微小RNA在葡萄膜疾病中的作用研究进展_Chinese Journal of Ocular Fundus Diseases

Authors：

陈琳 , 粘红 ,  李筱荣

300384 天津医科大学眼科医院天津医科大学眼科研究所天津医科大学眼视光学院;

Corresponding author：

李筱荣, Email: xiaorli@163.com

Keywords：

葡萄膜疾病/病因学; 微RNAs; 综述

DOI：

10.3760/cma.j.issn.1005-1015.2015.01.029

Video：

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Abstract Full text Figures/Tables Video References Cited by

微小RNA（miRNA）是一类新发现的内源性非编码小RNA，在细胞生长、发育、分化、增生、凋亡以及肿瘤的发生等生理病理过程中发挥着重要调控作用。多种miRNA在葡萄膜组织中表达，其在葡萄膜炎动物模型的发病过程中表现出一定的相关性。与葡萄膜疾病相关的miRNA基因多态性的临床研究也有助于从遗传学的角度了解疾病的发生发展规律，使葡萄膜疾病的预防以及具有针对性的个体化治疗变成了可能。但如何确定与葡萄膜疾病关系最为密切的miRNA以及与之相对应的靶基因，之后又如何安全的将药物运送至指定靶点还有待进一步研究。

Citation： 陈琳, 粘红, 李筱荣. 微小RNA在葡萄膜疾病中的作用研究进展. Chinese Journal of Ocular Fundus Diseases, 2015, 31(1): 101-104. doi: 10.3760/cma.j.issn.1005-1015.2015.01.029 Copy

