视神经脊髓炎相关性视神经炎临床研究进展_Chinese Journal of Ocular Fundus Diseases

Authors：

赵朔 , 徐全刚 ,  魏世辉

100853 北京, 解放军总医院眼科;

Corresponding author：

魏世辉, Email: weishihui706@hotmail.com

Keywords：

视神经脊髓炎; 视神经炎; 水通道蛋白4; 综述

DOI：

10.3760/cma.j.issn.1005-1015.2015.06.027

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

急性视神经炎(ON)可作为视神经脊髓炎(NMO)的首发症状。水通道蛋白4抗体(AQP4-Ab)导致的星形胶质细胞损伤是NMO谱系疾病主要的发病机制。NMO中发生的ON及合并血清AQP4-Ab阳性的ON定义为NMO相关性视神经炎(NMO-ON)。NMO-ON在亚洲人群中高发, 较其他类型ON表现为更重的视力损害及更大的复发倾向, 且可因脑干或脊髓受累而致残, 需要及早诊断并加用免疫抑制剂预防复发。了解NMO-ON的临床特点、实验室检查、治疗方法和预后转归可为NMO-ON的早期鉴别与提高诊治水平提供帮助。

Citation： 赵朔, 徐全刚, 魏世辉. 视神经脊髓炎相关性视神经炎临床研究进展. Chinese Journal of Ocular Fundus Diseases, 2015, 31(6): 605-608. doi: 10.3760/cma.j.issn.1005-1015.2015.06.027 Copy

