The Value of Bispectral Index Monitor in Assessing the Depth of Sedation of Ventilated Patients_West China Medical Journal

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Intensive Care Unit，the Third People Hospital of Chengdu,Sichuan Chengdu 610031,China;

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Keywords：

脑电双频指数; SAS评分; 镇静深度; 机械通气

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目的：探讨脑电双频指数(BIS)监测在机械通气患者镇静深度评价中的价值。方法：选取15例机械通气患者，静脉注射咪唑安定达到SAS评分3～4分，持续或间断给药维持镇静深度，记录患者每2小时的SAS镇静分级评分及BIS，观察24小时。比较SAS评分与BIS值的相关性。计算BIS的敏感度和特异度，根据ROC曲线和BIS评价镇静深度的敏感度和特异度，寻找最适BIS值。结果:随镇静深度的加深，BIS明显降低，BIS与SAS评分呈正相关(r=0.662，P＜0.05)；SAS评分3～4分(镇静适度)时对应的BIS临界值为69.5～79。结论：BIS监测与SAS评分之间具有良好的相关性，能同步客观地监测机械通气患者的镇静深度，具有一定的临床诊断价值。

Citation： ZHANG Chuan,LI Xiaojin,LI Xiaoyu,et al.. The Value of Bispectral Index Monitor in Assessing the Depth of Sedation of Ventilated Patients. West China Medical Journal, 2008, 23(1): 41-42. doi: Copy

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8.	Ibrahim AE，Taraday JK，Khamseh ED．Bislmetml index monitoring during sedation with sevoflurane，midazolam，and propofol[J]．Anesthesiology，2001,95(5)：1151－1159．.
9.	Jacobi J,Fraser GL,Coursin DB,et al.Clinical practice guidelines for the sustained use of sedatives and analgesics in the criticall.
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11.	Simmons L E,Riker R R,Prato B S，et al.Assessing sedation during intensive care unit mechanical ventilation with the Bispectral Index and the Sedation-Agitation Scale[J].Crit Care Med,1999,27(8):1499-504.
12.	顾勤,刘宁,葛敏,等.脑电双频指数监测在重症加强治疗病房机械通气患者镇静中的应用[J].中国危重病急救医学,2007,19(2):101-103.
13.	Berkenbosch J W，Fichter C R，Tobias J D．The correlation ofthe bispectral index monitor with clinical sedation scores duringmechanical ventilation in the pediatric intensive care unit[J]．Anesth Analg，2002，94(3)：506－511．.

1.
2. y ill adult[J].Crit Care Med,2002,30(1):119-141.
3. Lehmann A,KarzauJ,BoldtJ,et al.Bispectralindex-guided anesthesiain patients undergoing aortocoronary bypass grafting[J].Anesth Analg,2003,96:336-343.
4. Glass PS，Bloom M，Kearse L，et a1.Bislmetral analysis measur-sedation and me mory efects afpropofol，midasolam,isdlurane and alfentanil in healthy volunteers[J]．Anesthesiology，1997，86(4)：836－487．.
5. Liu J,Sin H,White PF.Electr-ncephalogram bispectral analy-8i8 predicts the depth ofmidazolam-induced sedation[J]．Anesthesiology，1996,84(1)：64－69．.
6. LeBlanc,J M,Dasta J F,Kane Gill S L，et al.Role of the bispectral index in sedation monitoring in the ICU.Ann-Pharmacother[J].2006,40(3):490-500.
7. NasrawaySASAJr,WuEC,KelleherRM,et al.How reliable is the Bispectral Index in critically ill patients?Aprospective,comparative,single blinded observer study[J].Crit Care Med,2002,30:1483-1487.
8. Ibrahim AE，Taraday JK，Khamseh ED．Bislmetml index monitoring during sedation with sevoflurane，midazolam，and propofol[J]．Anesthesiology，2001,95(5)：1151－1159．.
9. Jacobi J,Fraser GL,Coursin DB,et al.Clinical practice guidelines for the sustained use of sedatives and analgesics in the criticall.
10. Ramsay MAE，Savage TM，Simpson BRJ，et a1．Controlled sedation with alphaxalone-alphadolone[J]．Bri Med J，1974，2：656－659．.
11. Simmons L E,Riker R R,Prato B S，et al.Assessing sedation during intensive care unit mechanical ventilation with the Bispectral Index and the Sedation-Agitation Scale[J].Crit Care Med,1999,27(8):1499-504.
12. 顾勤,刘宁,葛敏,等.脑电双频指数监测在重症加强治疗病房机械通气患者镇静中的应用[J].中国危重病急救医学,2007,19(2):101-103.
13. Berkenbosch J W，Fichter C R，Tobias J D．The correlation ofthe bispectral index monitor with clinical sedation scores duringmechanical ventilation in the pediatric intensive care unit[J]．Anesth Analg，2002，94(3)：506－511．.

West China Medical Journal

The Value of Bispectral Index Monitor in Assessing the Depth of Sedation of Ventilated Patients

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