Disodium Cantharidinate and Vitamin B6 Injection plus Chemotherapy for Non-Small Cell Lung Cancer: A Systematic Review_Chinese Journal of Evidence-Based Medicine

Authors：

 SHENG Lei ¹ , LI Yan ¹ , CHEN Jianpeng ²

1. Department of Pharmaceutical Science, Shandong University, Jinan 250012, China;2. Department of Chemotherapy Oncology, Shandong Provincial Hospital, Jinan 250021, China;

Corresponding author：

SHENG Lei, Email: shenglei1988@yahoo.com.cn

Keywords：

Disodium cantharidinate and vitamin B6 injection; Non-small cell lung cancer; Chemotherapy; Randomized controlled trial; Meta-analysis; Systematic review

DOI：

10.7507/1672-2531.20120095

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective 　To systematically evaluate the effectiveness and safety of disodium cantharidinate and vitamin B6 injection plus chemotherapy compared with chemotherapy alone, in the treatment of non-small cell lung cancer (NSCLC).
Methods 　The Cochrane Library (Issue 1, 2011), MEDLINE (1966 to November 2011), EMbase (1984 to November 2011), CBM (1978 to November 2011), CNKI (1995 to November 2011) and VIP (1989 to November 2011) were searched electronically, and the randomized controlled trials (RCTs) about disodium cantharidinate and vitamin B6 injection plus chemotherapy for NSCLC were included. The quality of the included studies was assessed and crosschecked by two reviewers independently, and meta-analyses were performed for homogeneous studies by using Cochrane Collaboration’s RevMan 5.1 software.
Results 　Eight RCTs involving 539 patients met inclusion criteria were included in meta-analyses. The quality of all studies was in Grade B. The results of meta-analyses showed that disodium cantharidinate and vitamin B6 injection plus chemotherapy, compared with chemotherapy alone, could increase effective rate (RR=1.32, 95%CI 1.07 to 1.62) and clinical benefit rate (RR=1.24, 95%CI 1.12 to 1.37), improve quality of life (RR=2.23, 95%CI 1.55 to 3.19) and clinical symptoms (RR=1.55, 95%CI 1.24 to 1.95), increase body weight (RR=2.72, 95%CI 1.74 to 4.25), and decrease bone marrow suppression (leucocyte reduction rate) (RR=0.36, 95%CI 0.21 to 0.61).
Conclusion 　The evidence available indicates that the treatment regimen of disodium cantharidinate and vitamin B6 injection plus chemotherapy is superior to chemotherapy alone in increasing effects and decreasing toxicity for the patients with NSCLC. More high-quality and multi-center RCTs with larger sample and longer follow-up are proposed.

Citation： SHENG Lei,LI Yan,CHEN Jianpeng. Disodium Cantharidinate and Vitamin B6 Injection plus Chemotherapy for Non-Small Cell Lung Cancer: A Systematic Review. Chinese Journal of Evidence-Based Medicine, 2012, 12(5): 589-595. doi: 10.7507/1672-2531.20120095 Copy

1.	Athanasios P, Sophia A, Athina A, et al. A randomized phase III study of the docetaxel/carboplatin combination versus docetaxel single-agent as second line treatment for patients with advanced/metastatic Non-Small Cell Lung Cancer. BMC Cancer, 2010, 10: 633-640.
2.	张力, 任冠军, 肖毅. 晚期非小细胞肺癌一线治疗新进展. 中华内科杂志, 2010, 49(2): 168-170.
3.	梁枫, 王明艳. 斑蝥酸钠的研究进展.江西中医学院学报, 2006, 18(1): 67-68.
4.	王峰, 胡世莲, 赵卫刚. 斑蝥酸钠对晚期非小细胞肺癌治疗之Meta分析. 中国循证医学杂志, 2010, 09(增刊): 130-131.
5.	Moher D, Pham B, Jones A, et al. Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses? The Lancet, 1998, 352(9128): 609-613.
6.	Jadad AR, Moore RA, Carroll D, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Controlled clinical trials, 1996, 17(1): 1-12.
7.	杨琳红, 王岷, 陈文靖, 等. 斑蝥酸钠维生素B6联合化疗治疗非小细胞肺癌临床观察. 山东医药, 2010, 50(41): 86-87.
8.	魏红艳, 刘颖, 侯志华.斑蝥酸钠维生素B6注射液联合紫杉醇加顺铂治疗晚期非小细胞肺癌的临床观察. 临床荟萃, 2010, 25(22): 1989-1990.
9.	王淑珍. 艾易舒注射液联合化疗治疗晚期非小细胞肺癌33例临床观察. 河北中医, 2009, 31(12): 1863-1864.
10.	景年才, 杨吉利, 迟春艳. 艾易舒注射液治疗老年晚期非小细胞肺癌的疗效评价. 中国老年学杂志, 2009, 29(22): 2953-2954.
11.	常永芳, 葛明东, 唐爱明, 等. 艾易舒注射液治疗老年非小细胞肺癌的临床观察. 中华肿瘤防治杂志, 2008, 15(16): 1279-1280.
12.	汤福良, 张海平. 艾易舒注射液联合化疗治疗非小细胞肺癌临床疗效观察. 中国医药导报, 2007, 4(26): 46-47.
13.	魏素菊, 史健, 刘义冰, 等. 斑蟊酸钠维生素B6注射液联合NP方案治疗非小细胞肺癌. 肿瘤防治研究, 2005, 32(12): 787-789.
14.	陈锐深, 曹洋. 艾易舒注射液治疗晚期非小细胞肺癌的临床研究. 临床肿瘤学杂志, 2005, 10(4): 392-398.
15.	Zhang W, Zhao H, Yan Y, et al. Apoptosis induced by cantharidin in human pulmonary carcinoma cells A549 and its molecular mechanisms. Chinese Journal of Oncology, 2005, 27(6): 330-334.
16.	魏素菊, 苑素云, 刘义冰. 斑蝥酸钠维生素B6注射液体外调节细胞因子的实验研究. 现代肿瘤医学, 2007, 15(9): 1226-1228.
17.	Liang F, Wang M, Huang W, et al. Effect of Sodium Cantharidinate on the Angiogenesis of Nude Mice with Human Gastric Cancer. Journal of Chinese Medicinal Materials, 2011, 34(3): 343-346.
18.	徐淑云. 临床用药指南. 第1版. 安徽: 安徽科学技术, 2001: 1007-1008.

