Value of MRI and MDCT in Detecting Both Inferior Vena Cava Tumor Thrombus and Vena Cava Wall Invasion in Renal Cell Carcinoma: A Systematic Review_Chinese Journal of Evidence-Based Medicine

Authors：

ZHANG Ge ¹ , ZHOU Yin ² ,  LIU Rongbo ²

1. West China School of Medicine, Sichuan University, Chengdu 610041, China;2. Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding author：

LIU Rongbo, Email: medicalimage@163.com

Keywords：

Renal cell carcinoma; Tumor thrombus; Inferior vena cava; MRI; MDCT; Systematic review

DOI：

10.7507/1672-2531.20130007

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective 　To evaluate the value of MRI and MDCT in detecting both inferior vena cava tumor thrombus and vena cava wall invasion in renal cell carcinoma.
Methods 　Databases including PubMed, EMbase, The Cochrane Library, MEDLINE (Ovid), CBM, CNKI, VIP and WanFang Data were searched from January 2000 to February 2012. Relevant studies were screened on the basis of the inclusion and exclusion criteria, and then quality assessment and data extraction were conducted. Then heterogeneity test and meta-analysis were conducted using RevMan 5 and Meta-disc 1.4.
Results 　A total of 6 trials involving 244 patients and 246 cases of renal cell carcinoma were included. The results of meta-analysis showed that, for the MRI group and the MDCT group, the sensitivity was 0.963 and 0.952, the specificity was 0.969 and 0.979, the value of +LR was 9.759 and 15.57, the value of −LR was 0.091 and 0.108, and the dOR was 198.71 and 251.54, respectively. There were no significant differences in pooled effect-size among groups (P gt;0.05). The area under curve (AUC) of summary ROC curve analysis as well as Q index of the MDCT group were 0.981 8 and 0.940 7, respectively.
Conclusion　There is no significant difference in the value of MRI and MDCT in detecting inferior vena cava tumor thrombus induced by renal cell carcinoma. More original studies on vena cava wall invasion by tumor thrombus should be conducted in the future due to the limitation of current materials.

Citation： ZHANG Ge,ZHOU Yin,LIU Rongbo. Value of MRI and MDCT in Detecting Both Inferior Vena Cava Tumor Thrombus and Vena Cava Wall Invasion in Renal Cell Carcinoma: A Systematic Review. Chinese Journal of Evidence-Based Medicine, 2013, 13(1): 21-25. doi: 10.7507/1672-2531.20130007 Copy

1. Kabala JE. The kidneys and ureters. In: Sutton D, ed. Textbook of radiology and imaging. Churchill Livingstone: London; 2003: 953.

2. Kearney GP, Waters WB, Klein LA, et al. Results of inferior vena cava resection for renal cell carcinoma. J Urol, 1981, 125(6): 769-773.

3. Marshall FF, Dietrick DD, Baumgartner WA, et al. Surgical management of renal cell carcinoma with intracaval neoplastic extension above the hepatic veins. J Urol, 1988, 139(6): 1166-1172.

4. Hatcher PA, Anderson EE, Paulson DF, et al. Surgical management and prognosis of renal cell carcinoma invading the vena cava. J Urol, 1991, 145(1): 20-23; discussion 23-24.

5. Myneni L, Hricak H, Carroll PR. Magnetic resonance imaging of renal carcinoma with extension into the vena cava: staging accuracy and recent advances. Br J Urol, 1991, 68(6): 571-578.

6. Skinner DG, Pritchett TR, Lieskovsky G, et al. Vena caval involvement by renal cell carcinoma. Surgical resection provides meaningful long-term survival. Ann Surg, 1989, 210(3): 387-392; discussion 392-384.

7. Guo HF, Song Y, Na YQ. Value of abdominal ultrasound scan, CT and MRI for diagnosing inferior vena cava tumour thrombus in renal cell carcinoma. Chin Med J (Engl). 2009, 122(19): 2299-2302.

