Anxiety-Depression Influence on Serum TNF-α, IL-6, Platelet 5-HT Level and Blood Platelet Count of Patients with Burn Injury_Chinese Journal of Evidence-Based Medicine

Authors：

WU Xiaoping ^1,2 , WANG Dong ² , CHEN Zhonglun ² , SONG Zhongjin ² , SUN Chongzhou ² , XIAO Xiaolan ³ , HE Youde ³ , WANG Caiming ³ ,  SUN Xueli ¹

1. Mental Health Center, West China Hospital, West China University, Chengdu 610041, China; 2. Mianyang Central Hospital, Mianyang 621000, China;3. Pangang Group Hospital, Panzhihua, 617023, China;

Corresponding author：

SUN Xueli, Email: sunxueli@tom.com

Keywords：

Burn; Anxiety; Depression; Burn injury healing time; Tumor necrosis factor-α; Interleukin-6; 5-HT; Blood platelet count

DOI：

10.7507/1672-2531.20120163

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective 　To observe the serum levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), platelet 5-HT and blood platelet count, emotion and burn injury healing of patients with moderate and severe burn injury and anxiety-depression symptoms.
Methods 　In-patients with moderate and severe burn injury were selected from 2003.4 to 2005.2 and then divided into anxiety-depression group and control group according to their anxiety-depression scores by Hamilton Rating Scale for Depression (HAMD ) and Hamilton Rating Scale for Anxiety (HAMA) 3 days after being burnt. Routine therapy was given to two groups, which lasted 1 month. Their scores of anxiety and depression and the degree of injury healing were observed, and the serum levels of TNF-α and IL-6, platelet 5-HT and blood platelet count were measured in the two groups.
Results 　Fifty-one in-patients with moderate and severe burn injury were divided into the anxiety-depression group (24 cases) and the control group (27 cases). After 30-day treatment, the depression scores did not decrease in the anxiety-depression group (P=0.12), but the anxiety scores decreased (P=0.00). In the anxiety-depression group, the burn injury healing time was postponed (P=0.00), the serum levels of TNF-α increased (P=0.00), and the platelet 5-HT levels decreased (P=0.04) before and after treatment.
Conclusion 　Depressive reaction occurs in patients with moderate and severe burn injury, which is a continuously negative emotion. It can lead to high levels of serum TNF-α, reduction in platelet 5-HT, and delayed burn injury healing time. Due to the limited sample size and different location of patients, there may be some bias in this conclusion. We are prepared to increase the sample size and select patients in the same region in further relevant studies.

Citation： WU Xiaoping,WANG Dong,CHEN Zhonglun,SONG Zhongjin,SUN Chongzhou,XIAO Xiaolan,HE Youde,WANG Caiming,SUN Xueli. Anxiety-Depression Influence on Serum TNF-α, IL-6, Platelet 5-HT Level and Blood Platelet Count of Patients with Burn Injury. Chinese Journal of Evidence-Based Medicine, 2012, 12(9): 1047-1051. doi: 10.7507/1672-2531.20120163 Copy

