Analyzing the Systematic Review/Meta-analysis of Animal Studies Published in Chinese Journals_Chinese Journal of Evidence-Based Medicine

Authors：

CHENKuang-yang ^1,2,3 ^# , WANGYa-nan ^1,2,4 ^# , ZHAOYa-qin ^1,2,3 , CHENChao-hu ^1,2,4 , XUJia-ke ^1,2 , HUfang ^1,2 , QULi-na ^1,2 , YANGJing-jing ^1,2 , BAIXi ^1,2 , MATing ^1,2,3 , ZHANGYi-heng ^1,2 ,  MABin ^1,2

1. Evidence Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China;
2. Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province, Lanzhou 730000, China;
3. The First Clinical Medical College of Lanzhou University, Lanzhou 73000, China;
4. The Second Clinical Medical College of Lanzhou University, Lanzhou 73000, China;

Corresponding author：

MABin, Email: mab@lzu.edu.cn

Keywords：

Animal study; Systematic review; Meta-analysis; Current situation analysis

DOI：

10.7507/1672-2531.20150070

Video：

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Objective To survey the important characteristics, such as the number of time cited, methodological and reporting quality of the systematic review/meta-analysis (SR/MA) of animal studies published in Chinese journals. Methods The CNKI and WanFang Data databases were searched for SR/MA of animal studies published in Chinese journals from inception to March 2014. Two reviewers independently screened literature according to the inclusion and exclusion criteria, extracted basic characteristic and methodology characteristics of included studies. And then a descriptive analysis was conducted. Results A total of 18 studies published in 13 different journals were included. 77.8% studies were not been cited, 44.4% did not report the types of including studies. Besides, there were some certain weaknesses in the methodological quality, for example, over 60% studies did not assess the qualities and publication bias of the including studies, 22.2% SRs/MAs only searched Chinese databases, over 80% studies did not provide flow chart etc. Conclusion The number of SRs/MAs of animal studies published in Chinese journals is small and the number of times cited is low, and the methodological and reporting quality is poor. So, focusing on improving the quality of SRs/MAs is urgently needed in order to increase the value of these studies.

Citation： CHENKuang-yang, WANGYa-nan, ZHAOYa-qin, CHENChao-hu, XUJia-ke, HUfang, QULi-na, YANGJing-jing, BAIXi, MATing, ZHANGYi-heng, MABin. Analyzing the Systematic Review/Meta-analysis of Animal Studies Published in Chinese Journals. Chinese Journal of Evidence-Based Medicine, 2015, 15(4): 414-418. doi: 10.7507/1672-2531.20150070 Copy

