Correlation study between retinal thickness and age, gender of normal children in the urban of Beijing_Chinese Journal of Ocular Fundus Diseases

Authors：

HaoJianchen , ZhangJing , LiXiaoqing , 李雪迎 , 张世杰 , 彭媛 ,  杨柳

Department of Ophtalmology, Peking University First Hospital, Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing 100034, China;

Corresponding author：

杨柳, Email: Lucy02114@163.com

Keywords：

Retina/growth & development; Child; Age factors; Sex factors; Tomography, optical coherence

DOI：

10.3760/cma.j.issn.1005-1015.2015.05.007

Video：

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Objective To determine the retinal thickness of normal children 3-6 years old and its relationship with the age and gender. Methods In a cross-sectional study, 480 eyes of 240 normal preschool children including 115 male and 125 female, ages 3 to 6 years in the urban of Beijing, China were included. The average age was (4.93±0.77) years old. The visual acuity, slit-lamp microscopy and frequency domain optical coherence tomography (FD-OCT, Optvue, Inc. USA) were examined. The retinal thickness of the macular fovea and 500, 750, 1500 μm from temporal and nasal side around the fovea were measured. 32 eyes were excluded from the study because they couldn't cooperate. Pearson correlation analysis was used to determine the correlation between age and macular retinal thickness. Independent samples group t-test was used to compare the differences between boys and girls. Results The mean thickness of macular fovea was (169.10±20.587) μm. The mean macular thickness of boys was significantly higher than girls (t=-4.549, -6.167, -5.492, -5.163, -6.749, -7.494, -6.874; P≤0.001). The mean thickness of 500 μm and 750 μm from nasal side of macular fovea were significantly higher than temporal side (t=5.594, 15.778, 7.678, 18.180; P < 0.001). There was no significant relevance between macular thickness and age. Conclusions The mean macular thickness of boys is significantly higher than girls in normal children in the urban of Beijing. There is no significant relevance between macular thickness and age.

Citation： HaoJianchen, ZhangJing, LiXiaoqing. Correlation study between retinal thickness and age, gender of normal children in the urban of Beijing. Chinese Journal of Ocular Fundus Diseases, 2015, 31(5): 439-442. doi: 10.3760/cma.j.issn.1005-1015.2015.05.007 Copy

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8.	Huynh SC, Wang XY, Burlutsky G, et al. Symmetry of optical coherence tomography retinal measurements in young children[J].Am J Ophthalmol, 2007, 143(3):518-520.
9.	Costa RA, Skaf M, Melo LA, et al. Retinal assessment using optical coherence tomography[J].Prog Retin Eye Res, 2006, 25(3):325-353.
10.	Gerth C, Zawadzki RJ, Heon E, et al. High-resolution retinal imaging in young children using a handheld scanner and Fourier-domain optical coherence tomography[J].J AAPOS, 2009, 13(1):72-74.
11.	Scott AW, Farsiu S, Enyedi LB, et al. Imaging the infant retina with a hand-held spectral-domain optical coherence tomography device[J].Am J Ophthalmol, 2009, 147(2): 364-373.
12.	Mactier H, Maroo S, Bradnam M, et al. Ocular biometry in preterm infants: implications for estimation of retinal illuminance[J].Invest Ophthalmol Vis Sci, 2008, 49(1):453-457.
13.	Cook A, White S, Batterbury M, et al. Ocular growth and refractive error development in premature infants with or without retinopathy of prematurity[J]. Invest Ophthalmol Vis Sci, 2008, 49(12):5199-5207.
14.	Chan OY, Edwards M. Refractive errors in Hong Kong Chinese pre-school children[J].Optom Vis Sci, 1993, 70(6):501-505.
15.	Saunders KJ.Early refractive development in humans[J].Surv Ophthalmol, 1995, 40(3):207-216.
16.	Pennie FC, Wood IC, Olsen C, et al. A longitudinal study of the biometric and refractive changes in full-term infants during the first year of life[J].Vision Res, 2001, 41(21):2799-2810.
17.	Mactier H, Maroo S, Bradnam M, et al. Ocular biometry in preterm infants: implications for estimation of retinal illuminance[J].Invest Ophthalmol Vis Sci, 2008, 49(1):453-457.
18.	Wang J, Smith HA, Donaldson DL, et al. Macular structural characteristics in children with congenital and developmental cataracts[J]. J AAPOS, 2014, 18(5):417-422.
19.	Yanni SE, Wang J, Cheng CS, et al. Normative reference ranges for the retinal nerve fiber layer, macula, and retinal layer thicknesses in children[J].Am J Ophthalmol, 2013, 155(2):354-360.
20.	Altemir I, Pueyo V, Elía N, et al.Reproducibility of optical coherence tomography measurements in children[J].Am J Ophthalmol, 2013, 155(1):171-176.
21.	Asrani S, Zou S, d'Anna S, et al.Noninvasive mapping of the normal retinal thickness at the posterior pole[J].Ophthalmology, 1999, 106(2):269-273.
22.	Ecsedy M, Szamosi A, Karkó C, et al. A comparison of macular structure imaged by optical coherence tomography in preterm and full-term children[J].Invest Ophthalmol Vis Sci, 2007, 48(11):5207-5211.
23.	Grover S, Murthy RK, Brar VS, et al. Comparison of retinal thickness in normal eyes using Stratus and Spectralis optical coherence tomography[J].Invest Ophthalmol Vis Sci, 2010, 51(5):2644-2647.

