Analysis of macular choroidal and retinal pigment epithelium thickness in tilted disc syndrome_Chinese Journal of Ocular Fundus Diseases

Authors：

XuMeiping , YuXinping ,  ChenJie , 张敏 , 郑景伟

The Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China;

Corresponding author：

ChenJie, Email: chenjie@mail.eye.ac.cn

Keywords：

Optic disk/pathology; Choroid/anatomy & histology; Retinal pigment epithelium/anatomy & histology

DOI：

10.3760/cma.j.issn.1005-1015.2014.01.017

Video：

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Objective To observe the macular choroidal and retinal pigment epithelium (RPE) thickness in tilted disc syndrome (TDS). Methods This is a descriptive study. Thirty eyes of 22 TDS patients (TDS group) and 30 eyes of 15 normal subjects (control group) were analyzed. Among TDS group, there were 8 males (11 eyes) and 14 females (19 eyes), the average age was (9.00±2.78) years old. The best corrected visual acuity (BCVA) was 0.3-1.0, and the average spherical equivalent degree was (-3.44±2.22) DS. Among the control group, there were 8 males (16 eyes) and 7 females (14 eyes), the average age was (9.33±1.11) years old. The best corrected visual acuity (BCVA)≥1.0, and the average spherical equivalent degree was (-3.18±1.13)DS. The difference of the spherical equivalent degree between two groups was not statistically significant (t=-1.648, P=0.110). Enhanced depth imaging techniques of frequency-domain optical coherence tomography was used to measure the thickness of choroid and RPE at totally 17 sites. There sites included subfoveal, 4 sites each (500, 1000, 1500 and 2000 μm from the fovea) at the horizontal (nasal/temple) and vertical (superior/inferior) directions. Results The subfoveal choroidal thickness was (235.53±51.77) μm and (273.45±60.3) μm in TDS patients and control respectively, the difference was significant(t=-2.612,P=0.011). The difference of the choroidal thickness of the other 8 horizontal sites (F=24.180) and 8 vertical sites (F=23.390) in TDS group was statistically significant (P=0.000). The TDS choroidal thickness of all horizontal sites except nasal 1000 μm site was thinner than corresponding sites of the control group (P<0.05). The TDS choroidal thickness of the subfoveal site and 4 inferior vertical sites was thinner than corresponding sites of the control group (P<0.05). The subfoveal RPE thickness was (32.56±5.00) μm and (36.58±3.60) μm in TDS patients and control respectively, the difference was significant(t=-3.567,P=0.001). The subfoveal RPE thickness was the thickest among other 16 sites in both groups, and the TDS RPE thickness of all sites was thinner than control group, the difference was statistically significant (P<0.05). Conclusion The choroidal and RPE thickness of TDS patient was thinner than normal subjects.

Citation： XuMeiping, YuXinping, ChenJie. Analysis of macular choroidal and retinal pigment epithelium thickness in tilted disc syndrome. Chinese Journal of Ocular Fundus Diseases, 2014, 30(1): 66-70. doi: 10.3760/cma.j.issn.1005-1015.2014.01.017 Copy

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2.	张承芬.眼底先天性异常[M]//张承芬.眼底病学.2版.北京:人民卫生出版社,2010:187-188.
3.	Giuffrè G.Chorioretinal degenerative changes in the tilted disc syndrome[J]. Int Ophthalmol,1991,15:1-7.
4.	Young SE, Walsh FB,Knox DL. The tilted disc syndrome[J]. Am J Ophthalmol, 1976, 82:16-23.
5.	Spaide RF,Koizumi H, Pozzoni MC.Enhanced depth imaging spectral-domain optical coherence tomography[J]. Am J Ophthalmol, 2008,146:496-500.
6.	Cohen SY, Quentel G, Guiberteau B, et al. Macular serous retinal detachment caused by subretinal leakage in tilted disc syndrome[J]. Ophthalmology,1998,105:1831-1834.
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8.	Leys AM, Cohen SY. Subretinal leakage in myopic eyes with a posterior staphyloma or tilted disk syndrome[J]. Retina,2002,22:659-665.
9.	Prost M, De Laey JJ. Choroidal neovascularization in tilted disc syndrome[J]. Int Ophthalmol,1988,12:131-135.
10.	Stur M. Congenital tilted disk syndrome associated with par-afovealsubretinal neovascularization[J]. Am J Ophthalmol,1988,105:98-99.
11.	Tsuboi S, Uchihori Y, Manabe R.Subretinal neovascularisation in eyes with localised inferior posterior staphylomas[J]. Br J Ophthalmol, 1984,68:869-872.
12.	Mauget-Faÿsse M, Cornut PL, Quaranta El-Maftouhi M,et al. Polypoidal choroidal vasculopathy in tilted disk syndrome and high myopia with staphyloma[J].Am J Ophthalmol, 2006,142:970-975.
13.	Peiretti E, Iranmanesh R, Yannuzzi LA, et al. Polypoidal choroidal vasculopathy associated with tilted disk syndrome[J]. Retin Cases Brief Rep,2008,2:31-33.
14.	Furuta M, Iida T, Maruko I, et al.Submacular choroidal neovascularization at the margin of staphyloma in tilted disk syndrome[J]. Retina,2013,33:71-76.
15.	Dorrell D. The tilted disc[J]. Br J Ophthalmol, 1978, 62:16-20.
16.	Teschner S, Noack J,Birngruber R,et al. Characterization of leakage activity in exudative chorioretinal disease with three-dimensional confocal angiography[J]. Ophthalmology,2003,110:687-697.
17.	Manjunath V, Taha M, Fujimoto JG,et al.Choroidal thickness in normal eye measured using cirrus hd optical coherence tomography[J]. Am J Ophthalmol,2010,150:325-329.
18.	McCourt EA,Cadena BC,Barnett CJ,et al.Measurement of subfoveal choroidal thickness using spectral domain optical coherence tomography[J].Ophthalmic Surg Lasers Imaging, 2010, 41:28-33.
19.	郑茜匀,余新平,陈洁,等.视盘倾斜综合征临床特征初步观察[J].中华眼底病杂志,2011,27:281-283.
20.	Nishida Y, Fujiwara T, Imamura Y, et al. Choroidal thickness and visual acuity in highly myopic eyes[J].Retina,2012,32:1229-1236.
21.	Maruko I, Iida T, Sugano Y, et al. Morphologic choroidal and scleral changes at the macula in tilted disc syndrome with staphyloma using optical coherence tomography[J].Invest Ophthalmol Vis Sci,2011,52:8763-8768.

