SYRCLE's Risk of Bias Tool for Animal Studies_Chinese Journal of Evidence-Based Medicine

Authors：

 CHENKuang-yang ^1,2 ^# ,  MABin ^1,2 ^# , WANGYa-nan ^1,2 , CHENChao-hu ^1,2 , ZHAOYa-qin ^1,2 , ZHENGJian-xun ^1,2 , HUANGCheng-ben ^1,2 , ZHANGLiu-sheng ^1,2 , SUXu ^1,2 , YANGJia-hui ^1,2 , WEIGuo-qiang ^1,2 , ZHENGDe-xiu ^1,2,3 , WANGXin-yu ^1,2 , ZHUQian-ge ^1,2 , WANGYa-ping ^1,2 , QINQian ^1,2

1. Evidence-based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China;
2. Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province, Lanzhou 730000, China;
3. School of Public Health, Lanzhou University, Lanzhou 730000, China;

Corresponding author：

MABin, Email: kitty_mab@163.com

Keywords：

Animal study; Risk of bias; Methodological quality; SYRCLE

DOI：

10.7507/1672-2531.20140206

Video：

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At present, there are many items/checklists used to assess the methodological quality of animal studies. Yet, no tool has been specifically designed for assessing internal validity of animal studies. This articles introduce and interprets SYRCLE's risk of bias tool for animal studies in detail for Chinese scholars to accurately assess the methodological quality of animal studies when they develop systematic reviews on animal studies, so as to provide references for scientific design and implementation of animal studies.

Citation： CHENKuang-yang, MABin, WANGYa-nan, CHENChao-hu, ZHAOYa-qin, ZHENGJian-xun, HUANGCheng-ben, ZHANGLiu-sheng, SUXu, YANGJia-hui, WEIGuo-qiang, ZHENGDe-xiu, WANGXin-yu, ZHUQian-ge, WANGYa-ping, QINQian. SYRCLE's Risk of Bias Tool for Animal Studies. Chinese Journal of Evidence-Based Medicine, 2014, 14(10): 1281-1285. doi: 10.7507/1672-2531.20140206 Copy

