Clinical applications of optical fundus imaging technology_Chinese Journal of Ocular Fundus Diseases

Authors：

 SuGuanfang , LiuXin

Eye Center, The Second Hospital of Jilin University, Changchun 130041, China;

Corresponding author：

SuGuanfang, Email: sugf2012@163.com

Keywords：

Diagnostic techniques and procedures/trends; Diagnostic techniques, ophthalmological/trends; Fluorescein angiography; Indocyanine green/diagnostic use; Tomography, optical coherence/trends; Editorial

DOI：

10.3760/cma.j.issn.1005-1015.2014.06.001

Video：

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Abstract Full text Figures/Tables Video References Cited by

Optical imaging technology of ocular fundus, including fundus fluorescein angiography (FFA), optical coherence tomography (OCT) and fundus autofluorescence (FAF), is growing at an unprecedented speed and scale and is integrating into the routine clinical management of ocular fundus diseases, such as diagnosis, treatment, and mechanism study. While FFA allow us to observe the retinal and choroidal blood circulation, OCT and FAF are non-invasive, fast and quantifiable measurement; such techniques show even more unique advantages and are favored tools. All these retinal imaging technologies, together with a variety of retinal function assessments, bring us into the era of big data of ocular fundus diseases. All of these developments are the challenges and opportunities for the operator and user of these fundus optics imaging technologies. In order to improve its clinical applications and allocate resources rationally, we need to understand the optical properties of these retinal imaging technologies, and standardize diagnosis behavior. This is a continuous learning process needs to continue to explore.

Citation： SuGuanfang, LiuXin. Clinical applications of optical fundus imaging technology. Chinese Journal of Ocular Fundus Diseases, 2014, 30(6): 535-539. doi: 10.3760/cma.j.issn.1005-1015.2014.06.001 Copy

