Attentive Function in Patients with Epilepsy_West China Medical Journal

Authors：

WEI Wei ,  LUO Hua

Department of Neurology, Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan 646000, P. R. China;

Corresponding author：

LUO Hua, Email: purplecharm-22@sohu.com

Keywords：

癫痫; 持续注意; 选择注意; 分散注意

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【摘要】　目的　探讨癫痫患者注意功能受损的特点。　方法　 2008年12月-2009年12月选取69例癫痫患者作为病例组，35例正常人作为对照组，分别用持续操作任务实验（continuous performance test，CPT）、斯特鲁普实验（Stroop）和双任务实验测查持续注意、选择注意和分散注意功能。　结果　与对照组相比，病例组CPT反应时延长，漏报率增加（P lt;0.05）；Stroop实验冲突条件下反应时延长，冲突、一致和中性条件下错误率增加，冲突和中性条件下的反应时干扰量和错误率干扰量增加（P lt;0.05）；双任务比单任务划销方格数目减少，字符串正确率减少，双任务减退程度增加（P lt;0.05）。　结论　癫痫患者的持续注意、选择注意和分散注意功能均受损。
【Abstract】　Objective　 To observe the damages of attentive function in the patients with epilepsy. 　Methods　 From December 2008 to December 2009, 69 patients with epilepsy and 35 healthy people were selected as the patients group and control group. All the selected ones underwent continuous performance test (CPT), Stroop test and dual task, respetviely, to assess their sustained attention, selected attention and divided attention.　Results　 In CPT, the reaction time prolonged and the omission rate increased significantly in the patient group compared with those in the control group (P lt;0.05). In Stroop test, the reaction time in the patients group prolonged under incongruous condition, and error rate increased under incongruous, congruous and neutral conditions. The reaction time interfered effects and error interfered effects increased under incongruous and neutral conditions (P lt;0.05); the boxes crossed and right rate of digit strings decreased and decrement increased during dual task than single task in the patient group (P lt;0.05).　Conclusion　 The sustained attention, selected attention and divided attention of patients with epilepsy are impaired.

Citation： WEI Wei,LUO Hua. Attentive Function in Patients with Epilepsy. West China Medical Journal, 2011, 26(4): 503-506. doi: Copy

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14.	Johannsen P, Jakobsen J, Bruhn P, et al. Cortical sites of sustained and divided attention in normal elderly humans[J]. Neuroimage, 1997, 6(3): 145-155.
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16.	Bailet L, Turk W. The impact of childhood epilepsy on neurocognitive and behavioral performance: a prospective longitudinal study[J]. Epilepsia, 2000, 41(4): 426-431.

1. 　Richard J, Peter W, John R. The nature and staging of attention dysfunction in early (minimal and mind) Alzheimer’s disease: relationship to episodic and semantic memory impairment[J]. J Neuropsychologia, 2000, 38(3): 252.
2. 　Riccio CA, Reynolds CR, Lowe P, et al. The continuous performance test: a window on the neural substrates for attention?[J]. Arch Clin Neuropsychol, 2002, 17(3): 235-272.
3. 　Della SS, Baddely A, Papagno C, et al. Dual task paradigm: a means to examine the central exacutive[J]. Ann NY Acad Sci, 1995, 769(1): 161-171.
4. 　Cerminara C, D’Agati E, Lange KW, et al. Benign childhood epilepsy with centrotemporal spikes and the multicomponent model of attention: a matched control study[J]. Epilepsy Behav, 2010, 19(1): 69-77.
5. 　Zaidal DW, Esiri MM, Oxbury JM. Sex related asymmetries in the morphology of the left and right hippocampi? A follow-up study on epileptic patients[J]. J Neurol, 1994, 241(10): 620-623.
6. 　Blake RV, Wroe SJ, Breen EK, et al. Accelerated forgetting in patients with epilepsy: evidence for a impairment in memory consolidation[J]. Brain, 2000, 123(Pt 3): 472-483.
7. 　Sarter M, Givens B, Bruno JP. The cognitive neuroscience of sustained attention: where top-down meets bottom-up[J]. Brain Res Rev, 2001, 35(2): 146-160.
8. 　Metz-Lutz MN, Filippini M. Neuropsychological findings in rolandic epilepsy and Landau-Kleffner syndrome[J]. Epilepsia, 2006, 47 (Suppl 2): 71-75.
9. 　Mitchell WG, Zhou Y, Chavez JM, et al. Reaction time, attention, and impulsivity in epilepsy[J]. Pediatr Neurol, 1992, 8(1): 19-24.
10. 　Pardo JV, Pardo PJ, Janer KW, et al. The anterior cingulate cortex mediates processing selection in the Stroop attentional conflex paradigm[J]. Proc Natl Acad Sci USA, 1990, 87(1): 256-259.
11. 　王凌霄, 苗玲. 癫痫患者认知功能障碍45例临床分析[J]. 上海交通大学学报, 2007, 27(10): 1261-1264.
12. 　虞培敏, 郭起浩, 丁玎, 等. 癫痫患者认知功能特点的研究[J]. 中国临床神经科学, 2006, 14(5): 494-500.
13. 　Keller SS, Baker G, Downes JJ, et al. Quantitative MRI of the prefrontal cortex and executive function in patients with temporal lobe epilepsy[J]. Epilepsy Behav, 2009, 15(2): 186-195.
14. 　Johannsen P, Jakobsen J, Bruhn P, et al. Cortical sites of sustained and divided attention in normal elderly humans[J]. Neuroimage, 1997, 6(3): 145-155.
15. 　Sánchez-Carpinero R, Neville BG. Attentional ability in children with epilepsy[J]. Epilepsia, 2003, 44(10): 1340-1349.
16. 　Bailet L, Turk W. The impact of childhood epilepsy on neurocognitive and behavioral performance: a prospective longitudinal study[J]. Epilepsia, 2000, 41(4): 426-431.

West China Medical Journal

Attentive Function in Patients with Epilepsy

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