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2.	Chalmers I, Altman DG. Systematic Reviews. London:BMJ Publications, 1995.
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4.	Mignini LE, Khan KS. Methodological Quality of Systematic Reviews of Animal Studies:A Survey of Reviews of Basic Research. BMC Med Res Methodol, 2006, 6:10.
5.	刘鹏, 于钧, 杜琳琳, 等. RevMan软件用于碘酸钾、碘化钾对小鼠血液抗氧化能力影响的Meta分析. 中国地方病防治杂志, 2008, 23(5):328-330.
6.	Jadad AR, Moore RA, Carroll D, et al. Assessing the quality of reports of randomized clinical trials:is blinding necessary? Control Clin Trials, 1996, 17(1):1-12.
7.	Macleod MR, O`Collins T, Howells DW, et al. Pooling of animal experimental data reveals influence of study design and publication bias. Stroke, 2004, 35(5):1203-1208.
8.	吴倩妮, 田宏亮, 张丽菡, 等. 丹参对大鼠肝再生过程影响的Meta分析. 中国中药杂志, 2012, 37(17):2630-2634.
9.	Jonas S, Ayigari V, Viera D, et al. Neuroprotection against cerebral ischemia. A review of animal studies and correlation with human trial results. Ann N Y Acad Sci, 1999, 890:2-3.
10.	Macleod MR, Oacleod MT, Howells DW, et al. Pooling of Animal Experimental Data Reveals Influence of Study Design and Publication Bias. Stroke, 2004, 35(5):1203-1208.
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16.	Hooijmans CR, Pasker-de Jong PC, de Vries RB, et al. The effects of long-term omega-3 fatty acid supplementation on cognition and Alzheimer's pathology in animal models of Alzheimer's disease:a systematic review and mate-analysis. J Alzheimers Dis, 2012, 28(1):191-209.
17.	Krauth D, Woodruff TJ, Bero L. Instruments for assessing risk of bias and other methodological criteria of published animal studies:a systematic review. Environ Health Perspect, 2013, 121(9):985-992.
18.	Sena E, van der Worp HB, Howells D, et al. How can we improve the preclinical development of drugs for stroke? Trends Neurosci, 2007, 30(9):433-439.
19.	Wever KE, Menting TP, Rovers M, et al. Ischemic preconditioning in the animal kidney, a systematic review and meta-analysis. PLoS One, 2012, 7(2):e32296.
20.	Thayer K, Rooney A, Boyles A, et al. Draft protocol for systematic review to evaluate the evidence for an association between bisphenol A (BPA) exposure and obesity. In National Toxicology Program. U. S. Department of health and human services, 2013.
21.	Hooijmans CR, Rovers MM, de Vries RB, et al. SYRCLE's risk of bias tool for animal studies. BMC medical research methodology, 2014, 14:43.
22.	田慧敏, 李云. GBP影响Ⅱ型糖尿病大鼠空腹血糖及胰岛素的Meta分析. 西南国防医药, 2011, 21(7):715-718.
23.	周玉坤, 彭鸿灵. 人工韧带表面修饰重建前交叉韧带的系统评价. 中国组织工程研究与临床康复, 2010, 14(21):3965-3968.
24.	吴文桥, 单娟, 李幼平, 等. 不同途径过继回输致耐受树突状细胞延长小鼠移植心脏存活研究的系统评价. 中国循证医学杂志, 2012, 12(12):1432-1445.
25.	田甜, 郭兴青, 倪宏. 非药物手段对发育期惊厥性脑损伤动物干预的Meta分析. 中华实用儿科临床杂志, 2013, 28(1):36-41.
26.	袁小龙, 李婷, 王勤. 基于现有抗肿瘤类中药艾迪的动物试验有效性评价. 中国实验方剂学杂志, 2013, 19(10):349-354.
27.	齐广伟, 郑佳, 赵瑞波. 酒精干预对大(小)鼠缺血性卒中结局影响的系统评价. 中国循证医学杂志, 2013, 13(2):204-209.
28.	瞿浩, 李玫, 袁萍, 等. 可降解脑血管支架材料生物相容性的系统评价. 中国组织工程研究与临床康复, 2011, 15(42):7881-7884.
29.	焦建栋. 铅对雄性大鼠睾丸重量影响的Meta回归分析. 现代预防医学, 2009, 36(17):3225-3228.
30.	孙纳. 铅生殖毒性剂量-反应关系评定的Meta回归分析. 中国工业医学杂志, 2010, 23(6):418-420.
31.	周玉坤, 彭鸿灵. 不同材料重建前交叉韧带腱骨愈合的系统评价. 中国组织工程研究与临床康复, 2010, 14(25):4737-4740.
32.	黄成国, 袁萍, 董卫涛. 生物可降解心血管支架与人体相容性的系统评价. 中国组织工程研究与临床康复, 2011, 15(42):7955-7959.
33.	卢鑫, 孙文逵, 高伟, 等. 雾化吸入两性霉素B对侵袭性肺曲霉病预防效果的Meta分析. 中国呼吸与危重监护杂志, 2012, 11(1):28-36.
34.	吴伟, 朱章志, 江丹, 等. 小檗碱保护糖尿病大鼠肾脏的系统评价. 中华中医药杂志, 2013, 5:1622-1626.
35.	马昌科, 沈忆新. 嗅鞘细胞移植修复大鼠及人类脊髓损伤的Meta分析. 中国脊柱脊髓杂志, 2013, 23(10):905-911.
36.	文怡川, 邵瑛, 赖新生. 针刺痴呆模型大鼠随机对照实验的Meta分析. 中国中医基础医学杂志, 2009, 6:463-465.
37.	陈炜, 何丽娜, 李昂, 等. 嗅鞘细胞移植对大鼠脊髓损伤运动功能恢复影响的系统评价. 中国循证医学杂志, 2010, 10(10):1194-1198.

