Clinical features of in-patients with first seizure in Ganzi Tibetan Autonomous Prefecture: a retrospective analysis_Journal of Epilepsy

Authors：

HE Yongqiao ¹ , CHEN Jiani ² , LI Sisi ² , DENG Yongyi ¹ , CHEN Jie ¹ , FANG Wenyu ¹ , ZEREN Zhamu ¹ , MU Jie ² ,  ZHOU Dong ²

1. Department of Neurology, Ganzi Tibetan Autonomous Prefecture People’s Hospital, Ganzi Tibetan Autonomous Prefecture, 626000, China;
2. Department of Neurology, West China Hospital of Sichuan University, Chengdu, 610041, China;

Corresponding author：

ZHOU Dong, Email: zhoudong66@yahoo.de

Keywords：

Epilepsy management; Cerebral infection; Retrospective study; Ganzi Tibetan area

DOI：

10.7507/2096-0247.20180037

Video：

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Objective This study aimed to provide data about the clinical features of first seizure in the Ganzi Tibetan Autonomous Prefecture to improve the strategies for epilepsy prevention and control in this region. Methods We reviewed the clinical record of patients with first seizure in Neurology Department, Ganzi Tibetan Autonomous Prefecture People’s Hospital between January 2015 and October 2017 and summarised their clinical features. Results One hundred and one patients were included in this study with the average age of (43.0±18.4) years. Twenty-nine cases were diagnosed as statusepilepticus, 5 (17.2%) of whom died in 30 days. Among the 45 patients diagnosed with acute symptomatic seizure, 22 cases (48.9%) were caused by cerebral infection, including neurocysticercosis (n=4, 8.9%), tuberculous infection (n=8, 17.7%) and viral infection (n=7, 15.6%). Other causes of acute symptomatic seizure included cerebrovascular diseases (n=13, 28.8%), high altitude (n=3, 6.7%) and alcohol related or alcohol withdrawl (n=3, 6.7%). Conclutions These data suggest that the control of cerebral infections is essential for the prevention and treatment of seizures in the Ganzi Tibetan Autonomous Prefecture. Education of local primary doctors about status epilepticus will enable better management of seizures in this population.

Citation： HE Yongqiao, CHEN Jiani, LI Sisi, DENG Yongyi, CHEN Jie, FANG Wenyu, ZEREN Zhamu, MU Jie, ZHOU Dong. Clinical features of in-patients with first seizure in Ganzi Tibetan Autonomous Prefecture: a retrospective analysis. Journal of Epilepsy, 2018, 4(3): 214-219. doi: 10.7507/2096-0247.20180037 Copy

