Objective To analyze the effects and recurrence rate of single miconazole and the miconazole plus living preparation of lactobacillus for the treatment of the uncomplicated vulvovaginal candidiasis.
Methods We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library Issue 4, 2008) MEDLINE (1966 to January 2009); PubMed (1966 to January 2009); EMbase (1966 to January 2009); CNKI (1966 to January 2009), and the Chinese Biomedicine Database (CBM) (1966 to January 2009) to identify randomized controlled trials of single miconazole versus the miconazole plus living preparation of lactobacillus.The quality of the included trials was assessed. RevMan 5 software was used to conduct meta–analysis.
Results Eight trials involving 5 156 patients were included in the effect analysis. Meta-analysis showed miconazole plus with living preparation of lactobacillus was better compared with just miconazole (RR=0.96, 95%CI 0.92 to 1.00, Z=2.12, P=0.03; RR=0.92, 95%CI 0.85 to 0.99, Z=2.17, P=0.03).Seven trials involving 4 852 patients were included in recurrence rate analysis. Meta-analysis showed miconazole plus living preparation of lactobacillus had lower recurrence rate compared with single miconazole (RR=3.72, 95%CI 1.94 to 7.13, Z=3.97, P lt;0.000 1; RR=12.85, 95%CI 8.27 to 19.96, Z=11.37, P lt;0.000 01).
Conclusion Currently available evidence shows that the effect in the combined group is better, and the recurrence rate is lower.
Citation： CUI Ling,WANG Chao,FU Jing,XIE Lingxia,HULina. Miconazole versus Miconazole plus Living Preparation of Lactobacillus for Vulvovaginal Candidiasis: A Systematic Review. Chinese Journal of Evidence-Based Medicine, 2010, 10(1): 89-93. doi: 10.7507/1672-2531.20100217 Copy