5): 387-388.

1. 李连弟, 鲁凤珠, 张思维, 等. 中国恶性肿瘤死亡率20年变化趋势和近期预测分析. 中华肿瘤杂志, 1997, 19(1): 3-9.
2. 郑树, 蔡善荣. 中国大肠癌的病因学及人群防治研究. 中华肿瘤杂志, 2004, 26(1): 1-3.
3. Park JO, Lee SI, Song SY, et al. Measuring response in solid tumors:comparison of RECIST and WHO response criteria. Jpn J Clin Oncol, 2003, 33(10): 533-537.
4. Jadad AR, Moore RA, Carroll D, et al. Assessing the quality of reports of randomized clinical trials: Is blinding necessary. Control Clin Trials, 1996, 17(1): 1-12.
5. Moher D, Pham B, Jones A, et al. Does quality of reports of randomized trials affect estimates of intervention efficacy in Meta-analysis. Lancet, 1998, 352(9 128): 609-613.
6. 黄智芬, 黎汉忠, 刘俊波, 等. 健脾消积汤配合化疗治疗晚期大肠癌疗效观察. 现代中西医结合杂志, 2005, 14(10): 1281-1282.
7. 刘静, 王维平, 周奕阳, 等. 健脾活血中药联合化疗治疗大肠癌术后患者的疗效观察. 中国中西医结合杂志, 2005, 25(3): 207-209.
8. 马骏, 王国骅, 蔡定芳, 等. 健脾消瘤方预防大肠癌术后转移复发的临床观察. 上海中医药杂志, 2005, 39(1): 24-25.
9. 胡爱民, 解传勇, 黎治平. 中药联合化疗治疗晚期大肠癌的疗效观察. 实用癌症杂志, 2006, 21(1): 74-76.
10. 张青, 赵文硕, 于洁, 等. 益气活血中药联合化疗治疗晚期大肠癌的临床研究. 中国中医药信息杂志, 2006, 13(10): 17-18.
11. 毅俊, 陈劲智, 黄伟贤, 等. 温肾健脾方配合化疗治疗老年进展期大肠癌的临床研究. 福建中医药, 2007, 38(4): 13-14.
12. 刘静, 张军, 朱琦. 中医药治疗大肠癌辨证用药分析. 辽宁中医杂志, 2006, 33(9): 1166-1167.
13. 刘静, 朱琦, 张军. 中医药治疗大肠癌临床研究文献的质量分析. 中国中医基础医学杂志, 2006, 12(5): 387-388.

Chinese Journal of Evidence-Based Medicine

The Reduction of Adverse Drug Reaction Incidences of Colorectal Caner Patients Receiving Jianpi Herbs Combined with Chemotherapy: A Systematic Review

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