增生性玻璃体视网膜病变中上皮-间质转化机制研究现状_Chinese Journal of Ocular Fundus Diseases

Authors：

卢欣旻 ,  孙晓东

200080 上海交通大学附属第一人民医院眼科;

Corresponding author：

孙晓东, Email: xdsun@sjtu.edu.cn

Keywords：

玻璃体视网膜病, 增生性/病理生理学; 上皮-间质转化; 细胞因子类; 微RNAs; 综述

DOI：

10.3760/cma.j.issn.1005-1015.2015.04.029

Video：

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上皮-间质转化(EMT)是指上皮细胞在特定生理或病理情况下向间质细胞表型转变的过程;是增生性玻璃体视网膜病变(PVR)的重要病理变化。转化生长因子β等细胞因子通过调控下游信号通路诱导视网膜色素上皮(RPE)细胞发生EMT;微小RNA也参与调控RPE细胞发生EMT。深入了解EMT调控因素和相关信号通路,从而抑制RPE细胞发生EMT,将为PVR防治提供新的途径。

Citation： 卢欣旻, 孙晓东. 增生性玻璃体视网膜病变中上皮-间质转化机制研究现状. Chinese Journal of Ocular Fundus Diseases, 2015, 31(4): 412-414. doi: 10.3760/cma.j.issn.1005-1015.2015.04.029 Copy

1.	惠延年. 增生性玻璃体视网膜病变: 带入21世纪的课题[J]. 中华眼底病杂志,1999,15(2): 67-68.
2.	Friedlander M. Fibrosis and diseases of the eye[J]. J Clin Invest,2007,117(3): 576-586.
3.	Kalluri R, Neilson EG. Epithelial-mesenchymal transition and its implications for fibrosis[J]. J Clin Invest,2003,112(12): 1776-1784.
4.	Saika S, Kono-Saika S, Tanaka T, et al. Smad3 is required for dedifferentiation of retinal pigment epithelium following retinal detachment in mice[J]. Lab Invest,2004,84(10): 1245-1258.
5.	Sippy BD, Hofman FM, He S, et al. SV40-immortalized and primary cultured human retinal pigment epithelial cells share similar patterns of cytokine-receptor expression and cytokine responsiveness[J]. Curr Eye Res,1995,14(6): 495-503.
6.	Heldin CH, Miyazono K, Ten Dijke P. TGF-β signalling from cell membrane to nucleus through SMAD proteins[J]. Nature,1997,390(6659): 465-471.
7.	Itoh Y, Kimoto K, Imaizumi M, et al. Inhibition of RhoA/Rho-kinase pathway suppresses the expression of type Ⅰ collagen induced by TGF-β₂ in human retinal pigment epithelial cells[J]. Exp Eye Res,2007,84(3): 464-472.
8.	Lee J, Ko M, Joo CK. Rho plays a key role in TGF-beta1-induced cytoskeletal rearrangement in human retinal pigment epithelium[J]. J Cell Physiol,2008,216(2): 520-526.
9.	Lee SC, Kwon OW, Seong GJ, et al. Epitheliomesenchymal transdifferentiation of cultured RPE cells[J]. Ophthalmic Res,2001,33(2): 80-86.
10.	Parapuram SK, Chang B, Li L, et al. Differential Effects of TGF and vitreous on the transformation of retinal pigment epithelial cells[J]. Invest Ophthalmol Vis Sci,2009,50(12): 5965-5974.
11.	Cheng HC, Ho TC, Chen SL, et al. Troglitazone suppresses transforming growth factor beta-mediated fibrogenesis in retinal pigment epithelial cells[J]. Mol Vis,2008,14: 95-104.
12.	Kita T, Hata Y, Arita R, et al. Role of TGF-β in proliferative vitreoretinal diseases and ROCK as a therapeutic target[J]. Proc Natl Acad Sci USA,2008,105(45):17504-17509.
13.	Kawahara S, Hata Y, Kita T, et al. Potent inhibition of cicatricial contraction in proliferative vitreoretinal diseases by statins[J]. Diabetes,2008,57(10):2784-2793.
