Current Research Advancement of Hepatocyte Transplantation_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LIU Shicheng , LI Jing

Department of Hepatobiliary Surgery, Xinqiao Hospital of The Third Military Medical Universty, Chongqing 400037, China Corresponding Author: LI Jing, E-mail : xqyylijing@tom.com;

Corresponding author：

Keywords：

Hepatocyte,Transplantation【Foundation item】National Natural Science Foundation of China (No.30570843)

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Objective 　To investigate the application and advancement of hepatocyte t ransplantation ( HCT) .
Methods 　Literatures about the advancement of HCT were reviewed and analyzed. Results 　There have been many
novel technologies and advancement s in the application of HCT. For example , gene modified cell can be used as seed
cell , subcutaneous t ransplantation can be taken when combined with giant molecule material and the encap sulation
preconditioning technique can also carried before operation to improve the rate of survival. Conclusion 　With more
and deeper understanding of hepatocyte t ransplantation and the development of advanced techniques such as the application of giant molecule , HCT will be extensively used in the clinical t reatment of acute and chronic hepatic diseases.

Citation： LIU Shicheng,LI Jing,.. Current Research Advancement of Hepatocyte Transplantation. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2008, 15(2): 109-111. doi: Copy

1.	Berry MN,Friend DS.High-yield preparation of isolated rat liver parenchymal cells:a biochemical and fine structural study[J].J Cell Biol,1969; 43(3):506.
2.	Tanaka K,Soto-Gutierrez A,Navarro-Alvarez N,et al.Functional hepatocyte culture and its application to cell therapies[J].Cell Transplant,2006; 15(10):855.
3.	李晓芳,范昕建,王文雅.人工肝临床应用的研究进展[J].西部医学,2005; 17(1):70.
4.	Mazaris EM,Roussos CT,Papalois VE.Hepatocyte transplantation:a review of worldwide clinical developments and experiences[J].Exp Clin Transplant,2005; 3(1):306.
5.	Chen Y,Kobayashi N,Suzuki S,et al.Transplantation of human hepatocytes cultured with deleted variant of hepatocyte growth factor prolongs the survival of mice with acute liver failure[J].Transplantation,2005; 79(10):1378.
6.	Khan AA,Habeeb A,Parveen N,et al.Peritoneal transplantation of human fetal hepatocytes for the treatment of acute fatty liver of pregnancy:a case report[J].Trop Gastroenterol,2004; 25(3):141.
7.	Lagasse E,Connors H,Al-Dhalimy M,et al.Purified hematopoietic stem cells can differentiate into hepatocytes in vivo[J].Nat Med,2000; 6(11):1229.
8.	Auth MK,Woitaschek D,Beste M,et al.Preservation of the synthetic and metabolic capacity of isolated human hepatocytes by coculture with human biliary epithelial cells[J].Liver Transpl,2005; 11(4):410.
9.	Murasawa S,Asahara T.Gene modified cell transplantation for vascular regeneration[J].Curr Gene Ther,2007; 7(1):1.
10.	Li J,Li LJ,Cao HC,et al.Establishment of highly differentiated immortalized human hepatocyte line with simian virus 40 large tumor antigen for liver based cell therapy[J].ASAIO J,2005; 51(3):262.
11.	Mashalova EV,Guha C,Roy-Chowdhury N,et al.Prevention of hepatocyte allograft rejection in rats by transferring adenoviral early region 3 genes into donor cells[J].Hepatology,2007; 45(3):755.
12.	Yu CH,Chen HL,Chen WT,et al.Portal hemodynamic changes after hepatocyte transplantation in acute hepatic failure[J].J Biomed Sci,2004; 11(6):756.
13.	Kato K,Onodera K,Sawa M,et al.Effect of hepatocyte growth factor on the proliferation of intrasplenically transplanted hepatocytes in rats[J].Biochem Biophys Res Commun,1996; 222(1):101.
14.	Ahmad TA,Fujioka H,Eguchi S,et al.Long-term effect of hepatocyte transplantation on fulminant hepatic failure in rats[J].Hepatogastroenterology,2003; 50(50):467.
15.	Sigot V,Mediavilla MG,Furno G,et al.A simple and effective method to improve intrasplenic rat hepatocyte transplantation[J].Cell Transplant,2004; 13(7-8):775.
16.	Yokoyama T,Ohashi K,Kuge H,et al.In vivo engineering of metabolically active hepatic tissues in a neovascularized subcutaneous cavity[J].Am J Transplant,2006; 6(1):50.
17.	Terry C,Dhawan A,Mitry RR,et al.Preincubation of rat and human hepatocytes with cytoprotectants prior to cryopreservation can improve viability and function upon thawing[J].Liver Transpl,2006; 12(1):165.
18.	Jamal HZ,Weglarz TC,Sandgren EP.Cryopreserved mouse hepatocytes retain regenerative capacity in vivo[J].Gastroenterology,2000; 118(2):390.
19.	Aleem Khan A,Parveen N,Habeeb MA,et al.Journey from hepatocyte transplantation to hepatic stem cells:a novel treatment strategy for liver diseases[J].Indian J Med Res,2006; 123(5):601.
20.	Rahman TM,Diakanov I,Selden C,et al.Co-transplantation of encapsulated HepG2 and rat Sertoli cells improves outcome in a thioacetamide induced rat model of acute hepatic failure[J].Transpl Int,2005; 18(8):1001.
21.	侯辉,耿小平.肝切除及肝移植术中缺血预处理的临床研究进展[J].国际外科学杂志,2007; 34(2):128.
22.	Dagher I,Boudechiche L,Branger J,et al.Efficient hepatocyte engraftment in a nonhuman primate model after partial portal vein embolization[J].Transplantation,2006; 82(8):1067.
23.	Bilir BM,Guinette D,Karrer F,et al.Hepatocyte transplantation in acute liver failure[J].Liver Transpl,2000; 6(1):32.
24.	Dhawan A,Mitry RR,Hughes RD.Hepatocyte transplantation for liver-based metabolic disorders[J].J Inherit Metab Dis,2006; 29(2-3):431.

