P2X7 receptor and relationship with the death of retinal neurons_Chinese Journal of Ocular Fundus Diseases

Authors：

YaoXieyi ,  XuXun

Department of Ophthalmology, The First People's Hospital Affiliated to Shanghai JiaoTong University, Shanghai 200080, China;

Corresponding author：

XuXun, Email: drxuxun@sjtu.edu.cn

Keywords：

Retinal Neurons/cytology; Cell death; Receptors, purinergic P2X7; Review

DOI：

10.3760/cma.j.issn.1005-1015.2016.01.030

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Retinal neuronal cells are crucial in the formation of vision. Injury or death of these cells may lead to irreversible damage to visual function due to their low regenerative capacity. The P2X7 receptor is a trimeric adenosine triphosphate (ATP)-gated cation channel. Recent studies have shown that P2X7 receptor plays a role in retinal neuronal death. In a series of animal models, when exposed to conditions of hypoxia or ischemia, elevated ocular pressure, trauma and exogenous agonists, P2X7 receptor activated by extracellular ATP can cause death of retinal neuronal cells such as retinal ganglion cells and photoreceptor cells through direct or indirect pathways. Blocking the expression and function of P2X7 receptor by its specific antagonist and gene knocking-out, the loss of retinal neuronal cells is significantly attenuated. P2X7 receptor may become a potential novel neuroprotective target for diseases related to the loss of retinal neurons.

Citation： YaoXieyi, XuXun. P2X7 receptor and relationship with the death of retinal neurons. Chinese Journal of Ocular Fundus Diseases, 2016, 32(1): 108-110. doi: 10.3760/cma.j.issn.1005-1015.2016.01.030 Copy

