Association between Myopia and Open-angle Glaucoma: A Meta-Analysis_Chinese Journal of Evidence-Based Medicine

Authors：

 XIONGQi ^1,2 , ZENGXian-tao ³ ,  CAIXiao-jun ² , LIZhi-liang ⁴ , LIZhao-hui ² , LISheng ^1,5

1. The Second Clinical College of Wuhan University, Wuhan 430071, China;
2. Department of Ophthalmology, Zhongnan Hospital, Wuhan University, Wuhan 430071, China;
3. Center for Evidence-Based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China;
4. Department of Orthpedics, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China;
5. Department of Urology, Zhongnan Hospital, Wuhan University, Wuhan 430071, China;

Corresponding author：

CAIXiao-jun, Email: xiaojuncai168@163.com

Keywords：

Myopia; Open-angle glaucoma; Systematic review; Meta-analysis; Cross-sectional study

DOI：

10.7507/1672-2531.20140102

Video：

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Objective To systematically review the association between myopia and open-angle glaucoma (OAG). Methods Foreign and domestic articles published from January 2000 to May 2013 were searched in PubMed, EMbase, WanFang Data, VIP and CNKI for observational studies on the association between myopia and OAG. According to the inclusion and exclusion criteria, the studies were screened, the data were extracted, and the method quality of included studies was assessed. Then meta-analysis was performed using Stata 12.0 software. Results Eleven cross-sectional studies including 45 996 participants were finally included. The results of meta-analysis showed that, myopia increased the risk of OAG. Besides, the results of subgroup analysis by the severity of myopia showed that, low-degree myopia (more than-3.00 D) increased 1.52 times the risk (OR=1.52, 95%CI 1.23 to 1.88) while middle/high-degree myopia (no more than-3.00 D) increased 2.41 times (OR=2.41, 95%CI 1.91 to 3.03). Conclusion Individuals with myopia have increased risk of OAG.

Citation： XIONGQi, ZENGXian-tao, CAIXiao-jun, LIZhi-liang, LIZhao-hui, LISheng. Association between Myopia and Open-angle Glaucoma: A Meta-Analysis. Chinese Journal of Evidence-Based Medicine, 2014, 14(5): 618-624. doi: 10.7507/1672-2531.20140102 Copy

