【摘要】　目的　 对原发性肠道非霍奇金淋巴瘤穿孔患者的临床及病理特征、诊治、预后进行探讨。　方法　 回顾性分析1999年1月-2008年12月诊治的17例原发性肠道非霍奇金淋巴瘤穿孔患者的临床资料。　结果　 B细胞型9例，T细胞型8例。17例原发肠道非霍奇金淋巴瘤穿孔患者的穿孔部位:大肠7例，小肠7例，回盲部3例。所有患者均行手术治疗。除2例穿孔前行化疗的患者以外，其余患者术前均未明确诊断。有14例获得随访结果，6例术后3个月内死亡，术后接受化疗者7例，1、2、3年生存率分别为41.2%、 23.6%、11.7%，仅1例生存期超过5年。　结论　 原发性肠道非霍奇金淋巴瘤穿孔术前诊断困难，预后极差。
【Abstract】　Objective　 To analyze the clinical features, diagnosis, therapy and prognosis of primary intestinal non-hodgkin′s lymphoma perforation.　Methods　 The clinical data of 17 patients with the primary intestinal non-Hodgkin′s lymphoma perforation from January 1999 to December 2008 were retrospectively analyzed.　Results　 Nine patients had intestinal B-cell lymphoma, and eight had intestinal T-cell lymphoma. The sites of perforation were as follows: colon and rectum in 7 (41.2%), ileum and jejunum in 7 (41.2%), and ileocecal junction in 3 (17.6%). All patients had undergone the operations. The disease was not diagnosed before the operation in all of the patients except for the Two patients had a history of systemic chemotherapy before perforation. A total of 14 patients were followed up, in whom six died within three months after the operation; the survival rate 1, 2, and 3 years after the operation was 41.2%, 23.6%, and 11.7%, respectively in seven patients who had undergone the systemic chemotherapy before the operation; one patients lived more than 5 years.　Conclusion　 The diagnosis of primary colonic malignant lymphoma perforation is difficult; the prognosis is miserable.

Citation： GOU Hongfeng,CHEN Xinchuan. Prognosis of Primary Intestinal non-Hodgkin′s Lymphoma Perforation. West China Medical Journal, 2010, 25(11): 1960-1963. doi: Copy