乙酰肝素酶与糖尿病肾病_West China Medical Journal

Authors：

安丽娜 ¹ ,  李娟 ²

Corresponding author：

李娟, Email: lina1217146983@163.com

Keywords：

乙酰肝素酶; 蛋白尿; 糖尿病肾病

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【摘要】　乙酰肝素酶（heparanase，HPA）是目前发现的哺乳动物细胞中唯一能切割细胞外基质中硫酸肝素蛋白多糖侧链的内源性糖苷酶。因其可促进肿瘤细胞的浸润和转移，还可以促进肿瘤细胞生长和微血管形成，而被视为是抗肿瘤、抗炎症的理想靶点。研究表明HPA可以降解肾小球基底膜硫酸乙酰肝素多糖侧链，造成肾小球基底膜选择性滤过蛋白质功能下降，与糖尿病肾病（diabetic nephropathy，DN）蛋白尿的产生密切相关。HPA活性的高低对糖尿病肾病的研究有着重要的意义。现将HPA与DN之间的研究进展作一综述。

Citation： 安丽娜,李娟. 乙酰肝素酶与糖尿病肾病. West China Medical Journal, 2011, 26(6): 854-856. doi: Copy

1.	叶任高, 陆再英. 内科学[M]. 6版. 北京: 人民卫生出版社, 2004: 794-797.
2.	李燕杰, 李淑莲. 乙酰肝素酶的分子特性及其在生理病理过程中的作用[J]. 河南大学学报(医学版), 2008, 27(3): 14-16.
3.	Dong J, Kukula AK, Toyoshima M, et al. Genomic organization and chromosome localization of the newly identified human heparanase gene[J]. Gene, 2000, 253(2): 171-178.
4.	张文娟, 任明姬. 乙酰肝素酶研究进展[J]. 内蒙古医学杂志, 2010, 42(2): 202-205.
5.	Vlodavsky I, Friedmann Y, Elkin M. Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis[J]. Nat Med, 1999, 5(7): 793-802.
6.	Mckenzie E, Tyson K, StampsA, et al. Cloning and expression profiling of Hpa2, a novel mammalian heparanase family member[J]. Biochem Biolphy Res Commum, 2000, 276(3): 1170-1177.
7.	Bame KJ. Heparanase:endoglycosidases that degrade heparan sulfate proteglycans[J]. Glycobiology, 2001, 11(6): 91-98.
8.	李燕杰, 彭清忠. 乙酰肝素酶的结构、功能及调控[J]. 生物技术通讯, 2003, 14(2): 141-144.
9.	Raats CJ, Van Den Born J, Berden JH. Glomerular heparan sulfate alternations: mechanisms and relevance for proteinuria[J]. Kidney Int, 2000, 57(2): 385-400.
10.	Pillarisetti S. Lipoprotein modulation of subendothelial heparan sulfate proteoglycans(perlecan)and atherogenicity[J]. Trends Cardiovasc Med, 2000, 10(2): 60-65.
11.	倪寿翔, 李立. 乙酰肝素酶的研究进展与眼部疾病[J]. 重庆医科大学学报, 2006, 31(1): 65-68.
12.	阎妍, 王峥, 罗苇. 肾病鼠外周血白细胞乙酰肝素酶基因的表达及其与尿蛋白的相关性[J]. 四川大学学报(医学版), 2004, 35(4): 489-491.
13.	Levidiotis V, Kanellis J, lerino FL, et al. Increased expmssion of heparanasein pummycin aminonucleoside nephrosis[J]. Kidney Int, 2001, 60(4): 1287-1296.
14.	Katz A, Van-Dijk DJ, Aingorn H, et al. Involvement of human heparanase in the pathogenesis of diabetic nephropathy[J]. Isr Med Assoc J, 2002, 4(11): 996-1002.
15.	Maxhimer JB, Somenek M, Rao G, et al. Heparanase-l gene expression and regulation by high glucose in renal epithelial cells: a potential role in the pathogenesis of proteinuria in diabetic patients[J]. Diabetes, 2005, 54(7): 2172-2178.
16.	刘静云. 浅析糖尿病肾病与尿蛋白的关系[J]. 河北中医杂志, 2009, 31(8): 1141-1191.
17.	唐立平, 唐政权, 孙洪华. 糖尿病肾病的早期诊断及其临床意义[J]. 中国实用医药杂志, 2010, 5(25): 250.
18.	粱琳琅, 刘国良. 糖尿病性蛋白尿用药选择性研究[J]. 中华内分泌代谢杂志, 1996, 12(3): 138-140.
19.	洪郁芝, 徐新鹏, 叶迅, 等. 糖尿病肾病蛋白尿发生机制研究进展[J]. 中国中西医结合肾病杂志, 2008, 9(11): 1011-1013.
20.	Shafat I, Zcharia E, Nisman B, et al. An ELISA method for the detection and quantification of human heparanase[J]. Biochem Biophys Res Commun, 2006, 341(4): 958-963.
21.	Zcharia E, Metzger S, Chajek-Shaul T, et al. Transgenic expression of mammalian heparanase uncovers physiological functions of heparan in tissue morphogenesis, vascularization, and feeding behavior[J]. FASEB J, 2004, 18(2): 252-263.
22.	屈微, 张延丽. 乙酰肝素酶在妊娠期高血压疾病大鼠肾脏的表达及低分子量肝素干预治疗[J]. 中外医疗, 2010, 29(1): 24-27.
23.	Ma P, Luo Y, Zhu X, et al. Retinal heparanase expression in streptozotocin-induced diabetic rats[J]. Can J Ophthalmol, 2010, 45(1): 46-51.
24.	van den Hoven MJ, Rops AL, Bakker MA, et al. Increased expression of heparanase in overt diabetic nephropathy[J]. Kidney Int, 2006, 70(12): 2100-2108.
25.	王玉华, 唐琳, 刘章锁. 乙酰肝素酶与蛋白尿性肾脏疾病的关系[J]. 国际移植与血液净化杂志, 2007, 5(4): 10-15.