1.	Bartel DP. MicroRNAs:genomics, biogenesis, mechanism, and function[J]. Cell, 2004, 116(2):281-297.
2.	Ambros V. MicroRNA pathways in flies and worms:growth, death, fat, stress, and timing[J]. Cell, 2003, 113(6):673-676.
3.	Miska EA. How microRNAs control cell division, differentiation and death[J]. Curr Opin Genet Dev, 2005, 15(5):563-568.
4.	Nussenblatt RB. Bench to bedside:new approaches to the immunotherapy of uveitic disease[J]. Int Rev Immunol, 2002, 21(2-3):273-289.
5.	Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14[J]. Cell, 1993, 75(5):843-854.
6.	Kozomara A, Griffiths-Jones S. miRBase:annotating high confidence microRNAs using deep sequencing data[J]. Nucleic Acids Res, 2014, 42(Database issue):D68-73.
7.	Eulalio A, Huntzinger E, Izaurralde E. Getting to the root of miRNA-mediated gene silencing[J]. Cell, 2008, 132(1):9-14.
8.	Filipowicz W, Bhattacharyya SN, Sonenberg N. Mechanisms of post-transcriptional regulation by microRNAs:are the answers in sight?[J]. Nat Rev Genet, 2008, 9(2):102-114.
9.	Karali M, Peluso I, Gennarino VA, et al. miRNeye:a microRNA expression atlas of the mouse eye[J]. BMC Genomics, 2010, 11:715.
10.	Ryan DG, Oliveira-Fernandes M, Lavker RM. MicroRNAs of the mammalian eye display distinct and overlapping tissue specificity[J]. Mol Vis, 2006, 12:1175-1184.
11.	Frederikse PH, Donnelly R, Partyka LM. miRNA and Dicer in the mammalian lens:expression of brain-specific miRNAs in the lens[J]. Histochem Cell Biol, 2006, 126(1):1-8.
12.	Xu S, Witmer PD, Lumayag S, et al. MicroRNA (miRNA) transcriptome of mouse retina and identification of a sensory organ-specific miRNA cluster[J]. J Biol Chem, 2007, 282(34):25053-25066.
13.	Nussenblatt RB, Fortin E, Schiffman R, et al. Treatment of noninfectious intermediate and posterior uveitis with the humanized anti-Tac mAb:a phaseⅠ/Ⅱclinical trial[J]. Proc Natl Acad Sci USA, 1999, 96(13):7462-7466.
14.	Gritz DC, Wong IG. Incidence and prevalence of uveitis in Northern California:the Northern California Epidemiology of Uveitis Study[J]. Ophthalmology, 2004, 111(3):491-500.
15.	Caspi RR, Silver PB, Chan CC, et al. Genetic susceptibility to experimental autoimmune uveoretinitis in the rat is associated with an elevated Th1 response[J]. J Immunol, 1996, 157(6):2668-2675.
16.	Horai R, Caspi RR. Cytokines in autoimmune uveitis[J]. J Interferon Cytokine Res, 2011, 31(10):733-744.
17.	Agrawal R, Iyer J, Connolly J, et al. Cytokines and biologics in non-infectious autoimmune uveitis:bench to bedside[J]. Indian J Ophthalmol, 2014, 62(1):74-81.
18.	Peng Y, Han G, Shao H, et al. Characterization of IL-17+interphotoreceptor retinoid-binding protein-specific T cells in experimental autoimmune uveitis[J]. Invest Ophthalmol Vis Sci, 2007, 48(9):4153-4161.
19.	Na SY, Park MJ, Park S, et al. Up-regulation of Th17 and related cytokines in Behcet's disease corresponding to disease activity[J]. Clin Exp Rheumatol, 2013, 31(3 Suppl 77):S32-40.
20.	O'Connell RM, Kahn D, Gibson WS, et al. MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development[J]. Immunity, 2010, 33(4):607-619.
21.	Baumjohann D, Ansel KM. MicroRNA-mediated regulation of T helper cell differentiation and plasticity[J]. Nat Rev Immunol, 2013, 13(9):666-678.
22.	Fisson S, Ouakrim H, Touitou V, et al. Cytokine profile in human eyes:contribution of a new cytokine combination for differential diagnosis between intraocular lymphoma or uveitis[J/OL]. PLoS One, 2013, 8(2):52385[2013-02-06].http://dx.plos.org/10.1371/journal.pone.0052385.
23.	Chan CC, Sen HN. Current concepts in diagnosing and managing primary vitreoretinal (intraocular) lymphoma[J]. Discov Med, 2013, 15(81):93-100.
