Objective To compare the effects of intravitreal tamponade of C₃F₈ with silicon oil on postoperative vitreous hemorrhage and visual prognosis after vitrectomy for proliferative diabetic retinopathy (PDR). Methods The clinical data of 121 patients (127 eyes) who underwent primary vitrectomy due to PDR were analyzed retrospectively. All the patients were divided into two groups according to different intravitreal tamponade, including C₃F₈ tamponade group (53 patients with 56 eyes) and silicone oil tamponade group (68 patients with 71 eyes). There was no difference of gender (χ²=0.956), age (t=1.122), duratiion of diabetes (t=0.627), fasting blood glucose (t=1.049), systolic pressure (t=1.056), diastolic pressure (t=0.517), history of hypertension (χ²=0.356), nephropathy (χ²=1.242), preoperative laser photocoagulation (χ²=1.225) and All the patients underwent three port pars plana vitrectomy. The mean follow-up was 2 years ranging from 6 months to 4 years. And then the incidence and onset time of postoperative vitreous hemorrhage and postoperative BCVA of the two groups were compared. Results Postoperative vitreous hemorrhage occurred in 14 of 56 eyes (25.00%) in C₃F₈ tamponade group. The average onset time of postoperative vitreous hemorrhage were (64.64±59.09) days ranging from 7-225 days and mostly were within 30-60 days (35.71%, 5/14). Postoperative vitreous hemorrhage also occurred in 7 of 71 eyes (9.89%) of silicone oil tamponade group after silicone oil removal with an average onset time of (25.29±20.46) days ranging from 3-65 days and were mostly within 15-30 days (42.86%, 3/7). There was a significant difference in the incidence of postoperative vitreous hemorrhage between the two groups (χ²=5.200, P<0.05). BCVA of the two groups was improved significantly after operation (Z=2.472, 3.114; P<0.05). Postoperative BCVA of silicone oil tamponade group was poorer than C₃F₈ tamponade group (Z=1.968, P<0.05). Conclusion Both C₃F₈ and silicone oil tamponade can improve the visual acuity after vitrectomy for PDR. Compared with C₃F₈, silicone oil tamponade had lower incidence and late onset of postoperative vitreous hemorrhage after vitrectomy for PDR.

Citation： FanLingling, YanHua. Effects of C₃F₈ or silicon oil tamponade on postoperative vitreous hemorrhage and visual prognosis after vitrectomy for proliferative diabetic retinopathy. Chinese Journal of Ocular Fundus Diseases, 2015, 31(4): 333-336. doi: 10.3760/cma.j.issn.1005-1015.2015.04.005 Copy