1.	Zhao Y, Zhang Q, Tsering T, et al. Prevalence of convulsive epilepsy and health-related quality of life of the population with convulsive epilepsy in rural areas of Tibet Autonomous Region in China: An initial survey. Epilepsy Behav, 2008, 12(3): 373-381.
2.	Zhao YH, Zhang Q, Long N, et al. Prevalence of epilepsy and alcohol-related risk in Zayul County, Tibet Autonomous Region in China: An initial survey. Epilepsy Behav, 2010, 19(4): 635-638.
3.	Goverment GTAP. Brief introduction of Ganzi. GzzGovCn/10000/10011/10012/10015/2015/07/29/10481707Shtml n.d. http://gzz.gov.cn/10000/10001/10002/10437244.shtml (accessed December 6, 2017).
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5.	Fisher RS, Boas WVE, Blume W, et al. Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE). Epilepsia, 2005, 46(4): 470-472.
6.	Beghi E, Carpio A, Forsgren L, et al. Recommendation for a definition of acute symptomatic seizure. Epilepsia, 2010, 51(4): 671-675.
7.	Hauser WA, Annegers JF, Rocca WA. Descriptive epidemiology of epilepsy: contributions of population-based studies from rochester, minnesota. Mayo ClinProc, 1996, 71(6): 576-586.
8.	Trinka E, Cock H, Hesdorffer D, et al. A definition and classification of status epilepticus - Report of the ILAE Task Force on Classification of Status Epilepticus. Epilepsia, 2015, 56(10): 1515-1523.
9.	Commission on Classification and Terminology of the International League Against Epilepsy. Proposal for revised clinical and electroencephalographic classification of epileptic seizures. From the Commission on Classification and Terminology of the International League Against Epilepsy. Epilepsia, 1981, 22(4): 489-501.
10.	Commission on Classification and Terminology of the International League Against Epilepsy. Proposal for revised classification of epilepsies and epileptic syndromes. Commission on Classification and Terminology of the International League Against Epilepsy. Epilepsia, 1989, 30(4): 389-399.
11.	Hauser WA, Annegers JF, Kurland LT. Prevalence of Epilepsy in Rochester, Minnesota: 1940-1980. Epilepsia, 1991, 32(4): 429-445.
12.	Gao L, Xia L, Pan SQ, et al. Burden of epilepsy: A prevalence-based cost of illness study of direct, indirect and intangible costs for epilepsy. Epilepsy Res, 2015, 110: 146-156.
13.	Annegers JF, Hauser WA, Lee JRJ, et al. Incidence of acute symptomatic seizures in rochester, minnesota, 1935-1984. Epilepsia, 1995, 36(4): 327-333.
14.	Wang WZ, Wu JZ, Ma GY, et al. Efficacy assessment of phenobarbital in epilepsy: a large community-based intervention trial in rural China. Lancet Neurol, 2006, 5(1): 46-52.
15.	Ding D, Hong Z, Wang WZ, et al. Assessing the disease burden due to epilepsy by disability adjusted life year in rural China. Epilepsia 2006, 47(12): 2032-2037.
16.	Logroscino G, Hesdorffer DC, Cascino G, et al. Short‐term mortality after a first episode of status epilepticus. Epilepsia, 1997, 38(12): 1344-1349.
17.	Logroscino G, Hesdorffer DC, Cascino G, et al. Mortality after a first episode of status epilepticus in the United States and Europe. Epilepsia, 2005, 46(Suppl 11): 46-48.
18.	Nwani PO, Nwosu MC, Nwosu MN. Epidemiology of acute symptomatic seizures among adult medical admissions. Epilepsy Res Treat, 2016, 2016: 1-5.
19.	Li T, Craig PS, Ito A, et al. Taeniasis/cysticercosis in a Tibetan population in Sichuan Province, China. Acta Trop, 2006, 100(3): 223-231.
20.	Li TY, Qiu JM, Yang W, et al. Echinococcosis in Tibetan populations, western Sichuan Province, China. Emerg Infect Dis, 2005, 11(12): 1866-1873.
21.	Baumgartner RW, Siegel AM, Hackett PH. Going high with preexisting neurological conditions. High Alt Med Biol, 2007, 8(2): 108-116.
22.	Daleau P, Morgado DC, Iriarte CA, et al. New epilepsy seizure at high altitude without signs of acute mountain sickness or high altitude cerebral edema. High Alt Med Biol, 2006, 7(1): 81-83.