1.	Bebarta V, Luyten D, Heard K. Emergency medicine animal research:does use of randomization and blinding affect the results? Acad Emerg Med, 2003, 10(12):1410.
2.	Roberts I, Kwan I, Evans P, et al. Does animal experimentation inform human healthcare? Observations from a systematic review of international animal experiments on fluid resuscitation. BMJ, 2002, 324(7335):474-476.
3.	Perel P, Roberts I, Sena E, et al. Comparison of treatment effects between animal experiments and clinical trials:systematic review. BMJ, 2007, 334 (7586):197.
4.	Macleod MR, Fisher M, O'Collins V, et al. Good laboratory practice:preventing introduction of bias at the bench. Stroke, 2009, 40(3):e50-52.
5.	Schulz KF, Chalmers I, Hayes RJ, et al. Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. JAMA, 1995, 273(5):408-412.
6.	Hooijmans CR, Pasker-de Jong PC, de Vries RB, et al. The effects of long-term omega-3 fatty acid supplementation on cognition and Alzheimer's pathology in animal models of Alzheimer's disease:a systematic review and meta-analysis. J Alzheimers Dis, 2012, 28(1):191-209.
7.	Krauth D, Woodruff TJ, Bero L. Instruments for assessing risk of bias and other methodological criteria of published animal studies:a systematic review. Environ Health Perspect, 2013, 121(9):985-992.
8.	Sena E, van der Worp HB, Howells D, et al. How can we improve the preclinical development of drugs for stroke? Trends Neurosci, 2007, 3D(9):433-439.
9.	Wever KE, Menting TP, Rovers M, et al. Ischemic preconditioning in the animal kidney, a systematic review and meta-analysis. PLoS One, 2012, 7(2):e32296.
10.	Thayer K, Rooney A, Boyles A, et al. Draft protocol for systematic review to evaluate the evidence for an association between bisphenol A (BPA) exposure and obesity. In National Toxicology Program. U.S. Department of Health and Human Services, 2013.
11.	Hooijmans CR1, Ritskes-Hoitinga M. Progress in using systematic reviews of animal studies to improve translational research. PLoS Med, 2013, 10(7):e1001482.
12.	Hooijmans CR, Rovers MM, de Vries RB, et al. SYRCLE's risk of bias tool for animal studies. BMC Med Res Methodol, 2014, 14:43.
13.	Beynen ACGK, van Zutphen LFM. Standardization of the animal and its environment. In principles of laboratory animal science. Revised Edition. Edited by van Zutphen LFMB V, Beynen AC. Amsterdam and New York:Elsevier BV, 2001.
14.	Johnston NA, Nevalainen T. Impact of biotic and abiotic environment on animal experiments. In Handbook of Laboratory Animal Science (Book 1). 3^rd edition. Edited by Hau JS. Raton B. Florida:CRC Press, 2010:343-369.
15.	Donnelly H, Saibaba P. Light intensity and the oestrous cycle in albino and normally pigmented mice. Lab Anim, 1993, 27(4):385-390.
16.	Vanderschuren LJMJ, Niesink RJ, Spruijt BM, et al. Influence of environmental factors on social play behavior of juvenile rats. Physiol Behav, 1995, 58(1):119-123.
17.	Clough G. Environmental-effects on animals used in biomedicalresearch, 1982, 57(Pt 3):487-523.
18.	Harri MNE. Effect of body-temperature on cardiotoxicity of isoprenaline in rats. Acta Pharmacol Toxicol (Copenh), 1976, 39(2):214-224.
19.	Clough G. Environmental factors in relation to the comfort and well-being of laboratory rats and mice. In:Standards in Laboratory Animal Management, Volume 1. Wheathampstead:Universities Federation for Animal Welfare (UFAW), 1984:7-24.
20.	Bruguerolle B. Circadian changes in pharmacokinetics. Therapie, 1983, 38(3):223-235.
21.	Bruguerolle B, Valli M, Bouyard L, et al. Effect of the hour of administration on the pharmacokinetics of lidocaine in the rat. Eur J Drug Metab Pharmacokinet, 1983, 8(3):233-238.
22.	Marrino P, Gavish D, Shafrir E, et al. Diurnal variations of plasma lipids, tissue and plasma lipoprotein lipase, and VLDL secretion rates in the rat. A model for studies of VLDL metabolism. Biochim Biophys Acta, 1987, 920(3):277-284.
23.	Claassen V. Circadian and other rhytms. In:Neglected Factors in Pharmacology and Neuroscience Research Volume 12. Edited by Huston JP. Amsterdam and New York:Elsevier Science BV. 1994:243-381.
24.	Perel P, Roberts I, Sena E, et al. Comparison of treatment effects between animal experiments and clinical trials:systematic review. BMJ, 2007, 334(7586):197.