8. Belgrano E, Trombetta C, Siracusano S, et al. Surgical Management of Renal Cell Carcinoma (RCC) with Vena Cava Tumour Thrombus. European Urology Supplements, 2006, 5(8): 610-618.

9. Aslam Sohaib SA, Teh J, Nargund VH, et al. Assessment of tumor invasion of the vena caval wall in renal cell carcinoma cases by magnetic resonance imaging. J Urol, 2002, 167(3): 1271-1275.

10. Khan AR, Anwar K, Fatima N, et al. Comparison of CT scan and colour flow Doppler ultrasound in detecting venous tumour thrombous in renal cell carcinoma. J Ayub Med Coll Abbottabad, 2008, 20(3): 47-50.

11. Hallscheidt PJ, Fink C, Haferkamp A, et al. Preoperative staging of renal cell carcinoma with inferior vena cava thrombus using multidetector CT and MRI: prospective study with histopathological correlation. J Comput Assist Tomogr, 2005, 29(1): 64-68.

12. Ergen FB, Hussain HK, Caoili EM, et al. MRI for Preoperative Staging of Renal Cell Carcinoma Using the 1997 TNM Classification: Comparison with Surgical and Pathologic Staging. AJR, 2004, 182: 217-225.

13. Nazim SM, Ather MH, Hafeez K, et al. Accuracy of multidetector CT scans in staging of renal carcinoma. Int J Surg, 2011, 9(1): 86-90.

14. Guzzo TJ, Pierorazio PM, Schaeffer EM, et al. The accuracy of multidetector computerized tomography for evaluating tumor thrombus in patients with renal cell carcinoma. J Urol, 2009, 181(2): 486-490; discussion 491.

15. Cuevas C, Raske M, Bush WH, et al. Imaging primary and secondary tumor thrombus of the inferior vena cava: multi-detector computed tomography and magnetic resonance imaging. Curr Probl Diagn Radiol, 2006, 35(3): 90-101.

16. Yeh BM, Kurzman P, Foster E, et al. Clinical relevance of retrograde inferior vena cava or hepatic vein opacification during contrast-enhanced CT. AJR Am J Roentgenol, 2004, 183(5): 1227-1232.

17. Wotkowicz C, Wszolek MF, Libertino JA. Resection of renal tumors invading the vena cava. Urol Clin North Am, 2008, 35(4): 657-671; viii.

18. Jibiki M, Iwai T, Inoue Y, et al. Surgical strategy for treating renal cell carcinoma with thrombus extending into the inferior vena cava. Journal of Vascular Surgery, 2004, 39(4): 829-835.

19. Stern PR, Perkov D, Smiljanic R, et al. Venous spread of renal cell carcinoma: MDCT. Abdom Imaging, 2007, 32(4): 530-537.

20. Sheth S, Fishman EK. Imaging of the inferior vena cava with MDCT. AJR Am J Roentgenol, 2007, 189(5): 1243-1251.

1. Kabala JE. The kidneys and ureters. In: Sutton D, ed. Textbook of radiology and imaging. Churchill Livingstone: London; 2003: 953.

2. Kearney GP, Waters WB, Klein LA, et al. Results of inferior vena cava resection for renal cell carcinoma. J Urol, 1981, 125(6): 769-773.

3. Marshall FF, Dietrick DD, Baumgartner WA, et al. Surgical management of renal cell carcinoma with intracaval neoplastic extension above the hepatic veins. J Urol, 1988, 139(6): 1166-1172.

4. Hatcher PA, Anderson EE, Paulson DF, et al. Surgical management and prognosis of renal cell carcinoma invading the vena cava. J Urol, 1991, 145(1): 20-23; discussion 23-24.

5. Myneni L, Hricak H, Carroll PR. Magnetic resonance imaging of renal carcinoma with extension into the vena cava: staging accuracy and recent advances. Br J Urol, 1991, 68(6): 571-578.