24.	Wang Y, Shen D, Wang VM, et al. Molecular biomarkers for the diagnosis of primary vitreoretinal lymphoma[J]. Int J Mol Sci, 2011, 12(9):5684-5697.
25.	Tuo J, Shen D, Yang HH, et al. Distinct microRNA-155 expression in the vitreous of patients with primary vitreoretinal lymphoma and uveitis[J]. Am J Ophthalmol, 2014, 157(3):728-734.
26.	Agarwal RK, Silver PB, Caspi RR. Rodent models of experimental autoimmune uveitis[J]. Methods Mol Biol, 2012, 900:443-469.
27.	Singh VK, Biswas S, Anand R, et al. Experimental autoimmune uveitis as animal model for human posterior uveitis[J]. Indian J Med Res, 1998, 107:53-67.
28.	Ishida W, Fukuda K, Higuchi T, et al. Dynamic changes of microRNAs in the eye during the development of experimental autoimmune uveoretinitis[J]. Invest Ophthalmol Vis Sci, 2011, 52(1):611-617.
29.	Tarrant TK, Silver PB, Chan CC, et al. Endogenous IL-12 is required for induction and expression of experimental autoimmune uveitis[J]. J Immunol, 1998, 161(1):122-127.
30.	Yu CR, Lee YS, Mahdi RM, et al. Therapeutic targeting of STAT3(signal transducers and activators of transcription 3) pathway inhibits experimental autoimmune uveitis[J/OL]. PLoS One, 2012, 7(1):29742[2012-01-05].http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0029742.
31.	Escobar T, Yu CR, Muljo SA, et al. STAT3 activates miR-155 in Th17 cells and acts in concert to promote experimental autoimmune uveitis[J]. Invest Ophthalmol Vis Sci, 2013, 54(6):4017-4025.
32.	Xu Y, Jin H, Yang X, et al. MicroRNA-93 inhibits inflammatory cytokine production in LPS-stimulated murine macrophages by targeting IRAK4[J]. FEBS Lett, 2014, 588(9):1692-1698.
33.	Yang P, Fang W, Meng Q, et al. Clinical features of chinese patients with Behcet's disease[J]. Ophthalmology, 2008, 115(2):312-318.
34.	Zhou Q, Xiao X, Wang C, et al. Decreased microRNA-155 expression in ocular Behcet's disease but not in Vogt Koyanagi Harada syndrome[J]. Invest Ophthalmol Vis Sci, 2012, 53(9):5665-5674.
35.	Zhou Q, Hou S, Liang L, et al. MicroRNA-146a and Ets-1 gene polymorphisms in ocular Behcet's disease and Vogt-Koyanagi-Harada syndrome[J]. Ann Rheum Dis, 2014, 73(1):170-176.
36.	Qi J, Hou S, Zhang Q, et al. A functional variant of pre-miRNA-196a2 confers risk for Behcet's disease but not for Vogt-Koyanagi-Harada syndrome or AAU in ankylosing spondylitis[J]. Hum Genet, 2013, 132(12):1395-1404.
37.	Chu XK, Chan CC. Sympathetic ophthalmia:to the twenty-first century and beyond[J]. J Ophthalmic Inflamm Infect, 2013, 3(1):49.
38.	Arevalo JF, Garcia RA, Al-Dhibi HA, et al. Update on sympathetic ophthalmia[J]. Middle East Afr J Ophthalmol, 2012, 19(1):13-21.
39.	Kaneko Y, Wu GS, Saraswathy S, et al. Immunopathologic processes in sympathetic ophthalmia as signified by microRNA profiling[J]. Invest Ophthalmol Vis Sci, 2012, 53(7):4197-4204.
40.	Seftor EA, Meltzer PS, Kirschmann DA, et al. Molecular determinants of human uveal melanoma invasion and metastasis[J]. Clin Exp Metastasis, 2002, 19(3):233-246.
41.	Triozzi PL, Eng C, Singh AD. Targeted therapy for uveal melanoma[J]. Cancer Treat Rev, 2008, 34(3):247-258.
42.	Nicoloso MS, Spizzo R, Shimizu M, et al. MicroRNAs--the micro steering wheel of tumour metastases[J]. Nat Rev Cancer, 2009, 9(4):293-302.
43.	Yang C, Wei W. The miRNA expression profile of the uveal melanoma[J]. Sci China Life Sci, 2011, 54(4):351-358.
44.	Liu N, Sun Q, Chen J, et al. MicroRNA-9 suppresses uveal melanoma cell migration and invasion through the NF-kappaB1 pathway[J]. Oncol Rep, 2012, 28(3):961-968.
45.	Worley LA, Long MD, Onken MD, et al. Micro-RNAs associated with metastasis in uveal melanoma identified by multiplexed microarray profiling[J]. Melanoma Res, 2008, 18(3):184-190.