1. Bebarta V, Luyten D, Heard K. Emergency medicine animal research:does use of randomization and blinding affect the results? Acad Emerg Med, 2003, 10(12):1410.
2. Roberts I, Kwan I, Evans P, et al. Does animal experimentation inform human healthcare? Observations from a systematic review of international animal experiments on fluid resuscitation. BMJ, 2002, 324(7335):474-476.
3. Perel P, Roberts I, Sena E, et al. Comparison of treatment effects between animal experiments and clinical trials:systematic review. BMJ, 2007, 334 (7586):197.
4. Macleod MR, Fisher M, O'Collins V, et al. Good laboratory practice:preventing introduction of bias at the bench. Stroke, 2009, 40(3):e50-52.
5. Schulz KF, Chalmers I, Hayes RJ, et al. Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. JAMA, 1995, 273(5):408-412.
6. Hooijmans CR, Pasker-de Jong PC, de Vries RB, et al. The effects of long-term omega-3 fatty acid supplementation on cognition and Alzheimer's pathology in animal models of Alzheimer's disease:a systematic review and meta-analysis. J Alzheimers Dis, 2012, 28(1):191-209.
7. Krauth D, Woodruff TJ, Bero L. Instruments for assessing risk of bias and other methodological criteria of published animal studies:a systematic review. Environ Health Perspect, 2013, 121(9):985-992.
8. Sena E, van der Worp HB, Howells D, et al. How can we improve the preclinical development of drugs for stroke? Trends Neurosci, 2007, 3D(9):433-439.
9. Wever KE, Menting TP, Rovers M, et al. Ischemic preconditioning in the animal kidney, a systematic review and meta-analysis. PLoS One, 2012, 7(2):e32296.
10. Thayer K, Rooney A, Boyles A, et al. Draft protocol for systematic review to evaluate the evidence for an association between bisphenol A (BPA) exposure and obesity. In National Toxicology Program. U.S. Department of Health and Human Services, 2013.
11. Hooijmans CR1, Ritskes-Hoitinga M. Progress in using systematic reviews of animal studies to improve translational research. PLoS Med, 2013, 10(7):e1001482.
12. Hooijmans CR, Rovers MM, de Vries RB, et al. SYRCLE's risk of bias tool for animal studies. BMC Med Res Methodol, 2014, 14:43.
13. Beynen ACGK, van Zutphen LFM. Standardization of the animal and its environment. In principles of laboratory animal science. Revised Edition. Edited by van Zutphen LFMB V, Beynen AC. Amsterdam and New York:Elsevier BV, 2001.
14. Johnston NA, Nevalainen T. Impact of biotic and abiotic environment on animal experiments. In Handbook of Laboratory Animal Science (Book 1). 3^rd edition. Edited by Hau JS. Raton B. Florida:CRC Press, 2010:343-369.
15. Donnelly H, Saibaba P. Light intensity and the oestrous cycle in albino and normally pigmented mice. Lab Anim, 1993, 27(4):385-390.
16. Vanderschuren LJMJ, Niesink RJ, Spruijt BM, et al. Influence of environmental factors on social play behavior of juvenile rats. Physiol Behav, 1995, 58(1):119-123.
17. Clough G. Environmental-effects on animals used in biomedicalresearch, 1982, 57(Pt 3):487-523.
18. Harri MNE. Effect of body-temperature on cardiotoxicity of isoprenaline in rats. Acta Pharmacol Toxicol (Copenh), 1976, 39(2):214-224.
19. Clough G. Environmental factors in relation to the comfort and well-being of laboratory rats and mice. In:Standards in Laboratory Animal Management, Volume 1. Wheathampstead:Universities Federation for Animal Welfare (UFAW), 1984:7-24.
20. Bruguerolle B. Circadian changes in pharmacokinetics. Therapie, 1983, 38(3):223-235.
21. Bruguerolle B, Valli M, Bouyard L, et al. Effect of the hour of administration on the pharmacokinetics of lidocaine in the rat. Eur J Drug Metab Pharmacokinet, 1983, 8(3):233-238.
22. Marrino P, Gavish D, Shafrir E, et al. Diurnal variations of plasma lipids, tissue and plasma lipoprotein lipase, and VLDL secretion rates in the rat. A model for studies of VLDL metabolism. Biochim Biophys Acta, 1987, 920(3):277-284.
23. Claassen V. Circadian and other rhytms. In:Neglected Factors in Pharmacology and Neuroscience Research Volume 12. Edited by Huston JP. Amsterdam and New York:Elsevier Science BV. 1994:243-381.
24. Perel P, Roberts I, Sena E, et al. Comparison of treatment effects between animal experiments and clinical trials:systematic review. BMJ, 2007, 334(7586):197.

Chinese Journal of Evidence-Based Medicine

SYRCLE's Risk of Bias Tool for Animal Studies

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