1.	Wingerchuk DM, Lennon VA, Pittock SJ, et al.Revised diagnostic criteria for neuromyelitis optica[J]. Neurology, 2006, 66(10):1485-1489.
2.	Kleiter I, Hellwig K, Berthele A, et al.Failure of natalizumab to prevent relapses in neuromyelitis optica[J]. Arch Neurol, 2012, 69(2):239-245.
3.	Lennon VA, Wingerchuk DM, Kryzer TJ, et al.A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis[J]. Lancet, 2004, 364(9451):2106-2112.
4.	Wingerchuk DM, Banwell B, Bennett JL, et al.International consensus diagnostic criteria for neuromyelitis optica spectrum disorders[J].Neurology, 2015, 85(2):177-189.
5.	Zhang H, Bennett JL, Verkman AS. Ex vivo spinal cord slice model of neuromyelitis optica reveals novel immunopathogenic mechanisms[J].Ann Neurol, 2011, 70(6): 943-954.
6.	Asavapanumas N, Ratelade J, Papadopoulos MC, et al.Experimental mouse model of optic neuritis with inflammatory demyelination produced by passive transfer of neuromyelitis optica-immunoglobulin G[J].J Neuroinflammation, 2014, 11:16.
7.	Chang KH, Ro LS, Lyu RK, et al. Biomarkers for neuromyelitis optica[J].Clin Chim Acta, 2015, 440:64-71.
8.	Tingjun C, Zhaohui L, Zhaocai J, et al. Changes of CXCL12, CXCL14 and PDGF levels in the brain of patients with idiopathic demyelinating optic neuritis and neuromyelitis optica[J].J Neuroimmunol, 2015, 279:1-6.
9.	Asgari N, Lillevang ST, Skejoe HP, et al. A population-based study of neuromyelitis optica in Caucasians[J]. Neurology, 2011, 76(18):1589-1595.
10.	Chan KH, Lee R, Lee JC, et al. Central nervous system inflammatory demyelinating disorders among Hong Kong Chinese[J].J Neuroimmunol, 2013, 262(1-2):100-105.
11.	Wingerchuk DM, Lennon VA, Lucchinetti CF, et al. The spectrum of neuromyelitis optica[J].Lancet Neurol, 2007, 6(9):805-815.
12.	Wingerchuk DM, Weinshenker BG. Neuromyelitis optica: clinical predictors of a relapsing course and survival[J].Neurology, 2003, 60(5):848-853.
13.	Bourre B, Marignier R, Zephir H, et al. Neuromyelitis optica and pregnancy[J]. Neurology, 2012, 78(12):875-879.
14.	Graves J, Grandhe S, Weinfurtner K, et al. Protective environmental factors for neuromyelitis optica[J]. Neurology, 2014, 83(21):1923-1929.
15.	Papais-Alvarenga RM, Carellos SC, Alvarenga MP, et al. Clinical course of optic neuritis in patients with relapsing neuromyelitis optica[J].Arch Ophthalmol, 2008, 126(1):12-16.
16.	Wingerchuk DM, Hogancamp WF, O'Brien PC, et al. The clinical course of neuromyelitis optica (Devićs syndrome)[J]. Neurology, 1999, 53(5):1107-1114.
17.	Lim YM, Pyun SY, Lim HT, et al. First-ever optic neuritis: distinguishing subsequent neuromyelitis optica from multiple sclerosis[J].Neurol Sci, 2014, 35(5):781-783.
18.	Takagi M, Tanaka K, Suzuki T, et al. Anti-aquaporin-4 antibody-positive optic neuritis[J]. Acta Ophthalmol, 2009, 87(5):562-566.
19.	Mealy MA, Wingerchuk DM, Greenberg BM, et al. Epidemiology of neuromyelitis optica in the United States: a multicenter analysis[J].Arch Neurol, 2012, 69(9): 1176-1180.
20.	Kim SM, Go MJ, Sung JJ, et al.Painful tonic spasm in neuromyelitis optica: incidence, diagnostic utility, and clinical characteristics[J].Arch Neurol, 2012, 69(8): 1026-1031.
21.	Fernandes DB, Ramos Rde I, Falcochio C, et al. Comparison of visual acuity and automated perimetry findings in patients with neuromyelitis optica or multiple sclerosis after single or multiple attacks of optic neuritis[J].J Neuroophthalmol, 2012, 32(2):102-106.
22.	Nakajima H, Hosokawa T, Sugino M, et al. Visual field defects of optic neuritis in neuromyelitis optica compared with multiple sclerosis[J]. BMC Neurol, 2010, 10:45.
23.	Neto SP, Alvarenga RM, Vasconcelos CC, et al. Evaluation of pattern-reversal visual evoked potential in patients with neuromyelitis optica[J].Mult Scler, 2013, 19(2):173-178.
24.	Naismith RT, Tutlam NT, Xu J, et al. Optical coherence tomography differs in neuromyelitis optica compared with multiple sclerosis[J]. Neurology, 2009, 72(12): 1077-1082.
25.	Monteiro ML, Fernandes DB, Apostolos-Pereira SL, et al.Quantification of retinal neural loss in patients with neuromyelitis optica and multiple sclerosis with or without optic neuritis using Fourier-domain optical coherence tomography[J].Invest Ophthalmol Vis Sci, 2012, 53(7):3959-3966.
26.	Fernandes DB, Raza AS, Nogueira RG, et al.Evaluation of inner retinal layers in patients with multiple sclerosis or neuromyelitis optica using optical coherence tomography[J].Ophthalmology, 2013, 120(2):387-394.
27.	Sotirchos ES, Saidha S, Byraiah G, et al. In vivo identification of morphologic retinal abnormalities in neuromyelitis optica[J]. Neurology, 2013, 80(15): 1406-1414.
28.	Pula JH, Kattah JC, Keung B, et al. Longitudinally extensive optic neuritis in neuromyelitis optica spectrum disorder[J].J Neurol Sci, 2014, 345(1-2):209-212.
29.	Storoni M, Davagnanam I, Radon M, et al. Distinguishing optic neuritis in neuromyelitis optica spectrum disease from multiple sclerosis: a novel magnetic resonance imaging scoring system[J]. J Neuroophthalmol, 2013, 33(2):123-127.
30.	Pekcevik Y, Izbudak I. Perivascular enhancement in a patient with neuromyelitis optica spectrum disease during an optic neuritis attack[J].J Neuroimaging, 2015, 25(4):686-687.
31.	Cheng C, Jiang Y, Chen X, et al. Clinical, radiographic characteristics and immunomodulating changes in neuromyelitis optica with extensive brain lesions[J]. BMC Neurol, 2013, 13:72.
32.	Yoshimura S, Isobe N, Matsushita T, et al. Distinct genetic and infectious profiles in Japanese neuromyelitis optica patients according to anti-aquaporin 4 antibody status[J].J Neurol Neurosurg Psychiatry, 2013, 84(1):29-34.
33.	Waters PJ, McKeon A, Leite MI, et al. Serologic diagnosis of NMO: a multicenter comparison of aquaporin-4-IgG assays[J]. Neurology, 2012, 78(9):665-671.
34.	Lai C, Tian G, Takahashi T, et al. Neuromyelitis optica antibodies in patients with severe optic neuritis in China[J].J Neuroophthalmol, 2011, 31(1):16-19.
35.	Sato DK, Callegaro D, Lana-Peixoto MA, et al.Distinction between MOG antibody-positive and AQP4 antibody-positive NMO spectrum disorders[J]. Neurology, 2014, 82(6):474-481.
36.	Iyer A, Elsone L, Appleton R, et al. A review of the current literature and a guide to the early diagnosis of autoimmune disorders associated with neuromyelitis optica[J].Autoimmunity, 2014, 47(3):154-161.
37.	Iorio R, Rindi G, Erra C, et al. Neuromyelitis optica spectrum disorder as a paraneoplastic manifestation of lung adenocarcinoma expressing aquaporin-4[J].Mult Scler, 2015, 21(6):791-794.
38.	Trebst C, Jarius S, Berthele A, et al. Update on the diagnosis and treatment of neuromyelitis optica: recommendations of the Neuromyelitis Optica Study Group (NEMOS)[J].J Neurol, 2014, 261(1):1-16.
39.	Jarius S, Ruprecht K, Wildemann B, et al.Contrasting disease patterns in seropositive and seronegative neuromyelitis optica: a multicentre study of 175 patients[J]. J Neuroinflammation, 2012, 9:14.