1. Bartel DP. MicroRNAs:genomics, biogenesis, mechanism, and function[J]. Cell, 2004, 116(2):281-297.
2. Ambros V. MicroRNA pathways in flies and worms:growth, death, fat, stress, and timing[J]. Cell, 2003, 113(6):673-676.
3. Miska EA. How microRNAs control cell division, differentiation and death[J]. Curr Opin Genet Dev, 2005, 15(5):563-568.
4. Nussenblatt RB. Bench to bedside:new approaches to the immunotherapy of uveitic disease[J]. Int Rev Immunol, 2002, 21(2-3):273-289.
5. Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14[J]. Cell, 1993, 75(5):843-854.
6. Kozomara A, Griffiths-Jones S. miRBase:annotating high confidence microRNAs using deep sequencing data[J]. Nucleic Acids Res, 2014, 42(Database issue):D68-73.
7. Eulalio A, Huntzinger E, Izaurralde E. Getting to the root of miRNA-mediated gene silencing[J]. Cell, 2008, 132(1):9-14.
8. Filipowicz W, Bhattacharyya SN, Sonenberg N. Mechanisms of post-transcriptional regulation by microRNAs:are the answers in sight?[J]. Nat Rev Genet, 2008, 9(2):102-114.
9. Karali M, Peluso I, Gennarino VA, et al. miRNeye:a microRNA expression atlas of the mouse eye[J]. BMC Genomics, 2010, 11:715.
10. Ryan DG, Oliveira-Fernandes M, Lavker RM. MicroRNAs of the mammalian eye display distinct and overlapping tissue specificity[J]. Mol Vis, 2006, 12:1175-1184.
11. Frederikse PH, Donnelly R, Partyka LM. miRNA and Dicer in the mammalian lens:expression of brain-specific miRNAs in the lens[J]. Histochem Cell Biol, 2006, 126(1):1-8.
12. Xu S, Witmer PD, Lumayag S, et al. MicroRNA (miRNA) transcriptome of mouse retina and identification of a sensory organ-specific miRNA cluster[J]. J Biol Chem, 2007, 282(34):25053-25066.
13. Nussenblatt RB, Fortin E, Schiffman R, et al. Treatment of noninfectious intermediate and posterior uveitis with the humanized anti-Tac mAb:a phaseⅠ/Ⅱclinical trial[J]. Proc Natl Acad Sci USA, 1999, 96(13):7462-7466.
14. Gritz DC, Wong IG. Incidence and prevalence of uveitis in Northern California:the Northern California Epidemiology of Uveitis Study[J]. Ophthalmology, 2004, 111(3):491-500.
15. Caspi RR, Silver PB, Chan CC, et al. Genetic susceptibility to experimental autoimmune uveoretinitis in the rat is associated with an elevated Th1 response[J]. J Immunol, 1996, 157(6):2668-2675.
16. Horai R, Caspi RR. Cytokines in autoimmune uveitis[J]. J Interferon Cytokine Res, 2011, 31(10):733-744.
17. Agrawal R, Iyer J, Connolly J, et al. Cytokines and biologics in non-infectious autoimmune uveitis:bench to bedside[J]. Indian J Ophthalmol, 2014, 62(1):74-81.
18. Peng Y, Han G, Shao H, et al. Characterization of IL-17+interphotoreceptor retinoid-binding protein-specific T cells in experimental autoimmune uveitis[J]. Invest Ophthalmol Vis Sci, 2007, 48(9):4153-4161.
19. Na SY, Park MJ, Park S, et al. Up-regulation of Th17 and related cytokines in Behcet's disease corresponding to disease activity[J]. Clin Exp Rheumatol, 2013, 31(3 Suppl 77):S32-40.
20. O'Connell RM, Kahn D, Gibson WS, et al. MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development[J]. Immunity, 2010, 33(4):607-619.
21. Baumjohann D, Ansel KM. MicroRNA-mediated regulation of T helper cell differentiation and plasticity[J]. Nat Rev Immunol, 2013, 13(9):666-678.
22. Fisson S, Ouakrim H, Touitou V, et al. Cytokine profile in human eyes:contribution of a new cytokine combination for differential diagnosis between intraocular lymphoma or uveitis[J/OL]. PLoS One, 2013, 8(2):52385[2013-02-06].http://dx.plos.org/10.1371/journal.pone.0052385.
23. Chan CC, Sen HN. Current concepts in diagnosing and managing primary vitreoretinal (intraocular) lymphoma[J]. Discov Med, 2013, 15(81):93-100.
24. Wang Y, Shen D, Wang VM, et al. Molecular biomarkers for the diagnosis of primary vitreoretinal lymphoma[J]. Int J Mol Sci, 2011, 12(9):5684-5697.
