Association between Polymorphisms of Epidermal Growth Factor 61 and Susceptibility of Esophageal Carcinoma: A Meta-Analysis_Chinese Journal of Evidence-Based Medicine

Authors：

WANG Jun ,  DONG Weiguo , GUO Xufeng , YU Shijie , SONG Jia , ZHANG Jixiang , WANG Jing

Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430060, China;

Corresponding author：

DONG Weiguo, Email: dwg@whu.edu.cn

Keywords：

EGF; Esophageal carcinoma; Gene polymorphism; Case-control study; Meta-analysis

DOI：

10.7507/1672-2531.20130207

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective 　To systematically review the correlation between epidermal growth factor (EGF) 61A/G polymorphism and the risk of esophageal carcinoma.
Methods 　Such databases as PubMed, EMbase, CJFD, CBM, CNKI, VIP and WanFang Data were electronically searched from inception to January 1st, 2013, to collect case-control studies on the correlation between epidermal growth factor (EGF) 61A/G polymorphism and the risk of esophageal carcinoma. Two reviewers independently identified the literature according to inclusion and exclusion criteria, extracted data, and assessed the quality of the included studies. Then, meta-analysis was performed using RevMan 5.1 and Stata 12.0 software.
Results 　A total of six studies involving 1 448 cases and 1 728 control subjects were included. The results of meta-analysis showed that, there was no significant association between EGF 61A/G polymorphism and the risk of esophageal carcinoma (dominant model: AG+GG vs. AA: OR=1.22, 95%CI 0.91 to 1.65; and recessive model: GG vs. AG+AA: OR=1.35, 95%CI 0.94 to 1.94; AG vs. AA: OR=1.12, 95%CI 0.93 to 1.35; GG vs. AA: OR=1.43, 95%CI 0.83 to 2.47). The results of subgroup analysis grouped by ethnicity showed that, EGF 61A/G polymorphism increased the risk of esophageal carcinoma of the White population (dominant model: AG+GG vs. AA: OR=1.39, 95%CI 1.14 to 1.71; and recessive model: GG vs. AG+AA: OR=1.75, 95%CI 1.37 to 2.25; GG vs. AA: OR=1.93, 95%CI 1.47 to 2.55). However, it had no correlation to the risk of esophageal carcinoma of Asian population.
Conclusion 　Current studies showed that, EGF 61A/G polymorphism is not associated with susceptibility to esophageal carcinoma , but it may increase the risk of esophageal carcinoma in White population. Due to limited quality and quantity of the included studies, the above conclusion needs to be verified by more studies with large sample size.

Citation： WANG Jun,DONG Weiguo,GUO Xufeng,YU Shijie,SONG Jia,ZHANG Jixiang,WANG Jing. Association between Polymorphisms of Epidermal Growth Factor 61 and Susceptibility of Esophageal Carcinoma: A Meta-Analysis. Chinese Journal of Evidence-Based Medicine, 2013, 13(10): 1209-1214. doi: 10.7507/1672-2531.20130207 Copy

1.	Jemal A, Bray F, Center MM, et al. Global cancer statistics. CA Cancer J Clin, 2011, 61(2): 69-90.
2.	Boonyaphiphat P, Thongsuksai P, Sriplung H, et al. Lifestyle habits and genetic susceptibility and the risk of esophageal cancer in the Thai population. Cancer Lett, 2002, 186(2): 193-199.
3.	Li TF, Ren KW, Liu PF. Meta-analysis of epidermal growth factor polymorphisms and cancer risk: involving 9,779 cases and 15,932 controls. DNA Cell Biol, 2012, 31(4): 568-574.
4.	Kasza A. IL-1 and EGF regulate expression of genes important in inflammation and cancer. Cytokine, 2013, 62(1): 22-33.
5.	Lau J, Ioannidis JP, Schmid CH. Quantitative synthesis in systematic reviews. Ann Intern Med, 1997, 127(9): 820-826.
6.	Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst, 1959, 22(4): 719-748.
7.	DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials, 1986, 7(3): 177-188.
8.	Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics, 1994, 50(4): 1088-1101.
9.	Egger M, Davey Smith G, Schneider M, et al. Bias in meta-analysis detected by a simple, graphical test. BMJ, 1997, 315(7109): 629-634.
10.	Cheung WY, Zhai R, Kulke MH, et al. Epidermal growth factor A61G gene polymorphism, gastroesophageal reflux disease and esophageal adenocarcinoma risk. Carcinogenesis, 2009, 30(8): 1363-1367.
11.	Cui L, Pan XM, Ma CF, et al. Association between epidermal growth factor polymorphism and esophageal squamous cell carcinoma susceptibility. Dig Dis Sci, 2010, 55(1): 40-45.
12.	Lanuti M, Liu G, Goodwin JM, et al. A functional epidermal growth factor (EGF) polymorphism, EGF serum levels, and esophageal adenocarcinoma risk and outcome. Clin Cancer Res, 2008, 14(10): 3216-3222.
13.	Menke V, Pot RG, Moons LM, et al. Functional single-nucleotide polymorphism of epidermal growth factor is associated with the development of Barrett’s esophagus and esophageal adenocarcinoma. J Hum Genet, 2012, 57(1): 26-32.
14.	Upadhyay R, Jain M, Kumar S, et al. Interaction of EGFR 497Arg>Lys with EGF +61A>G polymorphism: modulation of risk in esophageal cancer. Oncol Res, 2008, 17(4): 167-174.
15.	夏晴晖, 寿明霞, 陈岳明. 表皮生长因子G61A多态性与食管鳞状细胞癌发生及其病理特征之间的关系. 中华实验外科杂志, 2011, 28(12): 2229.
16.	Lurje G, Leers JM, Pohl A, et al. Genetic variations in angiogenesis pathway genes predict tumor recurrence in localized adenocarcinoma of the esophagus. Ann Surg, 2010, 251(5): 857-864.
17.	Jain M, Kumar S, Upadhyay R, et al. Influence of apoptosis (BCL2, FAS), cell cycle (CCND1) and growth factor (EGF, EGFR) genetic polymorphisms on survival outcome: an exploratory study in squamous cell esophageal cancer. Cancer Biol Ther, 2007, 6(10): 1553-1558.
18.	唐巍峰, 孙斌, 顾海勇, 等. COX-2基因多态性与食管癌易感性关系的Meta分析. 中国循证医学杂志, 2011, 11(12): 1391-1394.
19.	Piao Y, Liu Z, Ding Z, et al. EGF +61A>G polymorphism and gastrointestinal cancer risk: a HuGE review and meta-analysis. Gene, 2013, 519(1): 26-33.
20.	Zhang G, Zhang Q, Zhang Q, et al. Expression of nucleostemin, epidermal growth factor and epidermal growth factor receptor in human esophageal squamous cell carcinoma tissues. J Cancer Res Clin Oncol, 2010, 136(4): 587-594.
21.	Boccia S, De Feo E, Galli P, et al. A systematic review evaluating the methodological aspects of meta-analyses of genetic association studies in cancer research. Eur J Epidemiol, 2010, 25(11): 765-775.