1. Wingerchuk DM, Lennon VA, Pittock SJ, et al.Revised diagnostic criteria for neuromyelitis optica[J]. Neurology, 2006, 66(10):1485-1489.
2. Kleiter I, Hellwig K, Berthele A, et al.Failure of natalizumab to prevent relapses in neuromyelitis optica[J]. Arch Neurol, 2012, 69(2):239-245.
3. Lennon VA, Wingerchuk DM, Kryzer TJ, et al.A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis[J]. Lancet, 2004, 364(9451):2106-2112.
4. Wingerchuk DM, Banwell B, Bennett JL, et al.International consensus diagnostic criteria for neuromyelitis optica spectrum disorders[J].Neurology, 2015, 85(2):177-189.
5. Zhang H, Bennett JL, Verkman AS. Ex vivo spinal cord slice model of neuromyelitis optica reveals novel immunopathogenic mechanisms[J].Ann Neurol, 2011, 70(6): 943-954.
6. Asavapanumas N, Ratelade J, Papadopoulos MC, et al.Experimental mouse model of optic neuritis with inflammatory demyelination produced by passive transfer of neuromyelitis optica-immunoglobulin G[J].J Neuroinflammation, 2014, 11:16.
7. Chang KH, Ro LS, Lyu RK, et al. Biomarkers for neuromyelitis optica[J].Clin Chim Acta, 2015, 440:64-71.
8. Tingjun C, Zhaohui L, Zhaocai J, et al. Changes of CXCL12, CXCL14 and PDGF levels in the brain of patients with idiopathic demyelinating optic neuritis and neuromyelitis optica[J].J Neuroimmunol, 2015, 279:1-6.
9. Asgari N, Lillevang ST, Skejoe HP, et al. A population-based study of neuromyelitis optica in Caucasians[J]. Neurology, 2011, 76(18):1589-1595.
10. Chan KH, Lee R, Lee JC, et al. Central nervous system inflammatory demyelinating disorders among Hong Kong Chinese[J].J Neuroimmunol, 2013, 262(1-2):100-105.
11. Wingerchuk DM, Lennon VA, Lucchinetti CF, et al. The spectrum of neuromyelitis optica[J].Lancet Neurol, 2007, 6(9):805-815.
12. Wingerchuk DM, Weinshenker BG. Neuromyelitis optica: clinical predictors of a relapsing course and survival[J].Neurology, 2003, 60(5):848-853.
13. Bourre B, Marignier R, Zephir H, et al. Neuromyelitis optica and pregnancy[J]. Neurology, 2012, 78(12):875-879.
14. Graves J, Grandhe S, Weinfurtner K, et al. Protective environmental factors for neuromyelitis optica[J]. Neurology, 2014, 83(21):1923-1929.
15. Papais-Alvarenga RM, Carellos SC, Alvarenga MP, et al. Clinical course of optic neuritis in patients with relapsing neuromyelitis optica[J].Arch Ophthalmol, 2008, 126(1):12-16.
16. Wingerchuk DM, Hogancamp WF, O'Brien PC, et al. The clinical course of neuromyelitis optica (Devićs syndrome)[J]. Neurology, 1999, 53(5):1107-1114.
17. Lim YM, Pyun SY, Lim HT, et al. First-ever optic neuritis: distinguishing subsequent neuromyelitis optica from multiple sclerosis[J].Neurol Sci, 2014, 35(5):781-783.
18. Takagi M, Tanaka K, Suzuki T, et al. Anti-aquaporin-4 antibody-positive optic neuritis[J]. Acta Ophthalmol, 2009, 87(5):562-566.
19. Mealy MA, Wingerchuk DM, Greenberg BM, et al. Epidemiology of neuromyelitis optica in the United States: a multicenter analysis[J].Arch Neurol, 2012, 69(9): 1176-1180.
20. Kim SM, Go MJ, Sung JJ, et al.Painful tonic spasm in neuromyelitis optica: incidence, diagnostic utility, and clinical characteristics[J].Arch Neurol, 2012, 69(8): 1026-1031.
21. Fernandes DB, Ramos Rde I, Falcochio C, et al. Comparison of visual acuity and automated perimetry findings in patients with neuromyelitis optica or multiple sclerosis after single or multiple attacks of optic neuritis[J].J Neuroophthalmol, 2012, 32(2):102-106.
22. Nakajima H, Hosokawa T, Sugino M, et al. Visual field defects of optic neuritis in neuromyelitis optica compared with multiple sclerosis[J]. BMC Neurol, 2010, 10:45.