1.	Keane PA, Sadda SR. Retinal imaging in the twenty-first century:state of the art and future directions. Ophthalmology, 2014, 121:E1.[2014-07-25]http://www.sciencedirect.com/science/article/pii/S0161642014007015.[published online ahead of print].
2.	Delori FC, Dorey CK, Staurenghi G, et al. In vivo fluorescence of the ocular fundus exhibits retinal pigment epithelium lipofuscin characteristics[J]. Invest Ophthalmol Vis Sci, 1995, 36:718-729.
3.	Gaillard ER, Atherton SJ, Eldred G, et al. Photophysical studies on human retinal lipofuscin[J]. Photochem Photobiol, 1995, 61:448-453.
4.	Spaide RF. Fundus autofluorescence and age-related macular degeneration[J]. Ophthalmology, 2003, 110:392-399.
5.	黎晓新, 赵明威.我国近五年眼底病诊疗技术进展[J].中华眼科杂志, 2010, 46:900-905.
6.	Klemm M, Dietzel A, Haueisen J, et al. Repeatability of autofluorescence lifetime imaging at the human fundus in healthy volunteers[J]. Curr Eye Res, 2013, 38:793-801.
7.	王莉菲, 李瑞峰.正确认识理解光学影像检查的原理特点, 提高光学影像检查技术的应用水平[J].中华眼底病杂志, 2011, 27:109-113.
8.	Bennett TJ, Barry CJ. Ophthalmic imaging today:an ophthalmic photographer's viewpoint-a review[J]. Clin Exp Ophthalmol, 2009, 37:2-13.
9.	Stanga PE, Lim JI, Hamilton P. Indocyanine green angiography in chorioretinal diseases:indications and interpretation:an evidence-based update[J]. Ophthalmology, 2003, 110:15-21.
10.	Baumal CR. Clinical applications of optical coherence tomography[J]. Curr Opin Ophthalmol, 1999, 10:182-188.
11.	Puliafito CA, Hee MR, Lin CP, et al. Imaging of macular diseases with optical coherence tomography[J]. Ophthalmology, 1995, 102:217-229.
12.	Drexler W. Ultrahigh-resolution optical coherence tomography[J]. J Biomed Opt, 2004, 9:47-74.
13.	Fujimoto JG, De Silvestri S, Ippen EP, et al. Femtosecond optical ranging in biological systems[J]. Opt Lett, 1986, 11:150.
14.	Fercher AF, Mengedoht K, Werner W. Eye-length measurement by interferometry with partially coherent light[J]. Opt Lett, 1988, 13:186-188.
15.	Huang D, Swanson EA, Lin CP, et al. Optical coherence tomography[J]. Science, 1991, 254:1178-1181.
16.	黎晓新, 陈玮志.频域光相干断层扫描:眼底影像检查技术的新时代[J].中华眼底病杂志, 2009, 25:161-163.
17.	Wojtkowski M, Leitgeb R, Kowalczyk A, et al. In vivo human retinal imaging by Fourier domain optical coherence tomography[J]. J Biomed Opt, 2002, 7:457-463.
18.	Chinn SR, Swanson EA, Fujimoto JG. Optical coherence tomography using a frequency-tunable optical source[J]. Opt Lett, 1997, 22:340-342.
19.	Ergun E, Hermann B, Wirtitsch M, et al. Assessment of central visual function in Stargardt's disease/fundus flavimaculatus with ultrahigh-resolution optical coherence tomography[J]. Invest Ophthalmol Vis Sci, 2005, 46:310-316.
20.	Adhi M, Liu JJ, Qavi AH, et al. Choroidal analysis in healthy eyes using swept-source optical coherence tomography compared to spectral domain optical coherence tomography[J]. Am J Ophthalmol, 2014, 157:1272-1281.
21.	Sayanagi K, Gomi F, Ikuno Y, et al. Comparison of spectral-domain and high-penetration OCT for observing morphologic changes in age-related macular degeneration and polypoidal choroidal vasculopathy[J]. Graefe's Arch Clin Exp Ophthalmol, 2014, 252:3-9.
