Safety Evaluation and Diagnostic Value of Domesticmade Adenosine in Pharmacological Stress with Myocardial Perfusion Imaging for Coronary Artery Disease_West China Medical Journal

Authors：

CHEN Li , HE Li Hua , YANG Wen Bo.

The Central Hospital of Suining, Department of Nuclear Medicine, SiChuan Suining, 629000 China;

Corresponding author：

Keywords：

腺苷; 冠心病; 心肌灌注显像

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目的:评价国产腺苷临床应用安全性及腺苷负荷心肌灌注显像对冠心病的诊断价值。方法:对51例临床疑诊冠心病患者,分别静脉注射腺苷,注射3min末,静脉注射核素显像剂99TcmMIBI 925 MBq,1～1.5h行心肌灌注断层显像,分析患者在腺苷注入后的血流动力学改变、副作用发生情况。经半年以上随访排除或确诊冠心病,评价腺苷负荷心肌灌注显像对冠心病的诊断价值。结果:腺苷输注后,86.3%(44/51) 患者出现各种副作用,停药后均很快缓解。腺苷负荷试验心肌灌注显像诊断冠心病的敏感性90.9%,特异性71.4%,准确性88.2%,阳性预测值95.2%,阴性预测值55.6%。结论:国产腺苷可安全地应用于负荷心肌灌注显像。腺苷负荷心肌灌注显像诊断冠心病敏感性较高,具有重要的临床应用价值。

Citation： CHEN Li,HE Li Hua,YANG Wen Bo.. Safety Evaluation and Diagnostic Value of Domesticmade Adenosine in Pharmacological Stress with Myocardial Perfusion Imaging for Coronary Artery Disease. West China Medical Journal, 2009, 24(6): 1468-1470. doi: Copy

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1. NEWBY A C. Adenosine and the concept of retaliatory metabolites[J]. Trends Biochem Sci,1984,9(1):42-44.
2. MARWICK T H. Current status of stress echocardiography for diagnosis and prognostic assessment of cornary artery disease[J]. Coron Artery Dis,1998,9(2):411-426.
3. CERQYEURA M D, VERANI M S, SCHWAIGER M, et al. Safety profile ofadenosine stress perfusion imaging: results from the Adenoscan Multicenter Trial Registry[J]. J Am Coll Cardiol,1994,23(2):384-389 .
4. 田月琴,王金城,何作祥,等.腺苷负荷试验心肌灌注显像诊断冠心病的临床价值[J].中华心血管病杂志,2005,33(1):58-60.
5. 冯雪凤,贾支俊,许守林,等.腺苷负荷实验:99 mTc-MIBI心肌灌注显像中不良反应的观察[J].实用诊断与治疗,2008,22(1):24-26.
6. 付巍,刘韬,董庆华,等.国产腺苷药物负荷试验210例临床安全性评价[J].山西医药杂志,2008,37(1):6-8.
7. 王倩,王金城,米宏志,等.国产腺苷介入心肌灌注断层显像对心肌缺血的诊断价值[J].中华核医学杂志,2006,26 (2):81.

West China Medical Journal

Safety Evaluation and Diagnostic Value of Domesticmade Adenosine in Pharmacological Stress with Myocardial Perfusion Imaging for Coronary Artery Disease

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