6. Skinner DG, Pritchett TR, Lieskovsky G, et al. Vena caval involvement by renal cell carcinoma. Surgical resection provides meaningful long-term survival. Ann Surg, 1989, 210(3): 387-392; discussion 392-384.

7. Guo HF, Song Y, Na YQ. Value of abdominal ultrasound scan, CT and MRI for diagnosing inferior vena cava tumour thrombus in renal cell carcinoma. Chin Med J (Engl). 2009, 122(19): 2299-2302.

8. Belgrano E, Trombetta C, Siracusano S, et al. Surgical Management of Renal Cell Carcinoma (RCC) with Vena Cava Tumour Thrombus. European Urology Supplements, 2006, 5(8): 610-618.

9. Aslam Sohaib SA, Teh J, Nargund VH, et al. Assessment of tumor invasion of the vena caval wall in renal cell carcinoma cases by magnetic resonance imaging. J Urol, 2002, 167(3): 1271-1275.

10. Khan AR, Anwar K, Fatima N, et al. Comparison of CT scan and colour flow Doppler ultrasound in detecting venous tumour thrombous in renal cell carcinoma. J Ayub Med Coll Abbottabad, 2008, 20(3): 47-50.

11. Hallscheidt PJ, Fink C, Haferkamp A, et al. Preoperative staging of renal cell carcinoma with inferior vena cava thrombus using multidetector CT and MRI: prospective study with histopathological correlation. J Comput Assist Tomogr, 2005, 29(1): 64-68.

12. Ergen FB, Hussain HK, Caoili EM, et al. MRI for Preoperative Staging of Renal Cell Carcinoma Using the 1997 TNM Classification: Comparison with Surgical and Pathologic Staging. AJR, 2004, 182: 217-225.

13. Nazim SM, Ather MH, Hafeez K, et al. Accuracy of multidetector CT scans in staging of renal carcinoma. Int J Surg, 2011, 9(1): 86-90.

14. Guzzo TJ, Pierorazio PM, Schaeffer EM, et al. The accuracy of multidetector computerized tomography for evaluating tumor thrombus in patients with renal cell carcinoma. J Urol, 2009, 181(2): 486-490; discussion 491.

15. Cuevas C, Raske M, Bush WH, et al. Imaging primary and secondary tumor thrombus of the inferior vena cava: multi-detector computed tomography and magnetic resonance imaging. Curr Probl Diagn Radiol, 2006, 35(3): 90-101.

16. Yeh BM, Kurzman P, Foster E, et al. Clinical relevance of retrograde inferior vena cava or hepatic vein opacification during contrast-enhanced CT. AJR Am J Roentgenol, 2004, 183(5): 1227-1232.

17. Wotkowicz C, Wszolek MF, Libertino JA. Resection of renal tumors invading the vena cava. Urol Clin North Am, 2008, 35(4): 657-671; viii.

18. Jibiki M, Iwai T, Inoue Y, et al. Surgical strategy for treating renal cell carcinoma with thrombus extending into the inferior vena cava. Journal of Vascular Surgery, 2004, 39(4): 829-835.

19. Stern PR, Perkov D, Smiljanic R, et al. Venous spread of renal cell carcinoma: MDCT. Abdom Imaging, 2007, 32(4): 530-537.

20. Sheth S, Fishman EK. Imaging of the inferior vena cava with MDCT. AJR Am J Roentgenol, 2007, 189(5): 1243-1251.

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Value of MRI and MDCT in Detecting Both Inferior Vena Cava Tumor Thrombus and Vena Cava Wall Invasion in Renal Cell Carcinoma: A Systematic Review