25. Tuo J, Shen D, Yang HH, et al. Distinct microRNA-155 expression in the vitreous of patients with primary vitreoretinal lymphoma and uveitis[J]. Am J Ophthalmol, 2014, 157(3):728-734.
26. Agarwal RK, Silver PB, Caspi RR. Rodent models of experimental autoimmune uveitis[J]. Methods Mol Biol, 2012, 900:443-469.
27. Singh VK, Biswas S, Anand R, et al. Experimental autoimmune uveitis as animal model for human posterior uveitis[J]. Indian J Med Res, 1998, 107:53-67.
28. Ishida W, Fukuda K, Higuchi T, et al. Dynamic changes of microRNAs in the eye during the development of experimental autoimmune uveoretinitis[J]. Invest Ophthalmol Vis Sci, 2011, 52(1):611-617.
29. Tarrant TK, Silver PB, Chan CC, et al. Endogenous IL-12 is required for induction and expression of experimental autoimmune uveitis[J]. J Immunol, 1998, 161(1):122-127.
30. Yu CR, Lee YS, Mahdi RM, et al. Therapeutic targeting of STAT3(signal transducers and activators of transcription 3) pathway inhibits experimental autoimmune uveitis[J/OL]. PLoS One, 2012, 7(1):29742[2012-01-05].http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0029742.
31. Escobar T, Yu CR, Muljo SA, et al. STAT3 activates miR-155 in Th17 cells and acts in concert to promote experimental autoimmune uveitis[J]. Invest Ophthalmol Vis Sci, 2013, 54(6):4017-4025.
32. Xu Y, Jin H, Yang X, et al. MicroRNA-93 inhibits inflammatory cytokine production in LPS-stimulated murine macrophages by targeting IRAK4[J]. FEBS Lett, 2014, 588(9):1692-1698.
33. Yang P, Fang W, Meng Q, et al. Clinical features of chinese patients with Behcet's disease[J]. Ophthalmology, 2008, 115(2):312-318.
34. Zhou Q, Xiao X, Wang C, et al. Decreased microRNA-155 expression in ocular Behcet's disease but not in Vogt Koyanagi Harada syndrome[J]. Invest Ophthalmol Vis Sci, 2012, 53(9):5665-5674.
35. Zhou Q, Hou S, Liang L, et al. MicroRNA-146a and Ets-1 gene polymorphisms in ocular Behcet's disease and Vogt-Koyanagi-Harada syndrome[J]. Ann Rheum Dis, 2014, 73(1):170-176.
36. Qi J, Hou S, Zhang Q, et al. A functional variant of pre-miRNA-196a2 confers risk for Behcet's disease but not for Vogt-Koyanagi-Harada syndrome or AAU in ankylosing spondylitis[J]. Hum Genet, 2013, 132(12):1395-1404.
37. Chu XK, Chan CC. Sympathetic ophthalmia:to the twenty-first century and beyond[J]. J Ophthalmic Inflamm Infect, 2013, 3(1):49.
38. Arevalo JF, Garcia RA, Al-Dhibi HA, et al. Update on sympathetic ophthalmia[J]. Middle East Afr J Ophthalmol, 2012, 19(1):13-21.
39. Kaneko Y, Wu GS, Saraswathy S, et al. Immunopathologic processes in sympathetic ophthalmia as signified by microRNA profiling[J]. Invest Ophthalmol Vis Sci, 2012, 53(7):4197-4204.
40. Seftor EA, Meltzer PS, Kirschmann DA, et al. Molecular determinants of human uveal melanoma invasion and metastasis[J]. Clin Exp Metastasis, 2002, 19(3):233-246.
41. Triozzi PL, Eng C, Singh AD. Targeted therapy for uveal melanoma[J]. Cancer Treat Rev, 2008, 34(3):247-258.
42. Nicoloso MS, Spizzo R, Shimizu M, et al. MicroRNAs--the micro steering wheel of tumour metastases[J]. Nat Rev Cancer, 2009, 9(4):293-302.
43. Yang C, Wei W. The miRNA expression profile of the uveal melanoma[J]. Sci China Life Sci, 2011, 54(4):351-358.
44. Liu N, Sun Q, Chen J, et al. MicroRNA-9 suppresses uveal melanoma cell migration and invasion through the NF-kappaB1 pathway[J]. Oncol Rep, 2012, 28(3):961-968.
45. Worley LA, Long MD, Onken MD, et al. Micro-RNAs associated with metastasis in uveal melanoma identified by multiplexed microarray profiling[J]. Melanoma Res, 2008, 18(3):184-190.

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微小RNA在葡萄膜疾病中的作用研究进展

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