1.	Johnson TV, Martin KR. Cell transplantation approaches to retinal ganglion cell neuroprotection in glaucoma[J]. Curr Opin Pharmacol,2013,13(1):78-82. DOI: 10.1016/j.coph.2012.08.003.
2.	Meyer-Rusenberg B, Pavlidis M, Stupp T, et al. Pathological changes in human retinalganglion cells associated with diabetic and hypertensive retinopathy[J]. Graefe's Arch Clin Exp Ophthalmol,2007,245(7):1009-1018. DOI 10.1007/s00417-006-0489-x.
3.	Tewari M, Seth P. Emerging role of P2X7 receptors in CNS health and disease[J]. Ageing Res Rev,2015, 24(Pt B):328-342. DOI: 10.1016/j.arr.2015.10.001.
4.	Bartlett R, Stokes L, Sluyter R. The P2X7 receptor channel: recent developments and the use of P2X7 antagonists in models of disease[J]. Pharmacol Rev,2014,66(3):638-675. DOI: 10.1124/pr.113.008003.
5.	Vessey KA, Fletcher EL. Rod and cone pathway signalling is altered in the P2X7 receptor knock out mouse[J/OL]. PLoS One,2012,7(1):29990[2012-01-10] . http://dx.plos.org/10.1371/journal.pone.0029990. DOI: 10.1371/journal.pone.0029990.
6.	Sanderson J, Dartt DA, Trinkaus-Randall V, et al. Purines in the eye: recent evidence for the physiological and pathological role of purines in the RPE, retinal neurons, astrocytes, muller cells, lens, trabecular meshwork, cornea and lacrimal gland[J]. Exp Eye Res,2014,127:270-279. DOI: 10.1016/j.exer.2014.08.009.
7.	Domercq M, Perez-Samartin A, Aparicio D, et al. P2X7 receptors mediate ischemic damage to oligodendrocytes[J]. Glia,2010,58(6):730-740. DOI: 10.1002/glia.20958.
8.	Hu H, Lu W, Zhang M, et al. Stimulation of the P2X7 receptor kills rat retinal ganglion cells in vivo[J]. Exp Eye Res,2010,91(3):425-432. DOI:10.1016/j.exer.2010.06.017.
9.	Sugiyama T, Oku H, Shibata M, et al. Involvement of P2X7 receptors in the hypoxia-induced death of rat retinal neurons[J]. Invest Ophthalmol Vis Sci,2010,51(6):3236-3243. DOI: 10.1167/iovs.09-4192.
10.	Niyadurupola N, Sidaway P, Ma N, et al. P2X7 receptor activation mediates retinal ganglion cell death in a human retina model of ischemic neurodegeneration[J]. Invest Ophthalmol Vis Sci,2013,54(3):2163-2170. DOI: 10.1167/iovs.12-10968.
11.	Kakurai K, Sugiyama T, Kurimoto T, et al. Involvement of P2X(7) receptors in retinal ganglion cell death after optic nerve crush injury in rats[J]. Neurosci Lett,2013,534:237-241. DOI: 10.1016/j.neulet.2012.11.060.
12.	Sugiyama T, Lee SY, Horie T, et al. P2X(7) receptor activation may be involved in neuronal loss in the retinal ganglion cell layer after acute elevation of intraocular pressure in rats[J]. Mol Vis,2013,19:2080-2091.
13.	Notomi S, Hisatomi T, Kanemaru T, et al. Critical involvement of extracellular ATP acting on P2RX7 purinergic receptors in photoreceptor cell death[J]. Am J Pathol,2011,179(6):2798-2809. DOI: 10.1016/j.ajpath.2011.08.035.
14.	Puthussery T, Fletcher E. Extracellular ATP induces retinal photoreceptor apoptosis through activation of purinoceptors in rodents[J]. J Comp Neurol,2009,513(4):430-440. DOI: 10.1002/cne.21964.
15.	Notomi S, Hisatomi T, Murakami Y, et al. Dynamic increase in extracellular ATP accelerates photoreceptor cell apoptosis via ligation of P2RX7 in subretinal hemorrhage[J/OL]. PLoS One,2013,8(1):e53338. http://dx.plos.org/10.1371/journal.pone.0053338. DOI: 10.1371/journal.pone.0053338.
16.	Barros-Barbosa AR, Lobo MG, Ferreirinha F, et al. P2X7 receptor activation downmodulates Na(+)-dependent high-affinity GABA and glutamate transport into rat brain cortex synaptosomes[J]. Neuroscience,2015,306:74-90. DOI:10.1016/j.neuroscience.2015.08.026.
17.	Anccasi RM, Ornelas IM, Cossenza M, et al. ATP induces the death of developing avian retinal neurons in culture via activation of P2X7 and glutamate receptors[J]. Purinergic Signal,2013,9(1):15-29. DOI: 10.1007/s11302-012-9324-5.
18.	Sakamoto K, Endo K, Suzuki T, et al. P2X7 receptor antagonists protect against N-methyl-d-aspartic acid-induced neuronal injury in the rat retina[J]. Eur J Pharmacol,2015,756:52-58. DOI: 10.1016/j.ejphar.2015.03.008.
19.	Baudelet D, Lipka E, Millet R, et al. Involvement of the P2X7 purinergic receptor in inflammation: an update of antagonists series since 2009 and their promising therapeutic potential[J]. Curr Med Chem,2015,22(6):713-729. DOI: 10.2174/0929867322666141212120926.
20.	Fowler BJ, Gelfand BD, Kim Y, et al. Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity[J]. Science,2014,346(6212):1000-1003. DOI: 10.1126/science.1261754.
21.	Kurashima Y, Amiya T, Nochi T, et al. Extracellular ATP mediates mast cell-dependent intestinal inflammation through P2X7 purinoceptors[J]. Nat Commun,2012,3:1034. DOI: 10.1038/ncomms2023.
22.	Pardon E, Laeremans T, Triest S, et al. A general protocol for the generation of nanobodies for structural biology[J]. Nat Protoc,2014,9(3):674-693. DOI:10.1038/nprot.2014.039.

