A Runa 1,2,3 , LUO Yunyao 1,2,3 , LI Sicong 1,2,3 , XU Liangzhi 1,2,3
  • 1. Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu, 610041, P.R.China;
  • 2. Reproductive Endocrinology and Regulation Laboratory, West China Second University Hospital, Sichuan University, Chengdu, 610041, P.R.China;
  • 3. Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Chengdu, 610041, P.R.China;
XU Liangzhi, Email: liangzxu@126.com
Premature ovarian insufficiency; Premature ovarian failure; Kuntai; Meta-analysis; Systematic review; Randomized controlled trial
10.7507/1672-2531.201812072
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Objectives To systematically review the efficacy and safety of traditional Chinese herbal medicine Kuntai in the treatment of premature ovarian insufficiency (POI).Methods PubMed, EMbase, The Cochrane Library, CBM, CNKI, WanFang Data and VIP databases were electronically searched to collect randomized controlled trials (RCTs) on Kuntai for treating premature ovarian insufficiency from inception to August, 2018. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies, then, meta-analysis was performed by using RevMan 5.3 software.Results Twenty-one RCTs involving 1 777 patients were included, which were categorized as Kuntai vs. western medicine and Kuntai combined with western medicine vs. western medicine. The results of meta-analysis showed that: the efficacy of Kuntai was equivalent to western medicine; effective rate (RR=2.78, 95%CI 1.73 to 4.45, P<0.000 01), the change of Kupperman’s score (MD=−3.25, 95%CI −3.75 to −2.76, P<0.000 01), the change of serum FSH (MD=−6.99, 95%CI −8.07 to −5.90, P<0.000 01), E2 (MD=7.01, 95%CI 3.01 to 11.01, P=0.000 6) and LH (MD=−4.66, 95%CI −6.45 to −2.86, P<0.000 01) in Kuntai combined with hormone replacement therapy (HRT) group were higher than that in the HRT group.Conclusions Kuntai combined with HRT is superior to HRT alone in the effective rate, the change of Kupperman’s score, the change of serum FSH, E2 and LH for patients with premature ovarian insufficiency. Due to limited quality and quantity of the included studies, more high-quality studies are required to verify above conclusion.

Citation： A Runa, LUO Yunyao, LI Sicong, XU Liangzhi. The efficacy and safety of traditional Chinese herbal medicine Kuntai in treatment of premature ovarian insufficiency: a meta-analysis. Chinese Journal of Evidence-Based Medicine, 2019, 19(8): 953-959. doi: 10.7507/1672-2531.201812072 Copy

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