22.	王琴慧, 喻晓兵, 戴虹, 等.光动力疗法联合玻璃体腔注射雷珠单抗治疗息肉样脉络膜血管病变疗效观察[J].中华眼底病杂志, 2014, 30:245-248.
23.	Sayanagi K, Gomi F, Akiba M, et al. En-face high-penetration optical coherence tomography imaging in polypoidal choroidal vasculopathy. Br J Ophthalmol, 2014, 98:E1.[2014-08-08]http://bjo.bmj.com/content/early/2014/08/08/bjophthalmol-2013-304658.long.[published online ahead of print].
24.	Nakai K, Gomi F, Ikuno Y, et al. Choroidal observations in Vogt-Koyanagi-Harada disease using high-penetration optical coherence tomography[J]. Graefe's Arch Clin Exp Ophthalmol, 2012, 250:1089-1095.
25.	Uchihori H, Nakai K, Ikuno Y, et al. Choroidal observations in posterior scleritis using high-penetration optical coherence tomography[J]. Int Ophthalmol, 2014, 34:937-943.
26.	Maruko I, Iida T, Sugano Y, et al. Morphologic analysis in pathologic myopia using high-penetration optical coherence tomography[J]. Invest Ophthalmol Vis Sci, 2012, 53:3834-3838.
27.	范雯, 孙杏红, 聂桥, 等.糖尿病视网膜病变患者黄斑中心凹下脉络膜厚度分析[J].中华眼底病杂志, 2014, 30:124-127.
28.	臧晶, 王文娟, 陈立伦, 等.非增生型糖尿病视网膜病变患者黄斑中心凹下脉络膜厚度变化[J].中华眼底病杂志, 2014, 30:128-131.
29.	Huang LL, Hirose T. Portable optical coherence tomography in management of vitreoretinal diseases:current developments, indications, and implications[J]. Semin Ophthalmol, 2012, 27:213-220.
30.	Hahn P, Migacz J, O'Donnell R, et al. Preclinical evaluation and intraoperative human retinal imaging with a high-resolution microscope-integrated spectral domain optical coherence tomography device[J]. Retina, 2013, 33:1328-1337.
31.	Wang Y, Fawzi AA, Varma R, et al. Pilot study of optical coherence tomography measurement of retinal blood flow in retinal and optic nerve diseases[J]. Invest Ophthalmol Vis Sci, 2011, 52:840-845.
32.	Kurokawa K, Sasaki K, Makita S, et al. Three-dimensional retinal and choroidal capillary imaging by power Doppler optical coherence angiography with adaptive optics[J]. Opt Express, 2012, 20:22796-22812.
33.	魏文斌.重视眼底相干光断层成像技术的临床应用与图像解读[J].中华眼科杂志, 2012, 48:97-99.
34.	杨丽红, 田蓓, 史雪辉, 等.中心性浆液性脉络膜视网膜病变的脉络膜厚度改变[J].中华眼科杂志, 2012, 48:874-877.
35.	Brown DM, Regillo CD. Anti-VEGF agents in the treatment of neovascular age-related macular degeneration:applying clinical trial results to the treatment of everyday patients[J]. Am J Ophthalmol, 2007, 144:627-637.
36.	沈胤忱, 许迅, 刘堃.糖尿病黄斑水肿患者黄斑中心凹下脉络膜厚度观察[J].中华眼底病杂志, 2013, 29:9-12.
37.	杨晓璐, 邹海东, 许迅.不同类型糖尿病黄斑水肿患者视网膜敏感度和视力与黄斑厚度相关性分析[J].中华眼科杂志, 2013, 49:1081-1088.
38.	李岩, 曲鹏, 郑微微, 等.中心性浆液性脉络膜视网膜病变治疗前后脉络膜厚度的短期观察[J].中华眼视光学与视觉科学杂志, 2013, 15:14-17.
39.	周容, 贾晓林, 孙祖华, 等.中心性浆液性脉络膜视网膜病变治疗前后视网膜色素上皮-Bruch膜-脉络膜毛细血管复合体中Bruch膜的光相干断层扫描分型特征[J].中华眼底病杂志, 2011, 27:323-326.
40.	郝玉华, 杨娜, 陈鹏飞, 等.累及黄斑的孔源性视网膜脱离患眼巩膜扣带手术前后黄斑微结构改变及其与视力预后的相关性[J].中华眼底病杂志, 2014, 30:343-347.
41.	孙吉君, 杨嘉嵩, 李聪慧, 等.黄斑区脉络膜厚度与孔源性视网膜脱离成功手术复位后视力的相关性[J].中华眼底病杂志, 2013, 29:131-135.
42.	李略, 杨治坤, 董方田.应用增强深部成像的相干光断层扫描测量正常人脉络膜厚度[J].中华眼科杂志, 2012, 48:819-823.
43.	魏文斌, 邵蕾.重视对脉络膜厚度及结构的研究[J].中华眼科杂志, 2014, 50:401-405.
44.	Kim DY, Fingler J, Zawadzki RJ, et al. Optical imaging of the chorioretinal vasculature in the living human eye[J]. Proc Natl Acad Sci USA, 2013, 110:14354-14359.
45.	许迅.规范眼底影像检查数据采集、评估行为, 提升眼底影像检查诊断技术应用水平[J].中华眼底病杂志, 2013, 29:449-452.