1. Huang D, Swanson EA, Lin CP, et al. Optical coherence tomography[J].Science, 1991, 254(5035): 1178-1181.
2. Alamouti B, Funk J.Retinal thickness decreases with age: an OCT study[J].Br J Ophthalmol, 2003, 87(7):899-901.
3. Altemir I, Pueyo V, Elía N, et al.Reproducibility of optical coherence tomography measurements in children[J].Am J Ophthalmol, 2013, 155(1):171-176.
4. Park KA, Oh SY. Analysis of spectral-domain optical coherence tomography in preterm children: retinal layer thickness and choroidal thickness profiles[J].Invest Ophthalmol Vis Sci, 2012, 53(11):7201-7207.
5. El-Dairi MA, Asrani SG, Enyedi LB, et al. Optical coherence tomography in the eyes of normal children[J].Arch Ophthalmol, 2009, 127(1):50-58.
6. Samarawickrama C, Wang JJ, Huynh SC, et al. Macular thickness, retinal thickness, and optic disk parameters in dominant compared with nondominant eyes[J]. J AAPOS, 2009, 13(2):142-147.
7. Dickmann A, Petroni S, Perrotta V, et al. Measurement of retinal nerve fiber layer thickness, macular thickness, and foveal volume in amblyopic eyes using spectral-domain optical coherence tomography[J].J AAPOS, 2012, 16(1):86-88.
8. Huynh SC, Wang XY, Burlutsky G, et al. Symmetry of optical coherence tomography retinal measurements in young children[J].Am J Ophthalmol, 2007, 143(3):518-520.
9. Costa RA, Skaf M, Melo LA, et al. Retinal assessment using optical coherence tomography[J].Prog Retin Eye Res, 2006, 25(3):325-353.
10. Gerth C, Zawadzki RJ, Heon E, et al. High-resolution retinal imaging in young children using a handheld scanner and Fourier-domain optical coherence tomography[J].J AAPOS, 2009, 13(1):72-74.
11. Scott AW, Farsiu S, Enyedi LB, et al. Imaging the infant retina with a hand-held spectral-domain optical coherence tomography device[J].Am J Ophthalmol, 2009, 147(2): 364-373.
12. Mactier H, Maroo S, Bradnam M, et al. Ocular biometry in preterm infants: implications for estimation of retinal illuminance[J].Invest Ophthalmol Vis Sci, 2008, 49(1):453-457.
13. Cook A, White S, Batterbury M, et al. Ocular growth and refractive error development in premature infants with or without retinopathy of prematurity[J]. Invest Ophthalmol Vis Sci, 2008, 49(12):5199-5207.
14. Chan OY, Edwards M. Refractive errors in Hong Kong Chinese pre-school children[J].Optom Vis Sci, 1993, 70(6):501-505.
15. Saunders KJ.Early refractive development in humans[J].Surv Ophthalmol, 1995, 40(3):207-216.
16. Pennie FC, Wood IC, Olsen C, et al. A longitudinal study of the biometric and refractive changes in full-term infants during the first year of life[J].Vision Res, 2001, 41(21):2799-2810.
17. Mactier H, Maroo S, Bradnam M, et al. Ocular biometry in preterm infants: implications for estimation of retinal illuminance[J].Invest Ophthalmol Vis Sci, 2008, 49(1):453-457.
18. Wang J, Smith HA, Donaldson DL, et al. Macular structural characteristics in children with congenital and developmental cataracts[J]. J AAPOS, 2014, 18(5):417-422.
19. Yanni SE, Wang J, Cheng CS, et al. Normative reference ranges for the retinal nerve fiber layer, macula, and retinal layer thicknesses in children[J].Am J Ophthalmol, 2013, 155(2):354-360.
20. Altemir I, Pueyo V, Elía N, et al.Reproducibility of optical coherence tomography measurements in children[J].Am J Ophthalmol, 2013, 155(1):171-176.
21. Asrani S, Zou S, d'Anna S, et al.Noninvasive mapping of the normal retinal thickness at the posterior pole[J].Ophthalmology, 1999, 106(2):269-273.
22. Ecsedy M, Szamosi A, Karkó C, et al. A comparison of macular structure imaged by optical coherence tomography in preterm and full-term children[J].Invest Ophthalmol Vis Sci, 2007, 48(11):5207-5211.
23. Grover S, Murthy RK, Brar VS, et al. Comparison of retinal thickness in normal eyes using Stratus and Spectralis optical coherence tomography[J].Invest Ophthalmol Vis Sci, 2010, 51(5):2644-2647.

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Correlation study between retinal thickness and age, gender of normal children in the urban of Beijing

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