14.	Chen X, Xiao W, Liu X, et al. Blockade of Jagged/Notch pathway abrogates transforming growth factor beta2-induced epithelial-mesenchymal transition in human retinal pigment epithelium cells[J]. Curr Mol Med,2014,14(4):523-534.
15.	Chen X, Xiao W, Wang W, et al. The complex interplay between ERK1/2, TGFbeta/Smad, and Jagged/Notch signaling pathways in the regulation of epithelial-mesenchymal transition in retinal pigment epithelium cells[J/OL]. PLoS One,2014, 9(5): 96365[2014-05-02] .http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0096365.
16.	Lee J, Moon HJ, Lee JM, et al. Smad3 regulates Rho signaling via NET1 in the transforming growth factor-β-induced epithelial-mesenchymal transition of human retinal pigment epithelial cells[J]. J Biol Chem,2010,285(34): 26618-26627.
17.	Tsapara A, Luthert P, Greenwood J, et al. The RhoA activator GEF-H1/Lfc is a transforming growth factor-β target gene and effector that regulates α-smooth muscle actin expression and cell migration[J]. Mol Biol Cell,2010,21(6): 860-870.
18.	Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition[J]. J Clin Invest,2009,119(6): 1420-1428.
19.	Zhu J, Nguyen D, Ouyang H, et al. Inhibition of RhoA/Rho-kinase pathway suppresses the expression of extracellular matrix induced by CTGF or TGF-β in ARPE-19[J].Int J Ophthalmol, 2013,6(1): 8-14.
20.	Limb G, Alam A, Earley O, et al. Distribution of cytokine proteins within epiretinal membranes in proliferative vitreoretinopathy[J]. Curr Eye Res,1994,13(11): 791-798.
21.	Yang P. Human RPE expression of cell survival factors[J]. Invest Ophthalmol Vis Sci,2005,46(5): 1755-1764.
22.	Ponta H, Sherman L, Herrlich PA. CD44: from adhesion molecules to signalling regulators[J]. Nat Rev Mol Cell Biol,2003,4(1): 33-45.
23.	Takahashi E, Haga A, Tanihara H. Merlin regulates epithelial-to-mesenchymal transition of ARPE-19 cells via TAK1-p38MAPK-mediated activation[J]. Invest Ophthalmol Vis Sci,2015,56(4): 2449-2458.
24.	Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function[J]. Cell,2004,116(2): 281-297.
25.	Bartel DP. MicroRNAs: target recognition and regulatory functions[J]. Cell,2009,136(2): 215-233.
26.	Li M, Li H, Liu X, et al. MicroRNA-29b regulates TGF-beta1-mediated epithelial-mesenchymal transition of retinal pigment epithelial cells by targeting AKT2[J/OL]. Exp Cell Res,2014[2014-09-28]. http://www.sciencedirect.com/science/article/pii/S0014482714004315.[published online ahead of print].
27.	Wang FE, Zhang C, Maminishkis A, et al. MicroRNA-204/211 alters epithelial physiology[J]. FASEB J,2010,24(5): 1552-1571.
28.	Adijanto J, Castorino JJ, Wang ZX, et al. Microphthalmia-associated transcription factor (MITF) promotes differentiation of human retinal pigment epithelium (RPE) by regulating microRNAs-204/211 expression[J]. J Biol Chem,2012,287(24): 20491-20503.