1. Berry MN,Friend DS.High-yield preparation of isolated rat liver parenchymal cells:a biochemical and fine structural study[J].J Cell Biol,1969; 43(3):506.
2. Tanaka K,Soto-Gutierrez A,Navarro-Alvarez N,et al.Functional hepatocyte culture and its application to cell therapies[J].Cell Transplant,2006; 15(10):855.
3. 李晓芳,范昕建,王文雅.人工肝临床应用的研究进展[J].西部医学,2005; 17(1):70.
4. Mazaris EM,Roussos CT,Papalois VE.Hepatocyte transplantation:a review of worldwide clinical developments and experiences[J].Exp Clin Transplant,2005; 3(1):306.
5. Chen Y,Kobayashi N,Suzuki S,et al.Transplantation of human hepatocytes cultured with deleted variant of hepatocyte growth factor prolongs the survival of mice with acute liver failure[J].Transplantation,2005; 79(10):1378.
6. Khan AA,Habeeb A,Parveen N,et al.Peritoneal transplantation of human fetal hepatocytes for the treatment of acute fatty liver of pregnancy:a case report[J].Trop Gastroenterol,2004; 25(3):141.
7. Lagasse E,Connors H,Al-Dhalimy M,et al.Purified hematopoietic stem cells can differentiate into hepatocytes in vivo[J].Nat Med,2000; 6(11):1229.
8. Auth MK,Woitaschek D,Beste M,et al.Preservation of the synthetic and metabolic capacity of isolated human hepatocytes by coculture with human biliary epithelial cells[J].Liver Transpl,2005; 11(4):410.
9. Murasawa S,Asahara T.Gene modified cell transplantation for vascular regeneration[J].Curr Gene Ther,2007; 7(1):1.
10. Li J,Li LJ,Cao HC,et al.Establishment of highly differentiated immortalized human hepatocyte line with simian virus 40 large tumor antigen for liver based cell therapy[J].ASAIO J,2005; 51(3):262.
11. Mashalova EV,Guha C,Roy-Chowdhury N,et al.Prevention of hepatocyte allograft rejection in rats by transferring adenoviral early region 3 genes into donor cells[J].Hepatology,2007; 45(3):755.
12. Yu CH,Chen HL,Chen WT,et al.Portal hemodynamic changes after hepatocyte transplantation in acute hepatic failure[J].J Biomed Sci,2004; 11(6):756.
13. Kato K,Onodera K,Sawa M,et al.Effect of hepatocyte growth factor on the proliferation of intrasplenically transplanted hepatocytes in rats[J].Biochem Biophys Res Commun,1996; 222(1):101.
14. Ahmad TA,Fujioka H,Eguchi S,et al.Long-term effect of hepatocyte transplantation on fulminant hepatic failure in rats[J].Hepatogastroenterology,2003; 50(50):467.
15. Sigot V,Mediavilla MG,Furno G,et al.A simple and effective method to improve intrasplenic rat hepatocyte transplantation[J].Cell Transplant,2004; 13(7-8):775.
16. Yokoyama T,Ohashi K,Kuge H,et al.In vivo engineering of metabolically active hepatic tissues in a neovascularized subcutaneous cavity[J].Am J Transplant,2006; 6(1):50.
17. Terry C,Dhawan A,Mitry RR,et al.Preincubation of rat and human hepatocytes with cytoprotectants prior to cryopreservation can improve viability and function upon thawing[J].Liver Transpl,2006; 12(1):165.
18. Jamal HZ,Weglarz TC,Sandgren EP.Cryopreserved mouse hepatocytes retain regenerative capacity in vivo[J].Gastroenterology,2000; 118(2):390.
19. Aleem Khan A,Parveen N,Habeeb MA,et al.Journey from hepatocyte transplantation to hepatic stem cells:a novel treatment strategy for liver diseases[J].Indian J Med Res,2006; 123(5):601.
20. Rahman TM,Diakanov I,Selden C,et al.Co-transplantation of encapsulated HepG2 and rat Sertoli cells improves outcome in a thioacetamide induced rat model of acute hepatic failure[J].Transpl Int,2005; 18(8):1001.
21. 侯辉,耿小平.肝切除及肝移植术中缺血预处理的临床研究进展[J].国际外科学杂志,2007; 34(2):128.
22. Dagher I,Boudechiche L,Branger J,et al.Efficient hepatocyte engraftment in a nonhuman primate model after partial portal vein embolization[J].Transplantation,2006; 82(8):1067.
23. Bilir BM,Guinette D,Karrer F,et al.Hepatocyte transplantation in acute liver failure[J].Liver Transpl,2000; 6(1):32.
24. Dhawan A,Mitry RR,Hughes RD.Hepatocyte transplantation for liver-based metabolic disorders[J].J Inherit Metab Dis,2006; 29(2-3):431.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Current Research Advancement of Hepatocyte Transplantation

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