1. 　叶任高, 陆再英. 内科学[M]. 6版. 北京: 人民卫生出版社, 2004: 794-797.
2. 　李燕杰, 李淑莲. 乙酰肝素酶的分子特性及其在生理病理过程中的作用[J]. 河南大学学报(医学版), 2008, 27(3): 14-16.
3. 　Dong J, Kukula AK, Toyoshima M, et al. Genomic organization and chromosome localization of the newly identified human heparanase gene[J]. Gene, 2000, 253(2): 171-178.
4. 　张文娟, 任明姬. 乙酰肝素酶研究进展[J]. 内蒙古医学杂志, 2010, 42(2): 202-205.
5. 　Vlodavsky I, Friedmann Y, Elkin M. Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis[J]. Nat Med, 1999, 5(7): 793-802.
6. 　Mckenzie E, Tyson K, StampsA, et al. Cloning and expression profiling of Hpa2, a novel mammalian heparanase family member[J]. Biochem Biolphy Res Commum, 2000, 276(3): 1170-1177.
7. 　Bame KJ. Heparanase:endoglycosidases that degrade heparan sulfate proteglycans[J]. Glycobiology, 2001, 11(6): 91-98.
8. 　李燕杰, 彭清忠. 乙酰肝素酶的结构、功能及调控[J]. 生物技术通讯, 2003, 14(2): 141-144.
9. 　Raats CJ, Van Den Born J, Berden JH. Glomerular heparan sulfate alternations: mechanisms and relevance for proteinuria[J]. Kidney Int, 2000, 57(2): 385-400.
10. 　Pillarisetti S. Lipoprotein modulation of subendothelial heparan sulfate proteoglycans(perlecan)and atherogenicity[J]. Trends Cardiovasc Med, 2000, 10(2): 60-65.
11. 　倪寿翔, 李立. 乙酰肝素酶的研究进展与眼部疾病[J]. 重庆医科大学学报, 2006, 31(1): 65-68.
12. 　阎妍, 王峥, 罗苇. 肾病鼠外周血白细胞乙酰肝素酶基因的表达及其与尿蛋白的相关性[J]. 四川大学学报(医学版), 2004, 35(4): 489-491.
13. 　Levidiotis V, Kanellis J, lerino FL, et al. Increased expmssion of heparanasein pummycin aminonucleoside nephrosis[J]. Kidney Int, 2001, 60(4): 1287-1296.
14. 　Katz A, Van-Dijk DJ, Aingorn H, et al. Involvement of human heparanase in the pathogenesis of diabetic nephropathy[J]. Isr Med Assoc J, 2002, 4(11): 996-1002.
15. 　Maxhimer JB, Somenek M, Rao G, et al. Heparanase-l gene expression and regulation by high glucose in renal epithelial cells: a potential role in the pathogenesis of proteinuria in diabetic patients[J]. Diabetes, 2005, 54(7): 2172-2178.
16. 　刘静云. 浅析糖尿病肾病与尿蛋白的关系[J]. 河北中医杂志, 2009, 31(8): 1141-1191.
17. 　唐立平, 唐政权, 孙洪华. 糖尿病肾病的早期诊断及其临床意义[J]. 中国实用医药杂志, 2010, 5(25): 250.
18. 　粱琳琅, 刘国良. 糖尿病性蛋白尿用药选择性研究[J]. 中华内分泌代谢杂志, 1996, 12(3): 138-140.
19. 　洪郁芝, 徐新鹏, 叶迅, 等. 糖尿病肾病蛋白尿发生机制研究进展[J]. 中国中西医结合肾病杂志, 2008, 9(11): 1011-1013.
20. 　Shafat I, Zcharia E, Nisman B, et al. An ELISA method for the detection and quantification of human heparanase[J]. Biochem Biophys Res Commun, 2006, 341(4): 958-963.
21. 　Zcharia E, Metzger S, Chajek-Shaul T, et al. Transgenic expression of mammalian heparanase uncovers physiological functions of heparan in tissue morphogenesis, vascularization, and feeding behavior[J]. FASEB J, 2004, 18(2): 252-263.
22. 　屈微, 张延丽. 乙酰肝素酶在妊娠期高血压疾病大鼠肾脏的表达及低分子量肝素干预治疗[J]. 中外医疗, 2010, 29(1): 24-27.
23. 　Ma P, Luo Y, Zhu X, et al. Retinal heparanase expression in streptozotocin-induced diabetic rats[J]. Can J Ophthalmol, 2010, 45(1): 46-51.
24. 　van den Hoven MJ, Rops AL, Bakker MA, et al. Increased expression of heparanase in overt diabetic nephropathy[J]. Kidney Int, 2006, 70(12): 2100-2108.
25. 　王玉华, 唐琳, 刘章锁. 乙酰肝素酶与蛋白尿性肾脏疾病的关系[J]. 国际移植与血液净化杂志, 2007, 5(4): 10-15.

West China Medical Journal

乙酰肝素酶与糖尿病肾病

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