1. Sowka J, Aoun P. Tilted disc syndrome[J]. Optom Vis Sci, 1999, 76:618-623.
2. 张承芬.眼底先天性异常[M]//张承芬.眼底病学.2版.北京:人民卫生出版社,2010:187-188.
3. Giuffrè G.Chorioretinal degenerative changes in the tilted disc syndrome[J]. Int Ophthalmol,1991,15:1-7.
4. Young SE, Walsh FB,Knox DL. The tilted disc syndrome[J]. Am J Ophthalmol, 1976, 82:16-23.
5. Spaide RF,Koizumi H, Pozzoni MC.Enhanced depth imaging spectral-domain optical coherence tomography[J]. Am J Ophthalmol, 2008,146:496-500.
6. Cohen SY, Quentel G, Guiberteau B, et al. Macular serous retinal detachment caused by subretinal leakage in tilted disc syndrome[J]. Ophthalmology,1998,105:1831-1834.
7. Tosti G. Serous macular detachment and tilted disc syndrome[J]. Ophthalmology, 1999,106:1453-1455.
8. Leys AM, Cohen SY. Subretinal leakage in myopic eyes with a posterior staphyloma or tilted disk syndrome[J]. Retina,2002,22:659-665.
9. Prost M, De Laey JJ. Choroidal neovascularization in tilted disc syndrome[J]. Int Ophthalmol,1988,12:131-135.
10. Stur M. Congenital tilted disk syndrome associated with par-afovealsubretinal neovascularization[J]. Am J Ophthalmol,1988,105:98-99.
11. Tsuboi S, Uchihori Y, Manabe R.Subretinal neovascularisation in eyes with localised inferior posterior staphylomas[J]. Br J Ophthalmol, 1984,68:869-872.
12. Mauget-Faÿsse M, Cornut PL, Quaranta El-Maftouhi M,et al. Polypoidal choroidal vasculopathy in tilted disk syndrome and high myopia with staphyloma[J].Am J Ophthalmol, 2006,142:970-975.
13. Peiretti E, Iranmanesh R, Yannuzzi LA, et al. Polypoidal choroidal vasculopathy associated with tilted disk syndrome[J]. Retin Cases Brief Rep,2008,2:31-33.
14. Furuta M, Iida T, Maruko I, et al.Submacular choroidal neovascularization at the margin of staphyloma in tilted disk syndrome[J]. Retina,2013,33:71-76.
15. Dorrell D. The tilted disc[J]. Br J Ophthalmol, 1978, 62:16-20.
16. Teschner S, Noack J,Birngruber R,et al. Characterization of leakage activity in exudative chorioretinal disease with three-dimensional confocal angiography[J]. Ophthalmology,2003,110:687-697.
17. Manjunath V, Taha M, Fujimoto JG,et al.Choroidal thickness in normal eye measured using cirrus hd optical coherence tomography[J]. Am J Ophthalmol,2010,150:325-329.
18. McCourt EA,Cadena BC,Barnett CJ,et al.Measurement of subfoveal choroidal thickness using spectral domain optical coherence tomography[J].Ophthalmic Surg Lasers Imaging, 2010, 41:28-33.
19. 郑茜匀,余新平,陈洁,等.视盘倾斜综合征临床特征初步观察[J].中华眼底病杂志,2011,27:281-283.
20. Nishida Y, Fujiwara T, Imamura Y, et al. Choroidal thickness and visual acuity in highly myopic eyes[J].Retina,2012,32:1229-1236.
21. Maruko I, Iida T, Sugano Y, et al. Morphologic choroidal and scleral changes at the macula in tilted disc syndrome with staphyloma using optical coherence tomography[J].Invest Ophthalmol Vis Sci,2011,52:8763-8768.

Chinese Journal of Ocular Fundus Diseases

Analysis of macular choroidal and retinal pigment epithelium thickness in tilted disc syndrome

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