1. Kilkenny C, Parsons N, Kadyszewski E, et al. Survey of the Quality of Experimental Design, Statistical Analysis and Reporting of Research Using Animals. PLoS ONE, 2009, 4(11):e7824.
2. Chalmers I, Altman DG. Systematic Reviews. London:BMJ Publications, 1995.
3. Perna A, Remuzzi G. Abnormal permeability to proteins and glomerular lesions:a meta-analysis of experimental and human studies. Am J Kidney Dis, 1996, 27(1):34-41.
4. Mignini LE, Khan KS. Methodological Quality of Systematic Reviews of Animal Studies:A Survey of Reviews of Basic Research. BMC Med Res Methodol, 2006, 6:10.
5. 刘鹏, 于钧, 杜琳琳, 等. RevMan软件用于碘酸钾、碘化钾对小鼠血液抗氧化能力影响的Meta分析. 中国地方病防治杂志, 2008, 23(5):328-330.
6. Jadad AR, Moore RA, Carroll D, et al. Assessing the quality of reports of randomized clinical trials:is blinding necessary? Control Clin Trials, 1996, 17(1):1-12.
7. Macleod MR, O`Collins T, Howells DW, et al. Pooling of animal experimental data reveals influence of study design and publication bias. Stroke, 2004, 35(5):1203-1208.
8. 吴倩妮, 田宏亮, 张丽菡, 等. 丹参对大鼠肝再生过程影响的Meta分析. 中国中药杂志, 2012, 37(17):2630-2634.
9. Jonas S, Ayigari V, Viera D, et al. Neuroprotection against cerebral ischemia. A review of animal studies and correlation with human trial results. Ann N Y Acad Sci, 1999, 890:2-3.
10. Macleod MR, Oacleod MT, Howells DW, et al. Pooling of Animal Experimental Data Reveals Influence of Study Design and Publication Bias. Stroke, 2004, 35(5):1203-1208.
11. Ma B, Guo J, Qi G, et al. Epidemiology, Quality and Reporting Characteristics of Systematic Reviews of Traditional Chinese Medicine Interventions Published in Chinese Journals. PLoS ONE, 2011, 6(5):e20185.
12. Cochrane Handbook for Systematic Reviews of Interventions.Version5.1.0ed. Chichester. United Kingdom:John Wiley & Sons Ltd; 2011.
13. Hopewell S, Clarke M, Lefebvre C, et al. Handsearching versus electronic searching to identify reports of randomized trials. Cochrane Database Syst Rev, 2007, (2):MR000001.
14. Egger M, Juni P, Bartlett C, et al. How important are comprehensive literature searches and the assessment of trail quality in systematic reviews?. Health Technol Assess, 2003, 7(1):1-76.
15. Peters JL, Sutton AJ, Jones DR, et al. A systematic review of systematic reviews and meta-analyses of animal experiments with guidelines for reporting. J Environ Sci Health B, 2006, 41(7):1245-1258.