1.	Drost C, Burleson DG, Cioffi WG, et al. Plasma cytokines following the injury and their relationship with patient mortality burn size and time past burn. Trauma, 1993, 35(3): 335.
2.	王东, 吴孝苹, 宋中金, 等. 帕罗西汀联合音乐治疗中重度烧伤患者: 抑郁情绪与炎性因子的关系. 中国临床康复, 2007, 11(52): 10527-10529.
3.	吴孝苹, 王东, 段劲峰, 等. 抗焦虑抑郁治疗对烧伤患者血小板5-HT水平、血小板计数和细胞因子的影响. 四川大学学报(医学版), 2010, 41(2): 356-358.
4.	汤毓华. 汉密尔顿焦虑量表. 中国行为医学科学-行为医学量表手册. 2001, 10(10): 124-125.
5.	汤毓华. 汉密尔顿抑郁量表. 中国行为医学科学-行为医学量表手册. 2001, 10(10): 134-135.
6.	Fauerbach JA, Lezotte D, Hills RA, et al. Burden of burn:a norm-based inquiry into the influence of burn size and distress on recovery of physical and psychosocial function. Burn Care Rehabil, 2005, 26(1): 21-23.
7.	Wiechman SA, Ptacek JT, Patterson R, et al. Rates, trends, and severity of depression after burn injuries. Burn Care Rehabil, 2001, 22(6): 417-424.
8.	Pallua N, Kunsebeck HW, Noah EM, et al. Psychosocial adjustments 5 years after burn injury. Burns, 2003, 29(2): 143-152.
9.	Maass DL, White J, Horton JW. IL-1 bete and IL-6 actsynergistically with TNF-alpha to alter cardiac contractile function after burn tranma. Shock, 2002, 18(4): 360-366.
10.	陈晓东, 吴伯瑜, 王顺宾, 等. 严重烧伤患者TNF-α、IL-6和IL-8水平的变化及相关性研究. 急诊医学, 2000, 9(6): 387-388.
11.	郝江, 雷鸣. 多发伤早期血小板计数变化及其对预后的影响. 中国危重病急救医学, 2003, 15(10): 615-617.
12.	Shuttleworth RD, Brien JR. Intraplatelet serotonin and plasmas 5-hydroxyindoles in health and disease blood. Am J Psychiatry, 2001, 177: 505-509.
13.	Kim YK, NA KS, Shin KH, et al. Cytokine imbalance in the pathophysiology of major depressive disorder. Prog Neuropsychophamacol Biol Psychiatry, 2007, 31(5): 1044-1053.

1. Drost C, Burleson DG, Cioffi WG, et al. Plasma cytokines following the injury and their relationship with patient mortality burn size and time past burn. Trauma, 1993, 35(3): 335.
2. 王东, 吴孝苹, 宋中金, 等. 帕罗西汀联合音乐治疗中重度烧伤患者: 抑郁情绪与炎性因子的关系. 中国临床康复, 2007, 11(52): 10527-10529.
3. 吴孝苹, 王东, 段劲峰, 等. 抗焦虑抑郁治疗对烧伤患者血小板5-HT水平、血小板计数和细胞因子的影响. 四川大学学报(医学版), 2010, 41(2): 356-358.
4. 汤毓华. 汉密尔顿焦虑量表. 中国行为医学科学-行为医学量表手册. 2001, 10(10): 124-125.
5. 汤毓华. 汉密尔顿抑郁量表. 中国行为医学科学-行为医学量表手册. 2001, 10(10): 134-135.
6. Fauerbach JA, Lezotte D, Hills RA, et al. Burden of burn:a norm-based inquiry into the influence of burn size and distress on recovery of physical and psychosocial function. Burn Care Rehabil, 2005, 26(1): 21-23.
7. Wiechman SA, Ptacek JT, Patterson R, et al. Rates, trends, and severity of depression after burn injuries. Burn Care Rehabil, 2001, 22(6): 417-424.
8. Pallua N, Kunsebeck HW, Noah EM, et al. Psychosocial adjustments 5 years after burn injury. Burns, 2003, 29(2): 143-152.
9. Maass DL, White J, Horton JW. IL-1 bete and IL-6 actsynergistically with TNF-alpha to alter cardiac contractile function after burn tranma. Shock, 2002, 18(4): 360-366.
10. 陈晓东, 吴伯瑜, 王顺宾, 等. 严重烧伤患者TNF-α、IL-6和IL-8水平的变化及相关性研究. 急诊医学, 2000, 9(6): 387-388.
11. 郝江, 雷鸣. 多发伤早期血小板计数变化及其对预后的影响. 中国危重病急救医学, 2003, 15(10): 615-617.
12. Shuttleworth RD, Brien JR. Intraplatelet serotonin and plasmas 5-hydroxyindoles in health and disease blood. Am J Psychiatry, 2001, 177: 505-509.
13. Kim YK, NA KS, Shin KH, et al. Cytokine imbalance in the pathophysiology of major depressive disorder. Prog Neuropsychophamacol Biol Psychiatry, 2007, 31(5): 1044-1053.

Chinese Journal of Evidence-Based Medicine

Anxiety-Depression Influence on Serum TNF-α, IL-6, Platelet 5-HT Level and Blood Platelet Count of Patients with Burn Injury

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