Research Progress of MicroRNA as a Tumor Marker in Peripheral Blood_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

CHEN Rong , LIU Guanghui , ZHOU Zongguang

Department of Gastrointestinal Surgery Center， West China Hospital， Sichuan University， Chengdu 610041， Sichuan Province， China;

Corresponding author：

Keywords：

MicroRNA; Tumor markers; Diagnosis; Treatment

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective 　To summarize the research progress of microRNA （miRNA） as a tumor marker in peripheral blood.
Methods 　The domestic and international published literatures about circulating miRNA as a tumor marker in recent years were reviewed.
Results 　The miRNA expression has universality，stability and specificity，and it is related to the occurrence and development of viarous diseases.
Conclusion 　Circulating miRNA shows a broad application prospect in clinical diagnosis， treatment， and prognosis of tumor and other diseases.

Citation： CHEN Rong,LIU Guanghui,ZHOU Zongguang. Research Progress of MicroRNA as a Tumor Marker in Peripheral Blood. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2012, 19(9): 1020-1023. doi: Copy

1.	Kopreski MS， Benko FA， Gocke DC. Circulating RNA as a tumor marker：detection of 5T4 mRNA in breast and lung cancer patient serum[J]. Ann N Y Acad Sci， 2001， 945：172-178.
2.	Soifer HS， Rossi JJ， Saetrom P. MicroRNAs in disease andpotential therapeutic applications[J]. Mol Ther， 2007， 15(12)： 2070-2079.
3.	Lu J， Getz G， Miska EA， et al. MicroRNA expression profiles classify human cancers[J]. Nature， 2005， 435(7043)：834-838.
4.	Hanson EK， Lubenow H， Ballantyne J. Identification of forensically relevant body fluids using a panel of differentially expressed microRNAs[J]. Anal Biochem，2009， 387(2)：303-314.
5.	Chen X， Ba Y， Ma LJ， et al. Characterization of microRNAs in serum： a novel class of biomarkers for diagnosis of cancer and other diseases[J]. Cell Res， 2008， 18(10)： 997-1006.
6.	Xi Y， Nakajima G， Gavin E， et al. Systematic analysis ofmicroRNA expression of RNA extracted from fresh frozen and formalin-fixed paraffin-embedded samples[J]. Rna， 2007， 13(10)：1668-1674.
7.	Mitchell PS， Parkin RK， Kroh EM， et al. Circulating microRNAs as stable blood-based markers for cancer detection[J]. Proc Natl Acad Sci， 2008，105(30)：10513-10518.
8.	Rosenfeld N， Aharonov R， Meiri E， et al. MicroRNAs accurately identify cancer tissue origin[J]. Nat Biotechnol， 2008，26(4)：462-469.
9.	Huang ZM， Yang J， Shen XY， et al. MicroRNA expressionprofile in non-cancerous colonic tissue associated with lymph node metastasis of colon cancer[J]. J Dig Dis， 2009，10(3)：188-194.
10.	Gilad S， Meiri E， Yogev Y， et al. Serum microRNAs are promising novel biomarkers[J]. PLoS One， 2008，3(9)：e3148-e3154.
11.	Taylor DD， Gercel-Taylor C. MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer[J]. Gynecol Oncol， 2008， 110(1)：13-21.
12.	Benner SA. Extracellular ‘communicator RNA’[J]. FEBS Lett， 1988， 233(2)：225-228.
13.	Valadi H， Ekström K， Bossios A， et al. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells[J]. Nat Cell Biol， 2007， 9(6)：654-659.
14.	Skog J， Würdinger T， van Rijn S， et al. Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers[J]. Nature Cell Biology， 2008，10(12)：1470-1476.
15.	Wang CJ， Zhou ZG， Wang L， et al. Clinicopathological signiﬁcance of microRNA-31，-143 and -145 expression in colorectal cancer[J]. Disease Markers， 2009， 26(1)：27-34.
16.	Ai J， Zhang R， Li Y， et al. Circulating microRNA-1 as a potential novel biomarker for acute myocardial infarction[J]. Biochem Biophys Res Commun， 2010， 391(1)： 73-77.
17.	Vasilescu C， Rossi S， Shimizu M， et al. MicroRNA fingerprints identify miR-150 as a plasma prognostic marker in patients with sepsis[J]. PLoS One， 2009， 4(10)：e7405-e7414.
18.	Hartono C， Muthukumar T， Suthanthiran M. Noninvasive diagnosis of acute rejection of renal allografts[J]. Curr Opin Organ Transplant， 2010， 15(1)：35-41.
19.	Liu DZ， Tian Y， Ander BP， et al. Brain and blood microRNA expression profiling of ischemic stroke， intracerebral hemorrhage， and kainate seizures[J]. J Cereb Blood Flow Metab， 2010， 30(1)：92-101.
20.	Wang K， Zhang S， Marzolf B， et al. Circulating microRNAs， potential biomarkers for drug-induced liver injury[J]. Proc Natl Acad Sci， 2009， 106(11)：4402-4407.
21.	Pauley KM， Satoh M， Chan AL， et al. Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients[J]. Arthritis Res Ther， 2008， 10(4)：R101.
22.	Ng EK， Chong WW， Jin H， et al. Differential expression ofmicroRNAs in plasma of patients with colorectal cancer：apotential marker for colorectal cancer screening[J]. Gut， 2009， 58(10)：1375-1381.
23.	Chajut A， Benjamin S， Gilad S， et al. Circulating microRNAs as potential blood-based biomarkers for detection of colorectal cancer[J]. J Clin Oncol， 2009， 27(Suppl)：e15040.
24.	Jackson DB. Serum-based microRNAs： are we blinded by potential?[J]. Proc Natl Acad Sci U S A， 2009， 106(1)：E5.