1. 惠延年. 增生性玻璃体视网膜病变: 带入21世纪的课题[J]. 中华眼底病杂志,1999,15(2): 67-68.
2. Friedlander M. Fibrosis and diseases of the eye[J]. J Clin Invest,2007,117(3): 576-586.
3. Kalluri R, Neilson EG. Epithelial-mesenchymal transition and its implications for fibrosis[J]. J Clin Invest,2003,112(12): 1776-1784.
4. Saika S, Kono-Saika S, Tanaka T, et al. Smad3 is required for dedifferentiation of retinal pigment epithelium following retinal detachment in mice[J]. Lab Invest,2004,84(10): 1245-1258.
5. Sippy BD, Hofman FM, He S, et al. SV40-immortalized and primary cultured human retinal pigment epithelial cells share similar patterns of cytokine-receptor expression and cytokine responsiveness[J]. Curr Eye Res,1995,14(6): 495-503.
6. Heldin CH, Miyazono K, Ten Dijke P. TGF-β signalling from cell membrane to nucleus through SMAD proteins[J]. Nature,1997,390(6659): 465-471.
7. Itoh Y, Kimoto K, Imaizumi M, et al. Inhibition of RhoA/Rho-kinase pathway suppresses the expression of type Ⅰ collagen induced by TGF-β₂ in human retinal pigment epithelial cells[J]. Exp Eye Res,2007,84(3): 464-472.
8. Lee J, Ko M, Joo CK. Rho plays a key role in TGF-beta1-induced cytoskeletal rearrangement in human retinal pigment epithelium[J]. J Cell Physiol,2008,216(2): 520-526.
9. Lee SC, Kwon OW, Seong GJ, et al. Epitheliomesenchymal transdifferentiation of cultured RPE cells[J]. Ophthalmic Res,2001,33(2): 80-86.
10. Parapuram SK, Chang B, Li L, et al. Differential Effects of TGF and vitreous on the transformation of retinal pigment epithelial cells[J]. Invest Ophthalmol Vis Sci,2009,50(12): 5965-5974.
11. Cheng HC, Ho TC, Chen SL, et al. Troglitazone suppresses transforming growth factor beta-mediated fibrogenesis in retinal pigment epithelial cells[J]. Mol Vis,2008,14: 95-104.
12. Kita T, Hata Y, Arita R, et al. Role of TGF-β in proliferative vitreoretinal diseases and ROCK as a therapeutic target[J]. Proc Natl Acad Sci USA,2008,105(45):17504-17509.
13. Kawahara S, Hata Y, Kita T, et al. Potent inhibition of cicatricial contraction in proliferative vitreoretinal diseases by statins[J]. Diabetes,2008,57(10):2784-2793.
14. Chen X, Xiao W, Liu X, et al. Blockade of Jagged/Notch pathway abrogates transforming growth factor beta2-induced epithelial-mesenchymal transition in human retinal pigment epithelium cells[J]. Curr Mol Med,2014,14(4):523-534.
15. Chen X, Xiao W, Wang W, et al. The complex interplay between ERK1/2, TGFbeta/Smad, and Jagged/Notch signaling pathways in the regulation of epithelial-mesenchymal transition in retinal pigment epithelium cells[J/OL]. PLoS One,2014, 9(5): 96365[2014-05-02] .http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0096365.
16. Lee J, Moon HJ, Lee JM, et al. Smad3 regulates Rho signaling via NET1 in the transforming growth factor-β-induced epithelial-mesenchymal transition of human retinal pigment epithelial cells[J]. J Biol Chem,2010,285(34): 26618-26627.
17. Tsapara A, Luthert P, Greenwood J, et al. The RhoA activator GEF-H1/Lfc is a transforming growth factor-β target gene and effector that regulates α-smooth muscle actin expression and cell migration[J]. Mol Biol Cell,2010,21(6): 860-870.
18. Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition[J]. J Clin Invest,2009,119(6): 1420-1428.
19. Zhu J, Nguyen D, Ouyang H, et al. Inhibition of RhoA/Rho-kinase pathway suppresses the expression of extracellular matrix induced by CTGF or TGF-β in ARPE-19[J].Int J Ophthalmol, 2013,6(1): 8-14.
20. Limb G, Alam A, Earley O, et al. Distribution of cytokine proteins within epiretinal membranes in proliferative vitreoretinopathy[J]. Curr Eye Res,1994,13(11): 791-798.
21. Yang P. Human RPE expression of cell survival factors[J]. Invest Ophthalmol Vis Sci,2005,46(5): 1755-1764.
22. Ponta H, Sherman L, Herrlich PA. CD44: from adhesion molecules to signalling regulators[J]. Nat Rev Mol Cell Biol,2003,4(1): 33-45.
23. Takahashi E, Haga A, Tanihara H. Merlin regulates epithelial-to-mesenchymal transition of ARPE-19 cells via TAK1-p38MAPK-mediated activation[J]. Invest Ophthalmol Vis Sci,2015,56(4): 2449-2458.
24. Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function[J]. Cell,2004,116(2): 281-297.
25. Bartel DP. MicroRNAs: target recognition and regulatory functions[J]. Cell,2009,136(2): 215-233.
26. Li M, Li H, Liu X, et al. MicroRNA-29b regulates TGF-beta1-mediated epithelial-mesenchymal transition of retinal pigment epithelial cells by targeting AKT2[J/OL]. Exp Cell Res,2014[2014-09-28]. http://www.sciencedirect.com/science/article/pii/S0014482714004315.[published online ahead of print].
27. Wang FE, Zhang C, Maminishkis A, et al. MicroRNA-204/211 alters epithelial physiology[J]. FASEB J,2010,24(5): 1552-1571.
28. Adijanto J, Castorino JJ, Wang ZX, et al. Microphthalmia-associated transcription factor (MITF) promotes differentiation of human retinal pigment epithelium (RPE) by regulating microRNAs-204/211 expression[J]. J Biol Chem,2012,287(24): 20491-20503.

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