Effect of Local Application of Metronidazole with Scaling and Root Planing: A Meta-Analysis_Chinese Journal of Evidence-Based Medicine

Authors：

1. Department of Periodontology, School of Stomatology, China Medical University, Shenyang 110002, China;2. Xiqing District Center for Disease Control and Prevention, Tianjin 300380, China;

Corresponding author：

Keywords：

Periodontitis; Scaling; Root planing; Metronidazole; Meta-analysis

DOI：

10.7507/1672-2531.20090220

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Objective 　To assess the effectiveness of local delivery of metronidazole as an adjunct to scaling and root planing (SRP) versus SRP alone in patients with chronic periodontitis.
Methods 　We searched six major electronic databases including CNKI, PubMed, EBSCO, OVID, ScienceDirect, and Springrlink from establishment to May 2009. Randomized controlled trials (RCTs) comparing metronidazole plus SRP with SRP alone for at least 1 month of follow-up were included. The methodological quality of included trials was assessed by the method recommended by the Cochrane Collaboration and pooled analysis was conducted using Stata 10.0 software.
Results 　Seven RCTs met the inclusion and exclusion criteria. A significant mean reduction in probing depth with WMD –0.43 and 95%CI –0.72 to –0.13 for the combined metronidazole and SRP was observed, but there were no statistical significant differences at the clinical attachment level between the two treatments with WMD –0.23 and 95%CI –0.53 to 0.06.
Conclusion 　Metronidazole as an adjunct to SRP could reduce probing depth in the treatment of chronic adult periodontitis.

Citation： LI Xiaoyan,LIN Li,PAN Yaping,GUO Lichun. Effect of Local Application of Metronidazole with Scaling and Root Planing: A Meta-Analysis. Chinese Journal of Evidence-Based Medicine, 2009, 09(11): 1226-1230. doi: 10.7507/1672-2531.20090220 Copy

1.	Loesche WJ, Syed SA, Morrison EC, et al. Metronidazole in periodontitis. I. Clinical and bacteriological results after 15 to 30 weeks. J Periodontol, 1984, 55(6): 325-335.
2.	Lie T, Bruun G, Böe OE. Effects of topical metronidazole and tetracycline in treatment of adult periodontitis. J Periodontol, 1998, 69(7): 819-827.
3.	Stelzel M, Florès-de-Jacoby L. Topical metronidazole application as an adjunct to scaling and root planing. J Clin Periodontol, 2000, 27(6): 447-452.
4.	周爽英, 陈智滨, 段清宇, 等. 局部应用甲硝唑凝胶剂辅助治疗牙周炎的效果观察. 中国临床药理学杂志, 2001, 17(2): 100-103.
5.	黄忠锁, 丁晓红. 牙康棒在超声龈下刮治深牙周袋的临床体会. 安徽卫生职业技术学院学报, 2004, 3(4): 36-37.
6.	Perinetti G, Paolantonio M, Cordella C, et al. Clinical and microbiological effects of subgingival administration of two active gels on persistent pockets of chronic periodontitis patients. J Clin Periodontol, 2004, 31(4): 273-281.
7.	Leiknes T, Leknes KN, Böe OE, et al. Topical use of a metronidazole gel in the treatment of sites with symptoms of recurring chronic inflammation. J Periodontol, 2007, 78(8): 1538-1544.
8.	Kinane DF, Radvar M. A six-month comparison of three periodontal local antimicrobial therapies in persistent periodontal pockets. J Periodontol, 1999, 70(1): 1-7.

1. Loesche WJ, Syed SA, Morrison EC, et al. Metronidazole in periodontitis. I. Clinical and bacteriological results after 15 to 30 weeks. J Periodontol, 1984, 55(6): 325-335.
2. Lie T, Bruun G, Böe OE. Effects of topical metronidazole and tetracycline in treatment of adult periodontitis. J Periodontol, 1998, 69(7): 819-827.
3. Stelzel M, Florès-de-Jacoby L. Topical metronidazole application as an adjunct to scaling and root planing. J Clin Periodontol, 2000, 27(6): 447-452.
4. 周爽英, 陈智滨, 段清宇, 等. 局部应用甲硝唑凝胶剂辅助治疗牙周炎的效果观察. 中国临床药理学杂志, 2001, 17(2): 100-103.
5. 黄忠锁, 丁晓红. 牙康棒在超声龈下刮治深牙周袋的临床体会. 安徽卫生职业技术学院学报, 2004, 3(4): 36-37.
6. Perinetti G, Paolantonio M, Cordella C, et al. Clinical and microbiological effects of subgingival administration of two active gels on persistent pockets of chronic periodontitis patients. J Clin Periodontol, 2004, 31(4): 273-281.
7. Leiknes T, Leknes KN, Böe OE, et al. Topical use of a metronidazole gel in the treatment of sites with symptoms of recurring chronic inflammation. J Periodontol, 2007, 78(8): 1538-1544.
8. Kinane DF, Radvar M. A six-month comparison of three periodontal local antimicrobial therapies in persistent periodontal pockets. J Periodontol, 1999, 70(1): 1-7.

Chinese Journal of Evidence-Based Medicine

Effect of Local Application of Metronidazole with Scaling and Root Planing: A Meta-Analysis

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