Objective: We describe the features of non-contiguous 2-level cervical degenerative disc disease (NCDDD), investigate the safety and feasibility of artificial cervical disc replacement (ACDR) for the treatment of NCDDD, and expect that our study will provide spine surgeons with an alternative procedure for NCDDD. Methods: Twenty-five patients with NCDDD received ACDR with a Prestige-LP prosthesis. Clinical outcomes were evaluated using the 36-Short Form (SF-36, Mental Component Summary [MCS] and Physical Component Summary [PCS]), Visual Analog Scale (VAS), Japanese Orthopedic Association (JOA), and Neck Disability Index (NDI) scores. Radiographic evaluations included cervical lordosis (CL), range of motion (ROM), and disc height (DH). Data regarding complications were collected as well.

Results: The mean follow-up period was 32.24 months. Clinical outcomes, including SF-36 MCS and PCS, VAS, JOA, and NDI scores significantly improved at the 24-month follow-up (p < 0.05). There were no significant differences in CL and ROM at the 24-month follow-up (p > 0.05). Although there was a significant difference between the before and 3-month follow-up (p < 0.05), the ROM of the intermediate segment (IS) showed a tendency of returning to the preoperative state. The DH of the IS was maintained at each measurement while the DH of the upper and lower operated segments significantly increased at the 24-month follow-up (p < 0.05). One patient, whose prosthesis remained mobile at the last follow-up, showed evidence of heterotopic ossification (HO).

Conclusion: ACDR with the Prestige-LP prosthesis is a safe and feasible alternative procedure for treatment of NCDDD. In the future, a large-sample, prospective randomized controlled study with long-term follow-up will be needed to further demonstrate noncontiguous ACDR as an optimal surgical option for NCDDD. (C) 2016 Elsevier B.V. All rights reserved.

Citation： Wu Tingkui, Wang Beiyu, Ding Chen, Meng Yang, Lou Jigang, Yang Yi, Liu Hao. Artificial cervical disc replacement with the Prestige-LP prosthesis for the treatment of non-contiguous 2-level cervical degenerative disc disease: A minimum 24-month follow-up. West China medical Virtual Journal, 2000, 1(1): 57-62-. doi: 10.1016/j.clineuro.2016.11.015 Copy