1.	Cedrone C, Mancino R, Cerulli A, et al. Epidemiology of primary glaucoma:prevalence, incidence, and blinding effects. Prog Brain Res, 2008, 173:3-14.
2.	McMonnies CW. Intraocular pressure spikes in keratectasia, axial myopia, and glaucoma. Optom Vis Sci, 2008, 85(10):1018-1026.
3.	Blumen-Ohana E, Blumen MB, Bluwol E, et al. Primary open angle glaucoma and snoring:prevalence of OSAS. Eur Ann Otorhinolaryngol Head Neck Dis, 2010, 127(5):159-164.
4.	Hollands H, Johnson D, Hollands S, et al. Do findings on routine examination identify patients at risk for primary open-angle glaucoma? The rational clinical examination systematic review. JAMA, 2013, 309(19):2035-2042.
5.	Chang RT, Singh K. Myopia and glaucoma:diagnostic and therapeutic challenges. Curr Opin Ophthalmol, 2013, 24(2):96-101.
6.	Orzalesi N, Rossetti L, Omboni S. Vascular risk factors in glaucoma: the results of a national survey. Graefes Arch Clin Exp Ophthalmol, 2007, 245(6):795-802.
7.	Lee YA, Shih YF, Lin LL, et al. Association between high myopia and progression of visual field loss in primary open-angle glaucoma. Journal of the Formosan Medical Association, 2008, 107(12):952-957.
8.	Crombie I. Pocket Guide to Critical Appraisal. London:John Wiley & Sons, 1996:80-87.
9.	Weih LM, Nanjan M, McCarty CA, et al. Prevalence and predictors of open-angle glaucoma:results from the visual impairment project. Ophthalmology, 2001, 108(11):1966-1972.
10.	Wong TY, Klein BE, Klein R, et al. Refractive errors, intraocular pressure, and glaucoma in a white population. Ophthalmology, 2003, 110(1):211-217.
11.	Ramakrishnan R, Nirmalan PK, Krishnadas R, et al. Glaucoma in a rural population of southern India:the Aravind comprehensive eye survey. Ophthalmology, 2003, 110(8):1484-1490.
12.	李建军, 徐亮, 张蓉秀.原发性开角型青光眼与近视的关系.眼科, 2004, 13(3):168-171.
13.	Suzuki Y, Iwase A, Araie M, et al. Risk factors for open-angle glaucoma in a Japanese population:the Tajimi Study. Ophthalmology, 2006, 113(9):1613-1617.
14.	Xu L, Wang Y, Wang S, et al. High myopia and glaucoma susceptibility the Beijing Eye Study. Ophthalmology, 2007, 114(2):216-220.
15.	Casson RJ, Gupta A, Newland HS, et al. Risk factors for primary open-angle glaucoma in a Burmese population:the Meiktila Eye Study. Clin Experiment Ophthalmol, 2007, 35(8):739-744.
16.	Garudadri C, Senthil S, Khanna RC, et al. Prevalence and risk factors for primary glaucomas in adult urban and rural populations in the Andhra Pradesh Eye Disease Study. Ophthalmology, 2010, 117(7):1352-1359.
17.	Perera SA, Wong TY, Tay WT, et al. Refractive error, axial dimensions, and primary open-angle glaucoma:the Singapore Malay Eye Study. Arch Ophthalmol, 2010, 128(7):900-905.
18.	Kuzin AA, Varma R, Reddy HS, et al. Ocular biometry and openangle glaucoma:the Los Angeles Latino Eye Study. Ophthalmology, 2010, 117(9):1713-1719.
19.	Qiu M, Wang SY, Singh K, et al. Association between myopia and glaucoma in the United States population. Invest Ophthalmol Vis Sci, 2013, 54(1):830-835.
20.	陈耀龙, 李幼平, 杜亮.医学研究中证据分级和推荐强度的演进.中国循证医学杂志, 2008, 8(2):127-133.
21.	王艳, 孙兴怀.原发性开角型青光眼患者近视屈光状态的分析.眼视光学杂志. 2003, 5(2):92-94.
22.	Pan CW, Cheung CY, Aung T, et al. Differential associations of myopia with major age-related eye diseases:the Singapore Indian Eye Study. Ophthalmology, 2013, 120(2):284-291.
23.	王平.高度近视与原发性开角型青光眼.国外医学(眼科学分册), 2002, 26(1):23-26.
24.	赵燕燕, 张丰菊, 朱思泉.人眼巩膜组织中亮蛋白聚糖基因mRNA水平与高度近视及青光眼的相关性.中华医学杂志, 2012, 92(9): 608-611.
25.	Gentle A, Liu Y, Martin JE, et al. Collagen gene expression and the altered accumulation of scleral collagen during the development of high myopia. J Biol Chem, 2003, 278(19):16587-16594.
26.	Gao ZY, Huo LJ, Cui DM, et al. Distribution of bone morphogenetic protein receptors in human scleral fibroblasts cultured in vitro and human sclera. Int J Ophthalmol, 2012, 5(6):661-666.
27.	Guo MS, Wu YY, Liang ZB. Hyaluronic acid increases MMP-2 and MMP-9 expressions in cultured trabecular meshwork cells from patients with primary open-angle glaucoma. Mol Vis, 2012, 18:1175-1181.
28.	Wordinger RJ, Agarwal R, Talati M, et al. Expression of bone morphogenetic proteins (BMP), BMP receptors, and BMP associated proteins in human trabecular meshwork and optic nerve head cells and tissues. Mol Vis, 2002, 8:241-250.
29.	朱子诚.高度近视与原发性开角型青光眼关系的研究进展.实用防盲技术, 2009, 4(2):29-33.