23. Neto SP, Alvarenga RM, Vasconcelos CC, et al. Evaluation of pattern-reversal visual evoked potential in patients with neuromyelitis optica[J].Mult Scler, 2013, 19(2):173-178.
24. Naismith RT, Tutlam NT, Xu J, et al. Optical coherence tomography differs in neuromyelitis optica compared with multiple sclerosis[J]. Neurology, 2009, 72(12): 1077-1082.
25. Monteiro ML, Fernandes DB, Apostolos-Pereira SL, et al.Quantification of retinal neural loss in patients with neuromyelitis optica and multiple sclerosis with or without optic neuritis using Fourier-domain optical coherence tomography[J].Invest Ophthalmol Vis Sci, 2012, 53(7):3959-3966.
26. Fernandes DB, Raza AS, Nogueira RG, et al.Evaluation of inner retinal layers in patients with multiple sclerosis or neuromyelitis optica using optical coherence tomography[J].Ophthalmology, 2013, 120(2):387-394.
27. Sotirchos ES, Saidha S, Byraiah G, et al. In vivo identification of morphologic retinal abnormalities in neuromyelitis optica[J]. Neurology, 2013, 80(15): 1406-1414.
28. Pula JH, Kattah JC, Keung B, et al. Longitudinally extensive optic neuritis in neuromyelitis optica spectrum disorder[J].J Neurol Sci, 2014, 345(1-2):209-212.
29. Storoni M, Davagnanam I, Radon M, et al. Distinguishing optic neuritis in neuromyelitis optica spectrum disease from multiple sclerosis: a novel magnetic resonance imaging scoring system[J]. J Neuroophthalmol, 2013, 33(2):123-127.
30. Pekcevik Y, Izbudak I. Perivascular enhancement in a patient with neuromyelitis optica spectrum disease during an optic neuritis attack[J].J Neuroimaging, 2015, 25(4):686-687.
31. Cheng C, Jiang Y, Chen X, et al. Clinical, radiographic characteristics and immunomodulating changes in neuromyelitis optica with extensive brain lesions[J]. BMC Neurol, 2013, 13:72.
32. Yoshimura S, Isobe N, Matsushita T, et al. Distinct genetic and infectious profiles in Japanese neuromyelitis optica patients according to anti-aquaporin 4 antibody status[J].J Neurol Neurosurg Psychiatry, 2013, 84(1):29-34.
33. Waters PJ, McKeon A, Leite MI, et al. Serologic diagnosis of NMO: a multicenter comparison of aquaporin-4-IgG assays[J]. Neurology, 2012, 78(9):665-671.
34. Lai C, Tian G, Takahashi T, et al. Neuromyelitis optica antibodies in patients with severe optic neuritis in China[J].J Neuroophthalmol, 2011, 31(1):16-19.
35. Sato DK, Callegaro D, Lana-Peixoto MA, et al.Distinction between MOG antibody-positive and AQP4 antibody-positive NMO spectrum disorders[J]. Neurology, 2014, 82(6):474-481.
36. Iyer A, Elsone L, Appleton R, et al. A review of the current literature and a guide to the early diagnosis of autoimmune disorders associated with neuromyelitis optica[J].Autoimmunity, 2014, 47(3):154-161.
37. Iorio R, Rindi G, Erra C, et al. Neuromyelitis optica spectrum disorder as a paraneoplastic manifestation of lung adenocarcinoma expressing aquaporin-4[J].Mult Scler, 2015, 21(6):791-794.
38. Trebst C, Jarius S, Berthele A, et al. Update on the diagnosis and treatment of neuromyelitis optica: recommendations of the Neuromyelitis Optica Study Group (NEMOS)[J].J Neurol, 2014, 261(1):1-16.
39. Jarius S, Ruprecht K, Wildemann B, et al.Contrasting disease patterns in seropositive and seronegative neuromyelitis optica: a multicentre study of 175 patients[J]. J Neuroinflammation, 2012, 9:14.

Previous Article
视盘小凹合并黄斑裂孔一例
Next Article
颅脑病变导致的后视路损伤患者视觉康复治疗研究进展

Chinese Journal of Ocular Fundus Diseases

视神经脊髓炎相关性视神经炎临床研究进展

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content