1. Keane PA, Sadda SR. Retinal imaging in the twenty-first century:state of the art and future directions. Ophthalmology, 2014, 121:E1.[2014-07-25]http://www.sciencedirect.com/science/article/pii/S0161642014007015.[published online ahead of print].
2. Delori FC, Dorey CK, Staurenghi G, et al. In vivo fluorescence of the ocular fundus exhibits retinal pigment epithelium lipofuscin characteristics[J]. Invest Ophthalmol Vis Sci, 1995, 36:718-729.
3. Gaillard ER, Atherton SJ, Eldred G, et al. Photophysical studies on human retinal lipofuscin[J]. Photochem Photobiol, 1995, 61:448-453.
4. Spaide RF. Fundus autofluorescence and age-related macular degeneration[J]. Ophthalmology, 2003, 110:392-399.
5. 黎晓新, 赵明威.我国近五年眼底病诊疗技术进展[J].中华眼科杂志, 2010, 46:900-905.
6. Klemm M, Dietzel A, Haueisen J, et al. Repeatability of autofluorescence lifetime imaging at the human fundus in healthy volunteers[J]. Curr Eye Res, 2013, 38:793-801.
7. 王莉菲, 李瑞峰.正确认识理解光学影像检查的原理特点, 提高光学影像检查技术的应用水平[J].中华眼底病杂志, 2011, 27:109-113.
8. Bennett TJ, Barry CJ. Ophthalmic imaging today:an ophthalmic photographer's viewpoint-a review[J]. Clin Exp Ophthalmol, 2009, 37:2-13.
9. Stanga PE, Lim JI, Hamilton P. Indocyanine green angiography in chorioretinal diseases:indications and interpretation:an evidence-based update[J]. Ophthalmology, 2003, 110:15-21.
10. Baumal CR. Clinical applications of optical coherence tomography[J]. Curr Opin Ophthalmol, 1999, 10:182-188.
11. Puliafito CA, Hee MR, Lin CP, et al. Imaging of macular diseases with optical coherence tomography[J]. Ophthalmology, 1995, 102:217-229.
12. Drexler W. Ultrahigh-resolution optical coherence tomography[J]. J Biomed Opt, 2004, 9:47-74.
13. Fujimoto JG, De Silvestri S, Ippen EP, et al. Femtosecond optical ranging in biological systems[J]. Opt Lett, 1986, 11:150.
14. Fercher AF, Mengedoht K, Werner W. Eye-length measurement by interferometry with partially coherent light[J]. Opt Lett, 1988, 13:186-188.
15. Huang D, Swanson EA, Lin CP, et al. Optical coherence tomography[J]. Science, 1991, 254:1178-1181.
16. 黎晓新, 陈玮志.频域光相干断层扫描:眼底影像检查技术的新时代[J].中华眼底病杂志, 2009, 25:161-163.
17. Wojtkowski M, Leitgeb R, Kowalczyk A, et al. In vivo human retinal imaging by Fourier domain optical coherence tomography[J]. J Biomed Opt, 2002, 7:457-463.
18. Chinn SR, Swanson EA, Fujimoto JG. Optical coherence tomography using a frequency-tunable optical source[J]. Opt Lett, 1997, 22:340-342.
19. Ergun E, Hermann B, Wirtitsch M, et al. Assessment of central visual function in Stargardt's disease/fundus flavimaculatus with ultrahigh-resolution optical coherence tomography[J]. Invest Ophthalmol Vis Sci, 2005, 46:310-316.
20. Adhi M, Liu JJ, Qavi AH, et al. Choroidal analysis in healthy eyes using swept-source optical coherence tomography compared to spectral domain optical coherence tomography[J]. Am J Ophthalmol, 2014, 157:1272-1281.
21. Sayanagi K, Gomi F, Ikuno Y, et al. Comparison of spectral-domain and high-penetration OCT for observing morphologic changes in age-related macular degeneration and polypoidal choroidal vasculopathy[J]. Graefe's Arch Clin Exp Ophthalmol, 2014, 252:3-9.
22. 王琴慧, 喻晓兵, 戴虹, 等.光动力疗法联合玻璃体腔注射雷珠单抗治疗息肉样脉络膜血管病变疗效观察[J].中华眼底病杂志, 2014, 30:245-248.
