Early Prevention of Severe Acute Pancreatitis Complicated with Infection_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

WEI Wei ,  DUI Danhua

Department of Hepatobiliaropancreatic Surgery，Affiliated Hospital of Zunyi Medical College，Zunyi 563003，Guizhou Province，China;

Corresponding author：

DUI Danhua, Email: duidanhua@yahoo.com.cn

Keywords：

Severe acute pancreatitis; Infection; Mortality; Prevention

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective 　To explore the early prevention measures of severe acute pancreatitis （SAP） complicated with infection.
Methods 　The foreign and native related literatures of SAP complicated with infection in recent 10 years
were retrieved， and the effect of sooner measures for SAP complicated with infection were discussed.
Results 　It was beneficial to reduce the incidence of infection and improve the outcome in SAP by using antibiotics of apt through the blood-pancreatic barrier， using proton pump inhibitor properly， and using enteral nutrition， hemofiltration， and hyperbaric oxygen as soon as possible， and then combined with traditional Chinese medicine.
Conclusions 　SAP complicated with infection is the one of the main reasons of death. It is a must to take effective and comprehensive measures in the early stage in order to reduce the rate of infection. However， there are several unclear problems to probe in the future on this issue.

Citation： WEI Wei,DUI Danhua. Early Prevention of Severe Acute Pancreatitis Complicated with Infection. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2013, 20(6): 697-703. doi: Copy

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22. Al-Omran M， Albalawi ZH， Tashkandi MF， et al. Enteral versus parenteral nutrition for acute pancreatitis[J]. Cochrane Database Syst Rev， 2010， (1)：CD002837.
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27. Petrov MS， Pylypchuk RD， Uchugina AF. A systematic review on the timing of artificial nutrition in acute pancreatitis[J]. Br J Nutr， 2009， 101(6)：787-793.
28. Marik PE. What is the best way to feed patients with pancreatitis?[J]. Curr Opin Crit Care， 2009， 15(2)：131-138.
29. Xue P， Deng LH， Xia Q， et al. Impact of alanyl-glutaminedipeptide on severe acute pancreatitis in early stage[J]. World J Gastroenterol， 2008， 14(3)：474-478.
30. Zou XP， Chen M， Wei W， et al. Effects of enteral immunonutritionon the maintenance of gut barrier function and immune function in pigs with severe acute pancreatitis[J]. JPEN J Parenter Enteral Nutr， 2010， 34(5)：554-566.
31. Wang X， Li W， Zhang F， et al. Fish oil-supplemented parenteralnutrition in severe acute pancreatitis patients and effects on immunefunction and infectious risk：a randomized controlled trial[J]. Inflammation， 2009， 32(5)：304-309.
32. Petrov MS， Atduev VA， Zagainov VE. Advanced enteral therapy in acute pancreatitis：is there a room for immunonutrition? A meta-analysis[J]. Int J Surg， 2008， 6(2)：119-124.
33. Lutgendorff F， Trulsson LM， van Minnen LP， et al. Probiotics enhance pancreatic glutathione biosynthesis and reduce oxidative stress in experimental acute pancreatitis[J]. Am J Physiol Gastrointest Liver Physiol， 2008， 295(5)：G1111- G1121.
34. Lutgendorff F， Nijmeijer RM， Sandstrom PA， et al. Probiotics prevent intestinal barrier dysfunction in acute pancreatitis in rats via induction of ileal mucosal glutathione biosynthesis[J]. PloS One， 2009， 4(2)：e4512.
35. Rychter JW， van Minnen LP， Verheem A， et al. Pretreatment but not treatment with probiotics abolishes mouse intestinal barrier dysfunction in acute pancreatitis[J]. Surgery， 2009， 145(2)：157-167.
36. Plaudis H， Pupelis G， Zeiza K， et al. Early low volume oral synbiotic/prebiotic supplemented enteral stimulation of the gut in patients with severe acute pancreatitis：a prospective feasibility study[J]. Acta Chir Belg， 2012， 112(2)：131-138.
37. Sharma B， Srivastava S， Singh N， et al. Role of probiotics on gut permeability and endotoxemia in patients with acute pancreatitis：a double-blind randomized controlled trial[J]. J Clin Gastroenterol， 2011， 45(5)：442-448.
38. Besselink MG， van Santvoort HC， Buskens E， et al. Probiotic prophylaxis in predicted severe acute pancreatitis：a randomised， double-blind， placebo-controlled trial[J]. Lancet， 2008， 371(9613)：651-659.
39. Verma R， Dhamija R， Ross SC， et al. Symbiotic bacteria inducednecrotizing pancreatitis[J]. JOP， 2010， 11(5)：474-476.
40. Sun S， Yang K， He X， et al. Probiotics in patients with severe acute pancreatitis：a meta-analysis[J]. Langenbecks Arch Surg， 2009， 394(1)：171-177.
41. Zhang MM， Cheng JQ， Lu YR， et al. Use of pre-， pro- and synb-iotics in patients with acute pancreatitis：a meta-analysis[J]. World J Gastroenterol， 2010， 16(31)：3970-3978.
42. Petrov MS， Loveday BP， Pylypchuk RD， et al. Systematic reviewand meta-analysis of enteral nutrition formulations in acute pancr-eatitis[J]. Br J Surg， 2009， 96(11)：1243-1252.
43. Zhang XP， Jiang J， Yu YP， et al. Effect of Danshen on apoptosis and NF-kappaB protein expression of the intestinal mucosa of rats with severe acute pancreatitis or obstructive jaundice[J]. Hepatobiliary Pancreat Dis Int， 2010， 9(5)：537-546.
44. Zhang Z， Wang Y， Dong M， et al. Oxymatrine amelioratesL-arginine-induced acute pancreatitis in rats[J]. Inflammation， 2012， 35(2)：605-613.
45. Wang G， Sun B， Zhu H， et al. Protective effects of emodin combined with danshensu on experimental severe acute pancreatitis[J]. Inflamm Res， 2010， 59(6)：479-488.
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CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Early Prevention of Severe Acute Pancreatitis Complicated with Infection

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