1. Johnson TV, Martin KR. Cell transplantation approaches to retinal ganglion cell neuroprotection in glaucoma[J]. Curr Opin Pharmacol,2013,13(1):78-82. DOI: 10.1016/j.coph.2012.08.003.
2. Meyer-Rusenberg B, Pavlidis M, Stupp T, et al. Pathological changes in human retinalganglion cells associated with diabetic and hypertensive retinopathy[J]. Graefe's Arch Clin Exp Ophthalmol,2007,245(7):1009-1018. DOI 10.1007/s00417-006-0489-x.
3. Tewari M, Seth P. Emerging role of P2X7 receptors in CNS health and disease[J]. Ageing Res Rev,2015, 24(Pt B):328-342. DOI: 10.1016/j.arr.2015.10.001.
4. Bartlett R, Stokes L, Sluyter R. The P2X7 receptor channel: recent developments and the use of P2X7 antagonists in models of disease[J]. Pharmacol Rev,2014,66(3):638-675. DOI: 10.1124/pr.113.008003.
5. Vessey KA, Fletcher EL. Rod and cone pathway signalling is altered in the P2X7 receptor knock out mouse[J/OL]. PLoS One,2012,7(1):29990[2012-01-10] . http://dx.plos.org/10.1371/journal.pone.0029990. DOI: 10.1371/journal.pone.0029990.
6. Sanderson J, Dartt DA, Trinkaus-Randall V, et al. Purines in the eye: recent evidence for the physiological and pathological role of purines in the RPE, retinal neurons, astrocytes, muller cells, lens, trabecular meshwork, cornea and lacrimal gland[J]. Exp Eye Res,2014,127:270-279. DOI: 10.1016/j.exer.2014.08.009.
7. Domercq M, Perez-Samartin A, Aparicio D, et al. P2X7 receptors mediate ischemic damage to oligodendrocytes[J]. Glia,2010,58(6):730-740. DOI: 10.1002/glia.20958.
8. Hu H, Lu W, Zhang M, et al. Stimulation of the P2X7 receptor kills rat retinal ganglion cells in vivo[J]. Exp Eye Res,2010,91(3):425-432. DOI:10.1016/j.exer.2010.06.017.
9. Sugiyama T, Oku H, Shibata M, et al. Involvement of P2X7 receptors in the hypoxia-induced death of rat retinal neurons[J]. Invest Ophthalmol Vis Sci,2010,51(6):3236-3243. DOI: 10.1167/iovs.09-4192.
10. Niyadurupola N, Sidaway P, Ma N, et al. P2X7 receptor activation mediates retinal ganglion cell death in a human retina model of ischemic neurodegeneration[J]. Invest Ophthalmol Vis Sci,2013,54(3):2163-2170. DOI: 10.1167/iovs.12-10968.
11. Kakurai K, Sugiyama T, Kurimoto T, et al. Involvement of P2X(7) receptors in retinal ganglion cell death after optic nerve crush injury in rats[J]. Neurosci Lett,2013,534:237-241. DOI: 10.1016/j.neulet.2012.11.060.
12. Sugiyama T, Lee SY, Horie T, et al. P2X(7) receptor activation may be involved in neuronal loss in the retinal ganglion cell layer after acute elevation of intraocular pressure in rats[J]. Mol Vis,2013,19:2080-2091.
13. Notomi S, Hisatomi T, Kanemaru T, et al. Critical involvement of extracellular ATP acting on P2RX7 purinergic receptors in photoreceptor cell death[J]. Am J Pathol,2011,179(6):2798-2809. DOI: 10.1016/j.ajpath.2011.08.035.
14. Puthussery T, Fletcher E. Extracellular ATP induces retinal photoreceptor apoptosis through activation of purinoceptors in rodents[J]. J Comp Neurol,2009,513(4):430-440. DOI: 10.1002/cne.21964.
15. Notomi S, Hisatomi T, Murakami Y, et al. Dynamic increase in extracellular ATP accelerates photoreceptor cell apoptosis via ligation of P2RX7 in subretinal hemorrhage[J/OL]. PLoS One,2013,8(1):e53338. http://dx.plos.org/10.1371/journal.pone.0053338. DOI: 10.1371/journal.pone.0053338.
16. Barros-Barbosa AR, Lobo MG, Ferreirinha F, et al. P2X7 receptor activation downmodulates Na(+)-dependent high-affinity GABA and glutamate transport into rat brain cortex synaptosomes[J]. Neuroscience,2015,306:74-90. DOI:10.1016/j.neuroscience.2015.08.026.
17. Anccasi RM, Ornelas IM, Cossenza M, et al. ATP induces the death of developing avian retinal neurons in culture via activation of P2X7 and glutamate receptors[J]. Purinergic Signal,2013,9(1):15-29. DOI: 10.1007/s11302-012-9324-5.
18. Sakamoto K, Endo K, Suzuki T, et al. P2X7 receptor antagonists protect against N-methyl-d-aspartic acid-induced neuronal injury in the rat retina[J]. Eur J Pharmacol,2015,756:52-58. DOI: 10.1016/j.ejphar.2015.03.008.
19. Baudelet D, Lipka E, Millet R, et al. Involvement of the P2X7 purinergic receptor in inflammation: an update of antagonists series since 2009 and their promising therapeutic potential[J]. Curr Med Chem,2015,22(6):713-729. DOI: 10.2174/0929867322666141212120926.
20. Fowler BJ, Gelfand BD, Kim Y, et al. Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity[J]. Science,2014,346(6212):1000-1003. DOI: 10.1126/science.1261754.
21. Kurashima Y, Amiya T, Nochi T, et al. Extracellular ATP mediates mast cell-dependent intestinal inflammation through P2X7 purinoceptors[J]. Nat Commun,2012,3:1034. DOI: 10.1038/ncomms2023.
22. Pardon E, Laeremans T, Triest S, et al. A general protocol for the generation of nanobodies for structural biology[J]. Nat Protoc,2014,9(3):674-693. DOI:10.1038/nprot.2014.039.

Chinese Journal of Ocular Fundus Diseases

P2X7 receptor and relationship with the death of retinal neurons

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content