1. Jemal A, Bray F, Center MM, et al. Global cancer statistics. CA Cancer J Clin, 2011, 61(2): 69-90.
2. Boonyaphiphat P, Thongsuksai P, Sriplung H, et al. Lifestyle habits and genetic susceptibility and the risk of esophageal cancer in the Thai population. Cancer Lett, 2002, 186(2): 193-199.
3. Li TF, Ren KW, Liu PF. Meta-analysis of epidermal growth factor polymorphisms and cancer risk: involving 9,779 cases and 15,932 controls. DNA Cell Biol, 2012, 31(4): 568-574.
4. Kasza A. IL-1 and EGF regulate expression of genes important in inflammation and cancer. Cytokine, 2013, 62(1): 22-33.
5. Lau J, Ioannidis JP, Schmid CH. Quantitative synthesis in systematic reviews. Ann Intern Med, 1997, 127(9): 820-826.
6. Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst, 1959, 22(4): 719-748.
7. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials, 1986, 7(3): 177-188.
8. Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics, 1994, 50(4): 1088-1101.
9. Egger M, Davey Smith G, Schneider M, et al. Bias in meta-analysis detected by a simple, graphical test. BMJ, 1997, 315(7109): 629-634.
10. Cheung WY, Zhai R, Kulke MH, et al. Epidermal growth factor A61G gene polymorphism, gastroesophageal reflux disease and esophageal adenocarcinoma risk. Carcinogenesis, 2009, 30(8): 1363-1367.
11. Cui L, Pan XM, Ma CF, et al. Association between epidermal growth factor polymorphism and esophageal squamous cell carcinoma susceptibility. Dig Dis Sci, 2010, 55(1): 40-45.
12. Lanuti M, Liu G, Goodwin JM, et al. A functional epidermal growth factor (EGF) polymorphism, EGF serum levels, and esophageal adenocarcinoma risk and outcome. Clin Cancer Res, 2008, 14(10): 3216-3222.
13. Menke V, Pot RG, Moons LM, et al. Functional single-nucleotide polymorphism of epidermal growth factor is associated with the development of Barrett’s esophagus and esophageal adenocarcinoma. J Hum Genet, 2012, 57(1): 26-32.
14. Upadhyay R, Jain M, Kumar S, et al. Interaction of EGFR 497Arg>Lys with EGF +61A>G polymorphism: modulation of risk in esophageal cancer. Oncol Res, 2008, 17(4): 167-174.
15. 夏晴晖, 寿明霞, 陈岳明. 表皮生长因子G61A多态性与食管鳞状细胞癌发生及其病理特征之间的关系. 中华实验外科杂志, 2011, 28(12): 2229.
16. Lurje G, Leers JM, Pohl A, et al. Genetic variations in angiogenesis pathway genes predict tumor recurrence in localized adenocarcinoma of the esophagus. Ann Surg, 2010, 251(5): 857-864.
17. Jain M, Kumar S, Upadhyay R, et al. Influence of apoptosis (BCL2, FAS), cell cycle (CCND1) and growth factor (EGF, EGFR) genetic polymorphisms on survival outcome: an exploratory study in squamous cell esophageal cancer. Cancer Biol Ther, 2007, 6(10): 1553-1558.
18. 唐巍峰, 孙斌, 顾海勇, 等. COX-2基因多态性与食管癌易感性关系的Meta分析. 中国循证医学杂志, 2011, 11(12): 1391-1394.
19. Piao Y, Liu Z, Ding Z, et al. EGF +61A>G polymorphism and gastrointestinal cancer risk: a HuGE review and meta-analysis. Gene, 2013, 519(1): 26-33.
20. Zhang G, Zhang Q, Zhang Q, et al. Expression of nucleostemin, epidermal growth factor and epidermal growth factor receptor in human esophageal squamous cell carcinoma tissues. J Cancer Res Clin Oncol, 2010, 136(4): 587-594.
21. Boccia S, De Feo E, Galli P, et al. A systematic review evaluating the methodological aspects of meta-analyses of genetic association studies in cancer research. Eur J Epidemiol, 2010, 25(11): 765-775.

Chinese Journal of Evidence-Based Medicine

Association between Polymorphisms of Epidermal Growth Factor 61 and Susceptibility of Esophageal Carcinoma: A Meta-Analysis

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