23. Sayanagi K, Gomi F, Akiba M, et al. En-face high-penetration optical coherence tomography imaging in polypoidal choroidal vasculopathy. Br J Ophthalmol, 2014, 98:E1.[2014-08-08]http://bjo.bmj.com/content/early/2014/08/08/bjophthalmol-2013-304658.long.[published online ahead of print].
24. Nakai K, Gomi F, Ikuno Y, et al. Choroidal observations in Vogt-Koyanagi-Harada disease using high-penetration optical coherence tomography[J]. Graefe's Arch Clin Exp Ophthalmol, 2012, 250:1089-1095.
25. Uchihori H, Nakai K, Ikuno Y, et al. Choroidal observations in posterior scleritis using high-penetration optical coherence tomography[J]. Int Ophthalmol, 2014, 34:937-943.
26. Maruko I, Iida T, Sugano Y, et al. Morphologic analysis in pathologic myopia using high-penetration optical coherence tomography[J]. Invest Ophthalmol Vis Sci, 2012, 53:3834-3838.
27. 范雯, 孙杏红, 聂桥, 等.糖尿病视网膜病变患者黄斑中心凹下脉络膜厚度分析[J].中华眼底病杂志, 2014, 30:124-127.
28. 臧晶, 王文娟, 陈立伦, 等.非增生型糖尿病视网膜病变患者黄斑中心凹下脉络膜厚度变化[J].中华眼底病杂志, 2014, 30:128-131.
29. Huang LL, Hirose T. Portable optical coherence tomography in management of vitreoretinal diseases:current developments, indications, and implications[J]. Semin Ophthalmol, 2012, 27:213-220.
30. Hahn P, Migacz J, O'Donnell R, et al. Preclinical evaluation and intraoperative human retinal imaging with a high-resolution microscope-integrated spectral domain optical coherence tomography device[J]. Retina, 2013, 33:1328-1337.
31. Wang Y, Fawzi AA, Varma R, et al. Pilot study of optical coherence tomography measurement of retinal blood flow in retinal and optic nerve diseases[J]. Invest Ophthalmol Vis Sci, 2011, 52:840-845.
32. Kurokawa K, Sasaki K, Makita S, et al. Three-dimensional retinal and choroidal capillary imaging by power Doppler optical coherence angiography with adaptive optics[J]. Opt Express, 2012, 20:22796-22812.
33. 魏文斌.重视眼底相干光断层成像技术的临床应用与图像解读[J].中华眼科杂志, 2012, 48:97-99.
34. 杨丽红, 田蓓, 史雪辉, 等.中心性浆液性脉络膜视网膜病变的脉络膜厚度改变[J].中华眼科杂志, 2012, 48:874-877.
35. Brown DM, Regillo CD. Anti-VEGF agents in the treatment of neovascular age-related macular degeneration:applying clinical trial results to the treatment of everyday patients[J]. Am J Ophthalmol, 2007, 144:627-637.
36. 沈胤忱, 许迅, 刘堃.糖尿病黄斑水肿患者黄斑中心凹下脉络膜厚度观察[J].中华眼底病杂志, 2013, 29:9-12.
37. 杨晓璐, 邹海东, 许迅.不同类型糖尿病黄斑水肿患者视网膜敏感度和视力与黄斑厚度相关性分析[J].中华眼科杂志, 2013, 49:1081-1088.
38. 李岩, 曲鹏, 郑微微, 等.中心性浆液性脉络膜视网膜病变治疗前后脉络膜厚度的短期观察[J].中华眼视光学与视觉科学杂志, 2013, 15:14-17.
39. 周容, 贾晓林, 孙祖华, 等.中心性浆液性脉络膜视网膜病变治疗前后视网膜色素上皮-Bruch膜-脉络膜毛细血管复合体中Bruch膜的光相干断层扫描分型特征[J].中华眼底病杂志, 2011, 27:323-326.
40. 郝玉华, 杨娜, 陈鹏飞, 等.累及黄斑的孔源性视网膜脱离患眼巩膜扣带手术前后黄斑微结构改变及其与视力预后的相关性[J].中华眼底病杂志, 2014, 30:343-347.
41. 孙吉君, 杨嘉嵩, 李聪慧, 等.黄斑区脉络膜厚度与孔源性视网膜脱离成功手术复位后视力的相关性[J].中华眼底病杂志, 2013, 29:131-135.
42. 李略, 杨治坤, 董方田.应用增强深部成像的相干光断层扫描测量正常人脉络膜厚度[J].中华眼科杂志, 2012, 48:819-823.
43. 魏文斌, 邵蕾.重视对脉络膜厚度及结构的研究[J].中华眼科杂志, 2014, 50:401-405.
44. Kim DY, Fingler J, Zawadzki RJ, et al. Optical imaging of the chorioretinal vasculature in the living human eye[J]. Proc Natl Acad Sci USA, 2013, 110:14354-14359.
45. 许迅.规范眼底影像检查数据采集、评估行为, 提升眼底影像检查诊断技术应用水平[J].中华眼底病杂志, 2013, 29:449-452.

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Clinical applications of optical fundus imaging technology

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