1. Athanasios P, Sophia A, Athina A, et al. A randomized phase III study of the docetaxel/carboplatin combination versus docetaxel single-agent as second line treatment for patients with advanced/metastatic Non-Small Cell Lung Cancer. BMC Cancer, 2010, 10: 633-640.
2. 张力, 任冠军, 肖毅. 晚期非小细胞肺癌一线治疗新进展. 中华内科杂志, 2010, 49(2): 168-170.
3. 梁枫, 王明艳. 斑蝥酸钠的研究进展.江西中医学院学报, 2006, 18(1): 67-68.
4. 王峰, 胡世莲, 赵卫刚. 斑蝥酸钠对晚期非小细胞肺癌治疗之Meta分析. 中国循证医学杂志, 2010, 09(增刊): 130-131.
5. Moher D, Pham B, Jones A, et al. Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses? The Lancet, 1998, 352(9128): 609-613.
6. Jadad AR, Moore RA, Carroll D, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Controlled clinical trials, 1996, 17(1): 1-12.
7. 杨琳红, 王岷, 陈文靖, 等. 斑蝥酸钠维生素B6联合化疗治疗非小细胞肺癌临床观察. 山东医药, 2010, 50(41): 86-87.
8. 魏红艳, 刘颖, 侯志华.斑蝥酸钠维生素B6注射液联合紫杉醇加顺铂治疗晚期非小细胞肺癌的临床观察. 临床荟萃, 2010, 25(22): 1989-1990.
9. 王淑珍. 艾易舒注射液联合化疗治疗晚期非小细胞肺癌33例临床观察. 河北中医, 2009, 31(12): 1863-1864.
10. 景年才, 杨吉利, 迟春艳. 艾易舒注射液治疗老年晚期非小细胞肺癌的疗效评价. 中国老年学杂志, 2009, 29(22): 2953-2954.
11. 常永芳, 葛明东, 唐爱明, 等. 艾易舒注射液治疗老年非小细胞肺癌的临床观察. 中华肿瘤防治杂志, 2008, 15(16): 1279-1280.
12. 汤福良, 张海平. 艾易舒注射液联合化疗治疗非小细胞肺癌临床疗效观察. 中国医药导报, 2007, 4(26): 46-47.
13. 魏素菊, 史健, 刘义冰, 等. 斑蟊酸钠维生素B6注射液联合NP方案治疗非小细胞肺癌. 肿瘤防治研究, 2005, 32(12): 787-789.
14. 陈锐深, 曹洋. 艾易舒注射液治疗晚期非小细胞肺癌的临床研究. 临床肿瘤学杂志, 2005, 10(4): 392-398.
15. Zhang W, Zhao H, Yan Y, et al. Apoptosis induced by cantharidin in human pulmonary carcinoma cells A549 and its molecular mechanisms. Chinese Journal of Oncology, 2005, 27(6): 330-334.
16. 魏素菊, 苑素云, 刘义冰. 斑蝥酸钠维生素B6注射液体外调节细胞因子的实验研究. 现代肿瘤医学, 2007, 15(9): 1226-1228.
17. Liang F, Wang M, Huang W, et al. Effect of Sodium Cantharidinate on the Angiogenesis of Nude Mice with Human Gastric Cancer. Journal of Chinese Medicinal Materials, 2011, 34(3): 343-346.
18. 徐淑云. 临床用药指南. 第1版. 安徽: 安徽科学技术, 2001: 1007-1008.

Chinese Journal of Evidence-Based Medicine

Disodium Cantharidinate and Vitamin B6 Injection plus Chemotherapy for Non-Small Cell Lung Cancer: A Systematic Review

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content