16. Hooijmans CR, Pasker-de Jong PC, de Vries RB, et al. The effects of long-term omega-3 fatty acid supplementation on cognition and Alzheimer's pathology in animal models of Alzheimer's disease:a systematic review and mate-analysis. J Alzheimers Dis, 2012, 28(1):191-209.
17. Krauth D, Woodruff TJ, Bero L. Instruments for assessing risk of bias and other methodological criteria of published animal studies:a systematic review. Environ Health Perspect, 2013, 121(9):985-992.
18. Sena E, van der Worp HB, Howells D, et al. How can we improve the preclinical development of drugs for stroke? Trends Neurosci, 2007, 30(9):433-439.
19. Wever KE, Menting TP, Rovers M, et al. Ischemic preconditioning in the animal kidney, a systematic review and meta-analysis. PLoS One, 2012, 7(2):e32296.
20. Thayer K, Rooney A, Boyles A, et al. Draft protocol for systematic review to evaluate the evidence for an association between bisphenol A (BPA) exposure and obesity. In National Toxicology Program. U. S. Department of health and human services, 2013.
21. Hooijmans CR, Rovers MM, de Vries RB, et al. SYRCLE's risk of bias tool for animal studies. BMC medical research methodology, 2014, 14:43.
22. 田慧敏, 李云. GBP影响Ⅱ型糖尿病大鼠空腹血糖及胰岛素的Meta分析. 西南国防医药, 2011, 21(7):715-718.
23. 周玉坤, 彭鸿灵. 人工韧带表面修饰重建前交叉韧带的系统评价. 中国组织工程研究与临床康复, 2010, 14(21):3965-3968.
24. 吴文桥, 单娟, 李幼平, 等. 不同途径过继回输致耐受树突状细胞延长小鼠移植心脏存活研究的系统评价. 中国循证医学杂志, 2012, 12(12):1432-1445.
25. 田甜, 郭兴青, 倪宏. 非药物手段对发育期惊厥性脑损伤动物干预的Meta分析. 中华实用儿科临床杂志, 2013, 28(1):36-41.
26. 袁小龙, 李婷, 王勤. 基于现有抗肿瘤类中药艾迪的动物试验有效性评价. 中国实验方剂学杂志, 2013, 19(10):349-354.
27. 齐广伟, 郑佳, 赵瑞波. 酒精干预对大(小)鼠缺血性卒中结局影响的系统评价. 中国循证医学杂志, 2013, 13(2):204-209.
28. 瞿浩, 李玫, 袁萍, 等. 可降解脑血管支架材料生物相容性的系统评价. 中国组织工程研究与临床康复, 2011, 15(42):7881-7884.
29. 焦建栋. 铅对雄性大鼠睾丸重量影响的Meta回归分析. 现代预防医学, 2009, 36(17):3225-3228.
30. 孙纳. 铅生殖毒性剂量-反应关系评定的Meta回归分析. 中国工业医学杂志, 2010, 23(6):418-420.
31. 周玉坤, 彭鸿灵. 不同材料重建前交叉韧带腱骨愈合的系统评价. 中国组织工程研究与临床康复, 2010, 14(25):4737-4740.
32. 黄成国, 袁萍, 董卫涛. 生物可降解心血管支架与人体相容性的系统评价. 中国组织工程研究与临床康复, 2011, 15(42):7955-7959.
33. 卢鑫, 孙文逵, 高伟, 等. 雾化吸入两性霉素B对侵袭性肺曲霉病预防效果的Meta分析. 中国呼吸与危重监护杂志, 2012, 11(1):28-36.
34. 吴伟, 朱章志, 江丹, 等. 小檗碱保护糖尿病大鼠肾脏的系统评价. 中华中医药杂志, 2013, 5:1622-1626.
35. 马昌科, 沈忆新. 嗅鞘细胞移植修复大鼠及人类脊髓损伤的Meta分析. 中国脊柱脊髓杂志, 2013, 23(10):905-911.
36. 文怡川, 邵瑛, 赖新生. 针刺痴呆模型大鼠随机对照实验的Meta分析. 中国中医基础医学杂志, 2009, 6:463-465.
37. 陈炜, 何丽娜, 李昂, 等. 嗅鞘细胞移植对大鼠脊髓损伤运动功能恢复影响的系统评价. 中国循证医学杂志, 2010, 10(10):1194-1198.

Chinese Journal of Evidence-Based Medicine

Analyzing the Systematic Review/Meta-analysis of Animal Studies Published in Chinese Journals

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