1. Kopreski MS， Benko FA， Gocke DC. Circulating RNA as a tumor marker：detection of 5T4 mRNA in breast and lung cancer patient serum[J]. Ann N Y Acad Sci， 2001， 945：172-178.
2. Soifer HS， Rossi JJ， Saetrom P. MicroRNAs in disease andpotential therapeutic applications[J]. Mol Ther， 2007， 15(12)： 2070-2079.
3. Lu J， Getz G， Miska EA， et al. MicroRNA expression profiles classify human cancers[J]. Nature， 2005， 435(7043)：834-838.
4. Hanson EK， Lubenow H， Ballantyne J. Identification of forensically relevant body fluids using a panel of differentially expressed microRNAs[J]. Anal Biochem，2009， 387(2)：303-314.
5. Chen X， Ba Y， Ma LJ， et al. Characterization of microRNAs in serum： a novel class of biomarkers for diagnosis of cancer and other diseases[J]. Cell Res， 2008， 18(10)： 997-1006.
6. Xi Y， Nakajima G， Gavin E， et al. Systematic analysis ofmicroRNA expression of RNA extracted from fresh frozen and formalin-fixed paraffin-embedded samples[J]. Rna， 2007， 13(10)：1668-1674.
7. Mitchell PS， Parkin RK， Kroh EM， et al. Circulating microRNAs as stable blood-based markers for cancer detection[J]. Proc Natl Acad Sci， 2008，105(30)：10513-10518.
8. Rosenfeld N， Aharonov R， Meiri E， et al. MicroRNAs accurately identify cancer tissue origin[J]. Nat Biotechnol， 2008，26(4)：462-469.
9. Huang ZM， Yang J， Shen XY， et al. MicroRNA expressionprofile in non-cancerous colonic tissue associated with lymph node metastasis of colon cancer[J]. J Dig Dis， 2009，10(3)：188-194.
10. Gilad S， Meiri E， Yogev Y， et al. Serum microRNAs are promising novel biomarkers[J]. PLoS One， 2008，3(9)：e3148-e3154.
11. Taylor DD， Gercel-Taylor C. MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer[J]. Gynecol Oncol， 2008， 110(1)：13-21.
12. Benner SA. Extracellular ‘communicator RNA’[J]. FEBS Lett， 1988， 233(2)：225-228.
13. Valadi H， Ekström K， Bossios A， et al. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells[J]. Nat Cell Biol， 2007， 9(6)：654-659.
14. Skog J， Würdinger T， van Rijn S， et al. Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers[J]. Nature Cell Biology， 2008，10(12)：1470-1476.
15. Wang CJ， Zhou ZG， Wang L， et al. Clinicopathological signiﬁcance of microRNA-31，-143 and -145 expression in colorectal cancer[J]. Disease Markers， 2009， 26(1)：27-34.
16. Ai J， Zhang R， Li Y， et al. Circulating microRNA-1 as a potential novel biomarker for acute myocardial infarction[J]. Biochem Biophys Res Commun， 2010， 391(1)： 73-77.
17. Vasilescu C， Rossi S， Shimizu M， et al. MicroRNA fingerprints identify miR-150 as a plasma prognostic marker in patients with sepsis[J]. PLoS One， 2009， 4(10)：e7405-e7414.
18. Hartono C， Muthukumar T， Suthanthiran M. Noninvasive diagnosis of acute rejection of renal allografts[J]. Curr Opin Organ Transplant， 2010， 15(1)：35-41.
19. Liu DZ， Tian Y， Ander BP， et al. Brain and blood microRNA expression profiling of ischemic stroke， intracerebral hemorrhage， and kainate seizures[J]. J Cereb Blood Flow Metab， 2010， 30(1)：92-101.
20. Wang K， Zhang S， Marzolf B， et al. Circulating microRNAs， potential biomarkers for drug-induced liver injury[J]. Proc Natl Acad Sci， 2009， 106(11)：4402-4407.
21. Pauley KM， Satoh M， Chan AL， et al. Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients[J]. Arthritis Res Ther， 2008， 10(4)：R101.
22. Ng EK， Chong WW， Jin H， et al. Differential expression ofmicroRNAs in plasma of patients with colorectal cancer：apotential marker for colorectal cancer screening[J]. Gut， 2009， 58(10)：1375-1381.
23. Chajut A， Benjamin S， Gilad S， et al. Circulating microRNAs as potential blood-based biomarkers for detection of colorectal cancer[J]. J Clin Oncol， 2009， 27(Suppl)：e15040.
24. Jackson DB. Serum-based microRNAs： are we blinded by potential?[J]. Proc Natl Acad Sci U S A， 2009， 106(1)：E5.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Research Progress of MicroRNA as a Tumor Marker in Peripheral Blood

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