1. Zhao Y, Zhang Q, Tsering T, et al. Prevalence of convulsive epilepsy and health-related quality of life of the population with convulsive epilepsy in rural areas of Tibet Autonomous Region in China: An initial survey. Epilepsy Behav, 2008, 12(3): 373-381.
2. Zhao YH, Zhang Q, Long N, et al. Prevalence of epilepsy and alcohol-related risk in Zayul County, Tibet Autonomous Region in China: An initial survey. Epilepsy Behav, 2010, 19(4): 635-638.
3. Goverment GTAP. Brief introduction of Ganzi. GzzGovCn/10000/10011/10012/10015/2015/07/29/10481707Shtml n.d. http://gzz.gov.cn/10000/10001/10002/10437244.shtml (accessed December 6, 2017).
4. Fisher RS, Acevedo C, Arzimanoglou A, et al. ILAE Official Report: A practical clinical definition of epilepsy. Epilepsia, 2014, 55(4): 475-482.
5. Fisher RS, Boas WVE, Blume W, et al. Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE). Epilepsia, 2005, 46(4): 470-472.
6. Beghi E, Carpio A, Forsgren L, et al. Recommendation for a definition of acute symptomatic seizure. Epilepsia, 2010, 51(4): 671-675.
7. Hauser WA, Annegers JF, Rocca WA. Descriptive epidemiology of epilepsy: contributions of population-based studies from rochester, minnesota. Mayo ClinProc, 1996, 71(6): 576-586.
8. Trinka E, Cock H, Hesdorffer D, et al. A definition and classification of status epilepticus - Report of the ILAE Task Force on Classification of Status Epilepticus. Epilepsia, 2015, 56(10): 1515-1523.
9. Commission on Classification and Terminology of the International League Against Epilepsy. Proposal for revised clinical and electroencephalographic classification of epileptic seizures. From the Commission on Classification and Terminology of the International League Against Epilepsy. Epilepsia, 1981, 22(4): 489-501.
10. Commission on Classification and Terminology of the International League Against Epilepsy. Proposal for revised classification of epilepsies and epileptic syndromes. Commission on Classification and Terminology of the International League Against Epilepsy. Epilepsia, 1989, 30(4): 389-399.
11. Hauser WA, Annegers JF, Kurland LT. Prevalence of Epilepsy in Rochester, Minnesota: 1940-1980. Epilepsia, 1991, 32(4): 429-445.
12. Gao L, Xia L, Pan SQ, et al. Burden of epilepsy: A prevalence-based cost of illness study of direct, indirect and intangible costs for epilepsy. Epilepsy Res, 2015, 110: 146-156.
13. Annegers JF, Hauser WA, Lee JRJ, et al. Incidence of acute symptomatic seizures in rochester, minnesota, 1935-1984. Epilepsia, 1995, 36(4): 327-333.
14. Wang WZ, Wu JZ, Ma GY, et al. Efficacy assessment of phenobarbital in epilepsy: a large community-based intervention trial in rural China. Lancet Neurol, 2006, 5(1): 46-52.
15. Ding D, Hong Z, Wang WZ, et al. Assessing the disease burden due to epilepsy by disability adjusted life year in rural China. Epilepsia 2006, 47(12): 2032-2037.
16. Logroscino G, Hesdorffer DC, Cascino G, et al. Short‐term mortality after a first episode of status epilepticus. Epilepsia, 1997, 38(12): 1344-1349.
17. Logroscino G, Hesdorffer DC, Cascino G, et al. Mortality after a first episode of status epilepticus in the United States and Europe. Epilepsia, 2005, 46(Suppl 11): 46-48.
18. Nwani PO, Nwosu MC, Nwosu MN. Epidemiology of acute symptomatic seizures among adult medical admissions. Epilepsy Res Treat, 2016, 2016: 1-5.
19. Li T, Craig PS, Ito A, et al. Taeniasis/cysticercosis in a Tibetan population in Sichuan Province, China. Acta Trop, 2006, 100(3): 223-231.
20. Li TY, Qiu JM, Yang W, et al. Echinococcosis in Tibetan populations, western Sichuan Province, China. Emerg Infect Dis, 2005, 11(12): 1866-1873.
21. Baumgartner RW, Siegel AM, Hackett PH. Going high with preexisting neurological conditions. High Alt Med Biol, 2007, 8(2): 108-116.
22. Daleau P, Morgado DC, Iriarte CA, et al. New epilepsy seizure at high altitude without signs of acute mountain sickness or high altitude cerebral edema. High Alt Med Biol, 2006, 7(1): 81-83.

Journal of Epilepsy

Clinical features of in-patients with first seizure in Ganzi Tibetan Autonomous Prefecture: a retrospective analysis

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