1. Cedrone C, Mancino R, Cerulli A, et al. Epidemiology of primary glaucoma:prevalence, incidence, and blinding effects. Prog Brain Res, 2008, 173:3-14.
2. McMonnies CW. Intraocular pressure spikes in keratectasia, axial myopia, and glaucoma. Optom Vis Sci, 2008, 85(10):1018-1026.
3. Blumen-Ohana E, Blumen MB, Bluwol E, et al. Primary open angle glaucoma and snoring:prevalence of OSAS. Eur Ann Otorhinolaryngol Head Neck Dis, 2010, 127(5):159-164.
4. Hollands H, Johnson D, Hollands S, et al. Do findings on routine examination identify patients at risk for primary open-angle glaucoma? The rational clinical examination systematic review. JAMA, 2013, 309(19):2035-2042.
5. Chang RT, Singh K. Myopia and glaucoma:diagnostic and therapeutic challenges. Curr Opin Ophthalmol, 2013, 24(2):96-101.
6. Orzalesi N, Rossetti L, Omboni S. Vascular risk factors in glaucoma: the results of a national survey. Graefes Arch Clin Exp Ophthalmol, 2007, 245(6):795-802.
7. Lee YA, Shih YF, Lin LL, et al. Association between high myopia and progression of visual field loss in primary open-angle glaucoma. Journal of the Formosan Medical Association, 2008, 107(12):952-957.
8. Crombie I. Pocket Guide to Critical Appraisal. London:John Wiley & Sons, 1996:80-87.
9. Weih LM, Nanjan M, McCarty CA, et al. Prevalence and predictors of open-angle glaucoma:results from the visual impairment project. Ophthalmology, 2001, 108(11):1966-1972.
10. Wong TY, Klein BE, Klein R, et al. Refractive errors, intraocular pressure, and glaucoma in a white population. Ophthalmology, 2003, 110(1):211-217.
11. Ramakrishnan R, Nirmalan PK, Krishnadas R, et al. Glaucoma in a rural population of southern India:the Aravind comprehensive eye survey. Ophthalmology, 2003, 110(8):1484-1490.
12. 李建军, 徐亮, 张蓉秀.原发性开角型青光眼与近视的关系.眼科, 2004, 13(3):168-171.
13. Suzuki Y, Iwase A, Araie M, et al. Risk factors for open-angle glaucoma in a Japanese population:the Tajimi Study. Ophthalmology, 2006, 113(9):1613-1617.
14. Xu L, Wang Y, Wang S, et al. High myopia and glaucoma susceptibility the Beijing Eye Study. Ophthalmology, 2007, 114(2):216-220.
15. Casson RJ, Gupta A, Newland HS, et al. Risk factors for primary open-angle glaucoma in a Burmese population:the Meiktila Eye Study. Clin Experiment Ophthalmol, 2007, 35(8):739-744.
16. Garudadri C, Senthil S, Khanna RC, et al. Prevalence and risk factors for primary glaucomas in adult urban and rural populations in the Andhra Pradesh Eye Disease Study. Ophthalmology, 2010, 117(7):1352-1359.
17. Perera SA, Wong TY, Tay WT, et al. Refractive error, axial dimensions, and primary open-angle glaucoma:the Singapore Malay Eye Study. Arch Ophthalmol, 2010, 128(7):900-905.
18. Kuzin AA, Varma R, Reddy HS, et al. Ocular biometry and openangle glaucoma:the Los Angeles Latino Eye Study. Ophthalmology, 2010, 117(9):1713-1719.
19. Qiu M, Wang SY, Singh K, et al. Association between myopia and glaucoma in the United States population. Invest Ophthalmol Vis Sci, 2013, 54(1):830-835.
20. 陈耀龙, 李幼平, 杜亮.医学研究中证据分级和推荐强度的演进.中国循证医学杂志, 2008, 8(2):127-133.
21. 王艳, 孙兴怀.原发性开角型青光眼患者近视屈光状态的分析.眼视光学杂志. 2003, 5(2):92-94.
22. Pan CW, Cheung CY, Aung T, et al. Differential associations of myopia with major age-related eye diseases:the Singapore Indian Eye Study. Ophthalmology, 2013, 120(2):284-291.
23. 王平.高度近视与原发性开角型青光眼.国外医学(眼科学分册), 2002, 26(1):23-26.
24. 赵燕燕, 张丰菊, 朱思泉.人眼巩膜组织中亮蛋白聚糖基因mRNA水平与高度近视及青光眼的相关性.中华医学杂志, 2012, 92(9): 608-611.
25. Gentle A, Liu Y, Martin JE, et al. Collagen gene expression and the altered accumulation of scleral collagen during the development of high myopia. J Biol Chem, 2003, 278(19):16587-16594.
26. Gao ZY, Huo LJ, Cui DM, et al. Distribution of bone morphogenetic protein receptors in human scleral fibroblasts cultured in vitro and human sclera. Int J Ophthalmol, 2012, 5(6):661-666.
27. Guo MS, Wu YY, Liang ZB. Hyaluronic acid increases MMP-2 and MMP-9 expressions in cultured trabecular meshwork cells from patients with primary open-angle glaucoma. Mol Vis, 2012, 18:1175-1181.
28. Wordinger RJ, Agarwal R, Talati M, et al. Expression of bone morphogenetic proteins (BMP), BMP receptors, and BMP associated proteins in human trabecular meshwork and optic nerve head cells and tissues. Mol Vis, 2002, 8:241-250.
29. 朱子诚.高度近视与原发性开角型青光眼关系的研究进展.实用防盲技术, 2009, 4(2):29-33.

Chinese Journal of Evidence-Based Medicine

Association between Myopia and Open-angle Glaucoma: A Meta-Analysis

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