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1.	Kabala JE. The kidneys and ureters. In: Sutton D, ed. Textbook of radiology and imaging. Churchill Livingstone: London; 2003: 953.
2.	Kearney GP, Waters WB, Klein LA, et al. Results of inferior vena cava resection for renal cell carcinoma. J Urol, 1981, 125(6): 769-773.
3.	Marshall FF, Dietrick DD, Baumgartner WA, et al. Surgical management of renal cell carcinoma with intracaval neoplastic extension above the hepatic veins. J Urol, 1988, 139(6): 1166-1172.
4.	Hatcher PA, Anderson EE, Paulson DF, et al. Surgical management and prognosis of renal cell carcinoma invading the vena cava. J Urol, 1991, 145(1): 20-23; discussion 23-24.
5.	Myneni L, Hricak H, Carroll PR. Magnetic resonance imaging of renal carcinoma with extension into the vena cava: staging accuracy and recent advances. Br J Urol, 1991, 68(6): 571-578.
6.	Skinner DG, Pritchett TR, Lieskovsky G, et al. Vena caval involvement by renal cell carcinoma. Surgical resection provides meaningful long-term survival. Ann Surg, 1989, 210(3): 387-392; discussion 392-384.
7.	Guo HF, Song Y, Na YQ. Value of abdominal ultrasound scan, CT and MRI for diagnosing inferior vena cava tumour thrombus in renal cell carcinoma. Chin Med J (Engl). 2009, 122(19): 2299-2302.
8.	Belgrano E, Trombetta C, Siracusano S, et al. Surgical Management of Renal Cell Carcinoma (RCC) with Vena Cava Tumour Thrombus. European Urology Supplements, 2006, 5(8): 610-618.
9.	Aslam Sohaib SA, Teh J, Nargund VH, et al. Assessment of tumor invasion of the vena caval wall in renal cell carcinoma cases by magnetic resonance imaging. J Urol, 2002, 167(3): 1271-1275.
10.	Khan AR, Anwar K, Fatima N, et al. Comparison of CT scan and colour flow Doppler ultrasound in detecting venous tumour thrombous in renal cell carcinoma. J Ayub Med Coll Abbottabad, 2008, 20(3): 47-50.
11.	Hallscheidt PJ, Fink C, Haferkamp A, et al. Preoperative staging of renal cell carcinoma with inferior vena cava thrombus using multidetector CT and MRI: prospective study with histopathological correlation. J Comput Assist Tomogr, 2005, 29(1): 64-68.
12.	Ergen FB, Hussain HK, Caoili EM, et al. MRI for Preoperative Staging of Renal Cell Carcinoma Using the 1997 TNM Classification: Comparison with Surgical and Pathologic Staging. AJR, 2004, 182: 217-225.
13.	Nazim SM, Ather MH, Hafeez K, et al. Accuracy of multidetector CT scans in staging of renal carcinoma. Int J Surg, 2011, 9(1): 86-90.
14.	Guzzo TJ, Pierorazio PM, Schaeffer EM, et al. The accuracy of multidetector computerized tomography for evaluating tumor thrombus in patients with renal cell carcinoma. J Urol, 2009, 181(2): 486-490; discussion 491.
15.	Cuevas C, Raske M, Bush WH, et al. Imaging primary and secondary tumor thrombus of the inferior vena cava: multi-detector computed tomography and magnetic resonance imaging. Curr Probl Diagn Radiol, 2006, 35(3): 90-101.
16.	Yeh BM, Kurzman P, Foster E, et al. Clinical relevance of retrograde inferior vena cava or hepatic vein opacification during contrast-enhanced CT. AJR Am J Roentgenol, 2004, 183(5): 1227-1232.
17.	Wotkowicz C, Wszolek MF, Libertino JA. Resection of renal tumors invading the vena cava. Urol Clin North Am, 2008, 35(4): 657-671; viii.
18.	Jibiki M, Iwai T, Inoue Y, et al. Surgical strategy for treating renal cell carcinoma with thrombus extending into the inferior vena cava. Journal of Vascular Surgery, 2004, 39(4): 829-835.
19.	Stern PR, Perkov D, Smiljanic R, et al. Venous spread of renal cell carcinoma: MDCT. Abdom Imaging, 2007, 32(4): 530-537.
20.	Sheth S, Fishman EK. Imaging of the inferior vena cava with MDCT. AJR Am J Roentgenol, 2007, 189(5): 1243-1251.